Tom Kristensen

Image of Tom Kristensen
Norwegian version of this page
Phone +47-22856629
Room Room 2303B
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Visiting address Blindernveien 31 None 0316 OSLO

Academic Interests

I am interested in DNA sequencing techniques and methods for extracting information from biological sequences.

Teaching

Higher education and employment history

I took a "hovedfag" degree in biochemistry at Department of Biochemistry, University of Oslo in 1971. After 6 years as a scientific assistant at the same department and a researcher in the group of Hans Prydz at Institute of Internal Medicine Research at Rikshospitalet , I took the Dr. philos. degree at University of Oslo in 1984. Together with the rest of the Prydz group I moved to The Biotechnology Centre of Oslo when the centre opened. I had serveral research visits to the group of Wilhelm Ansorgen, EMBL, Heidelberg, developing a system for automated DNA sequencing. At The Biotechnology Centre of Oslo, I lead a service center of DNA sequening based on this technology. In 1994 I got an associated professor postition at Department of Biochemistry, University of Oslo. My position was later changed to full professor, and the department eventually was merged with the Department of Biology, leading to the formation of Department of Biosciences. 

Appointments

  • Web editor at IMBV
  • 2011: General Secretary elect of The Norwegian Biochemical Society

Collaborations

I am a member of the Biochemistry and Molecular Biology section of the institute and also a participant in CIME (Center for Integrative Microbial Evolution).

 

