Ute Krengel

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Phone +47 22855461
Room VU 74
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Visiting address Sem Sælands vei 26 0371 Oslo
Postal address Postboks 1033,Blindern 0315 Oslo

Academic interests

The structural biology group of Ute Krengel uses X-ray crystallography and complementary techniques to gain deep insight into important biological mechanisms and contribute to developing new treatments.The main focus is on proteins of medical interest, and in particular on enzymes and protein-carbohydrate interactions.

Curriculum vitae

Prof. Dr. Ute Krengel studied Chemistry in Göttingen (Germany), and obtained her PhD from the University of Heidelberg in 1991 (structure and molecular mechanism of p21ras). After positions in Toronto (Canada, 1991-1993), Groningen (The Netherlands, 1994-1997), and Gothenburg (Sweden, 1997-2004), she moved to Oslo (Norway), where she holds a full Professorship since 2006. In 2018, she was visiting professor at the ETH, Zurich (Switzerland). Prof. Krengel is particularly interested in molecular mechanisms of disease, including infectious diseases and cancer, with focus on receptor interactions and enzymes. She currently serves as coordinator of Norwegian Block Allocation Groups for Synchrotron Research and as Norwegian representative of the International Glycoconjugate Organization.

Teaching

English-Norwegian word list for biochemical terms

Main targets currently under investigation

Metabolic enzymes, lectins, adhesins, toxins, and anti-cancer antibodies.

Scientific significance and potential applications

Enzymes and protein-carbohydrate interactions are central to many biological processes (e.g., metabolism, cellular signaling and differentiation, cell-cell interaction, and immune response) that are at the core of important diseases. Understanding the roles of carbohydrates in these processes and how they interact with proteins is expected to have a large impact on the development of new treatments against many human diseases.

The work involves the close collaboration with research groups of different specializations (e.g., biochemists, molecular modelers, bioinformaticians, and experts in NMR spectroscoy, cryo-EM and mass spectrometry), thus warranting that the structural characterization of the chosen research targets can be pursued hand in hand with protein engineering and carbohydrate binding studies, molecular simulations, and drug design.

Selected publications

K. Bjerregaard-Andersen, H. Johannesen, F. Abraha, A. Šakanović, D. Groβer, Ü. Coskun, G. Anderluh, S. Oscarson, E. Moreno, M. Grzybek & U. Krengel (2020). Insight into glycosphingolipid crypticity: Crystal structure of the anti-tumor antibody 14F7 and recognition of NeuGc GM3 ganglioside. BioRxiv 294777

D. Manna, G. Cordara & U. Krengel (2020). Crystal structure of MOA in complex with a peptide fragment: A protease caught in flagranti. Curr Res Struct Biol. 2, 56-67

J.E. Heggelund, A. Varrot, A. Imberty & U. Krengel (2017). Histo-blood group antigens as mediators of infections. Curr Opin Struct Biol. 44, 190-200

U. Krengel & S. Törnroth-Horsefield (2015). Coping with oxidative stress. Science 347, 125-6

D. Burschowsky, A. van Eerde, M. Ökvist, A. Kienhöfer, P. Kast, D. Hilvert & U. Krengel (2014). Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis. Proc Natl Acad Sci U S A. 111, 17516-21

U. Krengel & P.A. Bousquet (2014). Molecular recognition of gangliosides and their potential for cancer immunotherapies. Front Immunol. 5, 325, 1-11

Å. Holmner, A. Mackenzie & U. Krengel (2010). Hypothesis: Molecular basis of cholera blood-group dependence and implications for a world characterized by climate change. FEBS Lett. 584, 2548-2555

G. Cordara & U. Krengel (2013). Lectin structure determination by X-ray crystallography – A hands-on approach. In: SPR Carbohydrate Chemistry Vol 39 (A. Rauter, Ed.), RSC, 222-246

U. Krengel & A. Imberty (2007), Crystallography and lectin structure database, In: Lectins: Analytical technologies (C. Nilsson, Ed.), Elsevier, 15-50

Research

Research interests

Association with UiO Research Areas and Networks:

Tags: Chemistry, Biological chemistry, Biochemistry, Structural Biology, Glycobiology, Life science

