New publication: Successive losses of central immune genes characterize the Gadiformes’ alternate immunity

Monica H. Solbakken*, Matthew L. Rise, Kjetill S. Jakobsen*, and Sissel Jentoft* in Genome Biology and Evolution


Great genetic variability among teleost immunomes, with gene losses and expansions of central adaptive and innate components, has been discovered through genome sequencing over the last few years. Here, we demonstrate that the innate Myxovirus resistance gene (Mx) is lost from the ancestor of Gadiformes and the closely related Stylephorus chordatus, thus predating the loss of Major Histocompatibility Complex class II (MHCII) in Gadiformes. Although the functional implication of Mx loss is still unknown, we demonstrate that this loss is one of several ancient events appearing in successive order throughout the evolution of teleost immunity. In particular, we find that the loss of Toll-like receptor 5predates the loss of Mx involving the entire Paracanthopterygii lineage. Using a time-calibrated phylogeny, we show that loss of MHCII and Mxoverlap with major paleoclimatic and geological events indicating thatthese genetic changes were adaptive responses to the changing environment at the time.

First published online 19 October 2016
DOI: 10.1093/gbe/evw250
Publication webpage.

*Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, UiO. See the publication for full author information.

Tags: Genome Biology and Evolution;
Published Dec. 5, 2016 11:01 AM - Last modified Oct. 5, 2018 2:55 PM