Ove Alexander Høgmoen Åstrand

Image of Ove Alexander Høgmoen Åstrand
Norwegian version of this page
Phone +47-22854478
Username
Visiting address Sem Sælands vei 3 Farmasibygningen 0371 OSLO
Postal address Postboks 1068 Blindern 0316 OSLO
Other affiliations School of Pharmacy

Academic Interests

 Organic chemistry, pharmacutical chemistry, organometallic chemistry, catalysis, chemical engineering, high energy chemistry, dissemination.

Teaching

I teach introductary lab courses in

FRM1000 - Pharmaceutical Chemistry, Part I

FRM1010 - Pharmaceutical Chemistry, Part II

Higher education and employment history

  • 2009: Started graduate studies in pharmacutical chemistry under guidance of assistant professor Pål Rongved.
  • 2009: Sivilingeniør(diploma engineer) in organic chemistry from NTNU (Norwegian University of Science and Technology) in Trondheim. Diploma thesis written in the field of organometallic aziridination of olefins using ruthenium catalysts under the guidance of assistant professor Odd R. Gautun.
  • 2007/2008: 1 year study abroad at the University of California, Berkeley

 

Tags: Medicinal chemistry, Chemistry, Life Science, Pharmaceuticals, Toxicology, Pharmaceutical chemistry

Publications

  • Viktorsson, Elvar Örn; Gabrielsen, Mari; Kumarachandran, Nugalya; Sylte, Ingebrigt; Rongved, Pål; Åstrand, Ove Alexander Høgmoen & Kase, Eili Tranheim (2017). Regulation of liver X receptor target genes by 22-functionalized oxysterols. Synthesis, in silico and in vitro evaluations. Steroids.  ISSN 0039-128X.  118, s 119- 127 . doi: 10.1016/j.steroids.2016.12.003
  • Viktorsson, Elvar Örn; Grøthe, Bendik Melling; Aesoy, Reidun; Sabir, Misbah; Snellingen, Simen; Prandina, Anthony; Åstrand, Ove Alexander Høgmoen; Bonge-Hansen, Tore; Doskeland, Stein Ove; Herfindal, Lars & Rongved, Pål (2017). Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  25(7), s 2285- 2293 . doi: 10.1016/j.bmc.2017.02.058
  • Åstrand, Ove Alexander Høgmoen; Viktorsson, Elvar Örn; Kristensen, Aleksander Lim; Ekeberg, Dag; Røberg-Larsen, Hanne; Wilson, Steven Ray Haakon; Gabrielsen, Mari; Sylte, Ingebrigt; Rustan, Arild; Thoresen, G. Hege; Rongved, Pål & Kase, Eili Tranheim (2017). Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors. Journal of Steroid Biochemistry and Molecular Biology.  ISSN 0960-0760.  165, s 323- 330 . doi: 10.1016/j.jsbmb.2016.07.010
  • Viktorsson, Elvar Örn; Åstrand, Ove Alexander Høgmoen; Haseeb, Rasha Sabah; Gorbitz, Carl Henrik & Rongved, Pål (2015). Crystal structure of (S)-2-[(3S,8S,9S,10R,13S,14S,-17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,-12,13,14,15,16,17-tetradecahydro-1 H-cyclopenta-[a]phenanthren-17-yl]-N-methoxy-N-methylpro-panamide (Fernholz Weinreb amide). Acta Crystallographica Section E: Structure Reports Online.  ISSN 1600-5368.  71(3), s 275- 277 . doi: 10.1107/S2056989015001747 Full text in Research Archive.
  • Smith, Robert; Åstrand, Ove Alexander Høgmoen; Nguyen, Luan Minh; Elvestrand, Tina; Hagelin, Gunnar; Solberg, Rigmor; Johansen, Harald Thidemann & Rongved, Pål (2014). Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  22(13), s 3309- 3315 . doi: 10.1016/j.bmc.2014.04.056
  • Åstrand, Ove Alexander Høgmoen; Gikling, Ingveig; Sylte, Ingebrigt; Rustan, Arild; Thoresen, G. Hege; Rongved, Pål & Kase, Eili Tranheim (2014). Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. European Journal of Medicinal Chemistry.  ISSN 0223-5234.  74, s 258- 263 . doi: 10.1016/j.ejmech.2014.01.003
  • Åstrand, Ove Alexander Høgmoen; Sandberg, Marcel; Sylte, Ingebrigt; Gorbitz, Carl Henrik; Thoresen, G. Hege; Kase, Eili Tranheim & Rongved, Pål (2014). Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  22(1), s 643- 650 . doi: 10.1016/j.bmc.2013.10.024
  • Åstrand, Ove Alexander Høgmoen; Austdal, Lars Peter Engeset; Paulsen, Ragnhild Elisabeth; Hansen, Trond Vidar & Rongved, Pål (2013). Synthesis and characterization of new selective Zn2+ fluorescent probes for functionalization: in vitro Cell imaging applications. Tetrahedron.  ISSN 0040-4020.  49(40), s 8645- 8654 . doi: 10.1016/j.tet.2013.07.049
  • Åstrand, Ove Alexander Høgmoen; Gorbitz, Carl Henrik; Kristoffersen, Kenneth Aase & Rongved, Pål (2013). Acetonitrile){2-[bis(pyridin-2-ylmethyl-κ2 N)amino-κN]-N-(2,6-dimethylphenyl)acetamide-κO}(perchlorato-κO)zinc (acetonitrile){2-[bis(pyridin-2-ylmethyl-κ2 N)amino-κN]-N-(2,6-dimethylphenyl)acetamide-κO}zinc tris(perchlorate). Acta Crystallographica Section E: Structure Reports Online.  ISSN 1600-5368.  69(2), s m112- m113 . doi: 10.1107/S1600536813001396
  • Åstrand, Ove Alexander; Aziz, Gul zeb; Ali, Sidra Farzand; Paulsen, Ragnhild Elisabeth; Hansen, Trond Vidar & Rongved, Pål (2013). Synthesis and initial in vitro biological evaluation of two new zinc-chelating compounds: Comparison with TPEN and PAC-1. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  21(17), s 5175- 5181 . doi: 10.1016/j.bmc.2013.06.037
  • Åstrand, Ove Alexander; Iqbal, Zeshan; Sandberg, Marcel; Kase, Eili Tranheim; Gorbitz, Carl Henrik & Rongved, Pål (2013). (2S,3S)-2,6-Dimethylheptane-1,3-diol, the oxygenated side chain of 22(S)-hydroxycholestrol, and its synthetic precursor (R)-4-benzyl-3-[(2R,3S)-3-hydroxy-2,6-dimethylheptanoyl]-1,3-oxazolidin-2-one. Acta Crystallographica Section C: Crystal Structure Communications.  ISSN 0108-2701.  69, s 647- + . doi: 10.1107/S0108270113011852

