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The main goal of this project is to use bioinformatics to develop new bioinformatics applications as a research tool.
Anthony Mathelier has recently been appointed as a new group leader in Computational Biology at the NCMM in Oslo, focusing on computational methods to study gene regulation. He will present one of his recent studies that coupled experimental data and targeted computational analysis with TF binding profiles to interpret cis-regulatory somatic mutations of 84 matched tumour-normal whole genomes from B-cell lymphomas. Transcription factor binding sites (TFBSs) representing the core of gene cis-regulation, he will finally introduce new models to improve the prediction of TFBSs from ChIP-seq data.
The PharmaTox Strategic Research Initiative aims to generate novel insight on effects of pharmaceuticals on human neurotoxicity and neurodevelopment.