Ole Christian Lingjærde

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Phone +47-22857964 +47-22852410
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Room 4423
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Visiting address Gaustadalléen 23B Ole Johan Dahls hus 0373 OSLO
Postal address Postboks 1080 Blindern 0316 OSLO
Other affiliations Department for Informatics

I am a professor of computer science affiliated with the Biomedical Informatics Research Group (BMI) at the Department of Informatics (IFI) at University of Oslo (UiO). I am also head of the Biostatistics and Bioinformatics group in the KG Jebsen Centre for Breast Cancer Research, head of Bioinformatics in the MetAction project, senior investigator in the Centre for Cancer Biomedicine (a Norwegian Centre of Excellence), and affiliated with CELS (Centre for Computational Inference in Evolutionary Life Science, UiO).

Research interests

Mathematical and statistical modeling is the natural language to use for making precise statements about associations and structures in biology, and indeed such models form the backbone of countless analysis methods and bioinformatics tools. Equally important, however, modeling may be used highly interactively to explore properties of biological systems and to confront hypotheses with reality (through simulations). I find both these perspectives very fruitful in my own work. While some applications inevitably require sophisticated models and computational schemes, it is surprising and comforting to see that even the simplest models (if rightly chosen) can be very powerful in terms of revealing key properties of extremely complex systems. The recent explosion in massively parallel observations obtained with microarrays, high-throughput sequencing and other technologies, constitute a serious challenge in many applications. Lack of computational power and data storage are serious problems in this context, but equally important is the need for more research to understand the theoretical limitations on what can be learned from studies involving thousands or even millions of parallel observations on a few hundred or a few thousand individuals. 

From a biological point of view, I have a particular interest in the various manifestations and implications of molecular evolution. The tremendous success of introducing concepts such as cancer 'driver' and 'passenger' genes, and more lately notions such as cancer life histories and archaeology of cancer illustrates the power of alluding to evolutionary concepts. Still, evolution is a very elusive concept, even if it is well understood from a mathematical perspective. As Stephen Wolfram has pointed out, very simple programs (such as those written in the DNA) often result in very complex behavior (i.e. phenotype). So even though biological processes adhere to evolutionary principles and the latter are reasonably well understood, we may not be able to predict what comes out of an evolutionary process any more than we are able to predict the weather beyond a few weeks. There are definitely certain regularities in evolutionary processes, however; in a study of 2000 breast carcinomas (the METABRIC cohort) Curtis et al (2012) found 10 distinct classes of tumors each being characterized by a unique set of genes driving cancer development. Also in other types of cancer one typically finds a small number of distinct subgroups, indicating that nature (and evolution) is not behaving completely at random but following certains paths (often with many detours, though).

From a methodological point of view, I have a particular interest in large-scale inference on the basis of thousands or even millions of parallel data sets that may come from a single or several different measurement sources (the latter case often being referred to in the genomics literature as 'integrative analysis'). Apart from the more obvious problems arising in such settings (such as the need to adjust for multiple comparisons), the deeper challenges concerns how to take advantage of the parallelity of the data (e.g. through empirical Bayes approaches) and developing means to impose biologically reasonable (and justifiable) constraints on the models in order to ensure uniqueness and stability of estimates. Answering such questions requires deep knowledge of statistics as well as biology and is a truly interdisciplinary task.

Examples of recent work

Here are a few selected projects over the last years where I have played a major part in the methodological development (names in parentheses indicating others who have also played a particularly central role in the methodological development):

  • CARMA (Copy Aberration Regional Mapping Analysis) is a computational approach to analyze allele-specific copy number data from tumor DNA obtained with SNP arrays or by high-throughput sequencing. A series of distinct patterns of genomic aberrations are identified, each representing a particular mode of variation in individual copy number profiles. The purpose is to derive a compact, biologically and clinically relevant representation of the genomic architecture in a tumor (together with Gro Nilsen, Hans Kristian Moen Vollan, Arne Pladsen and Hege Russnes and others).
  • ASCAT (Allele-Specific Copy Aberrations in Tumors) is an algorithm for estimation of allele-specific copy numbers, genome ploidy and tumor cell percentage on the basis of SNP array data or HTS data (together with Peter Van Loo and Silje Nord)
  • CAAI (Complex Arm-wise Aberration Index) is a score of genomic complexity which has been shown to be an independent DNA-based prognostic marker in breast cancer (together with Hege Russnes and Hans Kristian Moen Vollan)
  • PART (Partitioning Algorithm using Recursive Thresholding) is an algorithm for identification of clusters in hierarchical clustering trees (together with Gro Nilsen, Knut Liestøl and Ørnulf Borgan).
  • PCF (Piecewise Constant Fitting) is an algorithm for segmentation of array CGH data or SNP array data (together with Gro Nilsen and Knut Liestøl)

Over the last five years I have also been heavily involved in several genomics integration projects, including for example:

  • Prediction of histological transformation (most often to DLBCL) in follicular lymphoma, based on whole-genome copy number and gene expression data (together with Marianne Brodtkorb, Harald Holte, Erlend Smeland and others)
  • Identification of novel drivers of progression in breast cancer, based on whole-genome copy number and gene expression data (together with Miriam Ragle Aure, Lars Baumbusch, Israel Steinfeld, Anne-Lise Børresen-Dale, Zohar Yakhini and others)
  • Identification of genes for which the expression is deregulated in breast cancer both epigenetically (through methylation) and by copy number alteration (together with Miriam Ragle Aure and others)
  • Deriving a map of all direct and indirect interactions between whole-genome miRNA and a panel of 105 cancer related proteins (together with Miriam Ragle Aure, Sandra Jernstrøm, Marit Krohn and others)

PhD supervision

I am/has been involved in supervision of the following PhD students:

  • Maren Høland
  • Vandana Sandhu
  • Aliaksandr Hubin
  • Even Sannes Riiser
  • Hans Kristian Moen Vollan (2015)
  • Gro Nilsen (2015)
  • Miriam Ragle Aure (2013)
  • Eldrid Borgan (2012)
  • Xi Zhao (2011)

Master project supervision

I am/has been involved in supervision of the following master students:

  • Marius Bernklev
  • Anders Flisvang
  • Stian Lågstad
  • Jonas Meier Strømme
  • Kine Veronica Lund (2014)
  • Gro Nilsen (2009)
  • Espen Solberg (2007)
  • Stian Grenborgen (2007)
  • Olav Skjelkvåle Ligaarden (2007)
  • Daniel Løkken Rustad (2005)
  • Hege Leite Størvold (2004)
  • Kristin Robertsen (2003)
Tags: Bioinformatics