Publications

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  • Montserrat Canals, Mateu; Sekulic, Nikolina & Krengel, Ute (2024). UiO structural biology core facilities.
  • Sekulic, Nikolina; Krengel, Ute & Brech, Andreas (2023). Minisymposium on CryoEM and CryoET: From knowledge to cures.
  • Krengel, Ute (2023). Protein-Carbohydrate Interactions in Infection and Cancer Biology.
  • Stocker, Christian; Khatanbaatar, Tamjidmaa; Bressan, Luca; Würth-Roderer, Kathrin; Cordara, Gabriele & Krengel, Ute [Show all 7 contributors for this article] (2023). Novel exported bifunctional fusion enzymes with chorismate mutase and cyclohexadienyl dehydratase activity: shikimate pathway enzymes teamed up in no man's land. bioRxiv. ISSN 2692-8205. doi: 10.1101/2023.03.13.532365.
  • Kersten, Flore Marie Colette; Cordara, Gabriele & Krengel, Ute (2023). Cryo-EM reveals a novel domain fold of a fungal toxin.
  • Montserrat Canals, Mateu; Sørensen, Henrik Vinther; Oksanen, Esko & Krengel, Ute (2022). Neutron studies of the bacterial colonization factor GbpA.
  • Montserrat Canals, Mateu; Sørensen, Henrik Vinther; Oksanen, Esko O. & Krengel, Ute (2022). Structural studies on GbpA using neutron scattering methods.
  • Montserrat Canals, Mateu; Bjerregaard-Andersen, Kaare; Sørensen, Henrik Vinther & Krengel, Ute (2022). How salts modulate activity in chitin-active LPMOs relevant for environmental survival and human pahtogenicity.
  • Kersten, Flore Marie Colette; Cordara, Gabriele & Krengel, Ute (2022). Cryo-EM structure of a fungal toxin.
  • Kersten, Flore Marie Colette; Cordara, Gabriele & Krengel, Ute (2022). Cryo-EM structure of a fungal toxin.
  • Kersten, Flore Marie Colette; Cordara, Gabriele & Krengel, Ute (2022). Cryo-EM structure of a fungal chimerolectin.
  • Sekulic, Nikolina & Krengel, Ute (2022). PX-Oslo: Structural Biology Core Facilities .
  • Bousquet, Paula; Sandvik, Joe Alexander; Edin, Nina Frederike Jeppesen & Krengel, Ute (2022). Corrigendum to: Hypothesis: Hypoxia induces de novo synthesis of NeuGc gangliosides in humans through CMAH domain substitute (Biochemical and Biophysical Research Communications (2018) 495(1) (1562–1566), (S0006291X17323616), (10.1016/j.bbrc.2017.11.183)). Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 587. doi: 10.1016/j.bbrc.2021.11.074.
  • Krengel, Ute (2022). Academia meets Industry.
  • Krengel, Ute (2022). Molecular Mechanisms of Cholera Pathogenesis.
  • Krengel, Ute (2021). My experience with HALOS: Making the most of structural biology .
  • Mojica Cortez, Natalia & Krengel, Ute (2020). PX-Oslo- UiO Structural Biology Core Facilities. [Internet]. Department of Chemistry, UiO.
  • Pesci, Giacomo; Johannesen, Hedda; Løset, Geir Åge & Krengel, Ute (2020). A promising antibody to treat cancer. How does it work?
  • Sørensen, Henrik Vinther; Bjerregaard-Andersen, Kaare; Vaaje-Kolstad, Gustav; Krengel, Ute & Lund, Reidar (2020). Applying soft matter techniques to understand bacterial colonization.
  • Johannesen, Hedda; Bjerregaard-Andersen, Kaare; Grzybek, Michal; Løset, Geir Åge & Krengel, Ute (2020). Molecular basis of specificity of a promising anti-tumour antibody .
  • Krengel, Ute (2020). UiO Structural Biology Core Facilities: Who Are We and How Can We Help You?
  • Mojica Cortez, Natalia; Sekulic, Nikolina & Krengel, Ute (2020). UiO Structural Biology Core Facilities: Who Are We and How Can We Help You? .
  • Krengel, Ute (2019). Structural Chemistry - Past, Presence and Future.
  • Heggelund, Julie Elisabeth; Heim, Joel Benjamin & Krengel, Ute (2019). Cholera blood group association elucidated with synchrotron radiation.
  • Johannesen, Hedda; Bjerregaard-Andersen, Kaare; Løset, Geir Åge & Krengel, Ute (2019). An anti-tumour antibody that specifically recognises N-glycolyl GM3.
