COMPI: Comparative Infection Biology

In the project “Comparative Infection Biology (COMPI)”, we are using the fact that different pathogens use very similar pathogenicity factors in the infection process. Based on these common principles, we are trying to understand the similarities and differences of various bacterial pathogens. We try to understand why closely related pathogens specialize in infecting different species, from humans to fish, and why only distantly related pathogens use the same factors in the infection process. Our model system is the Yersiniae, a genus that comprises important human pathogens, but also pathogens that can infect fish and other animals.

Suggested reading:

Leo, J. et al. 2015.The inverse autotransporter family: intimin, invasin and related proteins. International Journal of Medical Microbiology 305: 276–282.

Haensch, S. et al. 2010. Distinct clones of Yersinia pestis caused the black death. PLoS Pathogens 6(10): e1001134.

Linke, D. et al. 2006. Trimeric autotransporter adhesins: variable structure, common function. Trends in Microbiology 14:264-270.

Published Dec. 18, 2014 1:25 PM - Last modified Sep. 12, 2016 12:32 PM