Espen Molden

Professor II - Farmasøytisk institutt
Bilde av Espen Molden
English version of this page
Telefon +47-22856561
Rom 484 B
Brukernavn
Besøksadresse Sem Sælands vei 3 Farmasibygningen 0371 OSLO
Postadresse Postboks 1068 Blindern 0316 OSLO

Faglige interesser

Primær faglig interesse er årsaker til individuell variabilitet i effekt og bivirkninger av legemidler, inkludert implementering av kunnskap innen dette området for å bedre legemiddelbehandling i klinisk praksis.

Undervisning

Underviser på det erfaringsbaserte masterprogrammet i klinisk farmasi.

Bakgrunn

Utdannet Cand.pharm. fra UiO i 1997, Dr.scient. samme sted i 2003. I dag ansatt i 20 % stilling som professor II ved Farmasøytisk institutt, UiO. Hovedstillingen er Forskningsleder ved Senter for Psykofarmakologi, Diakonhjemmet sykehus.

Priser

Årets farmasøyt, Norsk Farmaceutisk Forening, 2006

Samarbeid

Samarbeidspartnere innen aktuelle forskningsprosjekter:

Professor Torgeir Bruun Wyller, Oslo Universitetssykehus, Avdeling Ullevål

Professor Anette Hylen Ranhoff, Diakonhjemmet sykehus

Professor Tommy B. Andersson, Astra Zeneca, Mölndal, Sverige

Professor Erik Eliasson, Karolinska institutet, Stockholm, Sverige

Emneord: Farmakologi, Farmakokinetikk, Farmakogenetikk, Legemiddelinteraksjoner, Cytokrom P450, Klinisk farmasi

