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How the brain is able to store memories over long periods of time has been a persistent mystery to neuroscientists. In a new study, researchers from the Centre for Integrative Neuroplasticity (CINPLA) at the University of Oslo show that long-lived extracellular matrix molecules called perineuronal nets are essential for distant memories.
The new research published in Proceedings of the National Academy of Sciences, shows that removal of the nets disrupts distant but not recent memories.