Espen Molden

Professor II - Farmasøytisk institutt
Bilde av Espen Molden
English version of this page
Telefon +47 22856561
Rom 484 B
Brukernavn
Besøksadresse Sem Sælands vei 3 Farmasibygningen 0371 Oslo
Postadresse Postboks 1068 Blindern 0316 Oslo

Faglige interesser

Primær faglig interesse er årsaker til individuell variabilitet i effekt og bivirkninger av legemidler, inkludert implementering av kunnskap innen dette området for å bedre legemiddelbehandling i klinisk praksis.

Undervisning

Underviser på det erfaringsbaserte masterprogrammet i klinisk farmasi.

Bakgrunn

Utdannet Cand.pharm. fra UiO i 1997, Dr.scient. samme sted i 2003. I dag ansatt i 20 % stilling som professor II ved Farmasøytisk institutt, UiO. Hovedstillingen er Forskningsleder ved Senter for Psykofarmakologi, Diakonhjemmet sykehus.

Priser

Årets farmasøyt, Norsk Farmaceutisk Forening, 2006

Samarbeid

Samarbeidspartnere innen aktuelle forskningsprosjekter:

Professor Torgeir Bruun Wyller, Oslo Universitetssykehus, Avdeling Ullevål

Professor Anette Hylen Ranhoff, Diakonhjemmet sykehus

Professor Tommy B. Andersson, Astra Zeneca, Mölndal, Sverige

Professor Erik Eliasson, Karolinska institutet, Stockholm, Sverige

Emneord: Farmakologi, Farmakokinetikk, Farmakogenetikk, Legemiddelinteraksjoner, Cytokrom P450, Klinisk farmasi

