Dag Erlend Olberg

Førsteamanuensis II - Seksjon for farmasøytisk kjemi
Bilde av Dag Erlend Olberg
English version of this page
Mobiltelefon +47 41517119
Brukernavn
Besøksadresse Sem Sælands vei 3 Farmasibygningen 0371 Oslo
Postadresse Postboks 1068 Blindern O316 Oslo

Faglige interesser

Radiokjemi (PET), legemiddelkjemi, CNS, peptidkjemi, biomolekyler og molekylær avbilding

Samarbeid

Nasjonalt

Kjetil Wessel Andressen, Avdeling for farmakologi, UiO, http://www.med.uio.no/klinmed/personer/vit/kjetilwa/

Finn Olav Levy, Avdeling for farmakologi, UiO, http://www.med.uio.no/klinmed/personer/vit/finnolav/

Frits Alan Thorsen, UiB, http://www.uib.no/personer/Frits.Thorsen

Thor Audun Saga, Norsk Medisinsk Syklotronsenter AS, http://www.petsenteret.no

Ira Ronit Haraldsen, OUS-Rikshospitalet, http://www.ous-research.no/home/iraharaldsen/Group%20members/8376

Gjermund Henriksen, Norsk Medisinsk Syklotronsenter AS, http://www.petsenteret.no

Internasjonalt

Guy Bormans, KU Leuven, Belgia, http://www.kuleuven.be/wieiswie/en/person/00009552

Martin G. Pomper, John Hopkins Medicine, Baltimore, MD, USA, https://www.hopkinsmedicine.org/profiles/details/martin-pomper

 

