Current Metabolic Research with 13C and 1H NMR Spectroscopy.

Aldehyde and ketone membrane transport. Protein toxicity mediated by aldehydes and ketones.

About the project

  1. Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia. Cecilie Morland, Anne-Sofie Frøland, Mi Nguyen Pettersen, Jon Storm-Mathisen, Vidar Gundersen, Frode Rise, Bjørnar Hassel.
  2. Uptake and metabolism of fructose by rat neocortical cells in vivo and by isolated nerve terminals in vitro Hassel, Bjornar; Elsais, Ahmed; Froland, Anne-Sofie; Tauboll, Erik; Gjerstad, Leif; Quan, Yi; Dingledine, Raymond; Rise, Frode  Journal of Neurochemistry (2015), 133(4), 572-581.
  3. Nguyen, N. T. H.; Morland, C; Gonzales, S. V.; Rise, F.; Storm-Mathiesen, J; Gundersen, V.; Hassel, B. Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia.  Relevance for propionic acidemia.. Journal of Neurochemistry (2007), 101(3),  806-814.
  4. Nguyen, N. T. H.; Gonzales, S. V; Rise, F; Hassel, B.  Cerebral metabolism of glucose and pyruvate in soman poisoning A (13)C nuclear magnetic resonance spectroscopic study. Neurotoxicology (2007); 28(1):13-18.


The AVI600 nmr instrument from University of Oslo NMR Center is used in these studies.

Published Jan. 11, 2011 3:56 PM - Last modified Jan. 18, 2018 9:49 AM