Publications

  • Aure, Miriam Ragle; Vitelli, Valeria; Jernström, Sandra Johanna; Kumar, Surendra; Krohn, Marit; Due, Eldri Undlien; Haukaas, Tonje Husby; Leivonen, Suvi-Katri; Vollan, Hans Kristian Moen; Luders, Torben; Rødland, Einar Andreas; Vaske, Charles; Zhao, Wei; Møller, Elen Kristine; Nord, Silje; Giskeødegård, Guro F.; Bathen, Tone Frost; Caldas, Carlos; Tramm, Trine; Alsner, Jan; Overgaard, Jens; Geisler, Jürgen; Bukholm, Ida Rashida Khan; Naume, Bjørn; Schlichting, Ellen; Sauer, Torill; Mills, Gordon B.; Kåresen, Rolf; Mælandsmo, Gunhild; Lingjærde, Ole Christian; Frigessi, Arnoldo; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Sahlberg, Kristine Kleivi & OSBREAC, Oslo Breast Cancer Consortium (2017). Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome. Breast Cancer Research.  ISSN 1465-542X.  19(44) . doi: 10.1186/s13058-017-0812-y Full text in Research Archive.
  • Cheng, Jiqiu; Demeulemeester, Jonas; Wedge, David C.; Vollan, Hans Kristian Moen; Pitt, Jason; Russnes, Hege Elisabeth Giercksky; Pandey, Bina P.; Nilsen, Gro; Nord, Silje; Bignell, Graham R; White, Kevin P.; Børresen-Dale, Anne-Lise; Campbell, Peter J.; Kristensen, Vessela N.; Stratton, Michael R.; Lingjærde, Ole Christian; Moreau, Yves & Van Loo, Peter (2017). Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors. Nature Communications.  ISSN 2041-1723.  8:1221, s 1- 14 . doi: 10.1038/s41467-017-01355-0
  • Josefsson, Sarah Elisabet Göthberg; Huse, Kanutte; Kolstad, Arne; Beiske, Klaus; Pende, Daniela; Steen, Chloe Beate; Inderberg, Else Marit; Lingjærde, Ole Christian; Østenstad, Bjørn; Smeland, Erlend B; Levy, Ronald; Irish, Jonathan M. & Myklebust, June (2017). T cells expressing checkpoint receptor TIGIT are enriched in follicular lymphoma tumors and characterized by reversible suppression of T-cell receptor signaling. Clinical Cancer Research.  ISSN 1078-0432. . doi: 10.1158/1078-0432.CCR-17-2337
  • Lågstad, Stian; Zhao, Sen; Hoff, Andreas Midbøe; Johannessen, Bjarne; Lingjærde, Ole Christian & Skotheim, Rolf I. (2017). Chimeraviz: A tool for visualizing chimeric RNA. Bioinformatics.  ISSN 1367-4803.  33(18), s 2954- 2956 . doi: 10.1093/bioinformatics/btx329
  • Ree, Anne Hansen; Russnes, Hege Elisabeth Giercksky; Heinrich, Daniel; Dueland, Svein; Pedersen, Kjetil Boye; Nygaard, Vigdis; Silwal-Pandit, Laxmi; Østrup, Olga; Hovig, Eivind; Nygaard, Vegard; Rødland, Einar Andreas; Nakken, Sigve; Øien, Janne T; Johansen, Christin; Bergheim, Inger; Skarpeteig, Veronica; Sathermugathevan, Menaka; Sauer, Torill; Lund-Iversen, Marius; Beiske, Klaus; Nasser, Salah; Julsrud, Lars; Reisse, Claudius; Ruud, Espen Asak; Flørenes, Vivi Ann; Hagene, Kirsten T; Aas, Eline; Lurås, Hilde; Soriano, Siv Johnsen; Geitvik, Gry Aarum; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise; Mælandsmo, Gunhild & Flatmark, Kjersti (2017). Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate. ESMO Open Cancer Horizons.  ISSN 2059-7029.  2(2) . doi: 10.1136/esmoopen-2017-000158
  • Russnes, Hege Elisabeth Giercksky; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise & Caldas, Carlos (2017). Breast cancer molecular stratification– from intrinsic subtypes to integrative clusters. American Journal of Pathology.  ISSN 0002-9440. . doi: 10.1016/j.ajpath.2017.04.022
  • Silwal-Pandit, Laxmi; Nord, Silje; Gythfeldt, Hedda; Møller, Elen Kristine; Fleischer, Thomas; Rødland, Einar Andreas; Krohn, Marit; Borgen, Elin; Garred, Øystein; Olsen, Tone; Vu, Phuong; Skjerven, Helle; Fangberget, Anne; Holmen, Marit Muri; Schlichting, Ellen; Wille, Elisabeth; Stokke, Mette Nordberg; Vollan, Hans Kristian Moen; Kristensen, Vessela N.; Langerød, Anita; Lundgren, Steinar; Wist, Erik; Naume, Bjørn; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise & Engebråten, Olav (2017). The longitudinal transcriptional response to neoadjuvant chemotherapy with and without bevacizumab in breast cancer. Clinical Cancer Research.  ISSN 1078-0432.  23(16), s 4662- 4670 . doi: 10.1158/1078-0432.CCR-17-0160
  • Taraldsrud, Eli; Aukrust, Pål; Jørgensen, Silje; Lingjærde, Ole Christian; Olweus, Johanna; Myklebust, June & Fevang, Børre (2017). Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency. Clinical Immunology.  ISSN 1521-6616.  175, s 69- 74 . doi: 10.1016/j.clim.2016.11.014 Show summary
  • Blaker, Yngvild Nuvin; Spetalen, Signe; Eide, Marianne Brodtkorb; Lingjærde, Ole Christian; Beiske, Klaus; Østenstad, Bjørn; Sander, Birgitta; Wahlin, Björn Engelbrekt; Melen, Christopher Michael; Myklebust, June; Holte, Harald; Delabie, Jan & Smeland, Erlend B (2016). The tumour microenvironment influences survival and time to transformation in follicular lymphoma in the rituximab era. British Journal of Haematology.  ISSN 0007-1048.  175(1), s 102- 114 . doi: 10.1111/bjh.14201
  • Haukaas, Tonje Husby; Euceda, Leslie R.; Giskeødegård, Guro F.; Lamichhane, Santosh; Krohn, Marit; Jernström, Sandra Johanna; Aure, Miriam Ragle; Lingjærde, Ole Christian; Schlichting, Ellen; Garred, Øystein; Due, Eldri Undlien; Mills, Gordon B.; Sahlberg, Kristine Kleivi; Børresen-Dale, Anne-Lise & Bathen, Tone Frost (2016). Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes. Cancer & Metabolism.  ISSN 2049-3002.  4 . doi: 10.1186/s40170-016-0152-x Full text in Research Archive.
  • Kaveh, Fatemeh; Baumbusch, Lars Oliver; Nebdal, Daniel J.H.; Børresen-Dale, Anne-Lise; Lingjærde, Ole Christian; Edvardsen, Hege; Kristensen, Vessela N. & Solvang, Hiroko Kato (2016). A systematic comparison of copy number alterations in four types of female cancer. BMC Cancer.  ISSN 1471-2407.  16(913) . doi: 10.1186/s12885-016-2899-4
  • Kjersem, Janne Beathe; Thomsen, Maria; Guren, Tormod Kyrre; Hamfjord, Julian; Carlsson, G; Gustavsson, B.; Ikdahl, Tone; Indrebø, Gunnar; Pfeiffer, P; Lingjærde, Ole Christian; Tveit, Magne Kjell; Wettergren, Y & Kure, Elin H. (2016). AGXT and ERCC2 polymorphisms are associated with clinical outcome in metastatic colorectal cancer patients treated with 5-FU/oxaliplatin. The Pharmacogenomics Journal.  ISSN 1470-269X.  16(3), s 272- 279 . doi: 10.1038/tpj.2015.54
