Phenomics: the next challenge
David Houle, Diddahally R. Govindaraju and Stig Omholt in Nature Reviews Genetics
David Houle, Diddahally R. Govindaraju and Stig Omholt
A key goal of biology is to understand phenotypic characteristics, such as health, disease and evolutionary fitness. Phenotypic variation is produced through a complex web of interactions between genotype and environment, and such a 'genotype–phenotype' map is inaccessible without the detailed phenotypic data that allow these interactions to be studied. Despite this need, our ability to characterize phenomes — the full set of phenotypes of an individual — lags behind our ability to characterize genomes. Phenomics should be recognized and pursued as an independent discipline to enable the development and adoption of high-throughput and high-dimensional phenotyping.
December 2010, 11: 855-866 DOI: 10.1038/nrg2897