Emneord: Legemiddelkjemi, PET radiofarmaka, peptidsyntese, PET, Life sciences

Publikasjoner

  • Hoareau, Raphaël; Bach-Gansmo, Tore; Cumming, Paul & Olberg, Dag Erlend (2022). A new automated and putatively versatile synthesis of the PSMA-ligand derivative [18F]DCFPyL using the FASTlabTM synthesizer. EJNMMI Radiopharmacy and Chemistry. ISSN 2365-421X. 7(1), s. 1–11. doi: 10.1186/s41181-022-00157-0.
  • Lien, Vegard Torp; Celen, Sofie; Nuruddin, Syed; Attili, Bala; Doumont, Gilles & Van Simaeys, Gaetan [Vis alle 9 forfattere av denne artikkelen] (2021). Preclinical evaluation of [18F]cabozantinib as a PET imaging agent in a prostate cancer mouse model. Nuclear Medicine and Biology. ISSN 0969-8051. 93, s. 74–80. doi: 10.1016/j.nucmedbio.2020.12.002.
  • Syvänen, Stina; Fang, Xiaotian; Faresjö, Rebecca; Rokka, Johanna; Lannfelt, Lars & Olberg, Dag Erlend [Vis alle 8 forfattere av denne artikkelen] (2020). Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain. ACS Chemical Neuroscience. ISSN 1948-7193. 11(24), s. 4460–4468. doi: 10.1021/acschemneuro.0c00652.
  • Cumming, Paul; Marton, János; Lilius, Tuomas O.; Olberg, Dag Erlend & Rominger, Axel (2019). A survey of molecular imaging of opioid receptors. Molecules. ISSN 1420-3049. 24:4190(22), s. 1–35. doi: 10.3390/molecules24224190.
  • Aasen, Synnøve Nymark; Espedal, Heidi; Holte, Christopher Florian; Keunen, Olivier; Karlsen, Tine Veronica & Tenstad, Olav [Vis alle 18 forfattere av denne artikkelen] (2019). Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood-brain barrier. Molecular Cancer Therapeutics. ISSN 1535-7163. 18(11), s. 2171–2181. doi: 10.1158/1535-7163.MCT-19-0160.
  • Lien, Vegard Torp; Kristiansen, Margrethe Konstanse; Pettersen, Solveig; Haugen, Mads Haugland; Olberg, Dag Erlend & Waaler, Jo [Vis alle 7 forfattere av denne artikkelen] (2019). Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation. RSC Advances. ISSN 2046-2069. 9(63), s. 37092–37100. doi: 10.1039/c9ra08954c.
  • Lien, Vegard Torp; Olberg, Dag Erlend; Hagelin, Gunnar & Klaveness, Jo (2019). Synthesis and antiproliferative evaluation of novel N‑arylquinolones. Monatshefte für Chemie. ISSN 0026-9247. 150(11), s. 1947–1957. doi: 10.1007/s00706-019-02504-5.
  • Lien, Vegard Torp; Pettersen, Solveig; Haugen, Mads Haugland; Olberg, Dag Erlend; Mælandsmo, Gunhild Mari & Klaveness, Jo (2019). Design, synthesis and biological evaluation of 6‐substituted quinolines derived from cabozantinib as c‐Met inhibitors. Archiv der Pharmazie. ISSN 0365-6233. 352(9). doi: 10.1002/ardp.201900101. Fulltekst i vitenarkiv
  • Tungen, Jørn Eivind; Aursnes, Marius; Ramon, Sesquile; Colas, Romain A.; Serhan, Charles Nicholas & Olberg, Dag Erlend [Vis alle 9 forfattere av denne artikkelen] (2018). Synthesis of Protectin D1 Analogs: Novel Pro-resolution and Radiotracer Agents. Organic and biomolecular chemistry. ISSN 1477-0520. 16, s. 6818–6823. doi: 10.1039/c8ob01232f.
  • Lien, Vegard Torp; Grønås, Kari; Olberg, Dag Erlend & Klaveness, Jo (2018). Onkologiske legemidler: Utviklingen fra konvensjonelle cytostatika til nib-er, mab-er og andre nyvinninger. Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935. 8, s. 24–29.
  • Tukun, Feng-Ling; Olberg, Dag Erlend; Riss, Patrick; Haraldsen, Ira Hebold; Kåss, Anita Anjali Suri & Klaveness, Jo (2017). Recent development of non-peptide GnRH antagonists. Molecules. ISSN 1420-3049. 22:2188(12), s. 1–25. doi: 10.3390/molecules22122188. Fulltekst i vitenarkiv
  • Lien, Vegard Torp; Klaveness, Jo & Olberg, Dag Erlend (2017). One-step synthesis of [18F]cabozantinib for use in positron emission tomography imaging of c-Met. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 61(1), s. 11–17. doi: 10.1002/jlcr.3564.
  • Lien, Vegard Torp; Olberg, Dag Erlend; Klaveness, Jo & Görbitz, Carl Henrik (2017). Crystal structure of 6,7-dimeth­­oxy-1-(4-nitro­phen­yl)quinolin-4(1H)-one: a mol­ecular scaffold for potential tubulin polymerization inhibitors. Acta Crystallographica Section E: Crystallographic Communications. ISSN 2056-9890. 73, s. 441–444. doi: 10.1107/S2056989017002948.
  • Ahamed, Muneer; Vermeulen, Koen; Schnekenburger, Michael; Moltzau, Lise Roman; Levy, Finn Olav & Marton, Janos [Vis alle 10 forfattere av denne artikkelen] (2017). Synthesis, Enzyme Assays and Molecular Docking Studies of Fluorinated Bioisosteres of Santacruzamate A as Potential HDAC Tracers. Letters in Drug Design & Discovery. ISSN 1570-1808. 14(7), s. 787–797. doi: 10.2174/1570180813666161101152943.