Publikasjoner

  • Jukic, Marin M.; Smith, Robert Løvsletten; Haslemo, Tore; Molden, Espen & Ingelman-Sundberg, Magnus (2019). Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study. Lancet psychiatry.  ISSN 2215-0374.  6(5), s 418- 426 . doi: 10.1016/S2215-0366(19)30088-4
  • Olsen, Thomasch R. Risom; Rasmussen, Anders R.; Kringen, Marianne K. & Molden, Espen (2019). En jente i tidlig skolealder uten effekt av opioider ved generell anestesi. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  139(7) . doi: 10.4045/tidsskr.18.0561
  • Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2019). Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI. Psychoneuroendocrinology.  ISSN 0306-4530.  103, s 87- 95 . doi: 10.1016/j.psyneuen.2019.01.001
  • Baftiu, Arton; Feet, Silje Andrea; Larsson, Pål Gunnar; Burns, Margrete Larsen; Henning, Oliver Johannes; Sætre, Erik; Molden, Espen; Granås, Anne Gerd; Johannessen, Svein Ivar & Landmark, Cecilie Johannessen (2018). Utilisation and polypharmacy aspects of antiepileptic drugs in elderly versus younger patients with epilepsy: A pharmacoepidemiological study of CNS-active drugs in Norway, 2004-2015. Epilepsy Research.  ISSN 0920-1211.  139, s 35- 42 . doi: 10.1016/j.eplepsyres.2017.11.001
  • Haslemo, Tore; Eliasson, Erik; Jukic, Marin M.; Ingelman-Sundberg, Magnus & Molden, Espen (2018). Significantly lower CYP2D6 metabolism measured as the O/N-desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients. British Journal of Clinical Pharmacology.  ISSN 0306-5251. . doi: 10.1111/bcp.13788
  • Hole, Kristine; Heiberg, Petra Lybæk; Gjestad, Caroline; Mehus, Lise Larsen; Rø, Øyvind & Molden, Espen (2018). Elevated 4β‐hydroxycholesterol/cholesterol ratio in anorexianervosa patients. Pharmacology Research & Perspectives.  ISSN 2052-1707.  6(5), s 1- 5 . doi: 10.1002/prp2.430
  • Hole, Kristine; Wollmann, Birgit Malene Tovik; Nguyen, Camilla; Haslemo, Tore & Molden, Espen (2018). Comparison of CYP3A4-Inducing Capacity of Enzyme-Inducing Antiepileptic Drugs Using 4β-Hydroxycholesterol as Biomarker. Therapeutic Drug Monitoring.  ISSN 0163-4356.  40(4), s 463- 468 . doi: 10.1097/FTD.0000000000000518
  • Iversen, Trude Seselie Jahr; Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Mørch, Ragni Helene; Gardsjord, Erlend Strand; Jørgensen, Kjetil Nordbø; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Side effect burden of antipsychotic drugs in real life - Impact of gender and polypharmacy. Progress in Neuro-psychopharmacology and Biological Psychiatry.  ISSN 0278-5846.  82, s 263- 271 . doi: 10.1016/j.pnpbp.2017.11.004
  • Jukic, Marin M.; Haslemo, Tore; Molden, Espen & Ingelman-Sundberg, Magnus (2018). Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients. American Journal of Psychiatry.  ISSN 0002-953X.  175(5), s 463- 470 . doi: 10.1176/appi.ajp.2017.17050550
  • Pardiñas, Antonio F.; Holmans, Peter; Pocklington, Andrew J.; Escott-Price, Valentina; Ripke, Stephan; Carrera, Noa; Legge, Sophie E.; Bishop, Sophie; Cameron, Darren; Hamshere, Marian L.; Han, Jun; Hubbard, Leon; Lynham, Amy; Mantripragada, Kiran; Rees, Elliott; MacCabe, James H.; McCarroll, Steven A.; Baune, Bernhard T.; Breen, Gerome; Byrne, Enda M.; Dannlowski, Udo; Eley, Thalia C.; Hayward, Caroline; Martin, Nicholas G.; McIntosh, Andrew M.; Plomin, Robert; Porteous, David J.; Wray, Naomi R.; Caballero, Armando; Geschwind, Daniel H.; Huckins, Laura M.; Ruderfer, Douglas M.; Santiago, Enrique; Sklar, Pamela; Stahl, Eli A.; Won, Hyejung; Agerbo, Esben; Als, Thomas D.; Andreassen, Ole Andreas; Bækvad-Hansen, Marie; Mortensen, Preben Bo; Pedersen, Carsten Bøcker; Børglum, Anders D.; Bybjerg-Grauholm, Jonas; Djurovic, Srdjan; Durmishi, Naser; Pedersen, Marianne Giørtz; Golimbet, Vera; Grove, Jakob; Hougaard, David M.; Mattheisen, Manuel; Molden, Espen; Mors, Ole; Nordentoft, Merete; Pejovic-Milovancevic, Milica; Sigurdsson, Engilbert; Silagadze, Teimuraz; Hansen, Christine Søholm; Stefansson, Kari; Stefansson, Hreinn; Steinberg, Stacy; Tosato, Sarah; Werge, Thomas; Collier, David A; Owen, Michael J; O'Donovan, Michael C; Walters, James T R; Collier, David A.; Rujescu, Dan; Kirov, George; Owen, Michael J.; O'Donovan, Michael C. & Walters, James T.R. (2018). Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics.  ISSN 1061-4036.  50(3), s 381- 389 . doi: 10.1038/s41588-018-0059-2