  • Nik-Zainal, Serena; Davies, Helen; Staaf, Johan; Ramakrishna, Manasa; Glodzik, Dominik; Zou, Xueqing; Martincorena, Inigo; Alexandrov, Ludmil B.; Martin, Sancha; Wedge, David C.; Van Loo, Peter; Ju, Young Seok; Smid, Marcel; Brinkman, Arie; Morganella, Sandro; Aure, Miriam Ragle; Lingjærde, Ole Christian; Langerød, Anita; Ringnér, Markus; Ahn, Sung-Min; Boyault, Sandrine; Brock, Jane E.; Broeks, Annegien; Butler, Adam; Desmedt, Christine; Dirix, Luc; Dronov, Serge; Fatima, Aquila; Foekens, John A.; Gerstung, Moritz; Hooijer, Gerrit K.J.; Jang, Se Jin; Jones, David R.; Kim, Hyung-Yong; King, Tari A.; Krishnamurthy, Savitri; Lee, Hee Jin; Lee, Jeong-Yeon; Li, Yilong; McLaren, Stuart; Menzies, Andrew; Mustonen, Ville; O'Meara, Sarah; Pauporté, Iris; Pivot, Xavier; Purdie, Colin A.; Raine, Keiran; Ramakrishnan, Kamna; Rodriguez-González, F. Germán; Romieu, Gilles; Sieuwerts, Anieta M.; Simpson, Peter T.; Shepherd, Rebecca; Stebbings, Lucy; Stefansson, Olafur A.; Teague, Jon; Tommasi, Stefania; Treilleux, Isabelle; Eynden, Gert G. Van den; Vermeulen, Peter; Vincent-Salomon, Anne; Yates, Lucy; Caldas, Carlos; Van't Veer, Laura; Tutt, Andrew; Knappskog, Stian; Tan, Benita Kiat Tee; Jonkers, Jos; Borg, Åke; Ueno, Naoto T.; Sotiriou, Christos; Viari, Alain; Futreal, P. Andrew; Campbell, Peter J.; Span, Paul N.; Van Laere, Steven; Lakhani, Sunil R.; Eyfjörd, Jórunn E.; Thompson, Alastair M.; Birney, Ewan; Stunnenberg, Hendrik G.; van de Vijver, Marc J.; Martens, John W. M.; Børresen-Dale, Anne-Lise; Richardson, Andrea L.; Kong, Gu; Thomas, Gilles & Stratton, Michael R. (2016). Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature.  ISSN 0028-0836.  534(7605), s 47- 54 . doi: 10.1038/nature17676
  • Sandhu, Vandana; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Skrede, Martina; Hamfjord, Julian; Larsen, Astrid Marie; Buanes, Trond; Dube, Gugu; Kale, MM; Sawant, S; Kulkarni-Kale, U; Børresen-Dale, Anne-Lise; Lingjærde, Ole Christian & Kure, Elin H. (2016). Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma. Molecular Oncology.  ISSN 1574-7891.  10(2), s 303- 316 . doi: 10.1016/j.molonc.2015.10.011
  • Sandhu, Vandana; Wedge, David C.; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Dentro, Stefan C.; Buanes, Trond; Skrede, Martina; Larsen, Astrid Marie; Munthe, Else; Myklebost, Ola; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise; Andersen, Tone Ikdahl; Van Loo, Peter; Nord, Silje & Kure, Elin H. (2016). The genomic landscape of pancreatic and periampullary adenocarcinoma. Cancer Research.  ISSN 0008-5472.  76(17), s 5092- 5102 . doi: 10.1158/0008-5472.CAN-16-0658
  • Sas-Chen, Aldema; Aure, Miriam Ragle; Leibovich, Limor; Carvalho, Silvia; Enuka, Yehoshua; Körner, Cindy; Polycarpou-Schwarz, Maria; Lavi, Sara; Nevo, Nava; Kuznetsov, Yuri; Yuan, Justin; Azuaje, Francisco; Ulitsky, Igor; Diederichs, Sven; Wiemann, Stefan; Yakhini, Zohar; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Yarden, Yosef; Sauer, Torill; Geisler, Jürgen; Hofvind, Solveig; Bathen, Tone Frost; Borgen, Elin; Engebråten, Olav; Fodstad, Øystein; Garred, Øystein; Geitvik, Gry; Kåresen, Rolf; Naume, Bjørn; Mælandsmo, Gunhild; Russnes, Hege Elisabeth Giercksky; Schlichting, Ellen; Sørlie, Therese; Lingjærde, Ole Christian; Sahlberg, Kristine Kleivi; Skjerven, Helle & Fritzman, Britt (2016). LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer. EMBO Molecular Medicine.  ISSN 1757-4676.  8(9), s 1052- 1064 . doi: 10.15252/emmm.201606198 Full text in Research Archive.
  • Sveen, Anita; Løes, Inger Marie; Alagaratnam, Sharmini; Nilsen, Gro; Høland, Maren; Lingjærde, Ole Christian; Sorbye, Halfdan; Berg, Kaja Christine Graue; Horn, Arild; Angelsen, Jon-Helge; Knappskog, Stian; Lønning, Per Eystein & Lothe, Ragnhild A (2016). Intra-patient inter-metastatic genetic heterogeneity in colorectal cancer as a key determinant of survival after curative liver resection. PLoS Genetics.  ISSN 1553-7390.  12:e1006225(7) . doi: 10.1371/journal.pgen.1006225
  • Aure, Miriam Ragle; Jernström, Sandra Johanna; Krohn, Marit; Vollan, Hans Kristian Moen; Due, Eldri Undlien; Rødland, Einar Andreas; Kåresen, Rolf; Ram, Prahlad T.; Lu, Yiling; Mills, Gordon B.; Sahlberg, Kristine Kleivi; Børresen-Dale, Anne-Lise; Lingjærde, Ole Christian & Kristensen, Vessela N. (2015). Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer. Genome Medicine.  ISSN 1756-994X.  7:21 . doi: 10.1186/s13073-015-0135-5
  • Bjaanæs, Maria Moksnes; Nilsen, Gro; Solberg, Steinar; Brustugun, Odd Terje; Lingjærde, Ole Christian & Helland, Åslaug (2015). Whole-genome copy number analyses of NSCLC tumors reveal aberrations associated with EGFR mutations and may have prognostic impact. Journal of Thoracic Oncology.  ISSN 1556-0864.  10(9), s S581- S582
  • Borge, Kaja Sverdrup; Nord, Silje H.; Van Loo, Peter; Lingjærde, Ole Christian; Gunnes, Gjermund; Grenaker, Grethe Irene; Solvang, Hiroko Kato; Luders, Torben; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise & Lingaas, Frode (2015). Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN. PLoS ONE.  ISSN 1932-6203.  10(5) . doi: 10.1371/journal.pone.0126371 Full text in Research Archive.
  • Hamfjord, Julian; Saldova, Radka; Stockmann, Henning; Sandhu, Vandana; Lothe, Inger Marie Bowitz; Buanes, Trond; Lingjærde, Ole Christian; Labori, Knut Jørgen; Rudd, Pauline M & Kure, Elin H. (2015). Serum N-glycome characterization in patients with resectable periampullary adenocarcinoma. Journal of Proteome Research.  ISSN 1535-3893.  14(12), s 5144- 5156 . doi: 10.1021/acs.jproteome.5b00395
