Denis Zosen

Image of Denis Zosen
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Mobile phone +4798307211
Room 264
Username
Visiting address Sem Sælands vei 2 ZEB building 0371 OSLO
Postal address Postboks 1068 Blindern 0316 OSLO

PhD project description

The background for the project is the current international lack of knowledge about the possible long-term effect of pharmaceuticals on human neurodevelopment. The aim of the project is to conduct experimental research on human brain organoids and neuronally differentiated human stem cell cultures. The project addresses adverse effects on brain development of pharmaceuticals commonly used by pregnant women, including antidepressants and antiepileptic drugs.

Supervisors

Prof. Ragnhild E. Paulsen (Team leader: The PharmaTox Strategic Research Initiative & Group leader: Neurobiology and Toxicology lab, Department of Pharmacy, UiO).

Prof. Joel C. Glover (Director: Norwegian Center for Stem Cell Research, Oslo University Hospital & Head of Laboratory of Neural Development and Optical Recording (NDEVOR), Institute of Basic Medical Sciences, Department of Molecular Medicine, UiO).

Dr. Sigrid Bjørnstad (Consultant pathologist: Department of Pathology, Ullevål, Oslo University Hospital).

Academic interests

Interests

Drug testing platforms Development of the brain and spinal cord
Neuropharmacology Cell and Molecular biology
Pharmacotoxicology Spinal cord injury
Depression Neurogenesis
Epilepsy

3D cultures

Drugs Stem cells

Competence

Cell culturing, Differentiation protocols, Organoids production, Animal models (mice, rats, chickens), Proliferation/Survival/Cytotoxicity assays

Teaching assistance

  • FARM2140 – Pharmaceutical microbiology (in norwegian, every spring)
  • FRM4010 – Preparation Course for Research in Biology (in norwegian, every spring)

Background

  • 09/2010-07/2014 BSc in Physiology and Biomedicine (SPBU, St. Petersburg, Russia).
  • 09/2014-07/2016 MSc in Cell Biology, Cytology, Histology, and Immunology (SPBU, St. Petersburg, Russia).
  • 10/2012-01/2015 Student Assistant in the Group of Molecular Mechanisms of Neuronal Functioning (IEPHB RAS, St. Petersburg, Russia)
  • 01/2015-04/2017 Junior Researcher in the Laboratory of Comparative Biochemistry of Cellular Functions (Dr. Margarita Glazova, IEPHB RAS, St. Petersburg, Russia)
  • 01/2018-03/2018 Visiting Researcher in the Norwegian Center for Stem Cell Research (Prof. Joel Glover, Oslo University Hospital, Oslo, Norway)
  • 04/2017-09/2018 Researcher in the Laboratory of Developmental Biology (Prof. Seppo Vainio, Oulu University, Oulu, Finland).

Publications

  1. Zosen, D. V., Dorofeeva, N. A., Chernigovskaya, E. V., Bachteeva, V. T., & Glazova, M. V. (2018). ERK1/2 inhibition increases dopamine release from differentiated PC12 cells. Neuroscience letters, 684, 6-12. https://doi.org/10.1016/j.neulet.2018.06.056
  2. Dorofeeva N.A., Nikitina L.S., Zosen D.V., Glazova, M. V., & Chernigovskaya, E. V. audiogenic seizure expression. Russian Journal of Genetics: Applied Research, 7(3), 217-225. https://doi.org/10.1134/S2079059717030029
  3. Glazova, M., Saparova, V., Zosen, D., Nasluzova, E. & Chernigovskaya, E.J.O.M.e.P. Differentiation Fate of Neural Stem Cells in the Hippocampus of Epileptic Rats. (2017).
  4. Zosen, D. V., and M. V. Glazova. "The Role of the Interaction of p53 and the MAPK Cascade in Controlling Neuronal Differentiation in the PC12 Cell Line." Neuroscience and Behavioral Physiology 46.5 (2016): 559-565. https://doi.org/10.1007/s11055-016-0277-y
Tags: Neurobiology, Neuropharmacology, Pharmacotoxicology, Organoids, Stem Cells, Antidepressants, Depression, Epilepsy
Published Dec. 6, 2018 1:48 PM - Last modified Apr. 11, 2019 10:51 AM