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A reliable sense of space is essential for daily life and memory formation. Breaking down the extracellular matrix around grid cells makes the mental map unstable [Nature Communications 11th of January, 2021].
For the first time UiO:Lifescience granted undergraduate students with a salary to perform a research project during their summer vacation 2018. CINPLA were lucky to grab 4 talented students in various projects from gene-editing by crisper to behavioral analysis.
We show that systemic injections of PHP.eB AAVs to express GECIs is a highly promising technique for imaging neural activity and circumvent the need for transgenic GECI expressing mouse lines. We also establish the use of novel soma-targeted GECIs that outperform current Ca2+ indicators using both systemic and local virus injections.
The PharmaTox Strategic Research Initiative aims to generate novel insight on effects of pharmaceuticals on human neurotoxicity and neurodevelopment.