  • Smith, Robert Løvsletten; Haslemo, Tore; Chan, Hilde Fauskrud; Refsum, Helge & Molden, Espen (2018). Clinically Relevant Effect of UGT1A4*3 on Lamotrigine Serum Concentration Is Restricted to Postmenopausal Women—A Study Matching Therapeutic Drug Monitoring and Genotype Data From 534 Patients. Therapeutic Drug Monitoring.  ISSN 0163-4356.  40(5), s 567- 571 . doi: 10.1097/FTD.0000000000000540
  • Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen; Haslemo, Tore; Refsum, Helge; Hartberg, Cecilie Bhandari; Correll, Christoph U. & Høiseth, Gudrun (2018). Age Impacts Olanzapine Exposure Differently During Use of Oral Versus Long-Acting Injectable Formulations: An Observational Study Including 8,288 Patients. Journal of Clinical Psychopharmacology.  ISSN 0271-0749.  38(6), s 570- 576 . doi: 10.1097/JCP.0000000000000961
  • Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication. Journal of Psychiatric Research.  ISSN 0022-3956.  106, s 74- 81 . doi: 10.1016/j.jpsychires.2018.09.014
  • Viktil, Kirsten Kilvik; Lehre, Ina; Ranhoff, Anette Hylen & Molden, Espen (2018). Serum concentrations and elimination rates of direct-acting oral anticoagulants (DOACs) in older hip fracture patients hospitalized for surgery: a pilot study. Drugs & Aging.  ISSN 1170-229X.  36(1), s 65- 71 . doi: 10.1007/s40266-018-0609-4
  • Wollmann, Birgit Malene Tovik; Lunde, Hilde; Støten, Lene; Lunder, Niclas & Molden, Espen (2018). Substantial differences in serum concentrations of psychoactive drugs measured in samples stored for two days or more on standard serum tubes versus serum tubes containing gel separators. Therapeutic Drug Monitoring.  ISSN 0163-4356. . doi: 10.1097/FTD.0000000000000592
  • Wollmann, Birgit Malene Tovik; Syversen, Silje Watterdal; Vistnes, Maria; Lie, Elisabeth; Mehus, Lise Larsen & Molden, Espen (2018). Associations between cytokine levels and CYP3A4 phenotype in patients with rheumatoid arthritis. Drug Metabolism And Disposition.  ISSN 0090-9556.  46(10), s 1384- 1389 . doi: 10.1124/dmd.118.082065
  • Wollmann, Birgit Malene Tovik; Syversen, Silje Watterdal; Lie, Elisabeth; Gjestad, Caroline; Mehus, Lise Larsen; Olsen, Inge Christoffer & Molden, Espen (2017). 4β-hydroxycholesterol level in patients with rheumatoid arthritis before vs. after initiation of bDMARDs and correlation with inflammatory state. Clinical and Translational Science.  ISSN 1752-8054.  10(1), s 42- 49 . doi: 10.1111/cts.12431
  • Gjestad, Caroline; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2017). 4β-Hydroxycholesterol level significantly correlates with steady-state serum concentration of the CYP3A4 substrate quetiapine in psychiatric patients. British Journal of Clinical Pharmacology.  ISSN 0306-5251.  83(11), s 2398- 2405 . doi: 10.1111/bcp.13341
  • Hole, Kristine; Gjestad, Caroline; Heitmann, Kristine; Haslemo, Tore; Molden, Espen & Bremer, Sara (2017). Impact of genetic and nongenetic factors on interindividual variability in 4β-hydroxycholesterol concentration. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  73(3), s 317- 324 . doi: 10.1007/s00228-016-2178-y
  • Hole, Kristine; Størset, Elisabet; Olastuen, Ane; Haslemo, Tore; Kro, Grete Birkeland; Midtvedt, Karsten; Åsberg, Anders & Molden, Espen (2017). Recovery of CYP3A Phenotype after Kidney Transplantation. Drug Metabolism And Disposition.  ISSN 0090-9556.  45(12), s 1260- 1265 . doi: 10.1124/dmd.117.078030
  • Kringen, Marianne K.; Chalabianloo, Fatemeh; Bernard, Jean-Paul Anthony; Bramness, Jørgen Gustav; Molden, Espen & Høiseth, Gudrun (2017). Combined Effect of CYP2B6 Genotype and Other Candidate Genes on a Steady-State Serum Concentration of Methadone in Opioid Maintenance Treatment. Therapeutic Drug Monitoring.  ISSN 0163-4356.  39(5), s 550- 555 . doi: 10.1097/FTD.0000000000000437
  • Smith, Robert Løvsletten; Haslemo, Tore; Andreassen, Ole Andreas; Eliasson, Erik; Dahl, Marja-Liisa; Spigset, Olav & Molden, Espen (2017). Correlation between serum concentrations of N-desmethylclozapine and granulocyte levels in patients with schizophrenia: a retrospective observational study. CNS Drugs.  ISSN 1172-7047.  31(11), s 991- 997 . doi: 10.1007/s40263-017-0469-1
  • Solhaug, Vigdis & Molden, Espen (2017). Individual variability in clinical effect and tolerability of opioid analgesics ? Importance of drug interactions and pharmacogenetics. Scandinavian Journal of Pain.  ISSN 1877-8860.  17, s 193- 200 . doi: 10.1016/j.sjpain.2017.09.009
