Harald Thidemann Johansen

Image of Harald Thidemann Johansen
Norwegian version of this page
Phone +47-22856595
Mobile phone 91674070
Fax +47-22854402
Username
Visiting address Gydas vei 8 0363 OSLO
Postal address Postboks 1068 Blindern 0316 OSLO
Other affiliations School of Pharmacy

Professional interests

My professional interests are related to the effects of drugs as described in the dicipline of pharmacology. In research I have always worked with proteolytic enzymes, ie enzymes that cleave proteins. I'm especially interested in cysteine proteases and the role these enzymes play in the development of cancer and atherosclerosis.

Teaching

I teach pharmacology, physiology and pharmacotherapy. This teaching takes place in the following courses of the Pharmacy program:

Background

I graduated as Cand.pharm. from the School of Pharmacy in 1979.

Appointments

Member of The Promotion Committe, School of Pharmacy

 

Tags: Pharmacology, Cell and molecular biology, Pharmaceuticals, Pharmacy, Biochemistry, Physiology, Life Science, Oncology, Proteases, Proteolytic enzymes, Cathepsins, Legumain, Cystatin

Publications

  • Jafari, Abbas; Qanie, Diyako; Andersen, Thomas L.; Zhang, Yuxi; Chen, Li; Postert, Benno; Parsons, Stuart; Ditzel, Nicholas; Khosla, Sundeep; Johansen, Harald Thidemann; Kjærsgaard-Andersen, Per; Delaissé, Jean-Marie; Abdallah, Basem M.; Hesselson, Daniel; Solberg, Rigmor & Kassem, Moustapha (2017). Legumain regulates differentiation fate of human bone marrow stromal cells and is altered in postmenopausal osteoporosis. Stem Cell Reports.  ISSN 2213-6711.  8(2), s 373- 386 . doi: 10.1016/j.stemcr.2017.01.003
  • Lunde, Ngoc Nguyen Dieu; Haugen, Mads Haugland; Larsen, Kristina Broe Bodin; Damgaard, Ingrid; Pettersen, Solveig; Kasem, Roya; Rut, Wioletta; Drag, Marcin; Poreba, Marcin; Johansen, Harald Thidemann & Solberg, Rigmor (2017). Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions. Biochimie.  ISSN 0300-9084.  139, s 27- 37 . doi: 10.1016/j.biochi.2017.05.009
  • Lunde, Ngoc Nguyen Dieu; Holm, Sverre; Dahl, Tuva Børresdatter; Inass, Elyouncha; Sporsheim, Bjørnar; Gregersen, Ida; Abbas, Azhar; Skjelland, Mona; Espevik, Terje; Solberg, Rigmor; Johansen, Harald Thidemann & Halvorsen, Bente (2017). Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis. Atherosclerosis.  ISSN 0021-9150.  257, s 216- 223 . doi: 10.1016/j.atherosclerosis.2016.11.026
  • Johansen, Harald Thidemann; Seip, Knut Fredrik & Nielsen, Erik Waage (2016). Bradykininutløste angioødemer . Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  124(4), s 31- 35
  • Seip, Knut Fredrik; Evjenth, Bjørg; Hovland, Anders; Dybwik, Knut Gustav; Johansen, Harald Thidemann; Fure, Hilde; Mollnes, Tom Eirik & Nielsen, Erik Waage (2016). Bradykinin-Induced Shock Increase Exhaled Nitric Oxide, Complement Activation and Cytokine Production in Pigs . Journal of Cardiology & Clinical Research.  ISSN 2333-6676.  4(2) Full text in Research Archive
  • Berven, Lise; Skjeldal, Frode Miltzow; Prydz, Kristian; Zubaidi, Layla Mohammad Khader; Ballance, Simon; Johansen, Harald Thidemann & Samuelsen, Anne Berit C. (2015). Particulate yeast β-glucan is internalized by RAW 264.7 macrophages and reduces the activity of the tumor-associated protease legumain. Bioactive Carbohydrates and Dietary Fibre.  ISSN 2212-6198.  6(1), s 15- 23 . doi: 10.1016/j.bcdf.2015.06.003
