Jenny Lund

Postdoctoral fellow - Section of Pharmacology and Pharmaceutical Biosciences
Image of Jenny Lund
Norwegian version of this page
Phone +47-22856544
Room 488
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Visiting address Gydas vei 8 0363 Oslo
Postal address Postboks 1068 Blindern 0316 Oslo

Academic interests
I work in the field of pharmacology with main focus on diseases associated with altered energy metabolism and insulin resistance, including obesity and type 2 diabetes. I study use skeletal muscle cells and fat cells isolated from biopsies from various donors as in vitro models for the study of pathophysiology and potentially improved treatment of the diseases. I also study metabolism in various other cell types, including hepatocytes (HepG2 and HuH7), renal cells (HEK293), as well as macrophages. I also have experience with murine cells (skeletal muscle cells and macrophages).

A lot of my research has focused on the effects of exercise on energy metabolism as well as mapping roles of various proteins in energy metabolism. I manipulate the energy metabolism in the cells by treating with lactate, lipoproteins, using nuclear receptor modulators (for example for PPARs) and investigating the effect of new potential active substances.

Currently, I am part of a very exciting innovation project together with AstraZeneca (Gothenburg, Sweden). Here we are defining the role of sentrin-specific protease (SENP) 2 in human skeletal muscle and adipocyte metabolism. 

 

Background
2013-2017: Ph.D. Department of Pharmacy, University of Oslo. Thesis: Regulation of energy metabolism in cultured skeletal muscle cells: Effects of exercise, donor differences and perilipin 2.

2016: Basic pedagogical competence.

2008-2013: Master of Pharmacy. Department of Pharmacy, University of Oslo. Thesis: Will in vivo training affect skeletal muscle cells in vitro?

 

Work experience

Pharmacist in Vitusapotek (CC Vest and Bø in Telemark).

Web editor, the Norwegian Medicines Depot.

2015: External evaluator in pharmacokinetics, the Norwegian Medicines Agency (project-based).

 

Research abroad

I have been on two longer research stays:

  • AstraZeneca, Mölndal, Sweden (4 weeks in 2018)
  • Karolinska Institutet, Stockholm, Sweden (4 weeks in 2014)

In addition, I have been on a couple of shorter stays at the Deutsches Diabetes-Zentrum, Düsseldorf, Germany.

 

Teaching/supervision

In addition to research, I teach various courses at Department of Pharmacy, University of Oslo.
The main part of my teaching is in the autumn in the course FARM2110 - Pharmacotherapy 1. I am theme responsible for type 2 diabetes curriculum and also a supervisor for problem-based learning and various seminars.

Spring of 2021 I am teaching:

I have previously taught FRM1040, FRM1050, FRM2000, FRM2040, FRM3020, FRM3030 and FRM4010 (old programme, Department of Pharmacy, University of Oslo).

 

Currently I am supervisor for 1 doctoral fellow and 1 master student.

Over the years I have supervised 8 students on their master thesis.

 

Commisions of trust
Head of the section for pharmacology in the Norwegian Society for Pharmacology and Toxicology (2019-2023).

Representative for temporary scientific staff in the Education Committee at the Department of Pharmacy (2019-2021).

Deputy representative for temporary scientific staff in the Department Board at the Department of Pharmacy (2019-2021).

Representative for temporary scientific staff in the Program Council for the 1st department at the Department of Pharmacy (2014 and 2015-2017).

Deputy representative for temporary scientific staff in the Study Committee at the Department of Pharmacy (2015-2017).

Deputy representative for temporary scientific staff in the Program Council for the 1st department at the Department of Pharmacy (2013).

Referee for various scientific journals.

Tags: Pharmacology, Insulin resistance, Type 2 diabetes, Obesity, Energy metabolism, PPARdelta