  • Johannesen, Hedda; Bjerregaard-Andersen, Kaare; Grzybek, Michal; Ünal, Coskun; Løset, Geir Åge & Krengel, Ute (2019). Crystal structure of an anti-tumour antibody in complex with its tumour-specific antigen.
  • Sørensen, Henrik Vinther; Krengel, Ute; Lund, Reidar; Browning, Kathryn & Bjerregaard-Andersen, Kaare (2019). Bacterial colonization investigated with X-ray and neutron techniques.
  • Sørensen, Henrik Vinther; Krengel, Ute; Vaaje-Kolstad, Gustav; Lund, Reidar; Browning, Kathryn & Bjerregaard-Andersen, Kaare [Show all 7 contributors for this article] (2019). Using X-rays and neutrons to understand a bacterial colonization factor.
  • Sørensen, Henrik Vinther; Krengel, Ute; Browning, Kathryn; Bjerregaard-Andersen, Kaare; Cardenas, Marite & Lund, Reidar [Show all 7 contributors for this article] (2019). Study of bacterial colonization with X-ray and neutron scattering techniques.
  • Johannesen, Hedda; Bjerregaard-Andersen, Kaare; Heggelund, Julie Elisabeth; Løset, Geir Åge & Krengel, Ute (2019). 14F7 - A tumour specific antibody .
  • Sørensen, Henrik Vinther; Browning, Kathryn; Bjerregaard-Andersen, Kaare; Lund, Reidar & Krengel, Ute (2019). Applying X-rays and neutrons to understand a bacterial virulence factor.
  • Johannesen, Hedda; Bjerregaard-Andersen, Kaare; Heggelund, Julie Elisabeth; Løset, Geir Åge & Krengel, Ute (2018). NeuGc GM3 - a cancer-specific ganglioside that is recognised by the antibody 14F7.
  • Sørensen, Henrik Vinther; Browning, Kathryn; Bjerregaard-Andersen, Kaare; Lund, Reidar & Krengel, Ute (2018). Borrowing material science techniques to study biological problems.
  • Johannesen, Hedda; Mykland hoås, Helene; Heggelund, Julie Elisabeth; Bjerregaard-Andersen, Kaare; Løset, Geir Åge & Krengel, Ute (2018). 14F7, An anti-ganglioside scFv for cancer therapies.
  • Johannesen, Hedda; Mykland Hoås, Helene; Heggelund, Julie Elisabeth; Bjerregaard-Andersen, Kaare; Løset, Geir Åge & Krengel, Ute (2018). 14F7, an antibody that recognises a tumour-specific ganglioside with high specificity .
  • Krengel, Ute (2018). Cholera Toxin: Molecular Mechanisms and Drug Design .
  • Krengel, Ute (2018). Remote Control by Inter-Enzyme Allostery - Or: The Marvellous World of Chorismate Mutases .
  • Krengel, Ute (2018). Structure-Function Studies of Cholera Toxin: Molecular Underpinnings of Human Disease.
  • Krengel, Ute (2018). Interesting examples of allostery (?).
  • Krengel, Ute (2018). How to design posters and write competitive grant proposals.
  • Sørensen, Henrik Vinther; Bjerregaard-Andersen, Kaare; Lund, Reidar & Krengel, Ute (2018). A bacterial colonization factor studied by X-ray and neutron techniques.
  • Krengel, Ute (2018). Protein crystallography: Glimpses from my career.
  • Sørensen, Henrik Vinther; Browning, Kathryn; Lund, Reidar; Bjerregaard-Andersen, Kaare & Krengel, Ute (2018). A surface active enzyme and colonization factor investigated by x-ray and neutron techniques.
  • Krengel, Ute (2018). How to become an academic leader?
  • Heim, Joel Benjamin; Teter, Kenneth & Krengel, Ute (2018). Towards the molecular basis for the differential toxicity of cholera toxin and heat-labile enterotoxin.
  • Johannesen, Hedda; Hoås Mykland, Helene; Heggelund, Julie Elisabeth; Bjerregaard-Andersen, Kaare; Løset, Geir Åge & Krengel, Ute (2018). An anti-ganglioside scFv for cancer therapies.
  • Sørensen, Henrik Vinther; L. Browning, Kathryn; Lund, Reidar; Krengel, Ute & Bjerregaard-Andersen, Kaare (2018). A surface active enzyme and colonization factor investigated by x-ray and neutron scattering.
  • Sørensen, Henrik Vinther; Browning, Kathryn; Lund, Reidar; Bjerregaard-Andersen, Kaare & Krengel, Ute (2017). A surface active enzyme and colonization factor investigated by x-ray and neutron scattering - Hercules.
  • Krengel, Ute (2017). Molecular Mechanisms of Disease.