  • Potapenko, Ivan Olegovich; Luders, Torben; Russnes, Hege Elisabeth Giercksky; Helland, Åslaug; Sørlie, Therese; Kristensen, Vessela N.; Nordgard, Silje H.; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise & Haakensen, Vilde Drageset (2015). Glycan-related gene expression signatures in breast cancer subtypes; relation to survival. Molecular Oncology.  ISSN 1574-7891.  9(4), s 861- 876 . doi: 10.1016/j.molonc.2014.12.013
  • Sandhu, Vandana; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Lingjærde, Ole Christian; Buanes, Trond; Dalsgaard, Astrid Marie; Skrede, Martina; Hamfjord, Julian; Haaland, Therese Kristina; Eide, Tor Jacob; Børresen-Dale, Anne-Lise; Andersen, Tone Ikdahl & Kure, Elin H. (2015). Molecular signatures of mRNAs and miRNAs as prognostic biomarkers in pancreatobiliary and intestinal types of periampullary adenocarcinomas. Molecular Oncology.  ISSN 1574-7891.  9(4), s 758- 771 . doi: 10.1016/j.molonc.2014.12.002
  • Tinholt, Mari; Vollan, Hans Kristian Moen; Sahlberg, Kristine Kleivi; Jernström, Sandra Johanna; Kaveh, Fatemeh; Lingjærde, Ole Christian; Kåresen, Rolf; Sauer, Torill; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Sandset, Per Morten & Iversen, Nina (2015). Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF. Breast Cancer Research.  ISSN 1465-542X.  17(44), s 1- 15 . doi: 10.1186/s13058-015-0548-5
  • Vollan, Hans Kristian Moen; Rueda, Oscar M.; Chin, Suet-Feung; Curtis, Christina; Turashvili, Gulisa; Shah, Sohrab P.; Lingjærde, Ole Christian; Yuan, Yinyin; Ng, Charlotte K.; Dunning, Mark J.; Dicks, Ed; Provenzano, Elena; Sammut, Stephen; McKinney, Steven; Ellis, Ian O.; Pinder, Sarah; Purushotham, Arnie; Murphy, Leigh; Kristensen, Vessela N.; METABRIC, group; Brenton, James D.; Pharoah, Paul D.P.; Børresen-Dale, Anne-Lise; Aparicio, Samuel & Caldas, Carlos (2015). A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer. Molecular Oncology.  ISSN 1574-7891.  9(1), s 115- 127 . doi: 10.1016/j.molonc.2014.07.019
  • Wise, Jillian Frances; Nakken, Sigve; Vodak, Daniel; Trøen, Gunhild; Lingjærde, Ole Christian; Meza-Zepeda, Leonardo A; Myklebost, Ola; Beiske, Klaus; Myklebust, June Helene; Hovig, Eivind; Smeland, Erlend B & Holte, Harald (2015). Discovery of recurrent mutations associated with chemo-immunotherapy relapse in diffuse large B-cell lymphoma. Blood.  ISSN 0006-4971.  126(23), s 110- 110
  • Brodtkorb, Marianne; Lingjærde, Ole Christian; Huse, Kanutte; Trøen, Gunhild; Hystad, Marit Elise; Hilden, Vera Irene; Myklebust, June; Leich, Ellen; Rosenwald, Andreas; Delabie, Jan; Holte, Harald & Smeland, Erlend B (2014). Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma. Blood.  ISSN 0006-4971.  123(7), s 1051- 1054 . doi: 10.1182/blood-2013-07-512392
  • Kjersem, Janne Beathe; Ikdahl, Tone; Lingjærde, Ole Christian; Guren, Tormod Kyrre; Tveit, Magne Kjell & Kure, Elin H. (2014). Plasma microRNAs predicting clinical outcome in metastatic colorectal cancer patients receiving first-line oxaliplatin-based treatment. Molecular Oncology.  ISSN 1574-7891.  8(1), s 59- 67 . doi: 10.1016/j.molonc.2013.09.001
  • Kristensen, Vessela N.; Lingjærde, Ole Christian; Russnes, Hege Elisabeth Giercksky; Vollan, Hans Kristian Moen; Frigessi, Arnoldo & Børresen-Dale, Anne-Lise (2014). Principles and methods of integrative genomic analyses in cancer. Nature Reviews. Cancer.  ISSN 1474-175X.  14(5), s 299- 313 . doi: 10.1038/nrc3721
  • Russnes, Hege Elisabeth Giercksky; Lønning, Per Eystein; Børresen-Dale, Anne-Lise & Lingjærde, Ole Christian (2014). The multitude of molecular analyses in cancer: the opening of Pandora’s box. Genome Biology.  ISSN 1465-6906.  15:447 . doi: 10.1186/s13059-014-0447-6 Full text in Research Archive.
  • Zhao, Xi; Rødland, Einar Andreas; Sørlie, Therese; Vollan, Hans Kristian Moen; Russnes, Hege Elisabeth Giercksky; Kristensen, Vessela N.; Lingjærde, Ole Christian & Børresen-Dale, Anne-Lise (2014). Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status. BMC Cancer.  ISSN 1471-2407.  14(211) . doi: 10.1186/1471-2407-14-211
  • Aure, Miriam Ragle; Leivonen, Suvi-Katri; Fleischer, Thomas; Zhu, Qian; Overgaard, Jens; Alsner, Jan; Tramm, Trine; Louhimo, Riku; Grenaker, Grethe Irene; Åerälä, Merja; Busato, Florence; Touleimat, Nizar; Tost, Jörg; Børresen-Dale, Anne-Lise; Hautaniemi, Sampsa; Troyanskaya, Olga; Lingjærde, Ole Christian; Sahlberg, Kristine Kleivi & Kristensen, Vessela N. (2013). Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors. Genome Biology.  ISSN 1465-6906. . doi: 10.1186/gb-2013-14-11-r126
  • Aure, Miriam Ragle; Steinfeld, I; Baumbusch, Lars Oliver; Liestøl, Knut; Lipson, Doron; Nyberg, Sandra Johanna; Naume, Bjørn; Sahlberg, Kristine Kleivi; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Lingjærde, Ole Christian & Yakhini, Zohar (2013). Identifying In-Trans Process Associated Genes in Breast Cancer by Integrated Analysis of Copy Number and Expression Data. PLoS ONE.  ISSN 1932-6203.  8(1) . doi: 10.1371/journal.pone.0053014
  • Baumbusch, Lars Oliver; Helland, Åslaug; Wang, Yun; Liestøl, Knut; Schaner, M.E.; Holm, Ruth; Etemadmoghadam, D; Alsop, Kathryn; Brown, Pat; Mitchell, Gillian; Fereday, Sian; deFazio, Anna; Bowtell, David D.L.; Kristensen, Gunnar S Balle; Lingjærde, Ole Christian & Børresen-Dale, Anne-Lise (2013). High Levels of Genomic Aberrations in Serous Ovarian Cancers Are Associated with Better Survival. PLoS ONE.  ISSN 1932-6203.  8(1) . doi: 10.1371/journal.pone.0054356
  • Borgan, Eldrid; Lindholm, Evita Maria; Moestue, Siver Andreas; Mælandsmo, Gunhild; Lingjærde, Ole Christian; Gribbestad, Ingrid S; Børresen-Dale, Anne-Lise; Engebråten, Olav & Sørlie, Therese (2013). Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts. Molecular Oncology.  ISSN 1574-7891.  7(1), s 130- 142 . doi: 10.1016/j.molonc.2012.10.005 Full text in Research Archive.
  • Myhre, Simen; Lingjærde, Ole Christian; Hennessy, Bryan T; Aure, Miriam Ragle; Carey, Mark S; Alsner, Jan; Tramm, Trine; Ouergaard, Jens; Mills, Gordon B.; Børresen-Dale, Anne-Lise & Sørlie, Therese (2013). Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins. Molecular Oncology.  ISSN 1574-7891.  7(3), s 704- 718 . doi: 10.1016/j.molonc.2013.02.018