  • Seip, Knut Fredrik; Bjerknes, Kari Christiane; Johansen, Harald Thidemann; Nielsen, Erik Waage; Landrø, Linn Aina Ysland & Reubsaet, Leon (2014). Bradykinin analysis revived - A validated method for determination of its stable metabolite in whole blood by LC-MS/MS . Journal of chromatography. B.  ISSN 1570-0232.  947-948, s 139- 144 . doi: 10.1016/j.jchromb.2013.12.033
  • Smith, Robert; Solberg, Rigmor; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild; Thoresen, G. Hege & Johansen, Harald Thidemann (2014). Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. PLoS ONE.  ISSN 1932-6203.  9(1:85721) . doi: 10.1371/journal.pone.0085721
  • Smith, Robert; Åstrand, Ove Alexander Høgmoen; Nguyen, Luan Minh; Elvestrand, Tina; Hagelin, Gunnar; Solberg, Rigmor; Johansen, Harald Thidemann & Rongved, Pål (2014). Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  22(13), s 3309- 3315 . doi: 10.1016/j.bmc.2014.04.056
  • Solberg, Rigmor; Smith, Robert; Almlöf, Maria; Tewolde, Eyassu Araia; Nilsen, Hilde & Johansen, Harald Thidemann (2014). Atorvastatin inhibits processing, activity and secretion of legumain in macrophages. Biological chemistry (Print).  ISSN 1431-6730.  396(1), s 71- 80 . doi: 10.1515/hsz-2014-0172
  • Solberg, Rigmor; Smith, Robert; Almlöf, Maria; Tewolde, Eyassu Araia; Nilsen, Hilde & Johansen, Harald Thidemann (2014). Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin. Biological chemistry (Print).  ISSN 1431-6730.  396(1), s 71- 80 . doi: 10.1515/hsz-2014-0172
  • Berven, Lise; Johansen, Harald Thidemann; Solberg, Rigmor; Kolset, Svein Olav & Samuelsen, Anne Berit C. (2013). Autoactivation of prolegumain is accelerated by glycosaminoglycans. Biochimie.  ISSN 0300-9084.  95(4), s 772- 781 . doi: 10.1016/j.biochi.2012.11.002
  • Berven, Lise; Solberg, Rigmor; Truong, Hoa Hong Thi; Arlov, Øystein; Aachmann, Finn Lillelund; Skjåk-Bræk, Gudmund; Jacobsen, Wolfgang Mathias; Johansen, Harald Thidemann & Samuelsen, Anne Berit C. (2013). Alginates induce legumain activity in RAW 264.7 cells and accelerate autoactivation of prolegumain. Bioactive Carbohydrates and Dietary Fibre.  ISSN 2212-6198.  2, s 30- 44 . doi: 10.1016/j.bcdf.2013.08.003
  • Haugen, Mads Haugland; Johansen, Harald Thidemann; Pettersen, Solveig; Solberg, Rigmor; Brix, Klaudia; Flatmark, Kjersti & Mælandsmo, Gunhild (2013). Nuclear Legumain Activity in Colorectal Cancer. PLoS ONE.  ISSN 1932-6203.  8(1) . doi: 10.1371/journal.pone.0052980 Full text in Research Archive
  • Johansen, Harald Thidemann & Solberg, Rigmor (2012). Extracellular functions of cystein proteases, In Nikos K Karamanos (ed.),  Extracellular matrix: Pathobiology and signaling.  Walter de Gruyter.  ISBN 978-3-11-025876-9.  Kapittel 4.2.  s 239 - 260
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Haugen, Mads Haugland; Pettersen, Solveig; Mælandsmo, Gunhild; Abrahamson, Magnus & Solberg, Rigmor (2012). Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M. Biochimie.  ISSN 0300-9084.  94(12), s 2590- 2599 . doi: 10.1016/j.biochi.2012.07.026
