Yvette Dehnes

• Levernæs, Maren Christin Stillesby; Solheim, Sara A.; Broderstad, Lillian; Zandy, Essa; Mørkeberg, Jakob & Dehnes, Yvette (2024). Detection of doping substances in paired dried blood spots and urine samples collected during doping controls in Danish fitness centers. Drug Testing and Analysis. ISSN 1942-7603. doi: 10.1002/dta.3660.
• Equey, Tristan; Sletten, Camilla Johanne; Dehnes, Yvette; D`Onofrio, Guiseppe; Brugnara, Carlo & Baume, Norbert [Show all 7 contributors for this article] (2021). Standardization of reticulocyte counts in the athlete biological passport: A practical update. International Journal of Laboratory Hematology (IJLH). ISSN 1751-5521. 44(1), p. 112–117. doi: 10.1111/ijlh.13732.
• Solheim, Sara Amalie; Ringsted, Thomas Kamm; Nordsborg, Nikolai B.; Dehnes, Yvette; Levernæs, Maren Christin Stillesby & Mørkeberg, Jakob (2021). No pain, just gain: Painless, easy, and fast dried blood spot collection from fingertip and upper arm in doping control. Drug Testing and Analysis. ISSN 1942-7603. 13(10), p. 1783–1790. doi: 10.1002/dta.3135.
• Solheim, Sara Amalie; Levernæs, Maren Christin Stillesby; Mørkeberg, Jakob; Juul, Anders; Upners, Emmie N. & Nordsborg, Nikolai Baastrup [Show all 7 contributors for this article] (2021). Stability and detectability of testosterone esters in dried blood spots after intramuscular injections. Drug Testing and Analysis. ISSN 1942-7603. doi: 10.1002/dta.3030.
• Jessen, Søren; Becker, Victoria; Rzeppa, Sebastian; Backer, Vibeke; Bengtsen, Kasper Høtoft & Hullstein, Ingunn Riise [Show all 8 contributors for this article] (2020). Pharmacokinetics of salmeterol and its main metabolite α‐hydroxysalmeterol after acute and chronic dry powder inhalation in exercising endurance‐trained men: Implications for doping control. Drug Testing and Analysis. ISSN 1942-7603. doi: 10.1002/dta.2978. Show summary

  As of 2020, use of beta2‐agonist salmeterol is restricted by the World Anti‐Doping Agency (WADA) and is only permitted by inhalation at therapeutic doses not exceeding 200 μg in 24 h. In contrast to beta2‐agonists salbutamol and formoterol, WADA has not established a urine threshold for salmeterol despite its muscle hypertrophic actions observed in animals. Herein, we investigated plasma (0–4 h) and urine (0–24 h) concentrations (by ultra‐high‐performance liquid chromatography–tandem mass spectrometry [UHPLC–MS/MS]) of salmeterol and α‐hydroxysalmeterol after dry powder inhalation at supratherapeutic (400 μg) and high therapeutic (200 μg) doses, and after seven consecutive days of therapeutic inhalation (200 μg × day−1) in 11 healthy endurance‐trained men. During each trial, participants inhaled salmeterol before 1½ h moderate‐intensity cycling. Mean ± SD maximum urine concentrations of salmeterol unadjusted for specific gravity reached 4.0 ± 1.6, 2.1 ± 1.5, and 2.2 ± 1.1 ng × ml−1 for 400 μg, 200 μg, and seven consecutive days of 200 μg, respectively, with corresponding maximum urine concentrations of α‐hydroxysalmeterol being 11.6 ± 6.1, 5.7 ± 4.6, and 6.5 ± 2.6 ng × ml−1. Within the relevant window for doping control (first 6 h post‐inhalation), the present data (119 samples), along with 64 biobank urine samples, showed that a combined salmeterol and α‐hydroxysalmeterol urine threshold with equal cut‐offs of 3.3 ng × ml−1 was superior to a salmeterol‐only threshold to discriminate therapeutic (200 μg) from supratherapeutic use (400 μg) with a sensitivity of 24% with 0% false positives when applying the WADA technical document (TD2019DL.v2) method of specific gravity adjustment. Thus, a combination of urine salmeterol and α‐hydroxysalmeterol concentrations may be suitable for discriminating between therapeutic and supratherapeutic prohibited inhalation of salmeterol.

