LaMDa paper in Genome Biology – first genome-wide analysis of RNA decay in a bacterium at single nucleotide resolution

In a paper first-authored by Simen Kristoffersen, the Økstad group has performed the first ever analysis of global mRNA decay in a bacterium using RNA sequencing (RNA-Seq). 

The paper has been published in the May edition of the open access journal Genome Biology (impact factor 6.9), and was a collaboration with Timothy D. Read’s group at Emory University (Atlanta, USA) and 454, also featuring LaMDa co-workers Nicolas Tourasse and Anne-Brit Kolstø. In the paper, the authors identify several intrinsic genomic factors involved in regulating the life span of mRNAs in the cell, and present strong indications for bacterial mRNA processing and the regulation of mRNA decay forming parts of the machinery regulating levels of gene products in the cell.

Published May 8, 2012 1:20 AM - Last modified May 8, 2012 9:58 AM