  • Barratt-Due, Andreas; Johansen, Harald Thidemann; Sokolov, Andrey; Thorgersen, Ebbe Billmann; Hellerud, Bernt C; Reubsaet, Leon; Seip, Knut Fredrik; Tønnessen, Tor Inge; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Castellheim, Albert; Mollnes, Tom Eirik & Nielsen, Erik Waage (2011). The Role of Bradykinin and the Effect of the Bradykinin Receptor Antagonist Icatibant in Porcine Sepsis. Shock.  ISSN 1073-2322.  36(5), s 517- 523 . doi: 10.1097/SHK.0b013e3182336a34
  • Cordara, Gabriele; Jacobsen, Wolfgang Mathias; Johansen, Harald Thidemann; Winter, Harry C.; Goldstein, IJ; Sandvig, Kirsten & Krengel, Ute (2011). Marasmius oreades agglutinin (MOA) is a chimerolectin with proteolytic activity. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  408(3), s 405- 410 . doi: 10.1016/j.bbrc.2011.04.031
  • Øverbye, Anders; Sætre, Frank Ove; Hagen, Linda K Korsberg; Johansen, Harald Thidemann & Seglen, Per O. (2011). Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain. Autophagy.  ISSN 1554-8627.  7(9), s 1011- 1027 . doi: 10.4161/auto.7.9.16436
  • Briggs, Jon; Haugen, Mads Haugland; Johansen, Harald Thidemann; Riker, Adam I; Abrahamson, Magnus; Fodstad, Øystein; Mælandsmo, Gunhild M & Solberg, Rigmor (2010). Cystatin E/M suppresses legumain activity and invasion of human melanoma. BMC Cancer.  ISSN 1471-2407.  10(1), s 17 . doi: 10.1186/1471-2407-10-17
  • Thorgersen, Ebbe Billmann; Hellerud, Bernt C; Nielsen, Erik Waage; Barratt-Due, Andreas; Fure, Hilde; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Fosse, Erik; Tønnessen, Tor Inge; Johansen, Harald Thidemann; Castellheim, Albert & Mollnes, Tom Eirik (2010). CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs. The FASEB Journal.  ISSN 0892-6638.  24(3), s 712- 722 . doi: 10.1096/fj.09-140798
  • Elenjord, Renate; Allen, Jasmine Blue; Johansen, Harald Thidemann; Johansen, Harald T.; Kildalsen, hanne; Svineng, Gunbjørg; Mælandsmo, Gunhild; Loennechen, Thrina & Winberg, Jan-Olof (2009). Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. The FEBS Journal.  ISSN 1742-464X.  276(18), s 5275- 5286 . doi: 10.1111/j.1742-4658.2009.07223.x
  • Castellheim, A; Thorgersen, EB; Hellerud, BC; Pharo, A; Johansen, HT; Brosstad, F; Gaustad, P; Brun, H; Fosse, E; Tønnessen, Tor Inge; Tonnessen, TI; Nielsen, Erik Waage & Mollnes, Tom Erik (2008). New biomarkers in an acute model of live Escherichia coli-induced sepsis in pigs. Scandinavian Journal of Immunology.  ISSN 0300-9475.  68, s 75- 84 . doi: 10.1111/j.1365-3083.2008.02122.x
  • Bah, Sekou; Paulsen, Berit Smestad; Diallo, Drissa & Johansen, Harald Thidemann (2006). Characterization of cysteine proteases in Malian medicinal plants. Journal of Ethnopharmacology.  ISSN 0378-8741.  107(2), s 189- 198
  • Johansen, Harald Thidemann (2002). Fysiologi for farmasøyter - erfaringer med utviklingen av et fjernundervisningskurs basert på bruk av Internett, I: Per Arneberg & Olav Skare (red.),  SOFF-rapport nr. 2/2002.  SOFF - Sentralorganet for fleksibel læring i høgre utdanning.  ISBN 82-91308-28-4.  s 55 - 59
  • Bjørnland, Kristin; Bratland, Åse; Rugnes, Elin; Pettersen, Solveig; Johansen, Harald Thidemann; Aasen, Ansgar Oddne; Fodstad, Øystein; Ree, Anne Hansen & Mælandsmo, Gunhild Mari (2001). Expression of matrix metalloproteinases and the matastasis-associated gene S100A4 in human neuroblastoma and primitive neuroectodermal tumor cell lines. Journal of Pediatric Surgery.  ISSN 0022-3468.  s 1040- 1044
