Rigmor Solberg

Image of Rigmor Solberg
Norwegian version of this page
Phone +47-22857514
Mobile phone +47-97739048
Room 433, Gydas vei
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Visiting address Gydas vei 8 0363 Oslo
Postal address Postboks 1068 Blindern 0316 OSLO
Other affiliations School of Pharmacy

Academic Interests

My academic interests are within the area of pharmacology, involving the effects of drugs. Our research group (ProTarg; Proteolytic Enzymes as Drug Targets) is studying proteolytic enzymes, which are enzymes cleaving other proteins and thus, either activate or degrade the substrate proteins. The research group is particularly interested in cysteine proteases (legumain, cathepsins) and their roles in normal physiology and diseases (pathophysiology). Main projects involve studying the interplay between and drug effects on cysteine proteases and their endogenous inhibitors (cystatins) in atherosclerosis, cancer and osteoporosis.

Teaching

I teach physiology, pharmacology, and pharmacotherapy in the following courses of the Pharmacy program:

Appointments

  • Member of the board for evaluation of equal education in pharmacy, School of Pharmacy, UiO

Higher education and employment history

Higher education:

  • Ph.D. (Dr. philos.), Faculty of Medicine, University of Oslo (UiO), 1994
  • Master of Science in Pharmacy (M.Sci.Pharm.), School of Pharmacy, UiO, 1988
  • Bachelor in Pharmacy, Oslo University College, 1983

Employment history:

  • 2014-15: Visiting researcher (sabbatical), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA
  • 2005-today: Full professor in pharmacology, School of Pharmacy, University of Oslo (UiO)
  • 1998-2005: Associate professor in pharmacology, School of Pharmacy, UiO
  • 1996-1998: Researcher, Institute for Surgical Research, Oslo University Hospital - Rikshospitalet, Oslo
  • 1994-1996: Postdoc fellow (Norwegian Research Council), Institute for Medical Biochemistry, Preclinical Medicine, UiO
  • 1992/93 (1 year): Visiting research fellow, Department of Chemistry, University of California San Diego (UCSD), La Jolla, California, USA
  • 1991 (3 mounths): Visiting research fellow, Institute of Medical Genetics, University of Helsinki, Finland
  • 1988-1993: PhD-student (Norwegian Cancer Society), Laboratory for Gene Technology, Institute for Pathology, Rikshospitalet and Institute for Medical Biochemistry, Preclinical Medicine, UiO
  • 1984-1987: Pharmacist, various pharmacies and hospital in Norway
Tags: Pharmacology, Pharmacy, Drugs, Cell Biology, Molecular Biology, Biochemistry, Life science, Atherosclerosis, Cancer, Osteoporosis, Proteases, Proteolytic enzymes, Proteolysis, Cysteine proteases, Legumain, Cathepsins, Cystatins

