Åsmund Kaupang

Academic Interests
Computational biology, structural biology, chemical biology, medicinal chemistry, synthetic organic chemistry, biochemistry, life science didactics.
Teaching
(FARM1130), FARM1150, FARM2100, FARM4140
Higher education and employment history
2017 - 2019
Researcher, Dept. of Chemistry / Computational Biology Unit (CBU), University of Bergen
2011 - 2016
Ph.D. in Medicinal Chemistry/Chemical Biology, School of Pharmacy, University of Oslo
2008 - 2010
M.Sc. in Chemistry (synthetic organic chemistry), Department of Chemistry, University of Oslo
Publications
- Kaupang, Åsmund & Hansen, Trond Vidar (2020). The PPAR Ω Pocket: Renewed Opportunities for Drug Development. PPAR Research. ISSN 1687-4757. 2020 . doi: 10.1155/2020/9657380 Full text in Research Archive.
- Kaupang, Åsmund; Laitinen, Tuomo; Poso, Antti & Hansen, Trond Vidar (2017). Structural review of PPARγ in complex with ligands: Cartesian- and dihedral angle principal component analyses of X-ray crystallographic data. Proteins: Structure, Function, and Bioinformatics. ISSN 0887-3585. 85(9), s 1684- 1698 . doi: 10.1002/prot.25325 Full text in Research Archive.
- Kaupang, Åsmund; Kase, Eili Tranheim; Vo, Cecilie Xuan Trang; Amundsen, Marthe; Vik, Anders & Hansen, Trond Vidar (2016). Synthesis of 5-trifluoromethyl-2-sulfonylpyridine PPARβ/δ antagonists: Effects on the affinity and selectivity towards PPARβ/δ. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 24(2), s 247- 260 . doi: 10.1016/j.bmc.2015.12.012
- Kaupang, Åsmund; Hildonen, Siri; Halvorsen, Trine Grønhaug; Mortén, Magnus; Vik, Anders & Hansen, Trond Vidar (2015). Involvement of covalent interactions in the mode of action of PPARβ/δ antagonists. RSC Advances. ISSN 2046-2069. 5(93), s 76483- 76490 . doi: 10.1039/c5ra15707b
- Kaupang, Åsmund; Paulsen, Steinar Martin; Steindal, Calin Constantin; Ravna, Aina Westrheim; Sylte, Ingebrigt; Halvorsen, Trine Grønhaug; Thoresen, G. Hege & Hansen, Trond Vidar (2015). Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618. European Journal of Medicinal Chemistry. ISSN 0223-5234. 94, s 229- 236 . doi: 10.1016/j.ejmech.2015.03.006 Full text in Research Archive.
- Kaupang, Åsmund & Bonge-Hansen, Tore (2013). α-Bromodiazoacetamides – a new class of diazo compounds for catalyst-free, ambient temperature intramolecular C–H insertion reactions. Beilstein Journal of Organic Chemistry. ISSN 2195-951X. 9, s 1407- 1413 . doi: 10.3762/bjoc.9.157
- Kaupang, Åsmund; Gorbitz, Carl Henrik & Bonge-Hansen, Tore (2013). A solid-state oxidation of 1,1,3,3-tetramethylguanidinium 4-methylbenzenesulfinate to 1,1,3,3-tetramethylguanidinium 4-methylbenzenesulfonate. Acta Crystallographica Section C: Crystal Structure Communications. ISSN 0108-2701. 69, s 778- + . doi: 10.1107/S0108270113015011
- Kaupang, Åsmund; Gorbitz, Carl Henrik & Bonge-Hansen, Tore (2013). N,N'-Bis(2-diazoacetyl)piperazine. Acta Crystallographica Section E: Structure Reports Online. ISSN 1600-5368. 69(8), s o1241 . doi: 10.1107/S1600536813018801
- Kaupang, Åsmund; Gorbitz, Carl Henrik & Hansen, Tore (2011). 2-Diazo-1-(1,1-dioxothiomorpholin-4-yl)ethanone. Acta Crystallographica Section E: Structure Reports Online. ISSN 1600-5368. 67, s O1844- U2037 . doi: 10.1107/S1600536811023774
- Kaupang, Åsmund; Gorbitz, Carl Henrik & Hansen, Tore (2010). tert-Butyl 4-(2-diazoacetyl)piperazine-1-carboxylate. Acta Crystallographica Section E: Structure Reports Online. ISSN 1600-5368. 66, s O2199- U467 . doi: 10.1107/S1600536810016211
- Kaupang, Åsmund; Bolsones, M; Gamadeku, T; Hansen, Tore; Hennum, MJ & Gorbitz, Carl Henrik (2008). 2SR,3RS)-Benzyl[4-chloro-1-(4-chlorophenyl)-1-methoxycarbonyl-2-butyl]ammonium chloride. Acta Crystallographica Section E: Structure Reports Online. ISSN 1600-5368. 64, s O2038- U4798 . doi: 10.1107/S1600536808030742
- Kaupang, Åsmund (2016). Development of PPAR Modulators and Investigations on their Mode of Action. Full text in Research Archive. Show summary
- Kaupang, Åsmund; Hildonen, Siri; Halvorsen, Trine Grønhaug; Mortén, Magnus; Vik, Anders & Hansen, Trond Vidar (2015). Investigations on the covalent antagonistic modulation of PPARβ/δ.
- Kaupang, Åsmund; Laitinen, Tuomo; Poso, Antti & Hansen, Trond Vidar (2013). Vibrational fingerprinting of hPPARγ in complex with ligands – application to the natural product (-)-mucosin.
- Kaupang, Åsmund; Laitinen, Tuomo; Vik, Anders; Poso, Antti & Hansen, Trond Vidar (2013). Molecular modelling and synthesis of putative high-affinity inhibitors of hPPARδ.