  • Fiane, Arnt E.; Videm, Vibeke; Johansen, Harald Thidemann; Mellbye, Ove J.; Waage - Nielsen, E. & Mollnes, Tom Eirik (1999). C1 inhibitor prevents hyperacute rejection and inhibits complement, leukocyte and platelet activation in an ex vivo pig - to - human perfusion model. Immunopharmacology.  ISSN 0162-3109.
  • Fiane, Arnt E.; Videm, Vibeke; Johansen, Harald Thidemann; Mellbye, Ove J.; Waage - Nielsen, E. & Mollnes, Tom Eirik (1999). Ci inhibitor prevents hyperacute rejection and inhibits complement, leukocyte and platelet activation in an ex vivo pig - to - human perfusion model. Immunopharmacology.  ISSN 0162-3109.
  • Johansen, Harald Thidemann; Knight, C. Graham & Barrett, Alan J. (1999). Colorimetric and Fluorimetric Microplate Assays for Legumain and a Staining Reaction for Detection of the Enzyme after Electrophoresis. Analytical Biochemistry.  ISSN 0003-2697.  273, s 278- 283
  • Bjørnland, Kristin; Lehne, Gustav; Johansen, Harald Thidemann; Fodstad, Øystein; Rugstad, Hans Erik; Aasen, Ansgar Oddne & Ree, Anne Hansen (1998). Human hepatoma cells rich in P-glycoprotein display enhanced in vitro invasive properties compared to P-glycoprotein-poor hepatoma cells. Oncology Research.  ISSN 0965-0407.  10, s 255- 262
  • Ree, Anne Hansen; Bjørnland, Kristin; Brunner, N.; Johansen, Harald Thidemann; Pedersen, Kjetil Boye; Aasen, Ansgar Oddne & Fodstad, Øystein (1998). Regulation of tissue-degrading factors and in vitro invasiveness in progression of breast cancer cells. Clinical and Experimental Metastasis.  ISSN 0262-0898.  16, s 205- 215
  • Bjørnland, Kristin; Buø, Laila; Kjøniksen, Inge; Larsen, John Karl; Fodstad, Øystein; Johansen, Harald Thidemann & Aasen, Ansgar Oddne (1996). Cysteine proteinase inhibitors reduce malignant melanoma cell invasion in vitro. Anticancer Research.  ISSN 0250-7005.  16, s 1627- 1632
  • Karlsrud, Tove Sigstad; Buø, Laila; Aasen, Ansgar Oddne & Johansen, Harald Thidemann (1996). Cleavage of plasma high molecular weight kininogen in surgical ICU patients. Intensive Care Medicine.  ISSN 0342-4642.  22, s 760- 765
  • Karlsrud, Tove Sigstad; Buø, Laila; Aasen, Ansgar Oddne & Johansen, Harald Thidemann (1996). Quantification of kininogens in plasma. A functional method based on the cysteine proteinase inhibitor activity. Thrombosis Research.  ISSN 0049-3848.  s 265- 273
  • Nielsen, E. Waage; Gran, Jan Tore; Straume, Bjørn; Mellbye, Ove J.; Johansen, Harald Thidemann & Mollnes, Tom Eirik (1996). Hereditary angioedema. New clinical observations autoimmune screening, complement and kallikrein kinin analyses. Journal of Internal Medicine.  ISSN 0954-6820.  239, s 119- 130
  • Nielsen, E. Waage; Johansen, Harald Thidemann; Høgåsen, Kolbjørn; Wuillemin, W; Hack, C. E. & Mollnes, Tom Eirik (1996). Activation of the complement, coagulation, fibrinolytic and kallikrein-kinin systems during attacks of hereditary angioedema. Scandinavian Journal of Immunology.  ISSN 0300-9475.  44, s 185- 192
  • Scholz, Tim; Bäckman, Lars; Mathisen, Øystein; Buø, Laila; Karlsrud, Tove Sigstad; Johansen, Harald Thidemann; Bergan, Anstein Bjørnar; Klintmalm, Göran B. & Aasen, Ansgar Oddne (1995). Activation of the plasma cascade system and hemodynamic changes after graft revascularization in liver transplantation. Transplantation.  ISSN 0041-1337.  60(1), s 36- 40