Publications

  • Jafari, Abbas; Qanie, Diyako; Andersen, Thomas L.; Zhang, Yuxi; Chen, Li; Postert, Benno; Parsons, Stuart; Ditzel, Nicholas; Khosla, Sundeep; Johansen, Harald Thidemann; Kjærsgaard-Andersen, Per; Delaissé, Jean-Marie; Abdallah, Basem M.; Hesselson, Daniel; Solberg, Rigmor & Kassem, Moustapha (2017). Legumain regulates differentiation fate of human bone marrow stromal cells and is altered in postmenopausal osteoporosis. Stem Cell Reports.  ISSN 2213-6711.  8(2), s 373- 386 . doi: 10.1016/j.stemcr.2017.01.003
  • Lunde, Ngoc Nguyen Dieu; Haugen, Mads Haugland; Larsen, Kristina Broe Bodin; Damgaard, Ingrid; Pettersen, Solveig; Kasem, Roya; Rut, Wioletta; Drag, Marcin; Poreba, Marcin; Johansen, Harald Thidemann & Solberg, Rigmor (2017). Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions. Biochimie.  ISSN 0300-9084.  139, s 27- 37 . doi: 10.1016/j.biochi.2017.05.009
  • Lunde, Ngoc Nguyen Dieu; Holm, Sverre; Dahl, Tuva Børresdatter; Inass, Elyouncha; Sporsheim, Bjørnar; Gregersen, Ida; Abbas, Azhar; Skjelland, Mona; Espevik, Terje; Solberg, Rigmor; Johansen, Harald Thidemann & Halvorsen, Bente (2017). Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis. Atherosclerosis.  ISSN 0021-9150.  257, s 216- 223 . doi: 10.1016/j.atherosclerosis.2016.11.026 Show summary
  • Poreba, Marcin; Solberg, Rigmor; Rut, Wioletta; Lunde, Ngoc Nguyen Dieu; Kasperkiewicz, Paulina; Snipas, Scott J.; Mihelic, Marko; Turk, Dusan; Turk, Boris; Salvesen, Guy S. & Drag, Marcin (2016). Counter selection substrate library strategy for developing specific protease substrates and probes. Cell Chemical Biology.  ISSN 2451-9456.  23(8), s 1023- 1034 . doi: 10.1016/j.chembiol.2016.05.020
  • Smith, Robert; Solberg, Rigmor; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild; Thoresen, G. Hege & Johansen, Harald Thidemann (2014). Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. PLoS ONE.  ISSN 1932-6203.  9(1:85721) . doi: 10.1371/journal.pone.0085721
  • Smith, Robert; Åstrand, Ove Alexander Høgmoen; Nguyen, Luan Minh; Elvestrand, Tina; Hagelin, Gunnar; Solberg, Rigmor; Johansen, Harald Thidemann & Rongved, Pål (2014). Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  22(13), s 3309- 3315 . doi: 10.1016/j.bmc.2014.04.056
  • Solberg, Rigmor; Smith, Robert; Almlöf, Maria; Tewolde, Eyassu Araia; Nilsen, Hilde & Johansen, Harald Thidemann (2014). Atorvastatin inhibits processing, activity and secretion of legumain in macrophages. Biological chemistry (Print).  ISSN 1431-6730.  396(1), s 71- 80 . doi: 10.1515/hsz-2014-0172
  • Solberg, Rigmor; Smith, Robert; Almlöf, Maria; Tewolde, Eyassu Araia; Nilsen, Hilde & Johansen, Harald Thidemann (2014). Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin. Biological chemistry (Print).  ISSN 1431-6730.  396(1), s 71- 80 . doi: 10.1515/hsz-2014-0172
  • Berven, Lise; Johansen, Harald Thidemann; Solberg, Rigmor; Kolset, Svein Olav & Samuelsen, Anne Berit C. (2013). Autoactivation of prolegumain is accelerated by glycosaminoglycans. Biochimie.  ISSN 0300-9084.  95(4), s 772- 781 . doi: 10.1016/j.biochi.2012.11.002 Show summary
  • Berven, Lise; Solberg, Rigmor; Truong, Hoa Hong Thi; Arlov, Øystein; Aachmann, Finn Lillelund; Skjåk-Bræk, Gudmund; Jacobsen, Wolfgang Mathias; Johansen, Harald Thidemann & Samuelsen, Anne Berit C. (2013). Alginates induce legumain activity in RAW 264.7 cells and accelerate autoactivation of prolegumain. Bioactive Carbohydrates and Dietary Fibre.  ISSN 2212-6198.  2, s 30- 44 . doi: 10.1016/j.bcdf.2013.08.003
  • Haugen, Mads Haugland; Johansen, Harald Thidemann; Pettersen, Solveig; Solberg, Rigmor; Brix, Klaudia; Flatmark, Kjersti & Mælandsmo, Gunhild (2013). Nuclear Legumain Activity in Colorectal Cancer. PLoS ONE.  ISSN 1932-6203.  8(1) . doi: 10.1371/journal.pone.0052980 Full text in Research Archive.
  • Johansen, Harald Thidemann & Solberg, Rigmor (2012). Extracellular functions of cystein proteases, In Nikos K Karamanos (ed.),  Extracellular matrix: Pathobiology and signaling.  Walter de Gruyter.  ISBN 978-3-11-025876-9.  Kapittel 4.2.  s 239 - 260
