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Personalized Dosage Form Design (PersDrug)

We aim to design new dosage forms and innovative technological solutions to fulfill the potential of personalized medicine for individuals or groups of individuals.

Illustration: Colourbox.no

Background

Traditionally, most medical treatments have been designed for the "average patient" under the assumption that "one size fits all". Recent breakthrough in fields of diagnostics, genotyping and biomarkers enable the development of more tailor-made personalized solutions.

In the era of Personalized Medicine limited attention has so far been given to the development of dosage forms and formulations that are able to deliver requirements for optimal personalized therapy.

Projects

The research projects spans from pharmaceutical technology, formulations and process optimization (including physico-chemical and biopharmaceutical characteristics) to the assessment of potential risks of not-optimal solutions in a clinical context.

Central technologies and delivery systems

Thin film technology

3D-printing and hot-melt extrusion

Mucosal drug delivery

Amorphous solid dispersions

Multi-functional tablets

Project portfolio

Age-appropriate dosage forms for children

Mucoadhesive films for site-specific delivery to the upper intestine

Patient-centric formulations by hot-melt extrusion and 3D-printing

Effects of manipulations of adult medicine for use in children: Focus on dose accuracy and stability

Compatibility of i.v. drugs in paediatric intensive care

Collaboration

  • Professor Natasa Skalko-Basnet, Department of Pharmacy, UiT The Arctic University of Norway
  • Ass. Professor Željka Vanić, Faculty of Pharmacy and Biochemistry, University of Zagreb, Kroatia
  • Professor Ganesh Acharya and professor Purusotam Basnet, University Hospital of North Norway/UiT
  • Senior scientist Dr. Ellen Bruzell, Nordic Institute of Dental Materials (NIOM)
  • Professor Niklas Sandler, Åbo Akademi University, Finland
  • Dr. Sofia Mattsson, Umeå University, Sverige
  • Senior researcher Dr. Siri Wang, Statens Legemiddelverk
  • Hospital pharmacist Ingrid Grønlie, ​Medicines for Children Network, Norway
  • Researcher Dr. Jørgen Brustugun, Hospital Pharmacy Rikshospitalet
  • Dr. Kathrin Bjerknes, Hospital Pharmacy Lørenskog
Published Oct. 13, 2017 4:23 PM - Last modified Oct. 27, 2017 1:03 PM