View all works in Cristin

  • Arnekleiv, Guro L.; Nilsen, Hilde; Lunde, Ngoc Nguyen Dieu; Solberg, Rigmor & Johansen, Harald Thidemann (2017). Effekt av vitamin D3 på uttrykk, aktivitet og sekresjon av cysteinproteasen legumain studert i ulike cellemodeller.
  • Hemati, Paya Diana; Bosnjak, Tatjana; Nilsen, Hilde; Lunde, Ngoc Nguyen Dieu; Johansen, Harald Thidemann & Solberg, Rigmor (2017). The Proton Pump Inhibitor Lansoprazole Inhibits Protease Activity of Legumain.
  • Abdukadir, Nuriddin; Lunde, Ngoc Nguyen Dieu; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann (2016). Regulering av cysteinproteaser ved differensiering av monocytter til makrofager.
  • Johansen, Harald Thidemann (2016). Type 2 cystatins as inhibitors of legumain.
  • Larsen, Kristina Broe Bodin; Johansen, Harald Thidemann; Solberg, Rigmor & Lunde, Ngoc Nguyen Dieu (2016). Betydning av glykosylering for internalisering og aktivering av prolegumain i humane tykktarmskreftceller.
  • Lunde, Ngoc Nguyen Dieu; Dahl, Tuva Børresdatter; Abdukadir, Nuriddin; Halvorsen, Bente; Solberg, Rigmor & Johansen, Harald Thidemann (2016). Increased secretion of legumain from pro-inflammatory M1 compared to M2 macrophages.
  • Manna, Dipankar; Krengel, Ute & Johansen, Harald Thidemann (2016). Structure-function characterization and cytotoxicity studies of fungal chimerolectins.
  • Solberg, Rigmor & Johansen, Harald Thidemann (2016). Involvement of the cysteine protease legumain in human health and disease.
  • Johansen, Harald Thidemann; Elyouncha, Inass; Lunde, Ngoc Nguyen Dieu; Williams, Rich; Solberg, Rigmor; Nilsen, Hilde & Halvorsen, Bente (2015). Opposing effects of glucose on legumain and cysteine cathepsins.
  • Lunde, Ngoc Nguyen Dieu; Nilsen, Hilde; Damgaard, Ingrid; Kasem, Roya; Solberg, Rigmor; Haugen, Mads Haugland & Johansen, Harald Thidemann (2015). Importance of glycosylation for legumain and cystatin E/M functions.
  • Nielsen, Erik Waage; Lappegård, Knut Tore & Johansen, Harald Thidemann (2015). Re: Ny og bedre medisin mot hjertesvikt. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  135(9), s 830- 831 . doi: 10.4045/tidsskr.15.0486
  • Haugen, Mads Haugland; Flatmark, Kjersti; Tamhane, Tripti; Boye, Kjetil; Pettersen, Solveig; Solberg, Rigmor; Johansen, Harald Thidemann; Brix, Klaudia & Mælandsmo, Gunhild (2013). Nuclear localized legumain in colorectal cancer.
  • Johansen, Harald Thidemann; Solberg, Rigmor; Nilsen, Hilde & Smith, Robert (2013). Effects and interplay of legumain and cystatin E/M om migration and invasion of macrophages.
  • Seip, Knut Fredrik; Bjerknes, Kari Christiane; Johansen, Harald Thidemann; Landrø, Linn Aina Ysland; Helsing, Per; Reubsaet, Leon & Nielsen, Erik Waage (2013). Investigating bradykinin exposure in hereditary angioedema through the metabolite BK1-5.
  • Smith, Robert; Johansen, Harald Thidemann; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild; Thoresen, G. Hege & Solberg, Rigmor (2013). Simvastatin inhibits legumain activity and processing in human myotubes.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde & Solberg, Rigmor (2013). Effects and interplay of legumain and cystatin E/M on migration and invasion of macrophages.
  • Tina, Elvestrand; Åstrand, Ove Alexander; Smith, Robert; Rongved, Pål; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann (2013). Cellular effects of a colchicine-prodrug cleaved by legumain.
  • Voreland, Anette; Smith, Robert; Thoresen, G. Hege; Johansen, Harald Thidemann & Solberg, Rigmor (2013). The cysteine protease legumain is downregulated by simvastatin in primary human skeletal muscle cells.