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Haugen, Mads Haugland; Pettersen, Solveig; Mælandsmo, Gunhild; Abrahamson, Magnus & Solberg, Rigmor (2012). Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M. Biochimie.  ISSN 0300-9084.  94(12), s 2590- 2599 . doi: 10.1016/j.biochi.2012.07.026
  • Briggs, Jon; Haugen, Mads Haugland; Johansen, Harald Thidemann; Riker, Adam I; Abrahamson, Magnus; Fodstad, Øystein; Mælandsmo, Gunhild M & Solberg, Rigmor (2010). Cystatin E/M suppresses legumain activity and invasion of human melanoma. BMC Cancer.  ISSN 1471-2407.  10(1), s 17 . doi: 10.1186/1471-2407-10-17
  • Solberg, Rigmor; Aas, Vigdis; Thoresen, G. Hege; Kase, Eili Tranheim; Drevon, Christian A; Rustan, Arild & Reseland, Janne Elin (2005). Leptin expression in human primary skeletal muscle cells is reduced during differentiation. Journal of Cellular Biochemistry.  ISSN 0730-2312.  96(1), s 89- 96
  • Aas, Vigdis; Kase, Eili Tranheim; Solberg, Rigmor; Jensen, Jørgen & Rustan, Arild (2004). Chronic hyperglycaemia promotes lipogenesis and triacylglycerol accumulation in human skeletal muscle cells. Diabetologia.  ISSN 0012-186X.  47, s 1452- 1461
  • Saugstad, Ola Didrik; Ramji, S; Irani, S. F.; El-Meneza, S; Hernandez, E. A.; Vento, M; Talvik, T; Solberg, Rigmor; Rootwelt, Terje & Aalen, Odd Olai (2003). Resuscitation of newborn infants with 21% or 100% oxygen: follow-up at 18 to 24 months. Pediatrics.  ISSN 0031-4005.  11(2), s 296- 300 Show summary
  • Yaqub, Sheraz; Solhaug, Vigdis; Vang, Torkel; Solberg, Rigmor; Aasen, Ansgar Oddne; Tasken, Kjetil & Wang, Jacob Edward (2003). A human whole blood model of LPS mediated suppression on T cell activation. Medical Science Monitor.  ISSN 1234-1010.  s 120- 126
  • Yaqub, Sheraz; Solhaug, Vigdis; Vang, Torkel; Solberg, Rigmor; Aasen, Ansgar Oddne; Tasken, Kjetil & Wang, Jacob Edward (2003). A human whole blood model of LPS-mediated suppression of T-cell activation. Medical Science Monitor.  ISSN 1234-1010.  9(BR), s 120- 126
  • Scholz, Tim; Solberg, Rigmor; Okkenhaug, Cecilie; Videm, Vibeke; Gallimore, Michael J.; Mathisen, Øystein; Mollnes, Tom Eirik; Bergan, Anstein Bjørnar; Søreide, Odd; Klintmalm, Göran B. & Aasen, Ansgar Oddne (2002). The significance of heparin-coated veno-venous bypass circuits in liver transplantation. Perfusion.  ISSN 0267-6591.  17, s 45- 50
  • Scholz, Tim; Solberg, Rigmor; Okkenhaug, Cecilie; Videm, Vibeke; Gallimore, J Michael; Mathisen, Øystein; Pedersen, Thore H.; Mollnes, Tom Eirik; Bergan, Anstein Bjørnar; Søreide, Odd; Klintmalm, Göran B. & Aasen, Ansgar Oddne (2001). Veno-venous bypass in liver transplantation: heparin coated perfusion circuits reduce the activation of humoral defence systems in an in vitro model. Perfusion.  ISSN 0267-6591.  s 285- 292
  • Scholz, Tim; Solberg, Rigmor; Okkenhaug, Cecilie; Videm, Vibeke; Gallimore, Michael J.; Mathisen, Øystein; Pedersen, Thore H.; Mollnes, Tom Eirik; Bergan, Anstein Bjørnar; Søreide, Odd; Klintmalm, Göran B. & Aasen, Ansgar Oddne (2001). Veno-venous bypass in liver transplantation: heparin-coated perfusion circuits reduce the activation of humoral defense systems in an in vitro model. Perfusion.  ISSN 0267-6591.  16(4), s 285- 292 Show summary
  • Jørgensen, Pål Foyn; Wang, Jacob Edward; Almlöf, Mia; Solberg, Rigmor; Okkenhaug, Cecilie; Scholz, Tim; Thiemmermann, Christoph; Foster, Simon J & Aasen, Ansgar Oddne (2001). Sirolimus interferes with innate response to bacterial products in human whole blood by attenuation of IL-10 production. Scandinavian Journal of Immunology.  ISSN 0300-9475.  53, s 184- 191 Show summary
  • Jørgensen, Pål Foyn; Wang, Jacob Edward; Almlöf, Mia; Thiemmermann, Christoph; Foster, Simon J; Solberg, Rigmor & Aasen, Ansgar Oddne (2001). Peptidoglycan and lipoteichoic acid modify monocyte phenotype in human whole blood. Clinical and Laboratory Immunology.  ISSN 1071-412X.  8(3), s 515- 521 Show summary
  • Jørgensen, Pål Foyn; Wang, Jacob Edward; Solberg, Rigmor; Thiemmermann, Christoph; Foster, Simon J & Aasen, Ansgar Oddne (2001). Procalcitonin does not influence the surface expression of inflammatory receptors on whole blood leukocytes. Intensive Care Medicine.  ISSN 0342-4642.  27(2), s 430- 433 Show summary