Publications

  • Ekblad, Bie; Nissen-Meyer, Jon & Kristensen, Tom (2017). Whole-genome sequencing of mutants with increased resistance against the two-peptide bacteriocin plantaricin JK reveals a putative receptor and potential docking site. PLoS ONE.  ISSN 1932-6203. . doi: https://doi.org/10.1371/journal.pone.0185279
  • Krabberød, Anders Kristian; Orr, Russell; Bråte, Jon; Kristensen, Tom; Bjørklund, Kjell Rasmus & Shalchian-Tabrizi, Kamran (2017). Single cell transcriptomics, mega-phylogeny and the genetic basis of morphological innovations in Rhizaria. Molecular biology and evolution.  ISSN 0737-4038. . doi: https://doi.org/10.1093/molbev/msx075 Show summary
  • Oppegård, Camilla; Kjos, Morten; Veening, Jan-Willem; Nissen-Meyer, Jon & Kristensen, Tom (2016). A putative amino acid transporter determines sensitivity to the two-peptide bacteriocin plantaricin JK. MicrobiologyOpen.  ISSN 2045-8827. . doi: 10.1002/mbo3.363 Full text in Research Archive.
  • Kjos, Morten; Oppegård, Camilla; Diep, Dzung Bao; Nes, Ingolf; Veening, Jan-Willem; Nissen-Meyer, Jon & Kristensen, Tom (2014). Sensitivity to the two-peptide bacteriocin lactococcin G is dependent on UppP, an enzyme involved in cell-wall synthesis. Molecular Microbiology.  ISSN 0950-382X.  92(6), s 1177- 1187 . doi: 10.1111/mmi.12632
  • Håvelsrud, Othilde Else; Haverkamp, Thomas Hendricus Augustus; Kristensen, Tom; Jakobsen, Kjetill Sigurd & Rike, Anne Gunn Larsen (2013). Metagenomics in CO2 Monitoring. Energy Procedia.  ISSN 1876-6102.  37, s 4215- 4233 . doi: 10.1016/j.egypro.2013.06.324 Full text in Research Archive. Show summary
  • Sogge, Hanne; Rohrlack, Thomas; Rounge, Trine Ballestad; Sønstebø, Jørn Henrik; Tooming-Klunderud, Ave; Kristensen, Tom & Jakobsen, Kjetill Sigurd (2013). Gene flow, recombination, and selection in cyanobacteria: population structure of geographically related Planktothrix Freshwater Strains. Applied and Environmental Microbiology.  ISSN 0099-2240.  79(2), s 508- 515 . doi: 10.1128/AEM.02417-12 Full text in Research Archive. Show summary
  • Uzelac, Gordana; Kojic, Milan; Lozo, Jelena; Aleksandrzak-Piekarczyk, Tamara; Gabrielsen, Christina; Kristensen, Tom; Nes, Ingolf; Diep, Dzung Bao & Topisirovic, Ljubisa (2013). A Zn-dependent metallopeptidase is responsible for sensitivity to LsbB, a class II leaderless bacteriocin of Lactococcus lactis subsp. lactis BGMN1-5. Journal of Bacteriology.  ISSN 0021-9193. . doi: 10.1128/JB.00859-13
  • Bråte, Jon; Krabberød, Anders Kristian; Dolven, Jane Karine Lønne; Ose, Randi Frida; Kristensen, Tom; Bjørklund, Kjell Rasmus & Shalchian-Tabrizi, Kamran (2012). Radiolaria Associated with Large Diversity of Marine Alveolates. Protist.  ISSN 1434-4610.  163(5), s 767- 777 . doi: 10.1016/j.protis.2012.04.004 Show summary
  • Håvelsrud, Othilde Else; Haverkamp, Thomas Hendricus Augustus; Kristensen, Tom; Jakobsen, Kjetill Sigurd & Rike, Anne Gunn Larsen (2012). Metagenomic and geochemical characterization of pockmarked sediments overlaying the Troll petroleum reservoir in the North Sea. BMC Microbiology.  ISSN 1471-2180.  12(203) . doi: 10.1186/1471-2180-12-203 Full text in Research Archive.