Publikasjoner

  • Milosavljević, Filip; Molden, Espen; Ingelman-Sundberg, Magnus & Jukić, Marin M (2024). Current level of evidence for improvement of antidepressant efficacy and tolerability by pharmacogenomic-guided treatment: A Systematic review and meta-analysis of randomized controlled clinical trials. European Neuropsychopharmacology. ISSN 0924-977X. 81, s. 43–52. doi: 10.1016/j.euroneuro.2024.01.005.
  • Tveit, Kristine; Hermann, Monica; Nilsen, Roy Miodini; Wallerstedt, Susanna M.; Rongve, Arvid & Molden, Espen [Vis alle 7 forfattere av denne artikkelen] (2024). Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with sex and genotype: An observational study of 34,777 individuals. European Journal of Clinical Pharmacology. ISSN 0031-6970. doi: 10.1007/s00228-023-03611-3.
  • Koch, Elise Mirjam; Pardiñas, Antonio F.; O'Connell, Kevin Sean; Selvaggi, Pierluigi; Camacho-Collados, Jose & Babic, Aleksandar [Vis alle 26 forfattere av denne artikkelen] (2024). How real-world data can facilitate the development of precision medicine treatment in psychiatry. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2024.01.001.
  • Koch, Elise Mirjam; Kämpe, Anders; Alver, Maris; Sigurðarson, Sindri; Einarsson, Guðmundur & Partanen, Juulia [Vis alle 21 forfattere av denne artikkelen] (2024). Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank study. Neuropsychopharmacology. ISSN 0893-133X. doi: 10.1038/s41386-023-01792-0.
  • De las Cuevas, Carlos; Sanz, Emilio J.; Gross, Jason A.; Correll, Christoph U.; Verdoux, Hélène & Lally, John [Vis alle 14 forfattere av denne artikkelen] (2023). Revealing the reporting disparity: VigiBase highlights underreporting of clozapine in other Western European countries compared to the UK. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2023.11.010.
  • Hole, Kristine; Gangsø, Sofie; Jensstuen, Åse Tonette; Ormøy, Hanne Holte; Paulsen, Maren & Molden, Espen [Vis alle 7 forfattere av denne artikkelen] (2023). Effect of CYP2D6 genotype on duloxetine serum concentration. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 134(1), s. 186–192. doi: 10.1111/bcpt.13954.
  • de Leon, Jose; Schoretsanitis, Georgios; Smith, Robert Løvsletten; Molden, Espen; Solismaa, Anssi & Seppälä, Niko [Vis alle 104 forfattere av denne artikkelen] (2023). An international adult guideline for making clozapine titration safer by using six ancestry-based personalized dosing titrations, CRP, and clozapine levels. Psiquiatría Biológica. ISSN 1696-9138. 30(3). doi: 10.1016/j.psiq.2023.100415.
  • Hole, Kristine; Haslemo, Tore & Molden, Espen (2023). Impact of CYP2D6 Genotype on Paroxetine Serum Concentration. Therapeutic Drug Monitoring. ISSN 0163-4356. 45(5), s. 683–688. doi: 10.1097/FTD.0000000000001096.
  • Ruan, Can-Jun; Olmos, Ismael; Ricciardi, Carina; Schoretsanitis, Georgios; Vincent, Philippe D. & Anıl Yağcıoğlu, A. Elif [Vis alle 27 forfattere av denne artikkelen] (2023). Exploring low clozapine C/D ratios, inverted clozapine-norclozapine ratios and undetectable concentrations as measures of non-adherence in clozapine patients: A literature review and a case series of 17 patients from 3 studies. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2023.07.002.
  • Solhaug, Vigdis; Tveito, Marit; Waade, Ragnhild Birkeland; Høiseth, Gudrun; Molden, Espen & Smith, Robert Løvsletten (2023). Impact of age, sex and cytochrome P450 genotype on quetiapine and N-desalkylquetiapine serum concentrations: A study based on real-world data from 8118 patients. British Journal of Clinical Pharmacology. ISSN 0306-5251. doi: 10.1111/bcp.15849. Fulltekst i vitenarkiv
  • Faraj, Pari; Størset, Elisabet; Hole, Kristine; Smith, Godfrey L; Molden, Espen & Dietrichs, Erik Sveberg (2023). Pro-arrhythmic effect of escitalopram and citalopram at serum concentrations commonly observed in older patients – a study based on a cohort of 19,742 patients. EBioMedicine. ISSN 2352-3964. 95. doi: 10.1016/j.ebiom.2023.104779. Fulltekst i vitenarkiv
  • Schoretsanitis, Georgios; Anıl Yağcıoğlu, A. Elif; Ruan, Can-Jun; Eap, Chin B.; Molden, Espen & Baptista, Trino [Vis alle 24 forfattere av denne artikkelen] (2023). Clozapine ultrarapid metabolism during weak induction probably exists but requires careful diagnosis. A literature review, five new cases and a proposed definition. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2023.05.010.
  • Hjemås, Bodil Jahren; Bøvre, Katrine; Bjerknes, Kathrin; Mathiesen, Liv; Mellingsæter, Marte & Molden, Espen (2023). Implementation of pharmacogenetic testing in medication reviews in a hospital setting. British Journal of Clinical Pharmacology. ISSN 0306-5251. 89(10), s. 3116–3125. doi: 10.1111/bcp.15815. Fulltekst i vitenarkiv