  • Nilsen, Gro; Borgan, Ørnulf; Liestøl, Knut & Lingjærde, Ole Christian (2013). Identifying clusters in genomics data by recursive partitioning. Statistical Applications in Genetics and Molecular Biology.  ISSN 1544-6115.  12(5), s 637- 652 . doi: 10.1515/sagmb-2013-0016
  • Nilsen, Gro; Liestøl, Knut; Van Loo, P; Vollan, Hans Kristian Moen; Eide, Marianne Brodtkorb; Rueda, Oscar M.; Chin, Suet-Feung; Russel, Roslin; Baumbusch, Lars Oliver; Caldas, Carlos; Børresen-Dale, Anne-Lise & Lingjærde, Ole Christian (2012). Copynumber: Efficient algorithms for single and multi-track copy number segmentation. BMC Genomics.  ISSN 1471-2164.  13(591) . doi: 10.1186/1471-2164-13-591
  • Ruud Mathiesen, Randi Margit; Fjelldal, Renathe; Liestøl, Knut; Due, Eldri Undlien; Geigl, Jochen; Riethdorf, Sabine; Borgen, Elin; Rye, Inga Hansine; Schneider, Ida Johansson; Obenauf, Anna; Mauermann, Oliver; Nilsen, Gro; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise; Pantel, Klaus; Speicher, Michael R; Naume, Bjørn & Baumbusch, Lars Oliver (2012). High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer. International Journal of Cancer.  ISSN 0020-7136.  131(4), s E405- E415 . doi: 10.1002/ijc.26444
  • van Loo, Peter; Nilsen, Gro; Nordgard, Silje H.; Vollan, Hans Kristian Moen; Børresen-Dale, Anne-Lise; Kristensen, Vessela N. & Lingjærde, Ole Christian (2012). Analyzing cancer samples with SNP arrays, In Junbai Wang; Tianhai Tian & Aik Choon Tan (ed.),  Next Generation Microarray Bioinformatics.  Humana Press.  ISBN 978-1-61779-399-8.  4.  s 57 - 72
  • Borgan, Eldrid; Navon, Roy; Vollan, Hans Kristian Moen; Schlichting, Ellen; Sauer, Torill; Yakhini, Zohar; Lingjærde, Ole Christian; Sørlie, Therese & Børresen-Dale, Anne-Lise (2011). Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue. Molecular Oncology.  ISSN 1574-7891.  5(6), s 564- 576 . doi: 10.1016/j.molonc.2011.08.004
  • Haakensen, Vilde Drageset; Lingjærde, Ole Christian; Luders, Torben; Riis, Margit; Prat, Aleix; Troester, Melissa A; Holmen, Marit Muri; Frantzen, Jan Ole; Romundstad, Linda; Navjord, Dina; Bukholm, Ida Rashida Khan; Johannesen, Tom Børge; Perou, Charles M; Ursin, Giske; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise & Helland, Åslaug (2011). Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features. BMC Medical Genomics.  ISSN 1755-8794.  4 . doi: 10.1186/1755-8794-4-77 Show summary
  • Solvang, Hiroko Kato; Lingjærde, Ole Christian; Frigessi, Arnoldo; Børresen-Dale, Anne-Lise & Kristensen, Vessela N. (2011). Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer. BMC Bioinformatics.  ISSN 1471-2105.  12 . doi: 10.1186/1471-2105-12-197
  • Zhao, Xi; Rødland, Einar Andreas; Sørlie, Therese; Naume, Bjørn; Langerød, Anita; Frigessi, Arnoldo; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise & Lingjærde, Ole Christian (2011). Combining Gene Signatures Improves Prediction of Breast Cancer Survival. PLoS ONE.  ISSN 1932-6203.  6(3) . doi: 10.1371/journal.pone.0017845
  • Borgan, Eldrid; Sitter, Beathe; Lingjærde, Ole Christian; Johnsen, Hilde; Lundgren, Steinar; Bathen, Tone Frost; Sørlie, Therese; Børresen-Dale, Anne-Lise & Gribbestad, Ingrid S (2010). Merging transcriptomics and metabolomics - advances in breast cancer profiling. BMC Cancer.  ISSN 1471-2407.  10 . doi: 10.1186/1471-2407-10-628
  • Eide, Marianne Brodtkorb; Liestøl, Knut; Lingjærde, Ole Christian; Hystad, Marit Elise; Kresse, Stine Henrichson; Meza, Leonardo Zepeda; Myklebost, Ola; Trøen, Gunhild; Aamot, Hege; Holte, Harald; Smeland, Erlend B & Delabie, Jan (2010). Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones. Blood.  ISSN 0006-4971.  116(9), s 1489- 1497 . doi: 10.1182/blood-2010-03-272278
  • Haakensen, Vilde Drageset; Biong, Stine Margarethe; Lingjærde, Ole Christian; Holmen, Marit Muri; Frantzen, Jan Ole; Chen, Ying; Navjord, Dina; Romundstad, Linda; Luders, Torben; Bukholm, Ida Rashida Khan; Solvang, Hiroko Kato; Kristensen, Vessela N.; Ursin, Giske; Børresen-Dale, Anne-Lise & Helland, Åslaug (2010). Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density. Breast Cancer Research.  ISSN 1465-542X.  12(4) . doi: 10.1186/bcr2632
  • Potapenko, Ivan Olegovich; Haakensen, Vilde Drageset; Luders, Torben; Helland, Åslaug; Bukholm, Ida Rashida Khan; Sørlie, Therese; Kristensen, Vessela N.; Lingjærde, Ole Christian & Børresen-Dale, Anne-Lise (2010). Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression. Molecular Oncology.  ISSN 1574-7891.  4(2), s 98- 118 . doi: 10.1016/j.molonc.2009.12.001
  • Russnes, Hege Elisabeth Giercksky; Vollan, Hans Kristian Moen; Lingjærde, Ole Christian; Krasnitz, Alexander; Lundin, Pär; Naume, Bjørn; Sørlie, Therese; Borgen, Elin; Langerød, Anita; Chin, Suet-Feung; Teschendorft, Andrew E; Stephens, Philip J; Mànér, Susanne; Schlichting, Ellen; Baumbusch, Lars Oliver; Kåresen, Rolf; Stratton, Michael P; Wigler, Michael; Caldas, Carlos; Zetterberg, Anders; Hicks, James; Børresen-Dale, Anne-Lise & Rye, Inga Hansine (2010). Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients. Science Translational Medicine.  ISSN 1946-6234.  2(38), s 38- 47 . doi: 10.1126/scitranslmed.3000611
  • van Loo, Pete; Nordgard, Silje H.; Lingjærde, Ole Christian; Russnes, Hege Elisabeth Giercksky; Rye, Inga Hansine; Wei, Sun; Weigman, Victor J.; Marynen, Peter; Zetterberg, Anders; Naume, Bjørn; Perou, Charles M; Børresen-Dale, Anne-Lise & Kristensen, Vessela N. (2010). Allele-specific copy number analysis of tumors. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  107(39), s 16910- 16915 . doi: 10.1073/pnas.1009843107
  • Maus, Arne & Lingjærde, Ole Christian (2009). LASTING EFFECTS OF AUTOMATIC PLAGIARISM DETECTION IN AN INTRODUCTORY COURSE IN PROGRAMMING, In L Gómez Chova (ed.),  INTED2009 Proceedings CD.  The International Academy of Technology, Education and Development.  ISBN 978-84-612-7578-6.  i sessjonen:Emerging Technologies: Internet Based Technologies.