  • Ånonsen, Kjersti Bergh; Nilsen, Hilde; Smith, Robert; Johansen, Harald Thidemann & Solberg, Rigmor (2013). Regulering av legumain i samspillet mellom makrofager og kreftceller.
  • Berven, Lise; Johansen, Harald Thidemann; Solberg, Rigmor; Kolset, Svein Olav & Samuelsen, Anne Berit C. (2012). INTERACTIONS BETWEEN PROLEGUMAIN AND GLYCOSAMINOGLYCANS.
  • Bjerknes, Kari Christiane; Seip, Knut Fredrik; Johansen, Harald Thidemann; Landrø, Linn Aina Ysland; Nielsen, Erik Waage & Reubsaet, Leon (2012). Bradykinins rolle ved arvelig angiødemanfall – LC-MS/MS bestemmelse via metabolitten BK1-5 i fullblod.
  • Bjerknes, Kari Christiane; Seip, Knut Fredrik; Reubsaet, Leon; Nielsen, Erik Waage & Johansen, Harald Thidemann (2012). The role of Bradykinin in attacks of angioedema - Development of a method for measuring the stable metabolite BK1-5.
  • Jacobsen, Linn Løkken; Smith, Robert; Thoresen, G. Hege; Solberg, Rigmor & Johansen, Harald Thidemann (2012). Are the cysteine proteases legumain and cathepsins involved in statin-induced myotoxicity?.
  • Samuelsen, Anne Berit C.; Berven, Lise; Solberg, Rigmor; Johansen, Harald Thidemann & Truong, Hong Hoa Thi (2012). Effekt av alginat på legumain, en protease involvert i kreftutvikling.
  • Seip, Knut Fredrik; Bjerknes, Kari Christiane; Johansen, Harald Thidemann; Landrø, Linn Aina Ysland; Helsing, Per; Reubsaet, Leon & Nielsen, Erik Waage (2012). Investigating bradykinin exposure in hereditary angioedema through the metabolite BK1-5.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Yassen, Islam M.; Haugen, Mads Haugland; Pettersen, Solveig; Mælandsmo, Gunhild; Abrahamson, Magnus & Solberg, Rigmor (2012). SECRETION, INTERNALIZATION AND INTERPLAY OF LEGUMAIN AND CYSTATIN E/M.
  • Tran, Anny T.; Smith, Robert; Solberg, Rigmor & Johansen, Harald Thidemann (2012). Effects of atorvastatin on regulation of protease activities in macrophages.
  • Haugen, Mads Haugland; Mælandsmo, Gunhild; Johansen, Harald Thidemann; Solberg, Rigmor; Pettersen, Solveig; Boye, Kjetil & Flatmark, Kjersti (2011). Nuclear activity of the cysteine protease legumain in colorectal carcinoma.
  • Johansen, Harald Thidemann; Smith, Robert; Tewolde, Eyassu; Nilsen, Hilde & Solberg, Rigmor (2011). ATORVASTATIN INHIBITS LEGUMAIN ACTIVITY IN AND PROLEGUMAIN SECRETION FROM HUMAN ACTIVATED MACROPHAGES.
  • Samuelsen, Anne Berit C.; Berven, Lise; Solberg, Rigmor; Johansen, Harald Thidemann & Nguyen, Nga Thi (2011). Studier av alginats effekt på prolegumain og cellesekresjon av matriksmetalloproteaser.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Yassen, Islam M.; Haugen, Mads Haugland; Pettersen, Solveig J. & Solberg, Rigmor (2011). SUBCELLULAR LOCALIZATION, INTERPLAY AND SECRETION OF LEGUMAIN AND CYSTATIN E/M IN HEK 293 CELLS.
  • Smith, Robert; Johansen, Harald Thidemann & Solberg, Rigmor (2011). Cellular localization and interplay between legumain and its endogenous inhibitor cystatin E/M.
  • Thorgersen, Ebbe Billmann; Hellerud, Bernt C; Nielsen, Erik Waage; Barratt-Due, Andreas; Fure, Hilde; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Fosse, Erik; Tønnessen, Tor Inge; Johansen, Harald Thidemann; Castellheim, Albert & Mollnes, Tom Eirik (2010). Upstream inhibition of key innate immune pathways in vivo in sepsis. Molecular Immunology.  ISSN 0161-5890.  47(13), s 2268- 2268 . doi: 10.1016/j.molimm.2010.05.209
  • Briggs, Jon; Haugen, Mads Haugland; Johansen, Harald Thidemann; Riker, Adam I; Abrahamson, Magnus; Fodstad, Øystein; Mælandsmo, Gunhild Mari & Solberg, Rigmor (2009). Cystatin E/M suppresses legumain activity and invasion of human melanoma.
