Dirk Linke

Image of Dirk Linke
Norwegian version of this page
Phone +47-22857654
Room 3517
Username
Visiting address Blindernveien 31 None 0371 OSLO
Postal address Postboks 1066 Blindern 0316 OSLO

Academic Interests

My research group focusses on the structure and function of the bacterial cell surface. Currently, we work on three main topics:

  1. Bacterial Adhesion: How do bacteria stick to surfaces, or in the case of pathogens, to host cells?
  2. Membrane transport: how are adhesion molecules transported to the cell surface? And can this process be inhibited with novel antimicrobial substances?
  3. Vaccines and Biomarkers: can we exploit bacterial surface proteins as vaccine candidates or as biomarkers, e.g. for improved clinical diagnostics?

Our work is typically comparative – we do not work on a single pathogenic “pet” organism, but instead compare related surface proteins from different species, studying their similarities and subtle differences. Our work is also interdisciplinary – we use methods from bioinformatics, structural biology and biophysics on top of classical methods from microbiology, molecular biology and biochemistry.
 

Teaching

  • MBV 3060 (Basic Microbiology)
  • MBV 4910 (iGEM Competition)
  • ...


Higher education and employment history

  • since 2015 Full Professor, Department of Biosciences, UiO
  • since 2013 Associate Professor, Department of Biosciences, UiO
  • 2010 Habilitation, Department of Biology, University of Tübingen
  • 2007-2013 Project Leader, Max Planck Institute for Developmental Biology, Tübingen
  • 2003-2007 PostDoc, Max Planck Institute for Developmental Biology, Tübingen
  • 2002 PhD, Department of Chemistry, TU Berlin
  • 1991-1997, undergraduate studies in Biochemistry, FU Berlin
     

Honoraria

  • 2009 Young Academics Award from the German Society for Hygiene and Microbiology
  • 2008 and 2009 two 1-year stipends from the Bill & Melinda Gates Foundation
  • ...

Appointments

  • Advisory Board Member, Molecular Microbiology (Wiley)
  • Review Editor, Journal of Biological Chemistry
  • Review Editor, Frontiers in Microbiology

Publications

  • Balusek, Curtis; Linke, Dirk & Gumbart, JC (2018). The effect of beta-barrel geometry on ion conduction through Escherichia coli OmpX.
  • Joudeh, Nadeem; Leo, Jack Christoffer; Torgeman, Eric & Linke, Dirk (2018). Mechanism of Palladium and Gold uptake and reduction in E. coli.
  • Khalil, Hawzeen; Øgaard, Jonas; Linke, Dirk & Leo, Jack Christoffer (2018). Co-aggregation properties of trimeric autotransporter adhesins.
  • Leo, Jack Christoffer; Schütz, Monika & Linke, Dirk (2018). Type Ve Secretion in Enterobacteria.
  • Linke, Dirk & Saragliadis, Athanasios (2018). Trimeric Autotransporter Adhesins - Understanding adhesive function and screening for inhibitors.
  • Wrobel, Agnieszka; Ottoni, Claudio; Leo, Jack Christoffer & Linke, Dirk (2018). The repeat structure of two paralogous genes, Yersinia ruckeri invasin (yrInv) and a “Y. ruckeri invasin-like molecule”, (yrIlm) sheds light on the evolution of adhesive capacities of a fish pathogen.
  • Hatlem, Daniel; Leo, Jack Christoffer; Saragliadis, Athanasios; Krengel, Ute & Linke, Dirk (2017). Bacterial adhesion: Characterization of trimeric autotransporter binding.
  • Joudeh, Nadeem; Leo, Jack Christoffer; Torgeman, Eric; Mikheenko, Pavlo & Linke, Dirk (2017). Mechanism of Palladium and Gold uptake and transport in E. coli.
  • Joudeh, Nadeem & Linke, Dirk (2017). Mechanism of palladium and gold uptake and transport in E. coli.
  • Leo, Jack Christoffer & Linke, Dirk (2017). Inverse autotransport: the mechanism of type Ve secretion​..

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Published Oct. 16, 2013 9:37 AM - Last modified Jan. 29, 2015 11:58 AM