  • van Schaik, Ron Hn; Manolopoulos, Vangelis G.; Daly, Ann K.; Niemi, Mikko; Zukic, Branka & Patrinos, George P. [Vis alle 24 forfattere av denne artikkelen] (2023). The Sixth European Society of Pharmacogenomics and Personalised Therapy Congress. Pharmacogenomics (London). ISSN 1462-2416. 24(5), s. 243–246. doi: 10.2217/pgs-2023-0013.
  • Wollmann, Birgit Malene Tovik; Smith, Robert Løvsletten; Kringen, Marianne K.; Ingelman-Sundberg, Magnus; Molden, Espen & Størset, Elisabet (2023). Evidence for solanidine as a dietary CYP2D6 biomarker: Significant correlation with risperidone metabolism. British Journal of Clinical Pharmacology. ISSN 0306-5251. doi: 10.1111/bcp.15721. Fulltekst i vitenarkiv
  • Smith, Robert Løvsletten; Molden, Espen & Bernard, Jean-Paul Anthony (2023). Effect of CYP2D6 and CYP2C19 genotypes on atomoxetine serum levels: A study based on therapeutic drug monitoring data. British Journal of Clinical Pharmacology. ISSN 0306-5251. 89(7), s. 2246–2253. doi: 10.1111/bcp.15706. Fulltekst i vitenarkiv
  • O'Connell, Kevin Sean; Koch, Elise; Lenk, Hasan Cagin; Akkouh, Ibrahim Ahmed; Hindley, Guy Frederick Lanyon & Jaholkowski, Piotr Pawel [Vis alle 16 forfattere av denne artikkelen] (2023). Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia. Psychiatry Research. ISSN 0165-1781. 325. doi: 10.1016/j.psychres.2023.115217. Fulltekst i vitenarkiv
  • Wollmann, Birgit Malene Tovik; Størset, Elisabet; Kringen, Marianne K.; Molden, Espen & Smith, Robert Løvsletten (2023). Prediction of CYP2D6 poor metabolizers by measurements of solanidine and metabolites—a study in 839 patients with known CYP2D6 genotype. European Journal of Clinical Pharmacology. ISSN 0031-6970. 79(4), s. 523–531. doi: 10.1007/s00228-023-03462-y. Fulltekst i vitenarkiv
  • Faraj, Pari; Hermansen, Astrid; Molden, Espen & Hole, Kristine (2022). Identification of Escitalopram Metabolic Ratios as Potential Biomarkers for Predicting CYP2C19 Poor Metabolizers. Therapeutic Drug Monitoring. ISSN 0163-4356. 44(6), s. 720–728. doi: 10.1097/FTD.0000000000000991.
  • Lenk, Hasan Cagin; Smith, Robert Løvsletten; O'Connell, Kevin Sean; Jukić, Marin M.; Kringen, Marianne K. & Andreassen, Ole [Vis alle 8 forfattere av denne artikkelen] (2022). Impact of NFIB and CYP1A variants on clozapine serum concentration—A retrospective naturalistic cohort study on 526 patients with known smoking habits. Clinical and Translational Science (CTS). ISSN 1752-8054. doi: 10.1111/cts.13422. Fulltekst i vitenarkiv
  • Kappel, Djenifer B.; Legge, Sophie E.; Hubbard, Leon; Willcocks, Isabella R.; O'Connell, Kevin Sean & Smith, Robert Løvsletten [Vis alle 15 forfattere av denne artikkelen] (2022). Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores. Biological Psychiatry. ISSN 0006-3223. 93(2), s. 149–156. doi: 10.1016/j.biopsych.2022.07.014. Fulltekst i vitenarkiv
  • Hart, Xenia M.; Hiemke, Christoph; Eichentopf, Luzie; Lense, Xenija M.; Clement, Hans Willi & Conca, Andreas [Vis alle 15 forfattere av denne artikkelen] (2022). Therapeutic Reference Range for Aripiprazole in Schizophrenia Revised: a Systematic Review and Metaanalysis. Psychopharmacology. ISSN 0033-3158. 239(11), s. 3377–3391. doi: 10.1007/s00213-022-06233-2.
  • Nymoen, Lisbeth Damlien; Flatebø, Trude Eline; Moger, Tron Anders; Øie, Erik; Molden, Espen & Viktil, Kirsten Kilvik (2022). Impact of systematic medication review in emergency department on patients’ postdischarge outcomes—A randomized controlled clinical trial. PLOS ONE. ISSN 1932-6203. 17:e0274907(9), s. 1–19. doi: 10.1371/journal.pone.0274907. Fulltekst i vitenarkiv
  • Jukic, Marin; Milosavljević, Filip; Molden, Espen & Ingelman-Sundberg, Magnus (2022). Pharmacogenomics in treatment of depression and psychosis: an update. TIPS - Trends in Pharmacological Sciences. ISSN 0165-6147. 43(12), s. 1055–1069. doi: 10.1016/j.tips.2022.09.011.
  • Kyllesø, Lennart; Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Karlstad, Øystein; Andreassen, Ole & Molden, Espen (2022). Metabolite Profiling of Clozapine in Patients Switching Versus Maintaining Treatment: A Retrospective Pilot Study. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 42(5), s. 470–474. doi: 10.1097/JCP.0000000000001585. Fulltekst i vitenarkiv
  • Solhaug, Vigdis; Haslemo, Tore; Kringen, Marianne Kristiansen; Molden, Espen & Dietrichs, Erik Sveberg (2022). Genotyping av pasienter behandlet med selektive serotoninreopptakshemmere. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 142(13), s. 1–10. doi: 10.4045/tidsskr.22.0017. Fulltekst i vitenarkiv
