New publication: Independent losses of a xenobiotic receptor across teleost evolution

By Marta Eide, Halfdan Rydbeck*, Ole K. Tørresen*, Roger Lille-Langøy, Pål Puntervoll, Jared V. Goldstone, Kjetill S. Jakobsen*, John Stegeman, Anders Goksøyr, and Odd A. Karlsen in Scientific reports. Open access.

Abstract

Sensitivity to environmental stressors largely depend on the genetic complement of the organism. Recent sequencing and assembly of teleost fsh genomes enable us to trace the evolution of defense genes in the largest and most diverse group of vertebrates. Through genomic searches and in-depth analysis of gene loci in 76 teleost genomes, we show here that the xenosensor pregnane X receptor (Pxr, Nr1i2) is absent in more than half of these species. Notably, out of the 27 genome assemblies that belong to the Gadiformes order, the pxr gene was only retained in the Merluccidae family (hakes) and Pelagic cod (Melanonus zugmayeri). As an important receptor for a wide range of drugs and environmental pollutants, vertebrate PXR regulate the transcription of a number of genes involved in the biotransformation of xenobiotics, including cytochrome P450 enzymes (CYP). In the absence of Pxr, we suggest that the aryl hydrocarbon receptor (Ahr) have evolved an extended regulatory role by governing the expression of certain Pxr target genes, such as cyp3a, in Atlantic cod (Gadus morhua). However, as several independent losses of pxr have occurred during teleost evolution, other lineages and species may have adapted alternative compensating mechanisms for controlling crucial cellular defense mechanisms.


Scientific Reports, volume 8, Article number: 10404 (2018)
Published: 10 July 2018
Publication webpage.

* Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of Oslo, Oslo, Norway.
See the publication webpage for full author information.

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Published Aug. 10, 2018 2:36 PM - Last modified Aug. 10, 2018 2:36 PM