  • Størset, Elisabet; Hole, Kristine; Midtvedt, Karsten; Bergan, Stein; Molden, Espen & Åsberg, Anders (2017). The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation. British Journal of Clinical Pharmacology.  ISSN 0306-5251.  83(7), s 1457- 1465 . doi: 10.1111/bcp.13248 Fulltekst i vitenarkiv.
  • Svendsen, Torleiv; Brodtkorb, Eylert; Reimers, Arne; Molden, Espen; Sætre, Erik; Johannessen, Svein Ivar & Landmark, Cecilie Johannessen (2017). Pharmacokinetic variability, efficacy and tolerability of eslicarbazepine acetate – A national approach to the evaluation of therapeutic drug monitoring data and clinical outcome. Epilepsy Research.  ISSN 0920-1211.  129, s 125- 131 . doi: 10.1016/j.eplepsyres.2016.12.001
  • Waade, Ragnhild Birkeland; Molden, Espen; Martinsen, Mette; Hermann, Monica & Ranhoff, Anette Hylen (2017). Psychotropics and weak opioid analgesics in plasma samples of older hip fracture patients - detection frequencies and consistency with drug records. British Journal of Clinical Pharmacology.  ISSN 0306-5251.  83(7), s 1397- 1404 . doi: 10.1111/bcp.13244
  • Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Aadal, Marianne & Spigset, Olav (2017). Changes in drug disposition of lithium during pregnancy: A retrospective observational study of patient data from two routine therapeutic drug monitoring services in Norway. BMJ Open.  ISSN 2044-6055.  7(3) . doi: 10.1136/bmjopen-2016-015738 Fulltekst i vitenarkiv.
  • Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Castberg, Ingrid Mehli & Spigset, Olav (2017). Treatment with antipsychotics in pregnancy: changes in drug disposition. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  103(3), s 477- 484 . doi: 10.1002/cpt.770 Fulltekst i vitenarkiv.
  • Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik & Spigset, Olav (2017). Selective serotonin reuptake inhibitors and venlafaxine in pregnancy: Changes in drug disposition. PLoS ONE.  ISSN 1932-6203.  12(7) . doi: 10.1371/journal.pone.0181082 Fulltekst i vitenarkiv.
  • Gjestad, Caroline; Huynh, Duy Khanh; Haslemo, Tore & Molden, Espen (2016). 4β-Hydroxycholesterol correlates with dose but not steady-state concentration of carbamazepine: indication of intestinal CYP3A in biomarker formation?. British Journal of Clinical Pharmacology.  ISSN 0306-5251.  81(2), s 269- 276 . doi: 10.1111/bcp.12833
  • Lea, Marianne; Barstad, Ingeborg; Mathiesen, Liv; Mowe, Morten & Molden, Espen (2016). Effect of teaching and checklist implementation on accuracy of medication history recording at hospital admission. International Journal of Clinical Pharmacy.  ISSN 2210-7703.  38(1), s 20- 24 . doi: 10.1007/s11096-015-0218-9
  • Mannheimer, Buster; Haslemo, Tore; Lindh, Jonatan D.; Eliasson, Erik & Molden, Espen (2016). Risperidone and Venlafaxine Metabolic Ratios Strongly Predict a CYP2D6 Poor Metabolizing Genotype. Therapeutic Drug Monitoring.  ISSN 0163-4356.  38(1), s 127- 134 . doi: 10.1097/FTD.0000000000000251
  • Molden, Espen; Waade, Ragnhild Birkeland; Hoff, Maren & Haslemo, Tore (2016). Impact of Ageing on Serum Concentrations of Risperidone and Its Active Metabolite in Patients with Known CYP2D6 Genotype. Basic & Clinical Pharmacology & Toxicology.  ISSN 1742-7835.  119(5), s 470- 475 . doi: 10.1111/bcpt.12614
  • Smith, Robert Løvsletten; Haslemo, Tore; Refsum, Helge & Molden, Espen (2016). Impact of age, gender and CYP2C9/2C19 genotypes on dose-adjusted steady-state serum concentrations of valproic acid—a large-scale study based on naturalistic therapeutic drug monitoring data. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  72(9), s 1099- 1104 . doi: 10.1007/s00228-016-2087-0
  • Bakken, Gry Vibeke; Molden, Espen & Hermann, Monica (2015). Impact of genetic variability in CYP2D6, CYP3A5, and ABCB1 on serum concentrations of quetiapine and N-desalkylquetiapine in psychiatric patients. Therapeutic Drug Monitoring.  ISSN 0163-4356.  37(2), s 256- 261 . doi: 10.1097/FTD.0000000000000135
  • Hermann, Monica; Waade, Ragnhild Birkeland & Molden, Espen (2015). Therapeutic drug monitoring of selective serotonin reuptake inhibitors in elderly patients. Therapeutic Drug Monitoring.  ISSN 0163-4356.  37(4), s 546- 549 . doi: 10.1097/FTD.0000000000000169