  • Nordgard, Silje H.; Nordgard, Silje H.; Alnæs, Grethe I.G.; Alnaes, GIG; Hihn, Björn; Lingjærde, Ole Chr.; Liestøl, Knut; Tsalenko, Anya; Sørlie, Therese; Lønning, Per Eystein; Lonning, PE; Børresen-Dale, Anne-Lise & Kristensen, Vessela Nedelcheva (2008). Pathway based analysis of SNPs with relevance to 5-FU therapy: Relation to intratumoral mRNA expression and survival. International Journal of Cancer.  ISSN 0020-7136.  123(3), s 577- 585 . doi: 10.1002/ijc.23541
  • Baumbusch, Lars Oliver; Aarøe, Jørgen Mømb; Johansen, Finn Erik; Hicks, J; Sun, H; Bruhn, L; Gunderson, K; Naume, Bjørn; Kristensen, Vessela N.; Liestøl, Knut; Børresen-Dale, Anne-Lise & Lingjærde, Ole Christian (2008). Comparison of the Agilent, ROMA/NimbleGen and Illumnia platforms for classification of copy numer alterations in human breast tumors. BMC Genomics.  ISSN 1471-2164.  9, s 379 . doi: 10.1186/1471-2164-9-379
  • Maus, Arne & Lingjærde, Ole Christian (2008). The application of a novel plagiarism detection system to an introductory course in programming: lessons learned, In I. Gómes Chova; D. Martí Belenguer & I. Candel Torres (ed.),  INTED2008 IProceedings.  The International Academy of Technology, Education and Development.  ISBN 978-84-612-0190-7.  artikkel 578.
  • Nygård, Ståle; Borgan, Ørnulf; Lingjærde, Ole Christian & Størvold, Hege Leite (2008). Partial least squares Cox regression for genome-wide data. Lifetime Data Analysis.  ISSN 1380-7870.  14, s 179- 195 . doi: 10.1007/s10985-007-9076-7
  • Bøvelstad, Hege; Nygård, Ståle; Størvold, Hege Leite; Aldrin, Magne; Borgan, Ørnulf; Frigessi, Arnoldo & Lingjærde, Ole Christian (2007). Predicting survival from microarray data - a comparative study. Bioinformatics.  ISSN 1367-4803.  23, s 2080- 2087 . doi: 10.1093/bioinformatics/btm305
  • Naume, Bjørn; Zhao, Xi; Synnestvedt, Marit; Borgen, Elin; Giercksky, Hege E; Lingjærde, Ole Christian; Strømberg, M.; Wiedswang, Gro; Kvalheim, Gunnar; Kåresen, Rolf; Nesland, Jahn M; Børresen-Dale, Anne-Lise & Sørlie, Therese (2007). Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer. Molecular Oncology.  ISSN 1574-7891.  1(2), s 160- 171 . doi: 10.1016/j.molonc.2007.03.004 Show summary
  • Diep, C; Kleivi, Kristine; Ribeiro, FR; Teixeira, MR; Lingjærde, Ole Christian & Lothe, Ragnhild A (2006). The order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes. Genes, Chromosomes and Cancer.  ISSN 1045-2257.  45(1), s 31- 41
  • Kristensen, VN; Tsalenko, A; Geisler, J; Faldaas, A; Grenaker, GI; Lingjærde, Ole Christian; Fjeldstad, S; Yakhini, Z; Lonning, PE & Børresen-Dale, Anne-Lise (2006). Multilocus analysis of SNP and metabolic data within a given pathway. BMC Genomics.  ISSN 1471-2164.  7
  • Lagerløv, Per; Loeb, Mitchell; Slettevoll, Jorid; Lingjærde, Ole Christian & Fetveit, Arne (2006). Severity of illness and the use of paracetamol in febrile preschool children; a case simulation study of parents’ assessments. Family Practice.  ISSN 0263-2136.  23(6), s 618- 623 . doi: 10.1093/fampra/cml046
  • Ribeiro, FR; Diep, CB; Jeronimo, C; Henrique, R; Lopes, C; Eknæs, M; Lingjærde, Ole Christian; Lothe, Ragnhild A & Teixeira, MR (2006). Statistical dissection of genetic pathways involved in prostate carcinogenesis. Genes, Chromosomes and Cancer.  ISSN 1045-2257.  45(2), s 154- 163
  • Dahl, Tobias Gulden; Lingjærde, Ole Christian & Christophersen, Nils Damm (2005). Local-ICA: independent component analysis for sources with non-stationary amplitudes, In A. Bouzerdoum & A. Beghdadi (ed.),  Proceedings of the Eighth International Symposium on Signal Processing and Its Applications, 2005.  IEEE conference proceedings.  ISBN 0-7803-9243-4.  kapittel.
  • Lekve, Kyrre; Ellingsen, Kari Elsa; Lingjærde, Ole Christian; Gjøsæter, J & Stenseth, Nils Christian (2005). Spatio-temporal variability of richness estimators: coastal marine fish communities as examples. Oecologia.  ISSN 0029-8549.  144, s 308- 317
  • Kristensen, Vessela Nedelcheva; Sørlie, Therese; Sorlie, Therese; Geisler, Jürgen; Geisler, E; Yoshimura, Noriko; Lingjærde, Ole Christian; Linegjaerde, Ole-Christian; Glad, Ingrid; Frigessi, Arnoldo; Harada, Nobuhiro; Lonning, PE; Lønning, Per Eystein & Børresen-Dale, Anne-Lise (2005). Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer. Journal of Steroid Biochemistry and Molecular Biology.  ISSN 0960-0760.  95(1-5), s 105- 111 . doi: 10.1016/j.jsbmb.2005.04.028
  • Lingjærde, Ole Christian; Baumbusch, Lars Oliver; Liestøl, Knut; Glad, Ingrid Kristine & Børresen-Dale, Anne-Lise (2005). CGH-Explorer: a program for analysis of array-CGH data. Bioinformatics.  ISSN 1367-4803.  21 . doi: 10.1093/bioinformatics/bti113
  • Chan, Grace; Chan, Kung-Sik; Stenseth, Nils Christian & Lingjærde, Ole Christian (2004). Analyzing nonlinear population dynamics data. Journal of Agricultural Biological and Environmental Statistics.  ISSN 1085-7117.  9(2), s 200- 215
  • Stenseth, Nils Christian; Ehrich, Dorothee; Rueness, Eli Knispel; Lingjærde, Ole Christian; Chan, Kung-Sik; Boutin, S; O'Donoghue, M; Robinson, DA; Viljugrein, Hildegunn & Jakobsen, Kjetill Sigurd (2004). The effect of climatic forcing on population synchrony and genetic structuring of the Canadian lynx. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  101(16), s 6056- 6061 . doi: 10.1073/pnas.0307123101
  • Stenseth, Nils Christian; Shabbar, Amir; Chan, Kung-Sik; Boutin, Stan; Rueness, Eli Knispel; Ehrich, Dorothee; Hurrell, James; Lingjærde, Ole Christian & Jakobsen, Kjetill Sigurd (2004). Snow conditions may create an invisible barrier for lynx. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  101(29), s 10632- 10634 . doi: 10.1073/pnas.0308674101
  • Vik, Jon Olav; Stenseth, Nils Christian; Tavecchia, Giacomo; Mysterud, Atle & Lingjærde, Ole Christian (2004). Living in synchrony on Greenland coasts?. Nature.  ISSN 0028-0836.  427(6976), s 697- 698