• Solheim, Sara Amalie; Mørkeberg, Jakob; Dehnes, Yvette; Hullstein, Ingunn Riise; Juul, Anders & Upners, Emmie N. [Show all 7 contributors for this article] (2020). Changes in blood parameters after intramuscular testosterone ester injections – Implications for anti-doping. Drug Testing and Analysis. ISSN 1942-7603. 12(8), p. 1019–1030. doi: 10.1002/dta.2803.
• Solheim, Sara Amalie; Jessen, S.; Mørkeberg, Jakob; Thevis, Mario; Dehnes, Yvette & Eibye, Kasper [Show all 8 contributors for this article] (2020). Single-dose administration of clenbuterol is detectable in dried blood spots. Drug Testing and Analysis. ISSN 1942-7603. 12(9), p. 1366–1372. doi: 10.1002/dta.2872.
• Bejder, Jacob; Breenfeldt Andersen, Andreas; Bonne, Thomas Christian; Piil, Jacob Feder; Hauan Hagen, Linn Camilla & Dehnes, Yvette [Show all 9 contributors for this article] (2020). Tramadol Does Not Improve Performance or Impair Motor Function in Trained Cyclists. Medicine & Science in Sports & Exercise. ISSN 0195-9131. 52(5), p. 1169–1175. doi: 10.1249/MSS.0000000000002217.
• Solheim, Sara Amalie; Mørkeberg, Jakob; Juul, Anders; Freiesleben, Stine Yde; Upners, Emmie N. & Dehnes, Yvette [Show all 7 contributors for this article] (2020). An Intramuscular Injection of Mixed Testosterone Esters Does Not Acutely Enhance Strength and Power in Recreationally Active Young Men. Frontiers in Physiology. ISSN 1664-042X. 11. doi: 10.3389/fphys.2020.563620.
• Krug, Oliver; Thomas, Andreas; Malerød-Fjeld, Helle; Dehnes, Yvette; Laussmann, Tim & Feldmann, Ingo [Show all 8 contributors for this article] (2018). Analysis of new growth promoting black market products. Growth Hormone & IGF Research. ISSN 1096-6374. 41, p. 1–6. doi: 10.1016/j.ghir.2018.05.001.
• Pitarch-Motellón, Jorge; Roig-Navarro, Antoni Francesc; Sancho, Juan Vicente; Ibáñez, Maria; Fabregat-Cabello, Neus & Pozo, Oscar J. [Show all 15 contributors for this article] (2017). Evaluation of uncertainty sources in the determination of testosterone in urine by calibration-based and isotope dilution quantification using ultra high performance liquid chromatography tandem mass spectrometry. Journal of Chromatography A. ISSN 0021-9673. 1508, p. 73–80. doi: 10.1016/j.chroma.2017.05.072.
• Krogh, Nanna; Rzeppa, Sebastian; Dyreborg, Anders; Dehnes, Yvette; Hemmersbach, Peter J & Backer, Vibeke [Show all 7 contributors for this article] (2017). Terbutaline accumulates in blood and urine after daily therapeutic inhalation. Medicine & Science in Sports & Exercise. ISSN 0195-9131. 49(6), p. 1236–1243. doi: 10.1249/MSS.0000000000001199.
• Hullstein, Ingunn; Malerød-Fjeld, Helle; Dehnes, Yvette & Hemmersbach, Peter J (2015). Black market products confiscated in Norway 2011-2014 compared to analytical findings in urine samples. Drug Testing and Analysis. ISSN 1942-7603. 7(11-12), p. 1025–1029. doi: 10.1002/dta.1900.
• Dehnes, Yvette; Myrvold, Linda; Strøm, H.; Ericsson, M & Hemmersbach, Peter J (2014). MAIIA EPO SeLect - a rapid screening kit for the detection of recombinant EPO analogues in doping control: Inter-laboratory prevalidation and normative study of athlete urine and plasma samples. Drug Testing and Analysis. ISSN 1942-7603. 6(11-12), p. 1144–1150. doi: 10.1002/dta.1752.
• Dehnes, Yvette; Shan, Jufang; Beuming, Thijs; Shi, Lei; Weinstein, Harel & Javitch, Jonathan A. (2014). Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation. Neurochemistry International. ISSN 0197-0186. 73(1), p. 4–15. doi: 10.1016/j.neuint.2014.02.003.
• Martinov, Vladimir Nikolkaev; Dehnes, Yvette; Holmseth, Silvia; Shimamoto, Keiko; Danbolt, Niels Christian & Valen, Guro (2014). A novel glutamate transport blocker, LL-TBOA, attenuates ischemic injury in the isolated, perfused rat heart despite low transporter levels. European Journal of Cardio-Thoracic Surgery. ISSN 1010-7940. 45(4), p. 710–716. doi: 10.1093/ejcts/ezt487.
• Dehnes, Yvette; Shalina, Alexandra & Myrvold, Linda (2013). Detection of recombinanat EPO in blood and urine samples with EPO WGA MAIIIEF and SAR-PAGE after microdose injections. Drug Testing and Analysis. ISSN 1942-7603. doi: 10.1002/dta.1579.
• Holmseth, Silvia; Dehnes, Yvette; Huang, YHH; Follin-Arbelet, Virginie; Verket, Nina Julie & Mylonakou, Maria-Niki [Show all 12 contributors for this article] (2012). The Density of EAAC1 (EAAT3) Glutamate Transporters Expressed by Neurons in the Mammalian CNS. Journal of Neuroscience. ISSN 0270-6474. 32(17), p. 6000–6013. doi: 10.1523/JNEUROSCI.5347-11.2012.
• Dehnes, Yvette & Hemmersbach, Peter J (2011). Effect of single doses of methoxypolyethylene glycol-epoetin beta (CERA, Mircera) and epoetin delta (Dynepo) on isoelectric erythropoietin profiles and haematological parameters. Drug Testing and Analysis. ISSN 1942-7603. 3(5), p. 291–299. doi: 10.1002/dta.270.
• Lönnberg, Maria; Dehnes, Yvette; Drevin, Malin; Garle, Mats; Lamon, Séverine & Leuenberger, Nicolas [Show all 8 contributors for this article] (2010). Rapid affinity purification of erythropoietin from biological samples using disposable monoliths. Journal of Chromatography A. ISSN 0021-9673. 1217(45), p. 7031–7037. doi: 10.1016/j.chroma.2010.09.034.
• Dehnes, Yvette; Lamon, Séverine & Lönnberg, Maria (2010). Erythropoietin (EPO) immunoaffinity columns-A powerful tool for purifying EPO and its recombinant analogues. Journal of Pharmaceutical and Biomedical Analysis. ISSN 0731-7085. 53(4), p. 1028–1032. doi: 10.1016/j.jpba.2010.06.017.
• Furness, DN; Dehnes, Yvette; Akhtar, Aisha Qureshi; Rossi, DJ; Hamann, M & Grutle, Nina J. [Show all 14 contributors for this article] (2008). A QUANTITATIVE ASSESSMENT OF GLUTAMATE UPTAKE INTO HIPPOCAMPAL SYNAPTIC TERMINALS AND ASTROCYTES: NEW INSIGHTS INTO A NEURONAL ROLE FOR EXCITATORY AMINO ACID TRANSPORTER 2 (EAAT2). Neuroscience. ISSN 0306-4522. 157(1), p. 80–94. doi: 10.1016/j.neuroscience.2008.08.043.