  • Høiseth, Gudrun; Haslemo, Tore; Uthus, Linda Hårstad & Molden, Espen (2015). Effect of CYP2B6*6 on steady-state serum concentrations of bupropion and hydroxybupropion in psychiatric patients: A study based on therapeutic drug monitoring data. Therapeutic Drug Monitoring.  ISSN 0163-4356.  37(5), s 589- 593 . doi: 10.1097/FTD.0000000000000183
  • Hendset, Magnhild; Molden, Espen; Knape, Magnus & Hermann, Monica (2014). Serum concentrations of risperidone and aripiprazole in subgroups encoding CYP2D6 intermediate metabolizer phenotype. Therapeutic Drug Monitoring.  ISSN 0163-4356.  36(1), s 80- 85 . doi: 10.1097/FTD.0000000000000018
  • Kersten, Hege; Wyller, Torgeir Bruun & Molden, Espen (2014). Association between inherited CYP2D6/2C19 phenotypes and anticholinergic measures in elderly patients using anticholinergic drugs. Therapeutic Drug Monitoring.  ISSN 0163-4356.  36(1), s 125- 130 . doi: 10.1097/FTD.0b013e31829da990
  • Robertsen, Ida; Åsberg, Anders; Granseth, Tone; Vethe, Nils Tore; Akhlaghi, Fatemeh; Ghareeb, Mwlod; Molden, Espen; Reier-Nilsen, Morten; Holdaas, Hallvard & Midtvedt, Karsten (2014). More potent lipid-lowering effect by rosuvastatin compared with fluvastatin in everolimus-treated renal transplant recipients. Transplantation.  ISSN 0041-1337.  97(12), s 1266- 1272 . doi: 10.1097/01.TP.0000443225.66960.7e
  • Söderberg, Mao Mao; Molden, Espen & Dahl, Marja-Liisa (2014). No influence of CYP3A43 rs472660G>A on steady-state serum olanzapine concentrations in White psychiatric patients. Pharmacogenetics & Genomics.  ISSN 1744-6872.  24(5), s 272- 275 . doi: 10.1097/FPC.0000000000000041
  • Waade, Ragnhild Birkeland; Hermann, Monica; Moe, Hanne Louise & Molden, Espen (2014). Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  70(8), s 933- 940 . doi: 10.1007/s00228-014-1696-8
  • Watne, Leiv Otto; Hall, Roanna J.; Molden, Espen; Ræder, Johan; Frihagen, Frede Jon; MacLullich, Alasdair M.J.; Juliebø, Vibeke; Nyman, Anna Armika Tussilago; Meagher, David & Wyller, Torgeir Bruun (2014). Anticholinergic activity in cerebrospinal fluid and serum in individuals with hip fracture with and without delirium. Journal of The American Geriatrics Society.  ISSN 0002-8614.  62(1), s 94- 102 . doi: 10.1111/jgs.12612
  • Kersten, Hege; Molden, Espen; Tolo, Inga Kristin; Skovlund, Eva; Engedal, Knut Arne & Wyller, Torgeir Bruun (2013). Cognitive Effects of Reducing Anticholinergic Drug Burden in a Frail Elderly Population: A Randomized Controlled Trial. The journals of gerontology. Series A, Biological sciences and medical sciences.  ISSN 1079-5006.  68(3), s 271- 278 . doi: 10.1093/gerona/gls176
  • Kersten, Hege; Molden, Espen; Willumsen, Tiril; Engedal, Knut Arne & Wyller, Torgeir Bruun (2013). Higher anticholinergic drug scale (ADS) scores are associated with peripheral but not cognitive markers of cholinergic blockade. Cross sectional data from 21 Norwegian nursing homes. British Journal of Clinical Pharmacology.  ISSN 0306-5251.  75(3), s 842- 849 . doi: 10.1111/j.1365-2125.2012.04411.x
  • Lea, Marianne; Rognan, Stine Eidhammer; KORISTOVIC, RADOJKA; Wyller, Torgeir Bruun & Molden, Espen (2013). Severity and Management of Drug-Drug Interactions in Acute Geriatric Patients. Drugs & Aging.  ISSN 1170-229X.  30(9), s 721- 727 . doi: 10.1007/s40266-013-0091-y
  • Söderberg, Mao M.; Haslemo, Tore; Molden, Espen & Dahl, Marja-Liisa (2013). Influence of CYP1A1/CYP1A2 and AHR polymorphisms on systemic olanzapine exposure. Pharmacogenetics & Genomics.  ISSN 1744-6872.  23(5), s 279- 285 . doi: 10.1097/FPC.0b013e3283602876
  • Söderberg, Mao Mao; Haslemo, Tore; Molden, Espen & Dahl, Marja-Liisa (2013). Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients. The Pharmacogenomics Journal.  ISSN 1470-269X.  13(6), s 544- 550 . doi: 10.1038/tpj.2012.47
  • Ulvestad, Maria; Skottheim, Ine Blankenberg; Jakobsen, Gunn Signe; Bremer, Sara; Molden, Espen; Åsberg, Anders; Hjelmesæth, Jøran; Andersson, Tommy B; Sandbu, Rune & Christensen, Hege Staaland (2013). Impact of OATP1B1, MDR1, and CYP3A4 expression in liver and intestine on interpatient pharmacokinetic variability of atorvastatin in obese subjects. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  93(3), s 275- 282 . doi: 10.1038/clpt.2012.261