  • Håvelsrud, Othilde Else; Haverkamp, Thomas Hendricus Augustus; Kristensen, Tom; Jakobsen, Kjetill Sigurd & Rike, Anne Gunn Larsen (2011). A metagenomic study of methanotrophic microorganisms in Coal Oil Point seep sediments. BMC Microbiology.  ISSN 1471-2180.  11 . doi: 10.1186/1471-2180-11-221 Full text in Research Archive.
  • Krabberød, Anders Kristian; Bråte, Jon; Dolven, Jane Karine Lønne; Ose, Randi Frida; Klaveness, Dag; Kristensen, Tom; Bjørklund, Kjell Rasmus & Shalchian-Tabrizi, Kamran (2011). Radiolaria Divided into Polycystina and Spasmaria in Combined 18S and 28S rDNA Phylogeny. PLoS ONE.  ISSN 1932-6203.  6(8) . doi: 10.1371/journal.pone.0023526 Show summary
  • Rounge, Trine Ballestad; Rohrlack, Thomas; Decenciere, Fernandiere Beatriz; Edvardsen, Bente; Kristensen, Tom & Jakobsen, Kjetill Sigurd (2010). SUBPOPULATION DIFFERENTIATION ASSOCIATED WITH NONRIBOSOMAL PEPTIDE SYNTHETASE GENE CLUSTER DYNAMICS IN THE CYANOBACTERIUM PLANKTOTHRIX SPP.1. Journal of Phycology.  ISSN 0022-3646.  46(4), s 645- 652 . doi: 10.1111/j.1529-8817.2010.00856.x
  • Ellefsen, Stian; Stensløkken, Kåre-Olav; Fagernes, Cathrine Elisabeth; Kristensen, Tom & Nilsson, Gøran Erik (2009). Expression of genes involved in GABAergic neurotransmission in anoxic crucian carp brain (Carassius carassius). Physiological Genomics.  ISSN 1094-8341.  36(2), s 61- 68 . doi: 10.1152/physiolgenomics.90301.2008
  • Rounge, Trine Ballestad; Rohrlack, Thomas; Nederbragt, Alexander Johan; Kristensen, Tom & Jakobsen, Kjetill Sigurd (2009). A genome-wide analysis of nonribosomal peptide synthetase gene clusters and their peptides in a Planktothrix rubescens strain. BMC Genomics.  ISSN 1471-2164.  10 . doi: 10.1186/1471-2164-10-396
  • Fewer, DP; Tooming-Klunderud, Ave; Jokela, J; Wahsten, M; Rouhiainen, L; Kristensen, Tom; Rohrlack, T; Jakobsen, Kjetill Sigurd & Sivonen, K (2008). Natural occurrence of microcystin synthetase deletion mutants capable of producing microcystins in strains of the genus Anabaena (Cyanobacteria). Microbiology.  ISSN 1350-0872.  154, s 1007- 1014 . doi: 10.1099/mic.0.2007/016097-0
  • Ellefsen, Stian; Sandvik, Guro Katrine; Larsen, Helene Kile; Stensløkken, Kåre-Olav; Hov, Dag Are Steenhoff; Kristensen, Tom & Nilsson, Gøran Erik (2008). Expression of genes involved in excitatory neurotransmission in anoxic crucian carp (Carassius carassius) brain. Physiological Genomics.  ISSN 1094-8341.  35, s 5- 17
  • Ellefsen, Stian; Stenslokken, KO; Sandvik, Guro Katrine; Kristensen, Tom & Nilsson, Gøran Erik (2008). Improved normalization of real-time reverse transcriptase polymerase chain reaction data using an external RNA control. Analytical Biochemistry.  ISSN 0003-2697.  376 . doi: 10.1016/j.ab.2008.01.028
  • Rounge, Trine Ballestad; Rohrlack, Thomas; Kristensen, Tom & Jakobsen, Kjetill Sigurd (2008). Recombination and selectional forces in cyanopeptolin NRPS operons from highly similar, but geographically remote Planktothrix strains. BMC Microbiology.  ISSN 1471-2180.  8 . doi: 10.1186/1471-2180-8-141
  • Tooming-Klunderud, Ave; Fewer, DP; Rohrlack, Thomas; Jokela, J; Rouhiainen, L; Sivonen, K; Kristensen, Tom & Jakobsen, Kjetill Sigurd (2008). Evidence for positive selection acting on microcystin synthetase adenylation domains in three cyanobacterial genera. BMC Evolutionary Biology.  ISSN 1471-2148.  8 . doi: 10.1186/1471-2148-8-256