  • Frederiksen, Trine; Smith, Robert Løvsletten; Jukic, Marin M. & Molden, Espen (2022). Association Between CYP2D6 Metabolizer Status and Vortioxetine Exposure and Treatment Switching: A Retrospective, Naturalistic Cohort Study Using Therapeutic Drug Monitoring Data From 640 Patients. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 42(4), s. 396–399. doi: 10.1097/JCP.0000000000001563.
  • Bråten, Line Skute; Ingelman-Sundberg, Magnus; Jukic, Marin M.; Molden, Espen & Kringen, Marianne K. (2022). Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population. Clinical and Translational Science (CTS). ISSN 1752-8054. 15(9), s. 2135–2145. doi: 10.1111/cts.13347.
  • Gedde-Dahl, Ane; Spigset, Olav & Molden, Espen (2022). Co-prescription of metoprolol and CYP2D6-inhibiting antidepressants before and after implementation of an optimized drug interaction database in Norway. European Journal of Clinical Pharmacology. ISSN 0031-6970. 78(10), s. 1623–1632. doi: 10.1007/s00228-022-03364-5. Fulltekst i vitenarkiv
  • Kvitne, Kine Eide; Hole, Kristine; Krogstad, Veronica; Wollmann, Birgit Malene Tovik; Wegler, Christine & Johnson, Line Kristin [Vis alle 19 forfattere av denne artikkelen] (2022). Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range. European Journal of Clinical Pharmacology. ISSN 0031-6970. 78(8), s. 1289–1299. doi: 10.1007/s00228-022-03336-9. Fulltekst i vitenarkiv
  • Trubetskoy, Vassily; Pardiñas, Antonio F.; Qi, Ting; Panagiotaropoulou, Georgia; Awasthi, Swapnil & Bigdeli, Tim B. [Vis alle 434 forfattere av denne artikkelen] (2022). Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. ISSN 0028-0836. 604(7906), s. 502–508. doi: 10.1038/s41586-022-04434-5.
  • Lenk, Hasan Cagin; Klöditz, Katharina; Johansson, Inger; Smith, Robert Løvsletten; Jukic, Marin & Molden, Espen [Vis alle 7 forfattere av denne artikkelen] (2022). The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 111(5), s. 1165–1174. doi: 10.1002/cpt.2571. Fulltekst i vitenarkiv
  • Røed-Undlien, Henriette; Schultz, Nina Haagenrud; Lunnan, Asbjørn; Husebråten, Inger; Wollmann, Birgit Malene Tovik & Molden, Espen [Vis alle 7 forfattere av denne artikkelen] (2022). In Vitro Apixaban Removal By CytoSorb Whole Blood Adsorber: An Experimental Study. Journal of Cardiothoracic and Vascular Anesthesia. ISSN 1053-0770. 36(6), s. 1636–1644. doi: 10.1053/j.jvca.2022.01.038. Fulltekst i vitenarkiv
  • Veddeng, Sigbjørn; Madland, Håkon; Molden, Espen; Wyller, Torgeir Bruun & Romskaug, Rita (2022). Association between statin use and physical performance in home-dwelling older patients receiving polypharmacy: cross-sectional study. BMC Geriatrics. ISSN 1471-2318. 22(1). doi: 10.1186/s12877-022-02942-7. Fulltekst i vitenarkiv
  • Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Kausberg, Marianne; Mæland, Sondre; Tveito, Marit & O'Connell, Kevin Sean [Vis alle 8 forfattere av denne artikkelen] (2022). Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo. Current drug metabolism. ISSN 1389-2002. 23(1), s. 66–72. doi: 10.2174/1389200223666220201152953. Fulltekst i vitenarkiv
  • Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Kyllesø, Lennart; Tran, Thu Thuy Anh; Tveito, Marit & Molden, Espen (2022). Effect of Valproic Acid on the Metabolic Spectrum of Clozapine in Patients With Schizophrenia. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 42(1), s. 43–50. doi: 10.1097/JCP.0000000000001507.
  • Blokland, Gabriella A. M.; Grove, Jakob; Chen, Chia-Yen; Cotsapas, Chris; Tobet, Stuart & Handa, Robert [Vis alle 50 forfattere av denne artikkelen] (2021). Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biological Psychiatry. ISSN 0006-3223. 91, s. 102–117. doi: 10.1016/j.biopsych.2021.02.972. Fulltekst i vitenarkiv
  • de Leon, Leon; Schoretsanitis, Georgios; Smith, Robert Løvsletten; Molden, Espen; Solismaa, Anssi & Seppälä, Niko [Vis alle 104 forfattere av denne artikkelen] (2021). An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels. Pharmacopsychiatry. ISSN 0176-3679. s. 1–14. doi: 10.1055/a-1625-6388.
  • Schoretsanitis, Georgios; Smith, Robert Løvsletten; Molden, Espen; Solismaa, Anssi; Seppälä, Niko & Kopeček, Miloslav [Vis alle 13 forfattere av denne artikkelen] (2021). European Whites May Need Lower Minimum Therapeutic Clozapine Doses Than Those Customarily Proposed. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 41(2), s. 140–147. doi: 10.1097/JCP.0000000000001341.
  • Riede, Julia; Wollmann, Birgit Malene Tovik; Molden, Espen & Ingelman-Sundberg, Magnus (2021). Primary human hepatocyte spheroids as an in vitro tool for investigating drug compounds with low hepatic clearances. Drug Metabolism And Disposition. ISSN 0090-9556. 49(7), s. 501–508. doi: 10.1124/dmd.120.000340.
  • Molden, Espen (2021). Therapeutic drug monitoring of clozapine in adults with schizophrenia: a review of challenges and strategies. Expert Opinion on Drug Metabolism & Toxicology. ISSN 1742-5255. 17(10), s. 2011–2021. doi: 10.1080/17425255.2021.1974400.
