Visit by Professor John D. Scott from the Department of Pharmacology, University of Washington, Seattle, USA
In early September we were very happy to host Professor John D. Scott from the Department of Pharmacology, University of Washington, Seattle, USA as a guest speaker both at the School of Pharmacy, University of Oslo and at Department of Pharmacy, UiT The Arctic University of Tromsø. The invitation was made possible with funding from the Norwegian PhD School of Pharmacy.
Photo: University of Washington
Professor John D Scott is the chair of Pharmacology at the School of Medicine University of Washington and a fellow of the Howard Hughes Medical institute. The focus of professor Scott research is intracellular signalling and how specific anchoring proteins are important for transmitting signals from the second messenger cAMP to precise intracellular localizations.
He gave a talk entitled “Exploring and exploiting the constraints of local signalling” in Oslo on September 4th and in Tromsø on September 6th, 2017. In his lecture he described elegant studies into the mechanistic function of the protein kinase A (PKA) holoenzyme complex at the molecular level. The new data presented challenges the classical view on how cAMP mediates its effect through activation of PKA. In classical textbooks, the activation of PKA by cAMP depends on the release of the catalytic subunit of PKA from the holoenzyme complex after binding of cAMP to the regulatory subunits. In his talk professor Scott shows that the PKA can be activated by cAMP binding to the regulatory subunits without dissociation of the catalytic from the holoenzyme. After the talk Professor Scott had a lunch meeting with the PhD students at both Universities. During this meeting, Professor Scott and the students discussed the students’ research and their career opportunities, as well as the grant proposal evaluation by the respective national and international committees. The PhD students thanked Professor Scott with a small present for his remarkable lecture and the common lunch.