  • Haugen, Mads Haugland; Johansen, Harald Thidemann; Solberg, Rigmor; Flatmark, Kjersti & Mælandsmo, Gunhild M (2009). Expression and activity of the cysteine protease legumain in colorectal carcinoma cell lines.
  • Solberg, Rigmor; Almlöf, Maria; Nilsen, Hilde; Ali, Zana Abdullrahman; Abrahamson, Magnus & Johansen, Harald Thidemann (2009). Asparaginyl endopeptidase activity is upregulated during differentiation of monocytes to macrophages but only partly mediated by legumain.
  • Ben Omar, Sakina; Johansen, Harald Thidemann; Aukrust, Pål; Halvorsen, Bente & Solberg, Rigmor (2008). Lysosomal cysteine proteases in atherosclerosis: Do inflammatory modulators regulate expression and activity?.
  • Almlöf, Maria; Solberg, Rigmor & Johansen, Harald Thidemann (2007). Regulation of cystein proteases in monocytes/macrophages and in tumorigenesis.
  • Solberg, Rigmor; Nilsen, Hilde; Johansen, Harald Thidemann; Mælandsmo, Gunhild M. & Briggs, Jon (2007). SCREENING OF THE EXPRESSIONS OF LEGUMAIN AND ITS SPECIFIC INHIBITOR CYSTATIN M IN VARIOUS MELANOMA CELLS.
  • Almlöf, Maria; Elenjord, Renate; Solberg, Rigmor; Winberg, Jan Olof; Loennechen, Thrina & Johansen, Harald Thidemann (2006). The expression and activity of legumain is highly increased in malignant osteosarcoma cells compared to non-malignant cells.
  • Almlöf, Maria; Elenjord, Renate; Solberg, Rigmor; Winberg, Jan-Olof; Loennechen, Thrina & Johansen, Harald Thidemann (2006). Malignant osteosarcoma cells express higher levels of legumain compared to non-malignant cells.
  • Almlöf, Maria; Solberg, Rigmor; Nilsen, Hilde & Johansen, Harald Thidemann (2006). Legumain expression and activity is highly increased as monocytes differentiate toward macrophages.
  • Almløf, M; Elenjord, Renate; Solberg, R; Winberg, Jan-Olof; Loennechen, thrina & Johansen, HT (2006). Legumain activity is increased in malignant osteosarcoma cells compared to non-malignant cells.
  • Bah, Sekou; Diallo, Drissa; Paulsen, Berit Smestad & Johansen, Harald Thidemann (2006). Characterisation and partial purification of cystatins from Malian medicinal plants.
  • Bah, Sekou; Johansen, Harald Thidemann; Paulsen, Berit Smestad & Diallo, Drissa (2005). Characterization of cysteine proteases in medicinal plants from Mali.
  • Bah, Sekou; Johansen, Harald Thidemann; Paulsen, Berit Smestad & Diallo, Drissa (2005). Pharmacology of medicinal plants from Mali: Antiplasmodial amd Antischistosomial Activities.
  • Johansen, Harald Thidemann & Tangen-Jordan, Lise von (2002). Isolated cystatin domains from L-kininogen are not active as inhibitors of mammalian legumain.
  • Johansen, Harald Thidemann (2001). Legemidler som hemmer blodplateaggregasjonen. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  109(3), s 16- 18
  • Johansen, Harald Thidemann (2001). Legemidler som hemmer blodplateaggregasjonen. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  109(3), s 16- 18
  • Johansen, Harald Thidemann (2000). Spironolakton - et gammelt legemiddel med nye muligheter. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  108(3), s 12- 15
  • Bjørnland, Kristin; Rugnes, Elin; Pettersen, Solveig; Johansen, Harald Thidemann & Aasen, Ansgar Oddne (1999). neuroblastoma cell invasion in vitro correlates with expression of matrix metalloproteinase-2.
  • Bjørnland, Kristin; Rugnes, Elin; Mælandsmo, Gunhild Mari; Ree, Anne Hansen; Johansen, Harald Thidemann & Aasen, Ansgar Oddne (1999). expression of matrix metalloproteinases in neuroblastoma cells.

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Published Nov. 3, 2010 3:39 PM - Last modified Mar. 3, 2014 11:41 AM

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