The Saatcioglu Group studies how androgens, male sex hormones, exert their effects on the normal physiology, as well as their role in disease states.
About the group
The goal of the studies in our laboratory is to understand how androgens, male sex hormones, exert their effects on the normal physiology, as well as their role in disease states. Androgens bind to an intracellular receptor, called the androgen receptor (AR), which belongs to a superfamily of ligand-activated transcription factors, called nuclear receptors, which bring about changes in the phenotype of the cell through modulation of gene expression. To understand this process, we are using molecular, biochemical, cell biological and genetic approaches. During the course of these studies, we have cloned several genes and began to characterize the function of their products in normal physiology, as well as in cancer.