Joël Benjamin Heim

Image of Joël Benjamin Heim
Norwegian version of this page
Phone +47-22855465
Room VU 72
Username
Visiting address Sem Sælands vei 26 None 0371 OSLO
Postal address Postboks 1033 0315 OSLO
Other affiliations Faculty of Mathematics and Natural Sciences (Student)

Academic Interest

Bacterial toxins - Structure, function and molecular interactions

Member of the following national graduate schools:

  • BioStruct: The National Graduate School in Structural Biology
  • BioCat: The National Graduate School in Biocatalysis
  • IBA: The National Graduate School in Infection Biology and and Antimicrobials

Teaching

Planning committee member, new bachelor program: Chemistry and Biochemistry

Lab responsible:

  • KJM1140 - Biochemistry 1 for chemistry students

Group teacher in the following subjects:

  • KJM1001 - Introduction to chemistry
  • KJM5310/9310 - Biomolecular structure and function
  • KJM4350 - Protein crystallography
  • KJM1140 - Biochemistry 1 for chemistry students

Co-supervisor of students:

  • Siri Tveitan, Master student, 60 stp, 2017

Background

  • Master of Biochemistry, University of Tübingen, 2012-2015
    • Thesis: "Focal Adhesion Kinase: Role of Tyrosine 397 for Development and Epidermal Homeostasis", supervised by Alexander Meves, Mayo Clinic.
  • Bachelor of Biochemistry, University of Tübingen, 2009-2012
    • Thesis: "Crystallization and X-ray analysis of enzymes involved in the biosynthesis of natural products - RhiE from Burkholderia rhizoxinica and NovL from Streptomyces spheroides", supervised by Thilo Stehle, IFIB, University of Tübingen.

Publications

Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.

Heim JB, Squirewell EJ, Neu A, Zocher G, Sominidi-Damodaran S, Wyles SP, Nikolova E, Behrendt N, Saunte DM, Lock-Andersen J, Gaonkar KS, Yan H, Sarkaria JN, Krendel M, van Deursen J, Sprangers R, Stehle T, Böttcher RT, Lee JH, Ordog T, Meves A.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3933-3938. doi: 10.1073/pnas.1614894114. Epub 2017 Mar 27.

 

Tumor Cell Adhesion As a Risk Factor for Sentinel Lymph Node Metastasis in Primary Cutaneous Melanoma.

Meves A, Nikolova E, Heim JB, Squirewell EJ, Cappel MA, Pittelkow MR, Otley CC, Behrendt N, Saunte DM, Lock-Andersen J, Schenck LA, Weaver AL, Suman VJ.

J Clin Oncol. 2015 Aug 10;33(23):2509-15. doi: 10.1200/JCO.2014.60.7002. Epub 2015 Jul 6.

 

Vinylogous chain branching catalysed by a dedicated polyketide synthase module.

Bretschneider T, Heim JB, Heine D, Winkler R, Busch B, Kusebauch B, Stehle T, Zocher G, Hertweck C.

Nature. 2013 Oct 3;502(7469):124-8. doi: 10.1038/nature12588. Epub 2013 Sep 18.

  • Burschowsky, Daniel; Thorbjørnsrud, Helen Vikdal; Heim, Joel Benjamin; Fahrig-Kamarauskaite, Jurate; Würth-Roderer, Kathrin; Kast, Peter & Krengel, Ute (2017). Inter-Enzyme Allosteric Regulation of Chorismate Mutase in Corynebacterium glutamicum: Structural Basis of Feedback Activation by Trp. Biochemistry.  ISSN 1520-4995.  57(5), s 557- 573 . doi: 10.1021/acs.biochem.7b01018
  • Heggelund, Julie Elisabeth; Mackenzie, Alasdair; Martinsen, Tobias; Heim, Joël Benjamin; Cheshev, Pavel; Bernardi, Anna & Krengel, Ute (2017). Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics. Scientific Reports.  ISSN 2045-2322.  7(2326) . doi: 10.1038/s41598-017-02179-0

View all works in Cristin

  • Heim, Joel Benjamin; Teter, Kenneth & Krengel, Ute (2018). Towards the molecular basis for the differential toxicity of cholera toxin and heat-labile enterotoxin.
  • Heim, Joël Benjamin; Teter, Kenneth & Krengel, Ute (2017). Molecular interactions of cholera toxin – working with unstable proteins and complexes.
  • Heim, Joël Benjamin; Teter, Kenneth & Krengel, Ute (2017). Molecular interactions of cholera toxin – working with unstable proteins and complexes.
  • Tveitan, Siri Luise; Heim, Joël Benjamin & Krengel, Ute (2017). Structural Studies on Cholera.
  • Heim, Joël Benjamin (2016). Bacterial toxins.
  • Heim, Joël Benjamin (2016). Cholera - new medicine.
  • Heim, Joël Benjamin; Heggelund, Julie Elisabeth & Krengel, Ute (2016). Cholera blood-group dependence and role of secretor status.
  • Heim, Joël Benjamin; Heggelund, Julie Elisabeth & Krengel, Ute (2016). Cholera blood-group dependence and role of secretor status.
  • Heim, Joël Benjamin; Heggelund, Julie Elisabeth & Krengel, Ute (2016). How does blood group secretor status protect from cholera intoxication? – Structure and interaction analysis of carbohydrate binding.
  • Tveitan, Siri Luise; Heim, Joël Benjamin & Krengel, Ute (2016). Cholera under the Molecular Microscope.
  • Tveitan, Siri Luise; Heim, Joël Benjamin & Krengel, Ute (2016). Cholera under the Molecular Microscope.

View all works in Cristin

Published Sep. 18, 2015 11:57 AM - Last modified Oct. 5, 2017 4:53 PM