  • Jukic, Marin M.; Smith, Robert Løvsletten; Molden, Espen & Ingelman-Sundberg, Magnus (2021). Evaluation of the CYP2D6 Haplotype Activity Scores Based on Metabolic Ratios of 4,700 Patients Treated With Three Different CYP2D6 Substrates. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 110(3), s. 750–758. doi: 10.1002/cpt.2246.
  • Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole A. & Molden, Espen (2021). Absolute and Dose-Adjusted Serum Concentrations of Clozapine in Patients Switching vs. Maintaining Treatment: An Observational Study of 1979 Patients. CNS Drugs. ISSN 1172-7047. 35, s. 999–1008. doi: 10.1007/s40263-021-00847-4. Fulltekst i vitenarkiv
  • Bråten, Line Skute; Haslemo, Tore; Jukić, Marin M.; Ivanov, Maxim; Ingelman-Sundberg, Magnus & Molden, Espen [Vis alle 7 forfattere av denne artikkelen] (2021). A Novel CYP2C-Haplotype Associated With Ultrarapid Metabolism of Escitalopram. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 110(3), s. 786–793. doi: 10.1002/cpt.2233.
  • Hole, Kristine; Arnestad, Marianne; Molden, Espen & Haslemo, Tore (2021). Dose-Dependent Inhibition of CYP2D6 by Bupropion in Patients with Depression. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 41(3), s. 281–285. doi: 10.1097/JCP.0000000000001387.
  • Molden, Espen & Jukić, Marin M. (2021). CYP2D6 Reduced Function Variants and Genotype/Phenotype Translations of CYP2D6 Intermediate Metabolizers: Implications for Personalized Drug Dosing in Psychiatry. Frontiers in Pharmacology. ISSN 1663-9812. 12. doi: 10.3389/fphar.2021.650750.
  • Cheng, Weiqiu; Frei, Oleksandr; van der Meer, Dennis; Wang, Yunpeng; O`Connell, Kevin & Chu, Yunhan [Vis alle 20 forfattere av denne artikkelen] (2021). Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness. JAMA psychiatry. ISSN 2168-6238. 78(9), s. 1020–1030. doi: 10.1001/jamapsychiatry.2021.1435. Fulltekst i vitenarkiv
  • Frederiksen, Trine; Smith, Robert L.; Wollmann, Birgit Malene Tovik; Areberg, Johan & Molden, Espen (2021). Validation of a Population Pharmacokinetic Model of Vortioxetine Using Therapeutic Drug Monitoring Data. Clinical Pharmacokinetics. ISSN 0312-5963. doi: 10.1007/s40262-021-01029-7.
  • Tveito, Marit; Høiseth, Gudrun; Haslemo, Tore; Molden, Espen & Smith, Robert Løvsletten (2021). Impact of age and gender on paliperidone exposure in patients after administration of long-acting injectable formulations—an observational study using blood samples from 1223 patients. European Journal of Clinical Pharmacology. ISSN 0031-6970. 77(9), s. 1201–1208. doi: 10.1007/s00228-021-03114-z.
  • Thorén, Linda; Lindh, Jonatan D.; Ackehed, Gerd; Kringen, Marianne K.; Hall, Per & Bergh, Jonas [Vis alle 9 forfattere av denne artikkelen] (2020). Impairment of endoxifen formation in tamoxifen‐treated premenopausal breast cancer patients carrying reduced‐function CYP2D6 alleles. British Journal of Clinical Pharmacology. ISSN 0306-5251. doi: 10.1111/bcp.14500.
  • Anstensrud, Anne Kristine; Molden, Espen; Haug, Hans Jørgen; Qazi, Rehman Ul-Haq; Muriq, Hysen & Fosshaug, Linn Elisabeth Lillerud [Vis alle 8 forfattere av denne artikkelen] (2020). Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study. European Journal of Clinical Pharmacology. ISSN 0031-6970. 76, s. 673–683. doi: 10.1007/s00228-020-02832-0. Fulltekst i vitenarkiv
  • Lea, Marianne; Mowe, Morten; Molden, Espen; Kvernrød, Kristin; Skovlund, Eva & Mathiesen, Liv (2020). Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial. BMJ Open. ISSN 2044-6055. 10. doi: 10.1136/bmjopen-2020-041558. Fulltekst i vitenarkiv
  • Milosavljević, Filip; Bukvić, Nikola; Pavlović, Zorana; Miljević, Čedo; Pešić, Vesna & Molden, Espen [Vis alle 9 forfattere av denne artikkelen] (2020). Association of CYP2C19 and CYP2D6 Poor and Intermediate Metabolizer Status with Antidepressant and Antipsychotic Exposure: A Systematic Review and Meta-analysis. JAMA psychiatry. ISSN 2168-6238. doi: 10.1001/jamapsychiatry.2020.3643.
  • Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jucik, Marin M.; Ingelman-Sundberg, Magnus & Andreassen, Ole Andreas [Vis alle 7 forfattere av denne artikkelen] (2020). Rates of complete nonadherence among atypical antipsychotic drugs: A study using blood samples from 13,217 outpatients with psychotic disorders. Schizophrenia Research. ISSN 0920-9964. 228, s. 590–596. doi: 10.1016/j.schres.2020.11.025.
  • Smith, Robert Løvsletten; O`Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K. & Andreassen, Ole Andreas [Vis alle 7 forfattere av denne artikkelen] (2020). Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits. Translational Psychiatry. ISSN 2158-3188. 10(1), s. 1–10. doi: 10.1038/s41398-020-00888-1. Fulltekst i vitenarkiv
