Extending reference assembly models
One of the upcoming CELS projects is around Graph based representation of reference genomes. In the next episodes of the TGAC journal club, we will therefore discuss several papers around this subject. Some are very technical, some more applied.
Abstract: The human genome reference assembly is crucial for aligning and analyzing sequence data, and for genome annotation, among other roles. However, the models and analysis assumptions that underlie the current assembly need revising to fully represent human sequence diversity. Improved analysis tools and updated data reporting formats are also required.