  • Wang, Jacob Edward; Jørgensen, Pål Foyn; Almlöf, Maria; Thiemmermann, Christoph; Foster, Simon J; Aasen, Ansgar Oddne & Solberg, Rigmor (2001). Peptidoglycan primes for the LPS-induced release of proinflammatory cytokines in whole human blood. Shock.  ISSN 1073-2322.  16(3), s 178- 182
  • Jørgensen, Pål Foyn; Wang, Jacob Edward; Almlöf, Maria; Solberg, Rigmor; Okkenhaug, Cecilie; Scholz, Tim; Thiemmermann, Christoph; Foster, Simon J & Aasen, Ansgar Oddne (2000). Sirolinus interferes with the innate response to bacterial products in human whole blood by attenuation of IL-10 production. Scandinavian Journal of Immunology.  ISSN 0300-9475.  (53), s 1- 9
  • Wang, Jacob Edward; Jørgensen, Pål Foyn; Almlöf, Mia; Thiemmermann, Christoph; Foster, Simon J; Aasen, Ansgar Oddne & Solberg, Rigmor (2000). Peptidoglycan and lipoteichoic acid from Staphylococcus aureus induce tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-10 production in both T cells and monocytes in a human whole blood model. Infection and Immunity.  ISSN 0019-9567.  68(7), s 3965- 3979
  • Wang, Jacob Edward; Solberg, Rigmor; Okkenhaug, Cecilie; Jørgensen, Pål Foyn; Krohn, Claus Danckert & Aasen, Ansgar Oddne (2000). Cytokine modulation in experimental endotoxemia: characterization of an ex vivo whole blood model. European Surgical Research.  ISSN 0014-312X.  32, s 65- 73
  • Eide, Turid; Coglan, V.; Ørstavik, Sigurd; Holsve, Christian; Solberg, Rigmor; Skålhegg, Bjørn Steen; Lamb, N.J.C.; Langeberg, L.; Fernandez, Alicia; Scott, John D.; Jahnsen, Tore & Tasken, Kjetil (1998). Molecular Cloning, Chromosomal Localization and Cell Cycle-Dependent Subcellular Distribution of the A-kinase anchoring protein, AKAP95. Experimental Cell Research.  ISSN 0014-4827.  (238), s 305- 316
  • Solberg, Rigmor; Scholz, Tim; Videm, Vibeke; Okkenhaug, Cecilie & Aasen, Ansgar Oddne (1998). Heparin coating reduces cell activation and mediator release in an in vitro venovenous bypass model for liver transplantation. Transplant International.  ISSN 0934-0874.  11, s 252- 258 Show summary
  • Tasken, Kjetil; Naylor, Susan L.; Solberg, Rigmor & Jahnsen, Tore (1998). Mapping of the gene encoding the regulatory subunit RIIalpha of cAMP-dependent protein kinase (locus PRKAR2A) to human chromosome region 3p21.3-p21.2. Genomics.  ISSN 0888-7543.  (50), s 378- 381
  • Tasken, Kjetil; Skålhegg, Bjørn Steen; Taskén, Kristin Austlid; Solberg, Rigmor; Knutsen, Helle Katrine; Levy, Finn Olav; Sandberg, Mårten; Ørstavik, Sigurd; Larsen, Turid; Johansen, A. K.; Vang, Torkel; Schrader, H. P.; Reinton, Nils Torgny Kjelkevik; Torgersen, Knut Martin; Hansson, Vidar & Jahnsen, Tore (1997). Structure, function, and regulation of human cAMP-dependent protein kinases, In  Advances in Second Messenger and Phosphoprotein Research.   Kapitel.  s 191 - 204
  • Foss, Kari Bente; Solberg, Rigmor; Simard, J.; Myklebust, Frode; Hansson, Vidar; Jahnsen, Tore & Tasken, Kjetil (1997). Molecular cloning, upstream sequence and promoter studies of the human gene for the regulatory subunit RII alpha of cAMP-dependent protein kinase. Biochimica et Biophysica Acta.  ISSN 0006-3002.  1350(1), s 98- 108
  • Solberg, Rigmor; Sandberg, Mårten; Nataranjan, V.; Torjesen, Peter A.; Hansson, Vidar; Jahnsen, Tore & Tasken, Kjetil (1997). The human gene for the regulatory subunit RIalpha of cAMP-dependent protein kinase - Two distinct promoters provide differential regulation of alternately spliced mRNAs. Endocrinology.  ISSN 0013-7227.  138, s 169- 181 Show summary
  • Aasen, Ansgar Oddne; Solberg, Rigmor; Sveen, Ola Halvor & Gallimore, Michael J. (1996). Consequences of trauma on circulating cells and the plasma cascade systems, In Bo Risberg (ed.),  Trauma care - an update.  Pharmacia & Upjohn, Gøteborg.  ISBN 91-85794-32-5.  Kapittel 3.  s 118 - 128
  • Aasen, Ansgar Oddne; Solberg, Rigmor; Sveen, Ola Halvor; Gallimore, Michael J. & Holzheimer, RG (1996). Concequences of trauma on circulating cells and the plasma cascade systems, In Bo Risberg (ed.),  Trauma care - an update.  Pharmacia & Upjohn, Gøteborg.  ISBN 91-85794-32-5.  s 118 - 128
  • Orstavik, Sigurd; Solberg, Rigmor; Tasken, Kjetil; Nordahl, Marianne; Altherr, Michael R; Hansson, Vidar; Jahnsen, Tore & Sandberg, Mårten (1996). Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  220(3), s 759- 767 Show summary

