Roza Berhanu Lemma

Image of Roza Berhanu Lemma
Norwegian version of this page
Mobile phone +4740975997
Username
Visiting address Norway Blindernveien 31 0371 Oslo
Postal address Postboks 1137 Blindern 0318 Oslo

Academic interests

I have a broad range of academic interests including molecular biology, bioinformatics, several omics studies, structural biology, phylogenetics and so on. I have an increasing interest in my current field of study, which is transcriptional regulation and post translational modification, particularly SUMOylation. I have always been highly interested in interdisciplinary field of research and my current position is a great opportunity to entertain my long held interest. In my study I combine both molecular biological techniques (wet lab approach) as well as several bioinformatic analyses (dry lab approaches). Some of the bioinformatics approaches that I frequently use include

  • Genome wide analyses
    • Analysis of transcriptomic data (RNAseq)
    • Analysis of epigenomic data (ATACseq, ChIPseq)
  • 3D-structure prediction of proteins
  • Integration of protein structural information and evolutionary sequence conservation for identifying functionally important residues
  • Sequence evolutionary conservation and phylogeny 

Background

I have a B.Sc in Biology (Genetics and Molecular biology) from Ambo University in Ethiopia and an M.Sc in Biotechnology from Addis Ababa University in Ethiopia. I have a second masters degree in Molecular Biosciences with a project in Applied and structural bioinformatics that I obtained from department of Biosciences at the University of Oslo.

 

Publications

  • Rauluseviciute, Ieva; Riudavets-Puig, Rafael; Blanc-Mathieu, Romain; Castro Mondragon, Jaime Abraham; Ferenc, Katalin Terezia & Kumar, Vipin [Show all 20 contributors for this article] (2023). JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Research (NAR). ISSN 0305-1048. 52(D1), p. D174–D182. doi: 10.1093/nar/gkad1059.
  • Lemma, Roza Berhanu; Ledsaak, Marit; Fuglerud, Bettina Maria; Rodriguez- Castañeda, Fernando; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2023). MYB regulates the SUMO protease SENP1 and its novel interaction partner UXT, modulating MYB target genes and the SUMO landscape. Journal of Biological Chemistry. ISSN 0021-9258. 299(9). doi: 10.1016/j.jbc.2023.105062. Full text in Research Archive
  • Clarke, Mary L.; Lemma, Roza Berhanu; Walton, David Scott; Volpe, Giacomo; Noyvert, Boris & Gabrielsen, Odd Stokke [Show all 7 contributors for this article] (2023). MYB insufficiency disrupts proteostasis in hematopoietic stem cells, leading to age-related neoplasia. Blood. ISSN 0006-4971. 141(15), p. 1858–1870. doi: 10.1182/blood.2022019138. Full text in Research Archive
  • Lemma, Roza Berhanu; Fleischer, Thomas; Martinsen, Emily; Ledsaak, Marit; Kristensen, Vessela N. & Eskeland, Ragnhild [Show all 8 contributors for this article] (2022). Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers. Epigenetics & Chromatin. ISSN 1756-8935. 15. doi: 10.1186/s13072-022-00444-9. Full text in Research Archive
  • Clarke, Mary L.; Lemma, Roza Berhanu; Walton, David Scott; Volpe, G; Noyvert, Boris & Gabrielsen, Odd Stokke [Show all 7 contributors for this article] (2021). MYB insufficiency disrupts proteostasis in hematopoietic stem cells leading to age-related neoplasia. bioRxiv. ISSN 2692-8205. doi: 10.1101/2021.09.04.458970.
  • Castro Mondragon, Jaime Abraham; Riudavets Puig, Rafael; Rauluseviciute, Ieva; Lemma, Roza Berhanu; Turchi, Laura & Blanc-Mathieu, Romain [Show all 23 contributors for this article] (2021). JASPAR 2022: the 9th release of the open-acess database of transcription factor binding profiles. Nucleic Acids Research (NAR). ISSN 0305-1048. doi: 10.1093/nar/gkab1113. Full text in Research Archive
  • Lemma, Roza Berhanu; Ledsaak, Marit; Fuglerud, Bettina Maria; Sandve, Geir Kjetil; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2021). Chromatin occupancy and target genes of the haematopoietic master transcription factor MYB. Scientific Reports. ISSN 2045-2322. 11(9008). doi: 10.1038/s41598-021-88516-w. Full text in Research Archive
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie; Lucas, Christin & Vekterud, Kristin [Show all 15 contributors for this article] (2020). LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction. Cells. ISSN 2073-4409. 9(5), p. 1–26. doi: 10.3390/cells9051214. Full text in Research Archive
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin & Vekterud, Kristin [Show all 15 contributors for this article] (2019). Open the LID: LXRα regulates ChREBPα transactivity in a target gene-specific manner through an agonist-modulated LBD-LID interaction. bioRxiv. ISSN 2692-8205. doi: 10.1101/2019.12.20.869974.
  • Rodriguez- Castañeda, Fernando; Lemma, Roza Berhanu; Cuervo Torre, Ignacio; Bengtsen, Mads; Moen, Lisa Marie & Ledsaak, Marit [Show all 8 contributors for this article] (2018). The SUMO protease SENP1 and the chromatin remodeller CHD3 interact and jointly affect chromatin accessibility and gene expression. Journal of Biological Chemistry. ISSN 0021-9258. 293(40), p. 15439–15454. doi: 10.1074/jbc.RA118.002844. Full text in Research Archive
  • Fuglerud, Bettina Maria; Lemma, Roza Berhanu; Wanichawan, Pimthanya; Sundaram, Arvind; Eskeland, Ragnhild & Gabrielsen, Odd Stokke (2017). A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function. Nucleic Acids Research (NAR). ISSN 0305-1048. 45(13), p. 7681–7696. doi: 10.1093/nar/gkx364. Full text in Research Archive

