Vegard Torp Lien

Doctoral Research Fellow - Section for Pharmaceutical Chemistry
Image of Vegard Torp Lien
Norwegian version of this page
Mobile phone 99009244
Room Ø182
Username
Visiting address Chemistry building
Postal address Postboks 1068 Blindern 0316 OSLO
Other affiliations Faculty of Mathematics and Natural Sciences (Student)

Academic interests

The main goal of my project is to make new small-molecules that can be used both for therapy and diagnostics of cancer diseases, and especially the metastatic spread.  We do that by synthesizing:

  • new therapeutic small-molecule drugs for cancer
  • PET-ligands for diagnostication of cancer,

We focus mainly on the tyrosine kinase c-Met which has a central role in metastasis.

Courses taught

FRM1000/FRM1010

Background

  • 2014/2015: Lektor at Ullern high school. Chemsitry and mathematics.
  • 2013/2014: Deoartment of Chemistry (UiO): Organic and PET chemistry in Assoc. Prof Patrick Riss' group.
  • 2013: MSc in organic chemistry from NTNU, Trondheim.
Tags: Cancer metastasis, Medicinal chemistry

Publications

  • Lien, Vegard Torp; Kristiansen, Margrethe Konstanse; Pettersen, Solveig; Haugen, Mads Haugland; Olberg, Dag Erlend; Waaler, Jo & Klaveness, Jo (2019). Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation. RSC Advances.  ISSN 2046-2069.  9, s 37092- 37100 . doi: 10.1039/C9RA08954C
  • Lien, Vegard Torp; Olberg, Dag Erlend; Hagelin, Gunnar & Klaveness, Jo (2019). Synthesis and antiproliferative evaluation of novel N‑arylquinolones. Monatshefte für Chemie.  ISSN 0026-9247.  150(11), s 1947- 1957 . doi: 10.1007/s00706-019-02504-5
  • Lien, Vegard Torp; Pettersen, Solveig; Haugen, Mads Haugland; Olberg, Dag Erlend; Mælandsmo, Gunhild Mari & Klaveness, Jo (2019). Design, synthesis and biological evaluation of 6‐substituted quinolines derived from cabozantinib as c‐Met inhibitors. Archiv der Pharmazie.  ISSN 0365-6233.  352(9) . doi: 10.1002/ardp.201900101
  • Lien, Vegard Torp; Grønås, Kari; Olberg, Dag Erlend & Klaveness, Jo (2018). Onkologiske legemidler: Utviklingen fra konvensjonelle cytostatika til nib-er, mab-er og andre nyvinninger. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  8, s 24- 29
  • Lien, Vegard Torp; Klaveness, Jo & Olberg, Dag Erlend (2017). One-step synthesis of [18F]cabozantinib for use in positron emission tomography imaging of c-Met.. Journal of labelled compounds & radiopharmaceuticals.  ISSN 0362-4803.  61(1), s 11- 17 . doi: 10.1002/jlcr.3564
  • Lien, Vegard Torp; Olberg, Dag Erlend; Klaveness, Jo & Görbitz, Carl Henrik (2017). Crystal structure of 6,7-dimeth­­oxy-1-(4-nitro­phen­yl)quinolin-4(1H)-one: a mol­ecular scaffold for potential tubulin polymerization inhibitors. Acta Crystallographica Section E: Crystallographic Communications.  ISSN 2056-9890.  73, s 441- 444 . doi: 10.1107/S2056989017002948
  • Lien, Vegard Torp & Riss, Patrick (2014). Radiosynthesis of [18F]trifluoroalkyl groups: Scope and limitations. BioMed Research International.  ISSN 2314-6133.  2014:380124 . doi: 10.1155/2014/380124
  • Rühl, Thomas; Rafique, Waqas; Lien, Vegard Torp & Riss, Patrick (2014). Cu(I)-mediated 18F-trifluoromethylation of arenes: Rapid synthesis of 18F-labeled trifluoromethyl arenes†. Chemical Communications.  ISSN 1359-7345.  50(45), s 6056- 6059 . doi: 10.1039/c4cc01641f

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  • Kristiansen, Margrethe Konstanse; Lien, Vegard Torp & Klaveness, Jo (2019). Towards dual inhibitors of c-Met and WNT; synergistic treatment of cancerous diseases.
  • Lien, Vegard Torp; Hauge, Emily; Nuruddin, Syed; Klaveness, Jo & Olberg, Dag Erlend (2019). Synthesis and preclinical evaluation of a selective c-Met PET tracer.
  • Hauge, Emily; Olberg, Dag Erlend; Lien, Vegard Torp & Klaveness, Jo (2018). New 18F-labelled Selective c-Met Inhibitor; Synthesis, 18F-radiolabelling and Binding Affinity Studies of a New Selective c-Met Inhibitor for use in Positron Emission Tomography.
  • Lien, Vegard Torp; Klaveness, Jo & Olberg, Dag Erlend (2017). One-step synthesis of [18F]cabozantinib for use in positron emission tomography imaging of c-Met.

View all works in Cristin

Published Aug. 28, 2015 1:01 PM - Last modified Apr. 18, 2017 3:44 PM