View all works in Cristin

  • Arnekleiv, Guro L.; Nilsen, Hilde; Lunde, Ngoc Nguyen Dieu; Solberg, Rigmor & Johansen, Harald Thidemann (2017). Effekt av vitamin D3 på uttrykk, aktivitet og sekresjon av cysteinproteasen legumain studert i ulike cellemodeller.
  • Hemati, Paya Diana; Bosnjak, Tatjana; Nilsen, Hilde; Lunde, Ngoc Nguyen Dieu; Johansen, Harald Thidemann & Solberg, Rigmor (2017). The Proton Pump Inhibitor Lansoprazole Inhibits Protease Activity of Legumain.
  • Abdukadir, Nuriddin; Lunde, Ngoc Nguyen Dieu; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann (2016). Regulering av cysteinproteaser ved differensiering av monocytter til makrofager.
  • Larsen, Kristina Broe Bodin; Johansen, Harald Thidemann; Solberg, Rigmor & Lunde, Ngoc Nguyen Dieu (2016). Betydning av glykosylering for internalisering og aktivering av prolegumain i humane tykktarmskreftceller.
  • Lunde, Ngoc Nguyen Dieu; Dahl, Tuva Børresdatter; Abdukadir, Nuriddin; Halvorsen, Bente; Solberg, Rigmor & Johansen, Harald Thidemann (2016). Increased secretion of legumain from pro-inflammatory M1 compared to M2 macrophages.
  • Røsjø, Bjarne & Solberg, Rigmor (2016, 21. november). Desillusjonert over dopingbruken i idretten. [Internett].  titan.uio.no.
  • Solberg, Rigmor & Johansen, Harald Thidemann (2016). Involvement of the cysteine protease legumain in human health and disease.
  • Solberg, Rigmor; Rut, Wioletta; Lunde, Ngoc Nguyen Dieu; Kasperkiewicz, Paulina; Snipas, Scott J.; Mihelic, Marko; Turk, Dusan; Turk, Boris; Salvesen, Guy S.; Drag, Marcin & Poreba, Marcin (2016). New Selective Probes to Inhibit and Image Legumain in Living Cells.
  • Johansen, Harald Thidemann; Elyouncha, Inass; Lunde, Ngoc Nguyen Dieu; Williams, Rich; Solberg, Rigmor; Nilsen, Hilde & Halvorsen, Bente (2015). Opposing effects of glucose on legumain and cysteine cathepsins.
  • Lunde, Ngoc Nguyen Dieu; Nilsen, Hilde; Damgaard, Ingrid; Kasem, Roya; Solberg, Rigmor; Haugen, Mads Haugland & Johansen, Harald Thidemann (2015). Importance of glycosylation for legumain and cystatin E/M functions.
  • Solberg, Rigmor (2015). Novel legumain specific cell-permeable activity based probes.
  • Solberg, Rigmor; Poreba, Marcin; Rut, Wioletta; Kasperkiewicz, Paulina; Snipas, Scott; Turk, Boris; Salvesen, Guy & Drag, Marcin (2015). Novel legumain-specific activity based probes binds and inhibits legumain in living cells.
  • Berven, Lise; Solberg, Rigmor & Samuelsen, Anne Berit C. (2014). Effects of alginates on legumain Activity in RAW 264.7 cells and on prolegumain autoactivation. Planta Medica.  ISSN 0032-0943.  80(16), s 1358- 1358 . doi: DOI: 10.1055/s-0034-1394502
  • Haugen, Mads Haugland; Flatmark, Kjersti; Tamhane, Tripti; Boye, Kjetil; Pettersen, Solveig; Solberg, Rigmor; Johansen, Harald Thidemann; Brix, Klaudia & Mælandsmo, Gunhild (2013). Nuclear localized legumain in colorectal cancer.
  • Johansen, Harald Thidemann; Solberg, Rigmor; Nilsen, Hilde & Smith, Robert (2013). Effects and interplay of legumain and cystatin E/M om migration and invasion of macrophages.
  • Smith, Robert; Johansen, Harald Thidemann; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild; Thoresen, G. Hege & Solberg, Rigmor (2013). Simvastatin inhibits legumain activity and processing in human myotubes.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde & Solberg, Rigmor (2013). Effects and interplay of legumain and cystatin E/M on migration and invasion of macrophages.