  • Kringen, Marianne K.; Bråten, Line Skute; Haslemo, Tore & Molden, Espen (2020). The Influence of Combined CYP2D6 and CYP2C19 Genotypes on Venlafaxine and O -Desmethylvenlafaxine Concentrations in a Large Patient Cohort. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 40(2), s. 137–144. doi: 10.1097/JCP.0000000000001174.
  • Lao, Yvonne Elisabeth; Molden, Espen; Kringen, Marianne K.; Annexstad, Ellen Johanne; Sæverud, Håvard Andreassen & Jacobsen, Dag [Vis alle 7 forfattere av denne artikkelen] (2020). Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 127(1), s. 47–51. doi: 10.1111/bcpt.13389. Fulltekst i vitenarkiv
  • Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen & Høiseth, Gudrun (2020). Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients. European Journal of Clinical Pharmacology. ISSN 0031-6970. 77, s. 215–221. doi: 10.1007/s00228-020-03002-y. Fulltekst i vitenarkiv
  • Romskaug, Rita; Wyller, Torgeir Bruun; Straand, Jørund; Kersten, Hege & Molden, Espen (2020). Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy. Drugs & Aging. ISSN 1170-229X. 37(6), s. 425–433. doi: 10.1007/s40266-020-00763-0. Fulltekst i vitenarkiv
  • Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole Andreas & Molden, Espen (2020). Undetectable or subtherapeutic serum levels of antipsychotic drugs preceding switch to clozapine. Nature NPJ Schizophrenia. ISSN 2334-265X. 6. doi: 10.1038/s41537-020-0107-7. Fulltekst i vitenarkiv
  • Tveit, Kristine; Hermann, Monica; Waade, Ragnhild Birkeland; Nilsen, Roy Miodini; Wallerstedt, Susanna M. & Molden, Espen (2020). Use of Antidepressants in Older People during a 10-Year Period: An Observational Study on Prescribed Doses and Serum Levels. Drugs & Aging. ISSN 1170-229X. 37, s. 691–701. doi: 10.1007/s40266-020-00784-9. Fulltekst i vitenarkiv
  • Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jukic, Marin M.; Ingelman-Sundberg, Magnus & Andreassen, Ole A [Vis alle 7 forfattere av denne artikkelen] (2020). Impact of antipsychotic polypharmacy on nonadherence of oral antipsychotic drugs – A study based on blood sample analyses from 24,239 patients. European Neuropsychopharmacology. ISSN 0924-977X. 37, s. 64–69. doi: 10.1016/j.euroneuro.2020.06.007.
  • Tveito, Marit; Molden, Espen; Høiseth, Gudrun; Correll, Christoph U. & Smith, Robert Løvsletten (2019). Impact of age and CYP2D6 genetics on exposure of aripiprazole and dehydroaripiprazole in patients using long-acting injectable versus oral formulation: relevance of poor and intermediate metabolizer status. European Journal of Clinical Pharmacology. ISSN 0031-6970. 76, s. 41–49. doi: 10.1007/s00228-019-02768-0.
  • Bråten, Line Skute; Haslemo, Tore; Jukic, Marin M.; Ingelman-Sundberg, Magnus; Molden, Espen & Kringen, Marianne K. (2019). Impact of CYP2C19 genotype on sertraline exposure in 1200 Scandinavian patients. Neuropsychopharmacology. ISSN 0893-133X. 45, s. 570–576. doi: 10.1038/s41386-019-0554-x.
  • Tveito, Marit; Smith, Robert Løvsletten; Høiseth, Gudrun & Molden, Espen (2019). The Effect of Valproic Acid on Olanzapine Serum Concentration: A Study Including 2791 Patients Treated With Olanzapine Tablets or Long-Acting Injections. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 39(6), s. 561–566. doi: 10.1097/JCP.0000000000001126.
  • Romskaug, Rita; Skovlund, Eva; Straand, Jørund; Molden, Espen; Kersten, Hege & Pitkala, Kaisu H [Vis alle 8 forfattere av denne artikkelen] (2019). Effect of clinical geriatric assessments and collaborative medication reviews by geriatrician and family physician for improving health-related quality of life in home-dwelling older patients receiving polypharmacy: a cluster randomized clinical trial. JAMA Internal Medicine. ISSN 2168-6106. doi: 10.1001/jamainternmed.2019.5096. Fulltekst i vitenarkiv
  • Smith, Robert Løvsletten; Kyllesø, Lennart; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2019). Reduction in N-desmethylclozapine level is determined by daily dose but not serum concentration of valproic acid-indications of a presystemic interaction mechanism. Therapeutic Drug Monitoring. ISSN 0163-4356. 41(4), s. 503–508. doi: 10.1097/FTD.0000000000000619.
  • Lea, Marianne; Mowe, Morten; Mathiesen, Liv; Kvernrød, Kristin; Skovlund, Eva & Molden, Espen (2019). Prevalence and risk factors of drug-related hospitalizations in multimorbid patients admitted to an internal medicine ward. PLOS ONE. ISSN 1932-6203. 14(7). doi: 10.1371/journal.pone.0220071. Fulltekst i vitenarkiv
  • Gjestad, Caroline; Hole, Kristine; Haslemo, Tore; Diczfalusy, Ulf & Molden, Espen (2019). Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite 4β-Hydroxycholesterol—an Interaction Study in Healthy Volunteers. AAPS Journal. ISSN 1550-7416. 21(58). doi: 10.1208/s12248-019-0330-1.