  • Bakken, Gry Vibeke; Molden, Espen; Knutsen, Karoline; Lunder, Niclas & Hermann, Monica (2012). Metabolism of the Active Metabolite of Quetiapine, N-Desalkylquetiapine In Vitro. Drug Metabolism And Disposition.  ISSN 0090-9556.  40(9), s 1778- 1784 . doi: 10.1124/dmd.112.045237
  • Gedde-Dahl, Ane; Devold, Helene Margrethe & Molden, Espen (2012). Statin medication in patients treated with antiepileptic drugs in Norway. Pharmacoepidemiology and Drug Safety.  ISSN 1053-8569.  21(8), s 881- 885 . doi: 10.1002/pds.3287
  • Haslemo, Tore; Loryan, I; Ueda, N; Mannheimer, B; Bertilsson, L; Ingelman-Sundberg, M; Molden, Espen & Eliasson, E (2012). UGT1A4*3 Encodes Significantly Increased Glucuronidation of Olanzapine in Patients on Maintenance Treatment and in Recombinant Systems. Clinical Pharmacology and Therapeutics.  ISSN 0009-9236.  92(2), s 221- 227 . doi: 10.1038/clpt.2012.46
  • Haslemo, Tore; Olsen, Kristine Marie; Lunde, Hilde & Molden, Espen (2012). Valproic Acid Significantly Lowers Serum Concentrations of Olanzapine-An Interaction Effect Comparable With Smoking. Therapeutic Drug Monitoring.  ISSN 0163-4356.  34(5), s 512- 517 . doi: 10.1097/FTD.0b013e3182693d2a
  • Høiseth, Gudrun; Umair, Majid; Mørland, Jørg; Bramness, Jørgen Gustav & Molden, Espen (2012). CYP2C19 genetics in fatal carisoprodol intoxications. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  68(11), s 1561- 1565 . doi: 10.1007/s00228-012-1278-6
  • Ulvestad, Maria; Darnell, Malin; Molden, Espen; Ellis, Ewa; Åsberg, Anders & Andersson, Tommy B (2012). Evaluation of Organic Anion-Transporting Polypeptide 1B1 and CYP3A4 Activities in Primary Human Hepatocytes and HepaRG Cells Cultured in a Dynamic Three-Dimensional Bioreactor System. Journal of Pharmacology and Experimental Therapeutics.  ISSN 0022-3565.  343(1), s 145- 156 . doi: 10.1124/jpet.112.195750
  • Waade, Ragnhild Birkeland; Molden, Espen; Refsum, Helge & Hermann, Monica (2012). Serum Concentrations of Antidepressants in The Elderly. Therapeutic Drug Monitoring.  ISSN 0163-4356.  34(1), s 25- 30 . doi: 10.1097/FTD.0b013e318241dce0
  • Bakken, Gry Vibeke; Rudberg, Ida; Molden, Espen; Refsum, Helge & Hermann, Monica (2011). Pharmacokinetic Variability of Quetiapine and the Active Metabolite N-desalkylquetiapine in Psychiatric Patients. Therapeutic Drug Monitoring.  ISSN 0163-4356.  33(2), s 222- 226 . doi: 10.1097/FTD.0b013e31821160c4
  • Christensen, Hege Staaland; Hestad, Anette Leirvik; Molden, Espen & Mathiesen, Liv (2011). CYP3A5-mediated metabolism of midazolam in recombinant systems is highly sensitive to NADPH-cytochrome P450 reductase activity. Xenobiotica.  ISSN 0049-8254.  41(1), s 1- 5 . doi: 10.3109/00498254.2010.523734
  • Haslemo, Tore; Refsum, Helge & Molden, Espen (2011). The effect of ethinylestradiol-containing contraceptives on the serum concentration of olanzapine and N-desmethyl olanzapine. British Journal of Clinical Pharmacology.  ISSN 0306-5251.  71(4), s 611- 615 . doi: 10.1111/j.1365-2125.2010.03880.x
  • Jakobsen, Stine Mjåvatn; Kersten, Hege & Molden, Espen (2011). Evaluation of brain anticholinergic activities of urinary spasmolytic drugs using a high-throughput radio receptor bioassay. Journal of The American Geriatrics Society.  ISSN 0002-8614.  59(3), s 501- 505 . doi: 10.1111/j.1532-5415.2010.03307.x
  • Molden, Espen & Spigset, Olav (2011). Interaksjoner mellom metoprolol og antidepressive legemidler. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  131(18), s 1777- 1779 . doi: 10.4045/tidsskr.11.0143
  • Ulvestad, Maria; Björquist, Petter; Molden, Espen; Åsberg, Anders & Andersson, Tommy B (2011). OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture. Biochemical Pharmacology.  ISSN 0006-2952.  82(9), s 1219- 1226 . doi: 10.1016/j.bcp.2011.07.076
  • Hendset, Magnhild; Molden, Espen; Enoksen, Torill Bakko; Refsum, Helge & Hermann, Monica (2010). The Effect of Coadministration of Duloxetine on Steady-State Serum Concentration of Risperidone and Aripiprazole: A Study Based on Therapeutic Drug Monitoring Data. Therapeutic Drug Monitoring.  ISSN 0163-4356.  32(6), s 787- 790 . doi: 10.1097/FTD.0b013e3181fc50d5
  • Molden, Espen; Okkenhaug, Cecilie & Solberg, Erik Ekker (2010). Increased frequency of CYP2C9 variant alleles and homozygous VKORC1*2B carriers in warfarin-treated patients with excessive INR response. European Journal of Clinical Pharmacology.  ISSN 0031-6970.  66(5), s 525- 530 . doi: 10.1007/s00228-010-0813-6

