Late Lunch Talk: Computation and uses of pangenomes

Late Lunch Talk by Ole Tørresen

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Ole Tørresen


Since the first genomes were published in the middle of the 1990’s, species have been represented by a single reference genome. This single (haploid) genome cannot represent all the variation in a species, and can lead to bias in interpretations of everything from ecological and evolutionary inferences, to medicine. The pangeome is one way to address this. A pangenome can be defined as consisting of the full set of genomic elements of a population, species or clade. This would include single base changes, structural variants, regulatory regions and genes plus the rest. Earlier explorations into pangenomes based on short read data gave valuable insights, but now with the quality and affordability of long reads, capturing most or all of the complexity that are found in nature is possible. However, how to actually compute or construct pangeomes, and how to use them, are in active development currently.


Ole Tørresen


This talk will also be available on Zoom. The zoom link will be shared through the CEES seminar mailing list. Contact Tore Wallem if you would like to be forwarded the invitation e-mail.


A recording of this talk is available here

Published Dec. 8, 2021 5:29 PM - Last modified Dec. 14, 2021 1:56 PM