View all works in Cristin

  • Lemma, Roza Berhanu (2022). Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers (NBD2022).
  • Nederbragt, Lex; Lemma, Roza Berhanu; Belova, Tatiana; Cheneby, Jeanne; Ibrahim, Mohamed & Akdeniz, Byram Cevdet [Show all 7 contributors for this article] (2022). Oslo Bioinformatics Workshop Week 2022.
  • Kumar, Vipin; Fatima, Nazeefa; Hsieh, Ping-Han; Belova, Tatiana; Ferenc, Katalin Terezia & Rauluseviciute, Ieva [Show all 9 contributors for this article] (2022). Introducing ISCB's (International Society for Computational Biology) regional student group in Norway's (RSG-Norway's) activities to the PhD and postdoc forum at the Institute of Cancer research, Radium hospital, OUS .
  • Fatima, Nazeefa; Lemma, Roza Berhanu; Rauluseviciute, Ieva; Belova, Tatiana; Kumar, Vipin & Hsieh, Ping-Han [Show all 12 contributors for this article] (2022). Developing Bioinformatics Societies in Norway and Nordic.
  • Lemma, Roza Berhanu; Castro-Mondragon, Jaime Abraham & Mathelier, Anthony (2022). Large-scale investigation of noncoding elements associated with transcriptional deregulation involved in carcinogenesis.
  • Lemma, Roza Berhanu (2022). Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers.
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin & Vekterud, Kristin [Show all 15 contributors for this article] (2019). LXRα interacts with the glucose-sensing transcription factor ChREBPα to regulate its transcriptional activity.
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ulven, Stine Marie; Lucas, Christin & Bindesbøll, Christian [Show all 11 contributors for this article] (2018). LXRα interacts with the glucose-sensing transcription factor ChREBPα and increases its transcriptional activity.

View all works in Cristin

Published Aug. 29, 2017 11:14 PM - Last modified Nov. 15, 2017 8:42 PM