  • Tooming-Klunderud, Ave; Mikalsen, Bjørg; Kristensen, Tom & Jakobsen, Kjetill Sigurd (2008). The mosaic structure of the mcyABC operon in Microcystis. Microbiology.  ISSN 1350-0872.  154, s 1886- 1899 . doi: 10.1099/mic.0.2007/015875-0
  • Rounge, Trine Ballestad; Rohrlack, Thomas; Tooming-Klunderud, Ave; Kristensen, Tom & Jakobsen, Kjetill Sigurd (2007). Comparison of cyanopeptolin genes in Planktothrix, Microcystis, and Anabaena strains: Evidence for independent evolution within each genus. Applied and Environmental Microbiology.  ISSN 0099-2240.  73, s 7322- 7330 . doi: 10.1128/AEM.01475-07
  • Tooming-Klunderud, Ave; Rohrlack, Thomas; Shalchian-Tabrizi, Kamran; Kristensen, Tom & Jakobsen, Kjetill Sigurd (2007). Structural analysis of a non-ribosomal halogenated cyclic peptide and its putative operon from Microcystis: implications for evolution of cyanopeptolins. Microbiology.  ISSN 1350-0872.  153(5), s 1382- 1393 . doi: 10.1099/mic.0.2006/001123-0
  • Kristensen, V. N.; Kristensen, Vessela Nedelcheva; Kristensen, T.; Børresen-Dale, Anne-Lise & Kristensen, Tom Arne (2001). Hypervariable area in the 5´flanking region of GSTP1, previously reported as a minisatellite ATAAA repeat. Human Mutation.  ISSN 1059-7794.  17, s 238- 239 Show summary
  • Huynh, Ngoc Trang Thi; Vad, Randi; Kristensen, Tom & Øyen, Tordis Beate (2001). The Genes of Two G-Proteins Involved in Protein Transport in Pichia pastoris. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  280(2), s 454- 459 . doi: 10.1006
  • Huynh, Trang Thi Ngoc; Vad, Randi; Kristensen, Tom Arne & Øyen, Tordis Beate (2001). The genes of two G-proteins involved in protein transport in Pichia pastoris. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  180(2), s 454- 459 Show summary
  • Kristensen, Vessela Nedelcheva; Harada, Nobuhiro; Kristensen, Tom Arne & Børresen-Dale, Anne-Lise (2001). Genetic polymorphism and variation in steroid hormone metabolism.: connection with risk of developing breast neoplasms, In  Vopr. Onkol.   s 156 - 159
  • Kristensen, Vessela Nedelcheva; Kelefiotis, Dimitris; Kristensen, Tom Arne & Børresen-Dale, Anne-Lise (2001). High-throughput methods for detection of genetic variation. BioTechniques.  ISSN 0736-6205.  30, s 318- 332 Show summary
  • Tveit, Heidi & Kristensen, Tom Arne (2001). A fluorescence-based DNA polymerase assay. Analytical Biochemistry.  ISSN 0003-2697.  189, s 96- 98 Show summary
  • Warsame, Abdirashid; Vad, Randi; Kristensen, Tom Arne & Øyen, Tordis Beate (2001). Characterisation of a gene encoding a Pichia pastoris protein disulphide isomerase (PpPDI). Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  281, s 1176- 1182 Show summary
  • Kristensen, Tom Arne; Kristensen, Vessela Nedelcheva & Børresen-Dale, Anne-Lise (2000). High-throughput screening for known mutations by automated analysis of single sequencing reactions, In John D. Burczak & Elaine Mardis (ed.),  Polymorphism Detection & Analysis.  Eaton Publishing, Natick MA, USA.  ISBN 1-881299-47-3.  s 61 - 67 Show summary
  • Kristensen, Vessela Nedelcheva; Harada, Nobuhiro; Yoshimura, Noriko; Haraldsen, E.; Lønning, Per Eystein; Erikstein, Bjørn; Kåresen, Rolf; Kristensen, Tom Arne & Børresen-Dale, Anne-Lise (2000). Genetic variants of CYP19 (arometase) and breast cancer risk. Oncogene.  ISSN 0950-9232.  19(10), s 1329- 1333