  • Tina, Elvestrand; Åstrand, Ove Alexander; Smith, Robert; Rongved, Pål; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann (2013). Cellular effects of a colchicine-prodrug cleaved by legumain.
  • Voreland, Anette; Smith, Robert; Thoresen, G. Hege; Johansen, Harald Thidemann & Solberg, Rigmor (2013). The cysteine protease legumain is downregulated by simvastatin in primary human skeletal muscle cells.
  • Ånonsen, Kjersti Bergh; Nilsen, Hilde; Smith, Robert; Johansen, Harald Thidemann & Solberg, Rigmor (2013). Regulering av legumain i samspillet mellom makrofager og kreftceller.
  • Berven, Lise; Johansen, Harald Thidemann; Solberg, Rigmor; Kolset, Svein Olav & Samuelsen, Anne Berit C. (2012). INTERACTIONS BETWEEN PROLEGUMAIN AND GLYCOSAMINOGLYCANS.
  • Jacobsen, Linn Løkken; Smith, Robert; Thoresen, G. Hege; Solberg, Rigmor & Johansen, Harald Thidemann (2012). Are the cysteine proteases legumain and cathepsins involved in statin-induced myotoxicity?.
  • Samuelsen, Anne Berit C.; Berven, Lise; Solberg, Rigmor; Johansen, Harald Thidemann & Truong, Hong Hoa Thi (2012). Effekt av alginat på legumain, en protease involvert i kreftutvikling.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Yassen, Islam M.; Haugen, Mads Haugland; Pettersen, Solveig; Mælandsmo, Gunhild; Abrahamson, Magnus & Solberg, Rigmor (2012). SECRETION, INTERNALIZATION AND INTERPLAY OF LEGUMAIN AND CYSTATIN E/M.
  • Tran, Anny T.; Smith, Robert; Solberg, Rigmor & Johansen, Harald Thidemann (2012). Effects of atorvastatin on regulation of protease activities in macrophages.
  • Haugen, Mads Haugland; Mælandsmo, Gunhild; Johansen, Harald Thidemann; Solberg, Rigmor; Pettersen, Solveig; Boye, Kjetil & Flatmark, Kjersti (2011). Nuclear activity of the cysteine protease legumain in colorectal carcinoma.
  • Johansen, Harald Thidemann; Smith, Robert; Tewolde, Eyassu; Nilsen, Hilde & Solberg, Rigmor (2011). ATORVASTATIN INHIBITS LEGUMAIN ACTIVITY IN AND PROLEGUMAIN SECRETION FROM HUMAN ACTIVATED MACROPHAGES.
  • Samuelsen, Anne Berit C.; Berven, Lise; Solberg, Rigmor; Johansen, Harald Thidemann & Nguyen, Nga Thi (2011). Studier av alginats effekt på prolegumain og cellesekresjon av matriksmetalloproteaser.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Yassen, Islam M.; Haugen, Mads Haugland; Pettersen, Solveig J. & Solberg, Rigmor (2011). SUBCELLULAR LOCALIZATION, INTERPLAY AND SECRETION OF LEGUMAIN AND CYSTATIN E/M IN HEK 293 CELLS.
  • Smith, Robert; Johansen, Harald Thidemann & Solberg, Rigmor (2011). Cellular localization and interplay between legumain and its endogenous inhibitor cystatin E/M.
  • Briggs, Jon; Haugen, Mads Haugland; Johansen, Harald Thidemann; Riker, Adam I; Abrahamson, Magnus; Fodstad, Øystein; Mælandsmo, Gunhild Mari & Solberg, Rigmor (2009). Cystatin E/M suppresses legumain activity and invasion of human melanoma.
  • Haugen, Mads Haugland; Johansen, Harald Thidemann; Solberg, Rigmor; Flatmark, Kjersti & Mælandsmo, Gunhild M (2009). Expression and activity of the cysteine protease legumain in colorectal carcinoma cell lines.