  • Jukic, Marin M.; Smith, Robert Løvsletten; Haslemo, Tore; Molden, Espen & Ingelman-Sundberg, Magnus (2019). Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study. The Lancet Psychiatry. ISSN 2215-0374. 6(5), s. 418–426. doi: 10.1016/S2215-0366(19)30088-4.
  • Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Vis alle 11 forfattere av denne artikkelen] (2019). Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI. Psychoneuroendocrinology. ISSN 0306-4530. 103, s. 87–95. doi: 10.1016/j.psyneuen.2019.01.001. Fulltekst i vitenarkiv
  • Wollmann, Birgit Malene Tovik; Lunde, Hilde; Støten, Lene; Lunder, Niclas & Molden, Espen (2019). Substantial Differences in Serum Concentrations of Psychoactive Drugs Measured in Samples Stored for 2 Days or More on Standard Serum Tubes Versus Serum Tubes Containing Gel Separators. Therapeutic Drug Monitoring. ISSN 0163-4356. 41(3), s. 396–400. doi: 10.1097/FTD.0000000000000592.
  • Smith, Robert Løvsletten; Haslemo, Tore; Chan, Hilde Fauskrud; Refsum, Helge & Molden, Espen (2018). Clinically Relevant Effect of UGT1A4*3 on Lamotrigine Serum Concentration Is Restricted to Postmenopausal Women—A Study Matching Therapeutic Drug Monitoring and Genotype Data From 534 Patients. Therapeutic Drug Monitoring. ISSN 0163-4356. 40(5), s. 567–571. doi: 10.1097/FTD.0000000000000540.
  • Haslemo, Tore; Eliasson, Erik; Jukic, Marin M.; Ingelman-Sundberg, Magnus & Molden, Espen (2018). Significantly lower CYP2D6 metabolism measured as the O/N-desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients. British Journal of Clinical Pharmacology. ISSN 0306-5251. doi: 10.1111/bcp.13788.
  • Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Vis alle 11 forfattere av denne artikkelen] (2018). Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication. Journal of Psychiatric Research. ISSN 0022-3956. 106, s. 74–81. doi: 10.1016/j.jpsychires.2018.09.014.
  • Viktil, Kirsten Kilvik; Lehre, Ina; Ranhoff, Anette Hylen & Molden, Espen (2018). Serum concentrations and elimination rates of direct-acting oral anticoagulants (DOACs) in older hip fracture patients hospitalized for surgery: a pilot study. Drugs & Aging. ISSN 1170-229X. 36(1), s. 65–71. doi: 10.1007/s40266-018-0609-4.
  • Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen; Haslemo, Tore; Refsum, Helge & Hartberg, Cecilie Bhandari [Vis alle 8 forfattere av denne artikkelen] (2018). Age Impacts Olanzapine Exposure Differently During Use of Oral Versus Long-Acting Injectable Formulations: An Observational Study Including 8,288 Patients. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 38(6), s. 570–576. doi: 10.1097/JCP.0000000000000961.
  • Jukic, Marin M.; Haslemo, Tore; Molden, Espen & Ingelman-Sundberg, Magnus (2018). Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients. American Journal of Psychiatry. ISSN 0002-953X. 175(5), s. 463–470. doi: 10.1176/appi.ajp.2017.17050550.
  • Wollmann, Birgit Malene Tovik; Syversen, Silje Watterdal; Vistnes, Maria; Lie, Elisabeth; Mehus, Lise Larsen & Molden, Espen (2018). Associations between cytokine levels and CYP3A4 phenotype in patients with rheumatoid arthritis. Drug Metabolism And Disposition. ISSN 0090-9556. 46(10), s. 1384–1389. doi: 10.1124/dmd.118.082065.
  • Hole, Kristine; Wollmann, Birgit Malene Tovik; Nguyen, Camilla; Haslemo, Tore & Molden, Espen (2018). Comparison of CYP3A4-Inducing Capacity of Enzyme-Inducing Antiepileptic Drugs Using 4β-Hydroxycholesterol as Biomarker. Therapeutic Drug Monitoring. ISSN 0163-4356. 40(4), s. 463–468. doi: 10.1097/FTD.0000000000000518.
  • Hole, Kristine; Heiberg, Petra Lybæk; Gjestad, Caroline; Mehus, Lise Larsen; Rø, Øyvind & Molden, Espen (2018). Elevated 4β‐hydroxycholesterol/cholesterol ratio in anorexianervosa patients. Pharmacology Research & Perspectives. ISSN 2052-1707. 6(5), s. 1–5. doi: 10.1002/prp2.430. Fulltekst i vitenarkiv
  • Pardiñas, Antonio F.; Holmans, Peter; Pocklington, Andrew J.; Escott-Price, Valentina; Ripke, Stephan & Carrera, Noa [Vis alle 73 forfattere av denne artikkelen] (2018). Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics. ISSN 1061-4036. 50(3), s. 381–389. doi: 10.1038/s41588-018-0059-2.
  • Baftiu, Arton; Feet, Silje Andrea; Larsson, Pål Gunnar; Burns, Margrete Larsen; Henning, Oliver Johannes & Sætre, Erik [Vis alle 10 forfattere av denne artikkelen] (2018). Utilisation and polypharmacy aspects of antiepileptic drugs in elderly versus younger patients with epilepsy: A pharmacoepidemiological study of CNS-active drugs in Norway, 2004-2015. Epilepsy Research. ISSN 0920-1211. 139, s. 35–42. doi: 10.1016/j.eplepsyres.2017.11.001.