  • Olberg, Dag Erlend; Bauer, Nadine; Andressen, Kjetil Wessel; Hjornevik, Trine; Cumming, Paul & Levy, Finn Olav [Vis alle 9 forfattere av denne artikkelen] (2016). Brain penetrant small molecule 18F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats. Nuclear Medicine and Biology. ISSN 0969-8051. 43(8), s. 478–489. doi: 10.1016/j.nucmedbio.2016.05.003.
  • Olberg, Dag Erlend; Hausner, Sven H.; Bauer, Nadine; Klaveness, Jo; Indrevoll, Bård & Andressen, Kjetil Wessel [Vis alle 10 forfattere av denne artikkelen] (2015). Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats. MedChemComm. ISSN 2040-2503. 6, s. 708–714. doi: 10.1039/c4md00486h.
  • Cumming, Robin C.; Olberg, Dag Erlend & Sutcliffe, Julie L. (2014). Rapid 18F-radiolabeling of peptides from [18F] fluoride using a single microfluidics device. RSC Advances. ISSN 2046-2069. 4(90), s. 49529–49534. doi: 10.1039/c4ra10520f.
  • Olberg, Dag Erlend; Andressen, Kjetil Wessel; Levy, Finn Olav; Klaveness, Jo; Haraldsen, Ira Hebold & Sutcliffe, Julie L. (2014). Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 24(7), s. 1846–1850. doi: 10.1016/j.bmcl.2014.02.002.
  • Olberg, Dag Erlend; Hagen, Inger A.; Hagen, Anniken & Haraldsen, Ira Hebold (2012). Peptider for positronemisjonstomografi (PET). Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935. 120(1), s. 20–24.
  • Hjelstuen, ole kristian; Svadberg, Anders; Olberg, Dag Erlend & Rosser, Mark (2011). Standardization of fluorine-18 manufacturing processes: New scientific challenges for PET. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 78(3), s. 307–313. doi: 10.1016/j.ejpb.2011.01.002.
  • Wojniusz, Slawomir; Vögele, Claus; Ropstad, Erik; Evans, Neil; Robinson, Jane & Sütterlin, Stefan [Vis alle 11 forfattere av denne artikkelen] (2011). Prepubertal gonadotropin-releasing hormone analog leads to exaggerated behavioral and emotional sex differences in sheep. Hormones and Behavior. ISSN 0018-506X. 59, s. 22–27. doi: 10.1016/j.yhbeh.2010.09.010.
  • Olberg, Dag Erlend; Cuthbertson, Alan; Solbakken, Magne; Arukwe, Joseph M; Qu, Hong & Kristian, Alexandr [Vis alle 8 forfattere av denne artikkelen] (2010). Radiosynthesis and Biodistribution of a Prosthetic Group (F-18-FENMA) Conjugated to Cyclic RGD Peptides. Bioconjugate chemistry. ISSN 1043-1802. 21(12), s. 2297–2304. doi: 10.1021/bc1003229.
  • Olberg, Dag Erlend & Hjelstuen, ole kristian (2010). Labeling Strategies of Peptides with F-18 for Positron Emission Tomography. Current Topics in Medicinal Chemistry. ISSN 1568-0266. 10(16), s. 1669–1679.
  • Olberg, Dag Erlend; Arukwe, Joseph M; Grace, David; Hjelstuen, ole kristian; Solbakken, Magne & Kindberg, Grete M. [Vis alle 7 forfattere av denne artikkelen] (2010). One Step Radiosynthesis of 6-[F-18]Fluoronicotinic Acid 2,3,5,6-Tetrafluorophenyl Ester ([F-18]F-Py-TFP): A New Prosthetic Group for Efficient Labeling of Biomolecules with Fluorine-18. Journal of Medicinal Chemistry. ISSN 0022-2623. 53(4), s. 1732–1740. doi: 10.1021/jm9015813.
  • Høyem, Sverre; Bruheim, Skjalg; Mælandsmo, Gunhild M; Standal, Marius; Olberg, Dag Erlend & Brudeli, Bjarne [Vis alle 9 forfattere av denne artikkelen] (2009). Didanosine ester prodrugs: Synthesis, albumin binding properties and pharmacokinetic studies in rats. European Journal of Medicinal Chemistry. ISSN 0223-5234. 44(10), s. 3874–3879. doi: 10.1016/j.ejmech.2009.04.008.
  • Høyem, Sverre; Bruheim, Skjalg; Mælandsmo, Gunhild; Standal, Marius; Olberg, Dag Erlend & Brudeli, Bjarne [Vis alle 9 forfattere av denne artikkelen] (2009). Didanosine ester prodrugs: Synthesis, albumin binding properties and pharmacokinetic studies in rats. European Journal of Medicinal Chemistry. ISSN 0223-5234. 44, s. 3874–3879.
  • Olberg, Dag Erlend; Hjelstuen, ole kristian; Solbakken, Magne; Arukwe, Joseph M; Dyrstad, Knut & Cuthbertson, Alan (2009). Site-specific addition of an F-18-N-methylaminooxy-containing prosthetic group to a vinylsulfone modified peptide. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 52(13-14), s. 571–575. doi: 10.1002/Jlcr.1686.
  • Olberg, Dag Erlend; Hjelstuen, ole kristian; Solbakken, Magne; Arukwe, Joseph; Karlsen, Hege & Cuthbertson, Alan (2008). A novel prosthetic group for site-selective labeling of peptides for positron emission tomography. Bioconjugate chemistry. ISSN 1043-1802. 19(6), s. 1301–1308. doi: 10.1021/bc800007h.