  • Solberg, Rigmor; Almlöf, Maria; Nilsen, Hilde; Ali, Zana Abdullrahman; Abrahamson, Magnus & Johansen, Harald Thidemann (2009). Asparaginyl endopeptidase activity is upregulated during differentiation of monocytes to macrophages but only partly mediated by legumain.
  • Ben Omar, Sakina; Johansen, Harald Thidemann; Aukrust, Pål; Halvorsen, Bente & Solberg, Rigmor (2008). Lysosomal cysteine proteases in atherosclerosis: Do inflammatory modulators regulate expression and activity?.
  • Almlöf, Maria; Solberg, Rigmor & Johansen, Harald Thidemann (2007). Regulation of cystein proteases in monocytes/macrophages and in tumorigenesis.
  • Solberg, Rigmor; Nilsen, Hilde; Johansen, Harald Thidemann; Mælandsmo, Gunhild M. & Briggs, Jon (2007). SCREENING OF THE EXPRESSIONS OF LEGUMAIN AND ITS SPECIFIC INHIBITOR CYSTATIN M IN VARIOUS MELANOMA CELLS.
  • Almlöf, Maria; Elenjord, Renate; Solberg, Rigmor; Winberg, Jan Olof; Loennechen, Thrina & Johansen, Harald Thidemann (2006). The expression and activity of legumain is highly increased in malignant osteosarcoma cells compared to non-malignant cells.
  • Almlöf, Maria; Elenjord, Renate; Solberg, Rigmor; Winberg, Jan-Olof; Loennechen, Thrina & Johansen, Harald Thidemann (2006). Malignant osteosarcoma cells express higher levels of legumain compared to non-malignant cells.
  • Almlöf, Maria; Solberg, Rigmor; Nilsen, Hilde & Johansen, Harald Thidemann (2006). Legumain expression and activity is highly increased as monocytes differentiate toward macrophages.
  • Brekke, Stian; Rønning, Camilla; Värn, Christine; Aas, Vigdis; Thoresen, G. Hege & Solberg, Rigmor (2005). Moxonidine exhibits direct effects on human skeletal muscle cells.
  • Solberg, Rigmor (2005). FRM 2410 - Formulering og bruk av legemidler. Norges apotekerforenings tidsskrift.  ISSN 0802-8400.  113(2), s 104- 105
  • Barsett, Hilde & Solberg, Rigmor (2004). New curriculum for master of pharmacy, School of Pharmacy, University of Oslo, Norway.
  • Värn, Christine; Aas, Vigdis; Endresen, Marit JR & Solberg, Rigmor (2004). Moxonidine enhances glucose uptake in human skeletal muscle cells.
  • Rustan, Arild; Solberg, Rigmor; Reseland, Janne Elin; Andersen, Merethe H; Drevon, Christian A & Aas, Vigdis (2002). FATTY ACIDS MODULATE LEPTIN AND LEPTIN RECEPTOR (OB-RB) GENE EXPRESSION AND LEPTIN SECRETION IN CULTURED HUMAN SKELETAL MUSCLE CELLS. Show summary
  • Yaqub, Sheraz; Solhaug, Vigdis; Vang, Torkel; Solberg, Rigmor; Aasen, Ansgar Oddne; Tasken, Kjetil & Wang, Jacob Edward (2002). A Human Whole Blood Model Of LPS-Mediated Suppresion Of T-Cell Activation.
  • Wang, Jacob Edward; Warris, A.; Ellingsen, Espen Alme; Jørgensen, Pål Foyn; Flo, T. H.; Espevik, T; Solberg, Rigmor; Verweij, P. E. & Aasen, Ansgar Oddne (2001). Involvement of CD 14 and toll-like receptors in signaling by Aspergillus hypae.
  • Wang, Jacob Edward; Warris, A.; Ellingsen, Espen Alme; Jørgensen, Pål Foyn; Flo, T. H.; Espvik, T.; Solberg, Rigmor; Verweij, P. E. & Aasen, Ansgar Oddne (2001). Activation of Leykocytes By Hyphal Fragments: Invvolvment of CD14 And Toll-Like Receptors.
  • Jørgensen, Pål Foyn; Wang, Jacob Edward; Almlöf, Mia; Thiemmermann, Christoph; Foster, Simon J; Solberg, Rigmor & Aasen, Ansgar Oddne (2000). SIROLIMUS INHIBITS THE IL-10 PRODUCTION IN RESPONSE TO BACTERIAL PRODUCTS. Show summary