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  • Ingelman-Sundberg, Magnus; Jukic, Marin; Bråten, Line Skute; Kringen, Marianne K. & Molden, Espen (2023). What is the Current Clinical Impact of the CYP2CTG Haplotype? Clinical Pharmacology and Therapeutics. ISSN 0009-9236. doi: 10.1002/cpt.3094.
  • Faraj, Pari; Størset, Elisabet; Hole, Kristine; Smith, Godfrey L; Molden, Espen & Dietrichs, Erik Sveberg (2023). Pro-arrhythmic effect of escitalopram and citalopram at serum concentrations commonly observed in the elderly – a study based on a cohort of 19 742 patients.
  • Dietrichs, Erik Sveberg; Solhaug, Vigdis; Haslemo, Tore; Kringen, Marianne K. & Molden, Espen (2022). E.S. Dietrichs og medarbeidere svarer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 142(17). doi: 10.4045/tidsskr.22.0695. Fulltekst i vitenarkiv
  • Molden, Espen (2022). Personalized dosing of clozapine stratified by patients’ ancestry–international consensus guidelines. Nordic Journal of Psychiatry. ISSN 0803-9488. doi: 10.1080/08039488.2022.2146749.
  • Dietrichs, Erik Sveberg; Solhaug, Vigdis; Kringen, Marianne Kristiansen; Haslemo, Tore & Molden, Espen (2022). E. S. Dietrichs og medarbeidere svarer P. Gjerden. Tidsskrift for Den norske legeforening. ISSN 0029-2001.
  • Dietrichs, Erik Sveberg; Haslemo, Tore; Kringen, Marianne K.; Molden, Espen & Solhaug, Vigdis (2022). E. S. Dietrichs og medarbeidere svarer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 142(16). doi: 10.4045/tidsskr.22.0665.
  • Kvitne, Kine Eide; Hole, Kristine; Molden, Espen & Robertsen, Ida (2022). Response to: “Utility of endogenous 4β-hydroxycholesterol as a biomarker to assess cytochrome P 450 3A (CYP3A) activity: not quite ready for prime time”. European Journal of Clinical Pharmacology. ISSN 0031-6970. doi: 10.1007/s00228-022-03387-y.
  • Dietrichs, Erik Sveberg; Molden, Espen & Haslemo, Tore (2022). Senter for psykofarmakologi. LVS-info.
  • de Leon, Jose; Schoretsanitis, Georgios; Smith, Robert Løvsletten; Molden, Espen; Solismaa, Anssi & Seppälä, Niko [Vis alle 104 forfattere av denne artikkelen] (2022). Erratum: Correction: An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels (Pharmacopsychiatry (2022) 55 2 (73-86)). Pharmacopsychiatry. ISSN 0176-3679. 55(2). doi: 10.1055/a-1737-1527.
  • Smith, Robert Løvsletten; O’Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K. & Andreassen, Ole [Vis alle 7 forfattere av denne artikkelen] (2020). Correction: Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits (Translational Psychiatry, (2020), 10, 1, (198), 10.1038/s41398-020-00888-1). Translational Psychiatry. ISSN 2158-3188. 10(1). doi: 10.1038/s41398-020-01061-4.
  • Pardiñas, Antonio F.; Holmans, Peter A.; Pocklington, Andrew J.; Escott-Price, Valentina; Ripke, Stephan & Carrera, Noa [Vis alle 144 forfattere av denne artikkelen] (2019). Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection (Nature Genetics, (2018), 50, 3, (381-389), 10.1038/s41588-018-0059-2). Nature Genetics. ISSN 1061-4036. 51(7). doi: 10.1038/s41588-019-0450-7.
  • Tveit, Kristine; Hermann, Monica; Waade, Ragnhild Birkeland & Molden, Espen (2019). Dose intensity of antidepressants in older persons 2007-2017 – a study based on therapeutic drug monitoring data .
  • Olsen, Thomas Christian Risom; Rasmussen, Anders R.; Kringen, Marianne K. & Molden, Espen (2019). En jente i tidlig skolealder uten effekt av opioider ved generell anestesi. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(7). doi: 10.4045/tidsskr.18.0561.
  • Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Laskemoen, Jannicke F. [Vis alle 11 forfattere av denne artikkelen] (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders? Journal of Psychiatric Research. ISSN 0022-3956. doi: 10.1016/j.jpsychires.2018.11.012.
  • Dyrkorn, Roar; Lundgaard, Halvor; Stokes, Charlotte Lorentze; Molden, Espen & Spigset, Olav (2018). Serumkonsentrasjonsmålinger av DOAK-legemidler. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(7), s. 620–621. doi: 10.4045/tidsskr.18.0237.
  • Gjestad, Caroline; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2018). Gjestad et al. reply to 'Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?' by Neuhoff and Tucker. British Journal of Clinical Pharmacology. ISSN 0306-5251. 84(7), s. 1624–1625. doi: 10.1111/bcp.13606.
  • Ihle-Hansen, Håkon; Hagberg, Guri; Molden, Espen & Myrstad, Marius (2018). Hvem bør få klopidogrel etter hjerneslag? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(9). doi: 10.4045/tidsskr.18.0277.

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Publisert 3. nov. 2010 15:41 - Sist endret 14. feb. 2024 11:46