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  • Viktorsson, Elvar Örn; Åstrand, Ove Alexander Høgmoen; Bonge-Hansen, Tore; Doskeland, Stein Ove; Herfindal, Lars & Rongved, Pål (2016). Total synthesis and initial antileukemic evaluation of the phenazine 5,10-dioxide natural products iodinin and myxin.
  • Åstrand, Ove Alexander Høgmoen; Cokoja, Mirza; Pöthig, Alexander & Kühn, Fritz E. (2016). Zinc complexes in catalysis - Potential applications.
  • Åstrand, Ove Alexander Høgmoen; Schnaars, Christian; Kildahl-Andersen, Geir & Rongved, Pål (2016). Overcoming b-lactam resistance - A potential solution to antibiotic resistance.
  • Grøthe, Bendik Melling; Snellingen, Simen; Viktorsson, Elvar Örn; Prandina, Anthony; Åstrand, Ove Alexander Høgmoen; Bonge-Hansen, Tore & Rongved, Pål (2015). The first efficient synthesis and preliminary biological effect of the 1,6-dihydroxyphenazine-N5,N10-dioxide (Iodinin) and 1-hydroxy-6-methoxyphenazine-N5,N10-dioxide (Myxin).
  • Haseeb, Rasha Sabah; Viktorsson, Elvar Örn; Åstrand, Ove Alexander Høgmoen & Rongved, Pål (2015). Synthetic efforts towards oxysterol-based LXR-modulators.
  • Prandina, Anthony; Frøvold, Espen; Åstrand, Ove Alexander Høgmoen & Rongved, Pål (2015). Synthetic efforts towards new agents against resistant bacteria.
  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan & Leiros, Hanna-Kirsti S. (2015). The fight against metallo-beta-lactamases and antibiotic resistance.
  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan & Leiros, Hanna-Kirsti S. (2015). The fight against metallo-beta-lactamases and antibiotic resistance.
  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Christopeit, Tony; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samulesen, Ørjan & Leiros, Hanna-Kirsti S. (2015). The fight against metallo-beta-lactamases and antibiotic resistance.
  • Viktorsson, Elvar Örn; Åstrand, Ove Alexander Høgmoen; Rustan, Arild; Thoresen, G. Hege; Kase, Eili Tranheim & Rongved, Pål (2015). Analogs of 22-S-hydroxycholesterol as potential Liver X Receptor-modulators: Synthesis and biological evaluation.
  • Åstrand, Ove Alexander Høgmoen; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Bayer, Annette & Rongved, Pål (2015). Overcoming b-lactam resistance - A potential solution to multi-drug resistant bacteria.
  • Åstrand, Ove Alexander Høgmoen & Rongved, Pål (2015). OVERCOMING ANTIBIOTIC RESISTANCE - DEVELOPMENT OF NEW MBL INHIBITORS.
  • Tina, Elvestrand; Åstrand, Ove Alexander; Smith, Robert; Rongved, Pål; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann (2013). Cellular effects of a colchicine-prodrug cleaved by legumain.
  • Åstrand, Ove Alexander Høgmoen (2013). Drug discovery and design: Lead identifcation and discoveries made with zinc chelators, Liver X Receptor modulators and prodrug strategies. Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo.. 1429.
  • Åstrand, Ove Alexander; Hansen, Trond Vidar & Rongved, Pål (2011). Synthesis of new zinc2+ chelating molecules.
  • Åstrand, Ove Alexander; Hansen, Trond Vidar & Rongved, Pål (2010). Development of new selctive chelating agents for zinc.
  • Melnes, Silje; Åstrand, Ove Alexander; Reian, Gard; Aaseng, Jon Erik & Gautun, Odd Reidar (2009). Asymmetric catalytic aziridination of 1,2-dihydronaphtalenes.
  • Åstrand, Ove Alexander; Melnes, Silje & Gautun, Odd Reidar (2009). Preparation of New Ru-salen Complexes for the Catalytic Asymmetric Aziridination of Alkenes.

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Published June 3, 2014 11:29 AM - Last modified June 3, 2014 11:30 AM