  • Wang, Jacob Edward; Jørgensen, Pål Foyn; Almlöf, Maria; Thiemmermann, Christoph; Solberg, Rigmor & Aasen, Ansgar Oddne (2000). Staphylococcus aureus peptidoglycan and lipoteichoic acid induce cytokine production in whole human blood.
  • Wang, Jacob Edward; Jørgensen, Pål Foyn; Thiemmermann, Christoph; Solberg, Rigmor & Aasen, Ansgar Oddne (2000). Peptidoglycan and LPS act in synergy to cause the release of TNF-alfa and IL-6, but not IL-10 in whole human blood.
  • Wang, Jacob Edward; Jørgensen, Pål Foyn; Okkenhaug, Cecilie; Solberg, Rigmor & Aasen, Ansgar Oddne (1999). Sensitive responses to LPS in human blood depleted of CD14 positive monocytes.
  • Wang, Jacob Edward; Okkenhaug, Cecilie; Jørgensen, Pål Foyn; Solberg, Rigmor & Aasen, Ansgar Oddne (1998). Dose dependent dual effects of IL-4 and IL-13 on proinflammatory cytokine release in experimental endotoxemia.
  • Wang, Jacob Edward; Okkenhaug, Cecilie; Jørgensen, Pål Foyn; Solberg, Rigmor & Aasen, Ansgar Oddne (1998). Dose dependent dual effects of IL-4 or IL-13 on proinflammatory cytokine release in experimental endotoxemia.
  • Aasen, Ansgar Oddne; Solberg, Rigmor; Høgetveit, Jan Olav & Sveen, Ola Halvor (1997). Protease cascades in intraabdominal infection.
  • Tasken, Kjetil; Skålhegg, Bjørn Steen; Taskén, Kristin Austlid; Solberg, Rigmor; Knutsen, Helle Katrine; Levy, Finn Olav; Torgersen, Knut Martin; Reinton, Nils Torgny Kjelkevik; Larsen, Turid; Aandahl, Einar Martin; Hansson, Vidar & Jahnsen, Tore (1996). Specificity in cAMP-mediated signalling.
  • Tasken, Kjetil; Skålhegg, Bjørn Steen; Taskén, Kristin Austlid; Solberg, Rigmor; Knutsen, Helle Katrine; Levy, Finn Olav; Torgersen, Knut Martin; Reinton, Nils Torgny Kjelkevik; Larsen, Turid; Aandahl, Einar Martin; Hansson, Vidar & Jahnsen, Tore (1996). Specificity in cAMP-mediated signalling.
  • Larsen, Turid; Holsve, Christian; Scott, John D.; Tasken, Kjetil; Solberg, Rigmor; Hansson, Vidar & Jahnsen, Tore (1996). Molecular cloning of the human AKAP95 for the regulatory subunit type II of cyclic AMP-dependent protein kinase.
  • Larsen, Turid; Solberg, Rigmor; Scott, John D.; Tasken, Kjetil; Hansson, Vidar & Jahnsen, Tore (1996). Molecular cloning of the human AKAP95 for the regulatory subunit type II of cAMP-dependent protein kinase.
  • Larsen, Turid; Tasken, Kjetil; Solberg, Rigmor; Skålhegg, Bjørn Steen; Hansson, Vidar & Jahnsen, Tore (1996). Cyclic AMP-regulated A-kinase anchoring proteins (AKAPs) in rat Sertoli cells.
  • Reinton, Nils Torgny Kjelkevik; Tasken, Kjetil; Solberg, Rigmor; Levy, Finn Olav; Jahnsen, Tore & Hansson, Vidar (1996). The catalytic subunit, Cgamma, of cAMP-dependent protein kinase is a functional retroposon.
  • Reinton, Nils Torgny Kjelkevik; Tasken, Kjetil; Solberg, Rigmor; Skålhegg, Bjørn Steen; Levy, Finn Olav; Jahnsen, Tore & Hansson, Vidar (1996). The testis specific catalytic subunit Cgamma of cAMP-dependent protein kinase is a functional retroposon.
  • Solberg, Rigmor; Tasken, Kjetil; Hansson, Vidar & Jahnsen, Tore (1996). Exon-intron organization, 5' upstream sequence and alternate splicing of mRNAs for the regulatory subunit RIalpha of cAMP-dependent protein kinases.

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Published Nov. 3, 2010 3:44 PM - Last modified Apr. 5, 2017 8:31 AM

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