  • Krengel, Ute & Stehle, Thilo (2017). Editorial overview: A feast of structural glycobiology. Current Opinion in Structural Biology. ISSN 0959-440X. 44, p. iv–vi. doi: 10.1016/j.sbi.2017.05.005.
  • Thorbjørnsrud, Helen Vikdal; Fahrig-Kamarauskaite, Jurate; Burschowsky, Daniel; Kast, Peter & Krengel, Ute (2017). Structural elucidation of highly active chorismate mutase variants obtained by directed evolution.
  • Bjerregaard-Andersen, Kaare; Harby, Caroline; Loose, Jennifer Sarah Maria; Vaaje-Kolstad, Gustav & Krengel, Ute (2017). Chasing protons in lytic polysaccharide mono oxygenases - studying the Vibrio colonization factor GbpA by neutron crystallography.
  • Bjerregaard-Andersen, Kaare; Harby, Caroline & Krengel, Ute (2017). TOWARDS NEW INSIGHTS INTO VIBRIO CHOLERAE COLONIZATION BY X-RAY AND NEUTRON DIFFRACTION.
  • Tonjum, Tone; Krengel, Ute & Heggelund, Julie Elisabeth (2017). 5 alternativer til antibiotika.
  • Heim, Joël Benjamin; Teter, Kenneth & Krengel, Ute (2017). Molecular interactions of cholera toxin – working with unstable proteins and complexes.
  • Tveitan, Siri Luise; Heim, Joël Benjamin & Krengel, Ute (2017). Structural Studies on Cholera.
  • Heim, Joël Benjamin; Teter, Kenneth & Krengel, Ute (2017). Molecular interactions of cholera toxin – working with unstable proteins and complexes.
  • Krengel, Ute (2017). Molecular Basis of Blood-Group-Dependent Diseases Like Cholera.
  • Krengel, Ute (2017). Enzyme Catalysis and Regulation: A Model Enzyme Revisited .
  • Hatlem, Daniel; Leo, Jack Christopher; Saragliadis, Athanasios; Krengel, Ute & Linke, Dirk (2017). Bacterial adhesion: Characterization of trimeric autotransporter binding.
  • Falao, Eirik & Krengel, Ute (2023). Studies of interaction between the Vibrio cholerae colonization factor GbpA and chitin using NMR spectroscopy and electron microscopy imaging. Kjemisk Institutt, Universitetet i Oslo.
  • Krengel, Ute & Montserrat Canals, Mateu (2023). Molecular warfare: A structural biology view on pathogen weapons — GbpA from Vibrio cholerae — and host defenses — Vg from the honey bee. Universitetet i Oslo.
  • Khatanbaatar, Tamjidmaa & Krengel, Ute (2023). Partners in crime: Structure-function studies on chorismate mutases and their associated enzymes. Universitetet i Oslo. ISSN 1501-7710.
  • Hatlem, Daniel; Linke, Dirk & Krengel, Ute (2022). Probing the role of lipopolysaccharides in Gram-negative protein secretion and biogenesis. Universitetet i Oslo.
  • Kristiansen, Helene Sørum; Krengel, Ute; Løset, Geir Åge & Progida, Cinzia (2022). Let it bind, and light you may find - Investigation of 14F7's cellular journey and effects. Universitetet i Oslo.
  • Tislevoll, Abelone Martillas; Krengel, Ute & Sørensen, Henrik Vinther (2021). Isotope labelling and interaction studies of the Vibrio cholerae colonization factor GbpA. Universitetet i Oslo.
  • Sørensen, Henrik Vinther; Krengel, Ute; Lund, Reidar & Bjerregaard, Kaare (2021). Of Shellfish and Men: Applying X-ray and neutron techniques to investigate surface-active bacterial colonization factors. Universitetet i Oslo, Det matematisk-naturvitenskapelige fakultet. ISSN 1501-7710. 2021(2417).
  • Pesci, Giacomo; Krengel, Ute; Johannesen, Hedda & Løset, Geir Åge (2020). Follow the Light - Tracking 14F7’s cellular journey with luminescence. Universitetet i Oslo.
  • Solbakke, Kristoffer Gudesen; Krengel, Ute; Johannesen, Hedda; Løset, Geir Åge & Bjerregaard-Andersen, Kaare (2019). 4G9: An antibody that potentially imitates a cancer-related carbohydrate. Universitetet i Oslo.
  • Thorbjørnsrud, Helen Vikdal; Krengel, Ute & Cascella, Michele (2018). Escaping Mediocrity - Activity and Regulation of a Catalytically Inefficient Enzyme. Universistetet i Oslo. ISSN 1501-7710.

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Published Nov. 11, 2010 9:00 AM - Last modified Apr. 11, 2022 9:41 AM