Effects of ionizing radiation on biomolecular systems

a) Structure and Mechanisms

b) EPR-dosimetry

a) Structure and Mechanisms

Molecular mechanisms for the production and transfer of primary radiation induced damages in the macromolcule DNA

Studies of DNA-model systems are being performed using magnetic resonance spectroscopy (EPR, ENDOR and EIE) to elucidate the molecular structures of the primary radiation induced products (radicals) formed in DNA, their successor physical and chemical reaction mechanisms, and the driving forces for the various reaction pathways.

 

b)  EPR-dosimetry

EPR-dosimetry:  measuring doses of ionizing radiation using EPR-spectroscopy        

EPR-dosimetry is a non-destructive, highly accurate and highly precise method for measuring doses of ionizing radiation. The method is well adapted for industrial use (kGy), but not yet fully developed for practical use in the medical dose regions. The investigations include identification of basic radio physical and –chemical properties of various dosimeter materials, developing new dosimetry materials for EPR-dosimetry, and applications of EPR-dosimetry in medical physics studies (clinical relevant).

  

We exploit both experimental methods (EPR-, ENDOR-, EIE- spectroscopy) and various quantum chemical computation techniques in our studies.

 

Link to the web page for the EPR Laboratory (in English)

Link to the web page for the EPR-laboratory (in Norwegain) 

Link to the web page for Biophysics and Medical Physics (in English)

Link to the web page for Biophyiscs and Medical Physics (in Norwegain)

Tags: alanine, EPR-dosimetry, radiation physics, radical, LiFo
Published Feb. 15, 2011 4:57 PM - Last modified Feb. 28, 2011 8:13 PM