Publications

  • Aas, Vigdis; Thoresen, G. Hege; Rustan, Arild & Lund, Jenny (2020). Substrate oxidation in primary human skeletal muscle cells is influenced by donor age. Cell and Tissue Research.  ISSN 0302-766X.  382, s 599- 608 . doi: 10.1007/s00441-020-03275-w Full text in Research Archive.
  • Dalmao-Fernández, Andrea; Lund, Jenny; Hermida-Gómez, Tamara; Vazquez-Mosquera, María E; Rego-Pérez, Ignacio; Blanco, Francisco J. & Fernández-Moreno, Mercedes (2020). Impaired Metabolic Flexibility in the Osteoarthritis Process: A Study on Transmitochondrial Cybrids. Cells.  ISSN 2073-4409.  9(809) . doi: 10.3390/cells9040809
  • Krapf, Solveig Astrid; Lund, Jenny; Lundkvist, Malin; Grebstad Dale, Marianne; Nyman, Tuula Anneli; Thoresen, G. Hege & Kase, Eili Tranheim (2020). Pancreatic cancer cells show lower oleic acid oxidation and their conditioned medium inhibits oleic acid oxidation in human myotubes. Pancreatology (Print).  ISSN 1424-3903.  20(4), s 676- 682 . doi: 10.1016/j.pan.2020.04.014
  • Lund, Jenny & Rustan, Arild (2020). Fatty Acids: Structures and Properties. Encyclopedia of Life Sciences.  ISSN 1476-9506. . doi: 10.1002/9780470015902.a0029198
  • Løvsletten, Nils Gunnar; Vu, Helene Loang Ngo; Skagen, Christine; Lund, Jenny; Kase, Eili Tranheim; Thoresen, G. Hege; Zammit, Victor A. & Rustan, Arild (2020). Treatment of human skeletal muscle cells with inhibitors of diacylglycerol acyltransferases 1 and 2 to explore isozyme-specific roles on lipid metabolism. Scientific Reports.  ISSN 2045-2322.  10:238, s 1- 13 . doi: 10.1038/s41598-019-57157-5 Full text in Research Archive.
  • Lund, Jenny; Ouwens, D. Margriet; Wettergreen, Marianne; Bakke, Siril Skaret; Thoresen, G. Hege & Aas, Vigdis (2019). Increased glycolysis and higher lactate production in hyperglycemic myotubes. Cells.  ISSN 2073-4409.  8(9) . doi: 10.3390/cells8091101 Full text in Research Archive.
  • Lund, Jenny; Aas, Vigdis; Tingstad, Ragna Husby; Van Hees, Alfons & Nikolic, Natasa (2018). Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism. Scientific Reports.  ISSN 2045-2322.  8 . doi: 10.1038/s41598-018-28249-5 Full text in Research Archive.
  • Lund, Jenny; Helle, Siw A; Li, Yuchuan; Løvsletten, Nils Gunnar; Stadheim, Hans Kristian; Jensen, Jørgen; Kase, Eili Tranheim; Thoresen, G. Hege & Rustan, Arild (2018). Higher lipid turnover and oxidation in cultured human myotubes from athletic versus sedentary young male subjects. Scientific Reports.  ISSN 2045-2322.  8(1) . doi: 10.1038/s41598-018-35715-7 Full text in Research Archive. Show summary
  • Feng, Yuan Zeng; Lund, Jenny; Li, Yuchuan; Knabenes, Irlin; Bakke, Siril Skaret; Kase, Eili Tranheim; Lee, Yun K; Kimmel, Alan R; Thoresen, G. Hege; Rustan, Arild & Dalen, Knut Tomas (2017). Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation. Journal of Lipid Research.  ISSN 0022-2275.  58(11), s 2147- 2161 . doi: 10.1194/jlr.M079764 Full text in Research Archive.
  • Lund, Jenny; Rustan, Arild; Løvsletten, Nils Gunnar; Mudry, Jonathan M.; Langleite, Torgrim Mikal; Feng, Yuan Zeng; Stensrud, Camilla; Brubak, Mari G; Drevon, Christian A; Birkeland, Kåre I.; Kolnes, Kristoffer Jensen; Johansen, Egil Ivar; Tangen, Daniel S.; Stadheim, Hans Kristian; Gulseth, Hanne Løvdal; Krook, Anna; Kase, Eili Tranheim; Jensen, Jørgen & Thoresen, G. Hege (2017). Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism. PLOS ONE.  ISSN 1932-6203.  12:e0175441(4), s 1- 24 . doi: 10.1371/journal.pone.0175441 Full text in Research Archive.
  • Lund, Jenny; Tangen, Daniel S.; Wiig, Håvard; Stadheim, Hans Kristian; Siw, Anette Helle; Birk, Jesper B.; Ingemann-Hansen, Thorsten; Rustan, Arild; Thoresen, G. Hege; Wojtaszewski, Jørgen F.P.; Kase, Eili Tranheim & Jensen, Jørgen (2017). Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects. Archives of Physiology and Biochemistry.  ISSN 1381-3455.  124(2), s 119- 130 . doi: 10.1080/13813455.2017.1369547 Full text in Research Archive.
  • Lund, Jenny; Stensrud, Camilla; Rajender, Melanie Müller; Bohov, Pavol; Thoresen, G. Hege; Berge, Rolf Kristian; Wright, Michael; Kamal, Ahmed; Rustan, Arild; Miller, Andrew D. & Skorve, Jon (2016). The molecular structure of thio-ether fatty acids influences PPAR-dependent regulation of lipid metabolism. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  24(6), s 1191- 1203 . doi: 10.1016/j.bmc.2016.01.045
  • Aas, Vigdis; Lund, Jenny; Kase, Eili Tranheim; Feng, Yuan Zeng; Rustan, Arild & Thoresen, G. Hege (2015). Blodglukosesenkende legemidler ved type 2-diabetes. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  123(5), s 20- 24 Full text in Research Archive.

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  • Feng, Yuan Zeng; knabenes, Irlin Knivsland; Bakke, Siril S.; Lund, Jenny; Lee, Y.K.; kimmel, Alan; Thoresen, G. Hege; Rustan, Arild & Dalen, Knut Tomas (2015). Increased lipid oxidation and decreased lipid storage in myotubes lacking the lipid droplet binding protein perilipin2.
  • Feng, Yuan Zeng; knabenes, Irlin Knivsland; Lund, Jenny; Lee, Y.K.; kimmel, Alan; Thoresen, G. Hege; Rustan, Arild & Dalen, Knut Tomas (2014). Increased lipid oxidation and decreased lipid storage in myotubes lacking perilipin2.
  • Kase, Eili Tranheim; Lund, Jenny; Feng, Yuan Zeng; Langleite, Torgrim Mikal; Aas, Vigdis; Jensen, Jan S.; Birkeland, Kåre I.; Gulseth, Hanne Løvdal; Drevon, Christian A; Rustan, Arild & Thoresen, G. Hege (2013). Effect of exercise on fatty acid and glucose metabolism in cultured human myotubes. Diabetologia.  ISSN 0012-186X.  56, s S250- S250

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Published Jan. 9, 2014 3:51 PM - Last modified Feb. 5, 2021 1:28 PM

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