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  • Brunland, Anders; Hegna, Knut; Lingjærde, Ole Christian & Maus, Arne (2011). Rett på Java - 3.utg. Universitetsforlaget.  ISBN 978-82-15-01852-2.  390 s.
  • Brunland, Anders; Hegna, Knut; Lingjærde, Ole Christian & Maus, Arne (2005). Rett på Java, 2 utg. Universitetsforlaget.  ISBN 82-15-00781-3.  363 s.
  • Brunland, Anders; Hegna, Knut; Lingjærde, Ole Christian & Maus, Arne (2003). Rett på Java. Universitetsforlaget.  ISBN 82-15-00257-9.  280 s.
  • Fallmyr, Terje; Hadjerrouit, Said; Langmyhr, Dag; Lingjærde, Ole Chr.; Manne, Fredrik; Midtstraum, Roger; Stol, Norvald; Strøm, Torbjørn & Yu, Weihai (red.) (2003). Norsk Informatikkonferanse NIK'2003. Tapir Akademisk Forlag.  ISBN 82-519-1916-9.  264 s.

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  • Haukaas, Tonje Husby; Euceda, Leslie R.; Giskeødegård, Guro F.; Lamichhane, Santosh; Krohn, Marit; Jernström, Sandra; Aure, Miriam Ragle; Lingjærde, Ole Christian; Schlichting, Ellen; Garred, Øystein; Due, Eldri Undlien; Mills, Gordon B.; Sahlberg, Kristine Kleivi; Børresen-Dale, Anne-Lise & Bathen, Tone Frost (2016). Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes.
  • Haukaas, Tonje Husby; Euceda Wood, Leslie; Giskeødegård, Guro F.; Lamichhane, Santosh; Krohn, Marit; Schlichting, Ellen; Kåresen, Rolf; Lingjærde, Ole Christian; Jernström, Sandra; Aure, Miriam Ragle; Mills, Gordon B.; Sahlberg, Kristine Kleivi; Børresen-Dale, Anne-Lise & Bathen, Tone Frost (2015). Interpreting the clinical relevance of metabolic subgroups in breast cancer in combination with gene- and protein- expression subtypes.
  • Aure, Miriam Ragle; Jernstrøm, Sandra; Krohn, Marit; Due, Eldri Undlien; consortium, OSBREAC; Mills, Gordon B.; Børresen-Dale, Anne-Lise; Sahlberg, Kristine Kleivi; Lingjærde, Ole Christian; Kristensen, Vessela Nedelcheva & Kristensen, Vessela N. (2014). Integrative analysis reveals extensive association between microRNA expression and mRNA−protein translation. European Journal of Cancer.  ISSN 0959-8049.  50, s 79- 79
  • Høland, Maren; Kolberg, Mathias; Davidson, Ben; Sundby Hall, Kirsten; Mertens, Fredrik; van den Berg, E; Smeland, Sigbjørn; Picci, Piero; Lingjærde, Ole Christian & Lothe, Ragnhild A (2014). Genomic copy number changes and the prognostic impact of the encoded genes PTEN and BIRC5 in malignant peripheral nerve sheath tumours. European Journal of Cancer.  ISSN 0959-8049.  50, s 106- 106
  • Baumbusch, Lars Oliver; Helland, Åslaug; Wang, Yun; Liestøl, Knut; Schaner, Marci; Holm, Ruth; Etemadmoghadam, Dariush; Alsop, Kathryn; Brown, Patrick; Cancer Study Group, Australian Ovarian; Mitchell, Gillian; Fereday, Sian; DeFazio, Anna; Bowtell, David DL; Kristensen, Gunnar B.; Lingjærde, Ole Christian & Børresen-Dale, Anne-Lise (2012). High levels of genomic aberrations in serous ovarian cancers are associated with better survival.
  • Cheng, Jiqiu; Wedge, David C; Pandey, Bina P; Lingjærde, Ole Christian; Moreau, Yves & Van Loo, Peter (2012). Allele-specific copy number analysis of tumor genome across tumor types.
  • Nord, S; Lingjærde, Ole Christian; Nebdal, D; Sun, W.; Alnaes, GIG; Van Loo, P; Naume, Bjørn; Børresen-Dale, Anne-Lise & Kristensen, Vessela N. (2012). Proffered Paper: Dissecting the Genetic Components of Breast Cancer Transcriptomes. European Journal of Cancer.  ISSN 0959-8049.  48(supp. 5), s S9- S9
  • Nord, Silje; Lingjærde, Ole Christian; Nebdal, Daniel; Sun, Wei; Alnæs, Grete; Van Loo, Peter; Naume, Bjørn; Børresen-Dale, Anne-Lise & Kristensen, Vessela N. (2012). Dissecting the genetic components of breast cancer transcriptomes.
  • Aarøe, J; Vollan, Hans Kristian Moen; Nebdal, Daniel J.H.; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise; Kristensen, Vessela N. & Hiroko, K S (2010). Applying JISTIC to different stages for breast cancer. European Journal of Cancer.  ISSN 0959-8049.  8(5), s 210- 210
  • Aarøe, Jørgen Mømb; Myhre, Simen; Vollan, Hans Kristian Moen; Haakensen, Vilde Drageset; Baumbusch, Lars Oliver; Due, Eldri Undlien; Helland, Åslaug; Kristensen, Vessela N.; Lingjærde, Ole Christian & Børresen-Dale, Anne-Lise (2010). Measuring the level of genomic distortion in breast tumours with increasing histological grade - a progression model. European Journal of Cancer.  ISSN 0959-8049.  8(5), s 221- 221
  • Borgan, Eldrid; Sitter, Beathe; Lingjærde, Ole Christian; Johnsen, Hilde; Lundgren, Steinar; Bathen, Tone Frost; Sørlie, Therese; Børresen-Dale, Anne-Lise & Gribbestad, Ingrid S (2010). Transcriptomics meets metabolomics - correlating snapshots of breast cancer metabolism. European Journal of Cancer.  ISSN 0959-8049.  8(5), s 140- 140
  • Haakensen, Vilde Drageset; Lingjærde, Ole Christian; Holmen, Marit Muri; Frantzen, Jan Ole; Chen, Ying; Solvang, Hiroko Kato; Kristensen, Vessela N.; Ursin, Giske; Børresen-Dale, Anne-Lise & Helland, Åslaug (2010). UGT-expression in breast tissue from healthy women is associated with mammographic density. European Journal of Cancer.  ISSN 0959-8049.  8(5), s 38- 38