  • Kristensen, Vessela Nedelcheva; Harada, Nobuhiro; Yoshimura, Noriko; Haraldsen, Ellen Christine; Lønning, Per Eystein; Erikstein, Bjørn; Kåresen, Rolf; Kristensen, Tom Arne & Børresen-Dale, Anne-Lise (2000). Genetic variants of CYP19 (aromatase) and breast cancer risk. Oncogene.  ISSN 0950-9232.  19(10), s 1329- 1333 Show summary
  • Kristensen, Tom Arne; Kristensen, Vessela Nedelcheva & Børresen-Dale, Anne-Lise (1998). High-thorughput screening for known mutations by automated analysis of single sequencing reaction. BioTechniques.  ISSN 0736-6205.  24, s 832- 835
  • Kristensen, Tom Arne; Kristensen, Vessela Nedelcheva & Børresen-Dale, Anne-Lise (1998). High-throughput screening for known mutations by automated analysis of single sequencing reactions. BioTechniques.  ISSN 0736-6205.  24, s 832- 835
  • Nasir, Achmad I.; Gundersen, Lise-Lotte; Rise, Frode; Antonsen, Øyvind; Kristensen, Tom Arne; Langhelle, B.; Bast, Aalt; Custers, Ilse; Haenen, Guido R. M. M. & Wikstrøm, Håkan (1998). Inhibition of Lipid Peroxidation mediated by Indolizines. Bioorganic & Medicinal Chemistry Letters.  ISSN 0960-894X.  s 1828- 1832 Show summary
  • Heikal, Adam; Samuelsen, Ørjan; Kristensen, Tom & Økstad, Ole Andreas Løchen (2017). Complete genome sequence of a multidrug-resistant, blaNDM-1-expressing Klebsiella pneumoniae K66-45 clinical isolate from Norway. Genome Announcements.  ISSN 2169-8287.  5:e00601(27), s 1- 2 . doi: 10.1128/genomeA.00601-17
  • Kristensen, Tom; Nissen-Meyer, Jon; Oppegård, Camilla; Ekblad, Bie; Kjos, Morten; Diep, Dzung Bao & Nes, Ingolf (2015). Whole genome sequencing as a tool to elucidate the mechanism of action of AMPs.
  • Kristensen, Tom; Kjos, Morten; Oppegård, Camilla; Diep, Dzung Bao; Nes, Ingolf & Nissen-Meyer, Jon (2014). Identification of bacteriocin resistance-inducing mutations by whole genome sequencing without a reference genome: The putative receptor of plantaricin JK.
  • Oppegård, Camilla; Kjos, Morten; Diep, Dzung Bao; Nes, Ingolf; Veening, Jan-Willem; Nissen-Meyer, Jon & Kristensen, Tom (2014). Genome sequencing of lactococcin G-resistant strains identified UppP, an enzyme involved in cell wall synthesis, as a putative bacteriocin receptor.
  • Kristensen, Tom; Nissen-Meyer, Jon; Diep, Dzung Bao; Oppegård, Camilla; Nes, Ingolf & Kjos, Morten (2013). Genomic sequencing as a tool to identify bacteriocin receptors.
  • Kristensen, Tom (2013). Bioteknologi - til glede og fortvilelse.
  • Rike, Anne Gunn Larsen; Håvelsrud, Othilde Else; Haverkamp, Thomas Hendricus Augustus; Kristensen, Tom & Jakobsen, Kjetill Sigurd (2013). Metagenomics in methane seep detection and studies of the microbial methane sediment filter.
  • Nissen-Meyer, Jon; Kristensen, Tom; Diep, Dzung Bao & Nes, Ingolf (2012). Bakteriosiner: En gruppe antimikrobielle peptider med et stort potensial til å bekjempe patogene bakterier. NBS-nytt.  ISSN 0801-3535.  3
  • Bråte, Jon; Krabberød, Anders Kristian; Dolven, Jane Karine Lønne; Ose, Randi Frida; Kristensen, Tom; Bjørklund, Kjell Rasmus & Shalchian-Tabrizi, Kamran (2010). Diversity of unculturable Radiolaria and their symbionts revealed by 18S rDNA phylogeny.
