Joël Benjamin Heim

Image of Joël Benjamin Heim
Norwegian version of this page
Phone +47-22855465
Room VU 72
Username
Visiting address Sem Sælands vei 26 None 0371 OSLO
Postal address Postboks 1033 0315 OSLO

Academic Interest

Bacterial toxins - Structure, function and molecular interactions

Member of the following national graduate schools:

  • BioStruct: The National Graduate School in Structural Biology
  • BioCat: The National Graduate School in Biocatalysis
  • IBA: The National Graduate School in Infection Biology and and Antimicrobials

Teaching

Planning committee member, new bachelor program: Chemistry and Biochemistry

Lab responsible:

  • KJM1140 - Biochemistry 1 for chemistry students

Group teacher in the following subjects:

  • KJM1001 - Introduction to chemistry
  • KJM5310/9310 - Biomolecular structure and function
  • KJM4350 - Protein crystallography
  • KJM1140 - Biochemistry 1 for chemistry students

Co-supervisor of students:

  • Siri Tveitan, Master student, 60 stp, 2017

Background

  • Master of Biochemistry, University of Tübingen, 2012-2015
    • Thesis: "Focal Adhesion Kinase: Role of Tyrosine 397 for Development and Epidermal Homeostasis", supervised by Alexander Meves, Mayo Clinic.
  • Bachelor of Biochemistry, University of Tübingen, 2009-2012
    • Thesis: "Crystallization and X-ray analysis of enzymes involved in the biosynthesis of natural products - RhiE from Burkholderia rhizoxinica and NovL from Streptomyces spheroides", supervised by Thilo Stehle, IFIB, University of Tübingen.

Publications

Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.

Heim JB, Squirewell EJ, Neu A, Zocher G, Sominidi-Damodaran S, Wyles SP, Nikolova E, Behrendt N, Saunte DM, Lock-Andersen J, Gaonkar KS, Yan H, Sarkaria JN, Krendel M, van Deursen J, Sprangers R, Stehle T, Böttcher RT, Lee JH, Ordog T, Meves A.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3933-3938. doi: 10.1073/pnas.1614894114. Epub 2017 Mar 27.

 

Tumor Cell Adhesion As a Risk Factor for Sentinel Lymph Node Metastasis in Primary Cutaneous Melanoma.

Meves A, Nikolova E, Heim JB, Squirewell EJ, Cappel MA, Pittelkow MR, Otley CC, Behrendt N, Saunte DM, Lock-Andersen J, Schenck LA, Weaver AL, Suman VJ.

J Clin Oncol. 2015 Aug 10;33(23):2509-15. doi: 10.1200/JCO.2014.60.7002. Epub 2015 Jul 6.

 

Vinylogous chain branching catalysed by a dedicated polyketide synthase module.

Bretschneider T, Heim JB, Heine D, Winkler R, Busch B, Kusebauch B, Stehle T, Zocher G, Hertweck C.

Nature. 2013 Oct 3;502(7469):124-8. doi: 10.1038/nature12588. Epub 2013 Sep 18.

  • Heggelund, Julie Elisabeth; Mackenzie, Alasdair; Martinsen, Tobias; Heim, Joël Benjamin; Cheshev, Pavel; Bernardi, Anna & Krengel, Ute (2017). Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics. Scientific Reports.  ISSN 2045-2322.  7(2326) . doi: 10.1038/s41598-017-02179-0

View all works in Cristin

  • Heim, Joël Benjamin; Teter, Ken & Krengel, Ute (2017). Molecular interactions of cholera toxin – working with unstable proteins and complexes.
  • Heim, Joël Benjamin; Teter, Ken & Krengel, Ute (2017). Molecular interactions of cholera toxin – working with unstable proteins and complexes.
  • Tveitan, Siri Luise; Heim, Joël Benjamin & Krengel, Ute (2017). Structural Studies on Cholera.
  • Heim, Joël Benjamin (2016). Bacterial toxins.
  • Heim, Joël Benjamin (2016). Cholera - new medicine.
  • Heim, Joël Benjamin; Heggelund, Julie Elisabeth & Krengel, Ute (2016). Cholera blood-group dependence and role of secretor status.
  • Heim, Joël Benjamin; Heggelund, Julie Elisabeth & Krengel, Ute (2016). Cholera blood-group dependence and role of secretor status.
  • Heim, Joël Benjamin; Heggelund, Julie Elisabeth & Krengel, Ute (2016). How does blood group secretor status protect from cholera intoxication? – Structure and interaction analysis of carbohydrate binding.
  • Tveitan, Siri Luise; Heim, Joël Benjamin & Krengel, Ute (2016). Cholera under the Molecular Microscope.
  • Tveitan, Siri Luise; Heim, Joël Benjamin & Krengel, Ute (2016). Cholera under the Molecular Microscope.

View all works in Cristin

Published Sep. 18, 2015 11:57 AM - Last modified Oct. 5, 2017 4:53 PM