  • Nordgard, Silje H.; Nebdal, Daniel J.H.; Sun, Wei; van Loo, Pete; Naume, Bjørn; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise & Kristensen, Vessela N. (2010). Dissecting the genetic components of gene expression in breast carcinoma. European Journal of Cancer.  ISSN 0959-8049.  8(5), s 207- 207
  • Potapenko, Ivan Olegovich; Haakensen, Vilde Drageset; Luders, Torben; Helland, Åslaug; Bukholm, Ida Rashida Khan; Sørlie, Therese; Kristensen, Vessela N.; Lingjærde, Ole Christian & Børresen-Dale, Anne-Lise (2010). Glycan gene expression signatures distinguish normal and malignant breast tissue; possible role in diagnosis and progression. European Journal of Cancer.  ISSN 0959-8049.  8(5), s 102- 102
  • Sørlie, Therese; Borgan, Eldrid; Myhre, Simen; Vollan, Hans Kristian Moen; Russnes, Hege Elisabeth Giercksky; Zhao, Xi; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise & Rødland, Einar Andreas (2010). The importance of gene-centring microarray data. The Lancet Oncology.  ISSN 1470-2045.  11(8), s 719- 720
  • van Loo, Pete; Nordgard, Silje H.; Lingjærde, Ole Christian; Russnes, Hege Elisabeth Giercksky; Rye, Inga Hansine; Sun, Wei; Naume, Bjørn; Perou, Charles M.; Børresen-Dale, Anne-Lise & Kristensen, Vessela N. (2010). Allele-specific copy number analysis of breast carcinomas. European Journal of Cancer.  ISSN 0959-8049.  8(5), s 200- 200
  • Vollan, Hans Kristian Moen; Nilsen, G; Baumbusch, Lars Oliver; Schneider, Ida Johansson; Langerød, Anita; Naume, Bjørn; Schlichting, Ellen; Kåresen, Rolf; Lingjærde, Ole Christian & Børresen-Dale, Anne-Lise (2010). Array comparative genomic hybridization (aCGH) differentiates the major intrinsic subgroups of breast carcinomas. European Journal of Cancer.  ISSN 0959-8049.  8(5), s 163- 163
  • Zhao, Xi; Schultz, Nikolaus; Taylor, Barry S.; Cerami, Ethan; Baumbusch, Lars Oliver; Haakensen, Vilde Drageset; Lingjærde, Ole Christian; Kristensen, Vessela N.; Sander, Chris & Børresen-Dale, Anne-Lise (2010). Pathway signatures in breast cancer progression - a genome-scale study based on integration of biology networks, DNA copy number, gene expression and mutations. European Journal of Cancer.  ISSN 0959-8049.  8(5), s 207- 208
  • Potapenko, Ivan Olegovich; Haakensen, Vilde Drageset; Myhre, Simen; Luder, T; Naume, Bjørn; Lingjærde, Ole Christian; Russnes, HG; Sørlie, Therese; Kristensen, Vessela N. & Børresen-Dale, Anne-Lise (2009). Glycan signatures of breast cancer; possible role in diagnosis and progression of the disease. Annals of Oncology.  ISSN 0923-7534.  20, s 49- 49
  • Horlings, HM; Bergamaschi, A; Nordgard, Silje H.; Kim, YH; Han, W; Noh, DY; Salari, K; Joosse, SA; Reyal, F; Lingjærde, Ole Christian; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Pollack, J & van de Vijver, MJ (2008). ESR1 gene amplification in breast cancer: a common phenomenon?. Nature Genetics.  ISSN 1061-4036.  40(7), s 807- 808 . doi: 10.1038/ng0708-807
  • Dahl, Tobias Gulden; Lingjærde, Ole Christian; Christophersen, Nils Damm & Ekman, Torbjørn (2005). Local-ICA: independent component analysis for sources with non-stationary amplitudes.
  • Størvold, Hege Leite & Lingjærde, Ole Christian (2005). Towards a better prediction of survival from gene expression data: iterative regularization methods in Cox regression.
  • Kristoffersen, Anja Bråthen & Lingjærde, Ole Christian (2004). Choosing the right Method for Missing Value Estimation. Show summary
  • Wang, Yun; Schaner, Marci; Helland, Åslaug; Lingjærde, Ole Christian; Wang, Pei; Kim, Young H; Baumbusch, Lars; Baekelandt, Mark; Tibshirani, R.; Kristensen, Gunnar S Balle; Pollack, Jonathan; Brown, Patrick & Børresen-Dale, Anne-Lise (2004). Genome-wide analysis of DNA copy number alterations in patients with advanced ovarian carcinomas using cDNA microarrays. Abstr 013. International Journal of Gynecological Cancer.  ISSN 1048-891X.  14
  • Wang, Yun; Schaner, Marci; Helland, Åslaug; Lingjærde, Ole Christian; Wang, Pei; Kim, Young H; Baumbusch, Lars; Tibshirani, R.; Kristensen, Gunnar S Balle; Pollack, Jonathan; Brown, Patrick & Børresen-Dale, Anne-Lise (2004). Genome-wide analysis of DNA copy number alterations of advaced ovarian carcinomas using cDNA microarrays.
  • Baumbusch, Lars; Lingjærde, Ole Christian; Liestøl, Knut; Glad, Ingrid Kristine; Pollack, John; Chin, K.; Sørlie, Therese; Brown, Patrick; Botstein, David; Gray, Joe & Børresen-Dale, Anne-Lise (2003). A comparison of BAC- and cDNA-arrays for the detection of copy number alterations in human breast tumors.
  • Baumbusch, Lars; Lingjærde, Ole Christian; Liestøl, Knut; Glad, Ingrid Kristine; Pollack, John; Chin, K.; Sørlie, Therese; Brown, Patrick; Botstein, David; Gray, Joe & Børresen-Dale, Anne-Lise (2003). A comparison of BAC- and cDNA-arrays for the detection of copy number alterations in human breast tumors.

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Published Nov. 4, 2010 2:06 PM - Last modified Mar. 3, 2016 10:27 AM