  • Kristensen, Tom (2009). «Scavenger» – fjerner det som er uønsket. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  129(10), s 1016- 1016 . doi: doi:10.4045/tidsskr.09.0362
  • Kristensen, Tom (2006). Mikroterrorister - bakterie-, virus- og soppinfeksjoner som truer vår helse.
  • Kristensen, Tom (2005). Nobelprisen i kjemi, I: Øyvind Reisegg (red.),  Aschehoug og Gyldendals Store Norske Årbok.  Kunnskapsforlaget.  ISBN 82-573-1603-2.  Nobelprisen i kjemi.  s 444 - 446
  • Antonsen, Øyvind; Kristensen, Tom Arne; Langhelle, B.; Fosnes, K.; Larsen, V.; Gundersen, Lise-Lotte; Rise, Frode; Bast, Aalt; Custers, Ilse & Haenen, Guido R. M. M. (2001). Synthesis of Indolizines and Pyrrolo[1,2-b]pyridazine with Antioxidant Properties.
  • Kristensen, Tom Arne; Kalleberg, Ingvild Berlin & Plagemann, Thomas Peter (2001). Implementing Configurable Signalling in the MULTE-ORB.
  • Kristensen, Tom Arne (2000, 04. januar). Kappløpet om genene. [Radio].  Oslo : NRK P2 radio. Show summary
  • Øyen, Tordis Beate; Jorde, A. T. & Kristensen, Tom Arne (2000). The iron-containing catalytic subunit of Pichia pastoris ribonucleotide reductase, RNR2.
  • Kristensen, Tom Arne (1999). Biokjemi - hva er vitsen?.
  • Kristensen, Tom Arne (1999). DNA polymerases in PCR and DNA sequencing.
  • Kristensen, Tom Arne (1999). DNA polymerases in PCR and DNA sequencing.
  • Kristensen, Vessela Nedelcheva; Harada, Nobuhiro; Haraldsen, Ellen Christine; Yoshimura, Noriko; Lønning, Per Eystein; Erikstein, Bjørn; Kåresen, Rolf; Kristensen, Tom Arne & Børresen-Dale, Anne-Lise (1999). GENETIC POLYMORPHISMS OF CYP19 (AROMATASE), BREAST CANCER RISK AND CLINICAL AND HISTOPATHOLOGICAL PARAMETERS.
  • Kristensen, Vessela Nedelcheva; Harada, Nobuhiro; Haraldsen, Ellen Christine; Yoshimura, Noriko; Lønning, Per Eystein; Erikstein, Bjørn; Kåresen, Rolf; Kristensen, Tom Arne & Børresen-Dale, Anne-Lise (1999). GENETIC POLYMORPHISMS OF CYP19 (AROMATASE), BREAST CANCER RISK AND CLINICAL AND HISTOPATHOLOGICAL PARAMETERS.
  • Kristensen, Vessela Nedelcheva; Harada, Nobuhiro; Haraldsen, Ellen Christine; Yoshimura, Noriko; Lønning, Per Eystein; Kristensen, Tom Arne & Børresen-Dale, Anne-Lise (1999). GENETIC VARIANTS OF CYP19 (AROMATASE), mRNA LEVELS AND PUTATIVE STRUCTURE.
  • Kristensen, Vessela Nedelcheva; Harada, Nobuhiro; Haraldsen, Ellen Christine; Yoshimura, Noriko; Lønning, Per Eystein; Kristensen, Tom Arne & Børresen-Dale, Anne-Lise (1999). GENETIC VARIANTS OF CYP19 (AROMATASE), mRNA LEVELS AND PUTATIVE STRUCTURE OF THE TRANSCRIPT.
  • Tvermyr, Marianne; Kristiansen, Bjørn Evert & Kristensen, Tom Arne (1999). PROOFREADING ACTIVITY OF FAMILY A DNA POLYMERASES: THERE FROM THE BEGINNING. Show summary
  • Kristensen, Tom Arne (1998, 01. januar). Hva er bioinformatikk?. [Radio].  Forskning nr.7. : NRK.
  • Kristensen, Tom Arne (1997, 01. januar). Verdt å vite. [Radio].
  • Kristiansen, Bjørn Evert & Kristensen, Tom Arne (1997). Expression of Chloroflexus aurantiacus DNA polymerase I in Eschericia coli. There from the beginning?.
  • Rønneberg, J. A.; Kristensen, Tom Arne; Larsen, Frank & Bosnes, M. (1997). Optimalization of the Tth DNA polymerase reverse transcriptase activity for the use with Dynabeads (R).
  • Kristensen, Tom Arne (1996, 02. oktober). intervju. [Radio].  Verdt og vite, NRK.
Published Nov. 4, 2010 2:42 PM - Last modified Dec. 4, 2014 12:38 PM