Carl Henrik Gørbitz

Image of Carl Henrik Gørbitz
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Phone +47-22855460
Room VU 64
Username
Visiting address Sem Sælands vei 26 None 0371 OSLO
Postal address Postboks 1033 0315 OSLO

Academic Interests

We are studying the crystal structures of various amino acids and peptides, either alone or in complexes with other selected compounds.

We do systematic investigations of the way these molecules interact with each other. In this we become capable of using them as tools in crystal engineering of new classes of organic nanomaterials. These nanomaterials may be used for storageand slow release of bioactive substances by adsorption and desorption, as sensors, artificial receptors, in catalysts etc.

Single crystal X-ray diffraction is our main experimental method, but it is supplemented by a range of different model calculations, ab initio structure prediction,retrieval of information from structural databases and investigations carried out under extreme conditions (high pressure and/or temperature) at the University of Oslo or in cooperation with national and international partners.

 

Tags: Biological chemistry, Chemistry

Publications

  • Kristianslund, Renate; Aursnes, Marius; Tungen, Jørn Eivind; Görbitz, Carl Henrik & Hansen, Trond Vidar (2018). Synthesis, Biological Investigation, and Structural Revision of Sielboldianin A. Journal of natural products.  ISSN 0163-3864.  81, s 1007- 1013 . doi: 10.1021/acs.jnatprod.8b00020 Show summary
  • Antonsen, Simen Gjelseth; Gallantree-Smith, Harrison Christopher; Görbitz, Carl Henrik; Hansen, Trond Vidar; Stenstrøm, Yngve H. & Nolsøe, Jens Mortansson Jelstrup (2017). Stereopermutation on the Putative Structure of the Marine Natural Product Mucosin. Molecules.  ISSN 1420-3049.  22(10), s 1720- 1737 . doi: 10.3390/molecules22101720 Full text in Research Archive.
  • Khandar, Ali Akbar; Afkhami, Farhad Akbari; Krautscheid, Harald; Kristoffersen, Kenneth Aase; Atioglu, Zeliha; Akkurt, Mehmet & Görbitz, Carl Henrik (2017). Crystal structures of di­bromido­{N-[(pyridin-2-yl-κN)methyl­idene]picolinohydrazide-κ2N′,O}cadmium methanol monosolvate and di­iodido{N-[(pyridin-2-yl-κN)methyl­idene]picolinohydrazide-κ2N′,O}cadmium. Acta Crystallographica Section E: Crystallographic Communications.  ISSN 2056-9890.  73, s 698- 701 . doi: 10.1107/S2056989017005308
  • Lien, Vegard Torp; Olberg, Dag Erlend; Klaveness, Jo & Görbitz, Carl Henrik (2017). Crystal structure of 6,7-dimeth­­oxy-1-(4-nitro­phen­yl)quinolin-4(1H)-one: a mol­ecular scaffold for potential tubulin polymerization inhibitors. Acta Crystallographica Section E: Crystallographic Communications.  ISSN 2056-9890.  73, s 441- 444 . doi: 10.1107/S2056989017002948

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  • Kristianslund, Renate; Aursnes, Marius; Tungen, Jørn Eivind; Görbitz, Carl Henrik & Hansen, Trond Vidar (2018). Enantioselective bromolactonization using chiral squaramides - Application in the total synthesis of (-)-sielboldianin A.
  • Nolsøe, Jens Mortansson Jelstrup; Antonsen, Simen Gjelseth; Gallantree-Smith, Harrison Christopher; Görbitz, Carl Henrik; Hansen, Trond Vidar & Stenstrøm, Yngve H. (2018). Total synthesis targeting structural elucidation of marine hydrindane natural products.
  • Antonsen, Simen Gjelseth; Stenstrøm, Yngve H.; Hansen, Trond Vidar; Gallantree-Smith, Harrison Christopher; Nolsøe, Jens Mortansson Jelstrup & Görbitz, Carl Henrik (2017). Total synthesis based on the originally claimed structure of mucosin.
  • Kristianslund, Renate; Aursnes, Marius; Tungen, Jørn Eivind; Görbitz, Carl Henrik & Hansen, Trond Vidar (2017). Synthesis of (-)-sielboldianin A using a squaramide catalyzed enantioselective bromolactonization reaction.
  • Nolsøe, Jens Mortansson Jelstrup; Gallantree-Smith, Harrison; Antonsen, Simen Gjelseth; Gorbitz, Carl Henrik; Hansen, Trond Vidar & Stenstrøm, Yngve (2017). Total synthesis based on the originally claimed structure of mucosin.
  • Alebachew, Fassil & Görbitz, Carl Henrik (2016). X-ray structural investigation of protected oligopeptides as model compounds for the development of aquaporin inhibitors.

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Published Nov. 11, 2010 9:00 AM - Last modified Sep. 24, 2012 11:47 AM