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• Danbolt, Niels Christian; Holmseth, Silvia; Dehnes, Yvette; Huang, Y.; Follin-Arbelet, Virginie & Grutle, N [Show all 11 contributors for this article] (2011). QUANTIFICATION AND LOCALIZATION OF THE EAAC1 GLUTAMATE TRANSPORTER IN BRAIN. Glia. ISSN 0894-1491. 59, p. S66–S66.
• Danbolt, Niels Christian; Attwell, D; Bergles, D; Dehnes, Yvette; Furness, DN & Gundersen, Vidar [Show all 12 contributors for this article] (2006). Glutamate transporters around synapses. Journal of Neurochemistry. ISSN 0022-3042. 96, p. 87–87.
• Danbolt, Niels Christian; Attwell, David; Dehnes, Yvette; Furness, David N; Gundersen, Vidar & Hamann, Martine [Show all 10 contributors for this article] (2004). Cellular distribution and function of glutamate transporters.
• Holmseth, Silvia; Dehnes, Yvette; Bjørnsen, Lars Petter B.W.; Furness, David N; Bergles, Dwight & Danbolt, Niels Christian (2004). The determination of the concentrations of the glutamate transporter EAAT3 (EAAC) in brain tissue and unexpected cross-reactivities of antibodies directed to EAAT3.
• Bjørnsen, Lars Petter B.W.; Holmseth, Silvia; Dehnes, Yvette; Lehre, Knut Petter Dæhlin; Kanzler, A & Mylonakou, Maria-Niki [Show all 7 contributors for this article] (2003). The concentration of glutamate transporter 3 in rat brain and kidney. Journal of Neurochemistry. ISSN 0022-3042. 87, p. 114–114.
• Danbolt, Niels Christian; Bjomsen, LP; Dehnes, Yvette; Furness, DN; Holmseth, Silvia & Lehre, Knut Petter Dæhlin [Show all 10 contributors for this article] (2003). Synaptic distribution of glutamate transporters. Journal of Neurochemistry. ISSN 0022-3042. 87, p. 43–43.

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