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  • Dyrkorn, Roar; Lundgaard, Halvor; Stokes, Charlotte Lorentze; Molden, Espen & Spigset, Olav (2018). Serumkonsentrasjonsmålinger av DOAK-legemidler. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  138(7), s 620- 621 . doi: 10.4045/tidsskr.18.0237
  • Gjestad, Caroline; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2018). Gjestad et al. reply to 'Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?' by Neuhoff and Tucker. British Journal of Clinical Pharmacology.  ISSN 0306-5251.  84(7), s 1624- 1625 . doi: 10.1111/bcp.13606
  • Ihle-Hansen, Håkon; Hagberg, Guri; Molden, Espen & Myrstad, Marius (2018). Hvem bør få klopidogrel etter hjerneslag?. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  138(9) . doi: 10.4045/tidsskr.18.0277
  • Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Laskemoen, Jannicke F.; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders?. Journal of Psychiatric Research.  ISSN 0022-3956. . doi: 10.1016/j.jpsychires.2018.11.012
  • Lea, Marianne; Mathiesen, Liv; Mowe, Morten & Molden, Espen (2017). Baseline characteristics of multimorbid patients included in an RCT.
  • Romskaug, Rita; Molden, Espen; Straand, Jørund; Kersten, Hege; Skovlund, Eva; Pitkala, Kaisu H & Wyller, Torgeir Bruun (2017). Cooperation between geriatricians and general practitioners for improved pharmacotherapy in home-dwelling elderly people receiving polypharmacy - the COOP Study: Study protocol for a cluster randomised controlled trial. Trials.  ISSN 1745-6215.  18(1) . doi: 10.1186/s13063-017-1900-0 Fulltekst i vitenarkiv.
  • Solberg, Dag; Refsum, Helge & Molden, Espen (2017). Hvis du skal gjøre det, gjør det riktig!. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(12/13), s 854- 854 . doi: 10.4045/tidsskr.17.0441
  • Størset, Elisabet; Hole, Kristine; Midtvedt, Karsten; Bergan, Stein; Molden, Espen & Åsberg, Anders (2017). Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance. British Journal of Clinical Pharmacology.  ISSN 0306-5251.  83(6), s 1350- 1352 . doi: 10.1111/bcp.13188
  • Størset, Elisabet; Hole, Kristine; Midtvedt, Karsten; Bergan, Stein; Molden, Espen & Åsberg, Anders (2017). Response to: ‘Response to: Bodyweightadjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance’. British Journal of Clinical Pharmacology.  ISSN 0306-5251.  83(6), s 1357- 1358 . doi: 10.1111/bcp.13276
  • Lea, Marianne; Engnes, Anette; Mathiesen, Liv; Mowe, Morten & Molden, Espen (2016). Drug-related problems at hospital admission in multimorbid internal medical patients.
  • Lundgaard, Halvor; Dyrkorn, Roar; Stokes, Charlotte Lorentze; Molden, Espen & Spigset, Olav (2016). Tryggere behandling med serumkonsentrasjonsmåling av de nye antikoagulasjonsmidlene?. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  136(18), s 1556- 1560 . doi: 10.4045/tidsskr.16.0255
  • Solhaug, Vigdis & Molden, Espen (2016). Genetisk betinget variasjon i bioaktivering av tamoksifen og klopidogrel :. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  136(5), s 434- 436 . doi: 10.4045/tidsskr.15.0555
  • Waade, Ragnhild Birkeland; Hermann, Monica; Ranhoff, Anette Hylen; Martinsen, Mette & Molden, Espen (2015). Therapeutic drug monitoring of psychotropic drugs and mild opioid analgesics in elderly hip fracture patients at hospital admission.
  • Waade, Ragnhild Birkeland; Ranhoff, Anette Hylen; Hermann, Monica; Martinsen, Mette & Molden, Espen (2015). Screening of psychotropic drugs and mild opioid analgesics in older hip fracture patients at hospital admission.
  • Halbostad, Terje; Molden, Espen & Hagen, Håvard (2014). Implementering av et strukturert kvalitetssikringsverktøy for identifisering og håndtering av legemiddelrelaterte problemer ved geriatrisk sengepost.
  • Hendset, Magnhild; Hermann, Monica; Moe, Hanne L & Molden, Espen (2014). Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups.
