My research group focusses on the structure and function of the bacterial cell surface. Currently, we work on three main topics:
- Bacterial Adhesion: How do bacteria stick to surfaces, or in the case of pathogens, to host cells?
- Membrane transport: how are adhesion molecules transported to the cell surface? And can this process be inhibited with novel antimicrobial substances?
- Vaccines and Biomarkers: can we exploit bacterial surface proteins as vaccine candidates or as biomarkers, e.g. for improved clinical diagnostics?
Our work is typically comparative – we do not work on a single pathogenic “pet” organism, but instead compare related surface proteins from different species, studying their similarities and subtle differences. Our work is also interdisciplinary – we use methods from bioinformatics, structural biology and biophysics on top of classical methods from microbiology, molecular biology and biochemistry.
- MBV 3060 (Basic Microbiology)
- MBV 4910 (iGEM Competition)
Higher education and employment history
- since 2015 Full Professor, Department of Biosciences, UiO
- since 2013 Associate Professor, Department of Biosciences, UiO
- 2010 Habilitation, Department of Biology, University of Tübingen
- 2007-2013 Project Leader, Max Planck Institute for Developmental Biology, Tübingen
- 2003-2007 PostDoc, Max Planck Institute for Developmental Biology, Tübingen
- 2002 PhD, Department of Chemistry, TU Berlin
- 1991-1997, undergraduate studies in Biochemistry, FU Berlin
- 2009 Young Academics Award from the German Society for Hygiene and Microbiology
- 2008 and 2009 two 1-year stipends from the Bill & Melinda Gates Foundation
- Advisory Board Member, Molecular Microbiology (Wiley)
- Review Editor, Journal of Biological Chemistry
- Review Editor, Frontiers in Microbiology
- Leo, Jack Christopher & Linke, Dirk (2018). A unified model for BAM function that takes into account type Vc secretion and species differences in BAM composition. AIMS Microbiology. ISSN 2471-1888. 4(3), s 455- 468 . doi: 10.3934/microbiol.2018.3.455 Show summary
- Balusek, Curtis; Linke, Dirk & Gumbart, JC (2018). The effect of beta-barrel geometry on ion conduction through Escherichia coli OmpX.
- Joudeh, Nadeem; Leo, Jack Christoffer; Torgeman, Eric & Linke, Dirk (2018). Mechanism of Palladium and Gold uptake and reduction in E. coli.
- Khalil, Hawzeen; Øgaard, Jonas; Linke, Dirk & Leo, Jack Christoffer (2018). Co-aggregation properties of trimeric autotransporter adhesins.
- Leo, Jack Christoffer; Schütz, Monika & Linke, Dirk (2018). Type Ve Secretion in Enterobacteria.
- Linke, Dirk (2018). Trimeric Autotransporter Adhesins and routes to their inhibition.
- Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - Understanding adhesive function and screening for inhibitors.
- Wrobel, Agnieszka; Ottoni, Claudio; Leo, Jack Christoffer & Linke, Dirk (2018). The repeat structure of two paralogous genes, Yersinia ruckeri invasin (yrInv) and a “Y. ruckeri invasin-like molecule”, (yrIlm) sheds light on the evolution of adhesive capacities of a fish pathogen.
- Hatlem, Daniel; Leo, Jack Christoffer; Saragliadis, Athanasios; Krengel, Ute & Linke, Dirk (2017). Bacterial adhesion: Characterization of trimeric autotransporter binding.
- Joudeh, Nadeem; Leo, Jack Christoffer; Torgeman, Eric; Mikheenko, Pavlo & Linke, Dirk (2017). Mechanism of Palladium and Gold uptake and transport in E. coli.