Se alle arbeider i Cristin

  • Lien, Vegard Torp; Kristiansen, Margrethe Konstanse; Pettersen, Solveig; Haugen, Mads Haugland; Krauss, Stefan Johannes Karl & Olberg, Dag Erlend [Vis alle 8 forfattere av denne artikkelen] (2020). Erratum: Towards dual inhibitors of the MET kinase and WNT signaling pathway; Design, synthesis and biological evaluation (RSC Advances (2019) 9 (37092-37100) DOI: 10.1039/D0RA90007A). RSC Advances. ISSN 2046-2069. 10(9). doi: 10.1039/d0ra90007a.
  • Lien, Vegard Torp; Hauge, Emily; Nuruddin, Syed; Klaveness, Jo & Olberg, Dag Erlend (2019). Synthesis and preclinical evaluation of a selective c-Met PET tracer.
  • Lien, Vegard Torp; Klaveness, Jo & Olberg, Dag Erlend (2017). One-step synthesis of [18F]cabozantinib for use in positron emission tomography imaging of c-Met.
  • Cumming, Robin; Olberg, Dag Erlend & Sutcliffe, Julie (2013). Rapid high-yielding radiosynthesis of [F-18] F-Py-TFP using a microfluidic system. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 56, s. S477–S477.
  • Olberg, Dag Erlend; Haraldsen, Ira Hebold & Sutcliffe, J. (2013). Synthesis and evaluation of small molecular [F-18]labeled gonadotropin-releasing hormone (GnRH) receptor antagonist as potential PET imaging agents for GnRH receptor expression in CNS. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 56, s. S333–S333.
  • Olberg, Dag Erlend; Arukwe, J; Solbakken, M; Cuthbertson, A; Qu, H & Kristian, A [Vis alle 7 forfattere av denne artikkelen] (2009). RADIOSYNTHESIS AND BIODISTRIBUTION OF CYCLIC RGD PEPTIDES CONJUGATED WITH A NOVEL [18F] FLUORINATED N-METHYLAMINOOXY CONTAINING PROSTHETIC GROUP. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 52, s. S32–S32.
  • Olberg, Dag Erlend; Arukwe, J; Grace, D & Hjelstuen, ole kristian (2009). 2-TRIMETHYLAMMONIUM NICOTINIC ACID TFP-ESTER: A NOVEL PYRIDINE BASED SYSTEM FOR THE ONE-STEP LABELLING OF BIOMOLECULES WITH FLUORINE-18. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 52, s. S160–S160.
  • Olberg, Dag Erlend; Hjelstuen, ole kristian; Solbakken, M; Arukwe, J; Dyrstad, K & Cuthbertson, A (2009). SITE-SPECIFIC ADDITION OF AN 18F-N-METHYLAMINOOXY CONTAINING PROSTHETIC GROUP TO A VINYLSULFONE MODIFIED PEPTIDE. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 52, s. S161–S161.
  • Olberg, Dag Erlend; Arukwe, Joseph M; Grace, D & Hjelstuen, ole kristian (2009). 2-Trimethylammonium nicotinic acid TFP-ester: A novel pyridine based system for the one-step labelling of biomolecules with fluorine-18.
  • Olberg, Dag Erlend; Hjelstuen, ole kristian; Solbakken, Magne; Arukwe, Joseph M; Dyrstad, Knut & Cuthbertson, Alan (2009). Site-specific addition of an 18F-N-Methylaminooxy containing prosthetic group to a vinylsulfone modified peptide.
  • Hauge, Emily; Olberg, Dag Erlend; Lien, Vegard Torp & Klaveness, Jo (2018). New 18F-labelled Selective c-Met Inhibitor; Synthesis, 18F-radiolabelling and Binding Affinity Studies of a New Selective c-Met Inhibitor for use in Positron Emission Tomography . UiO.
  • Olberg, Dag Erlend (2009). Novel (18F)Fluorinated prosthetic groups for the labelling of peptides for positron emission tomography (PET). Tromsprodukt.

Se alle arbeider i Cristin

Publisert 27. jan. 2015 10:17 - Sist endret 18. juni 2021 07:09