  • Landmark, Cecilie Johannessen; Svendsen, Torleiv; Reimers, Arne; Brodtkorb, Eylert; Sætre, Erik; Molden, Espen & Johannessen, Svein Ivar (2014). Experience of therapeutic drug monitoring of eslicarbazepine acetate in clinical practice in Norway.
  • Landmark, Cecilie Johannessen; Svendsen, Torleiv; Reimers, Arne; Brodtkorb, Eylert; Sætre, Erik; Molden, Espen & Johannessen, Svein Ivar (2014). Klinisk erfaring med terapeutisk legeiddelmonitorering for eslicarbazepin acetat i Norge.
  • Bakken, Gry Vibeke; Hermann, Monica; Molden, Espen & Refsum, Helge (2013). Pharmacokinetic variabilityof quatiapine and the active metabolite N-desalkylquatiapine.
  • Efjestad, Anne; Molden, Espen & Øksengård, Anne Rita (2013). Pharmacist- initiated management of antagonistic interactions between anticholinergic drugs and acetyl cholinesterase inhibitors in individuals with dementia. Journal of The American Geriatrics Society.  ISSN 0002-8614.  61(9), s 1624- 1625
  • Grundvåg, Maris; Molden, Espen & Lundereng, Kristine (2013). LegemiddelRelaterte Problemer hos eldre pasienter innlagt på ortopedisk avdeling grunnet fallhendelser.
  • Grundvåg, Maris; Molden, Espen; Lundereng, Kristine & Strugstad, Elisabeth (2013). Legemiddelrelaterte problemer hos eldre pasienter på ortopedisk avdeling grunnet fallhendelser.
  • Lundereng, Kristine; Sund, Janne Kutschera; Sporsem, Hilde Margrete; Pedersen, R. & Molden, Espen (2013). Frequency and Management of Drug Realted Problems in an Intensive Care Unit.
  • Lundereng, Kristine; Sund, Janne Kutschera; Sporsem, Hilde Margrete; Pedersen, R. & Molden, Espen (2013). Frequency and Management of Drug Realted Problems in an Intensive Care Unit.
  • Lundereng, Kristine; Sund, Janne Kutschera; Sporsem, Hilde Margrete; Pedersen, R. & Molden, Espen (2013). Prevalence and management of drug related problems at an intensive care unit. International Journal of Clinical Pharmacology Research.  ISSN 0251-1649.  35(5), s 927- 927
  • Waade, Ragnhild Birkeland; Moe, Hanne Louise; Hermann, Monica & Molden, Espen (2013). Aldersbetinget variasjon i serumkonsentrasjon av venlafaksin og escitalopram i relasjon til CYP-genotype.
  • Haslemo, Tore; Refsum, Helge & Molden, Espen (2012). Pharmacokinetic Variability of Olanzapine – A Study Based on Therapeutic Drug Monitoring Data. Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo.. 1227.
  • Hotvedt, Tor Arne; Fleischer, Phillip; Molden, Espen; Åsberg, Anders & Christensen, Hege Staaland (2012). Cytokiners effekt på CYP3A4-mediert metabolisme av midazolam i THLE-celler.
  • Kersten, Hege; Bruun Wyller, Torgeir & Molden, Espen (2012). Elevated serum anticholinergic activity in CYP 2D6 poor metabolizers.
  • Lundereng, Kristine; Sund, Janne Kutschera; Sporsem, Hilde Margrete & Molden, Espen (2012). Legemiddelrelaterte problem på intensivavdeling.
  • Lundereng, Kristine; Sund, Janne Kutschera; Sporsem, Hilde Margrete; Pedersen, R. & Molden, Espen (2012). Frequency and Management of Drug Related Problems in an Intensive Care Unit.
  • Nyman, Anna Armika Tussilago; Barsett, Hilde & Molden, Espen (2012). Antikolinerg aktivitet i lupinbønner og antikolinerg belastning i hoftebruddspasienter.
  • Waade, Ragnhild Birkeland; Hermann, Monica & Molden, Espen (2011). Serum concentrations of antidepressants in the elderly.
  • Gedde-Dahl, Ane & Molden, Espen (2010). APRIORI - et interaksjonsverktøy tilpasset apotek.
  • Gedde-Dahl, Ane & Molden, Espen (2010). Forskrivning av statiner ved samtidig bruk av enzyminduserende antiepileptika. Vis sammendrag
  • Lynum, Berit; Barsett, Hilde & Molden, Espen (2010). Antikolinerg aktivitet i utvalgte naturpreparater og næringsmidler.

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Publisert 3. nov. 2010 15:41 - Sist endret 26. apr. 2019 10:28

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