Espen Molden

Professor II - Farmasøytisk institutt
Bilde av Espen Molden
English version of this page
Telefon +47 22856561
Rom 484 B
Brukernavn
Besøksadresse Sem Sælands vei 3 Farmasibygningen 0371 Oslo
Postadresse Postboks 1068 Blindern 0316 Oslo

Faglige interesser

Primær faglig interesse er årsaker til individuell variabilitet i effekt og bivirkninger av legemidler, inkludert implementering av kunnskap innen dette området for å bedre legemiddelbehandling i klinisk praksis.

Undervisning

Underviser på det erfaringsbaserte masterprogrammet i klinisk farmasi.

Bakgrunn

Utdannet Cand.pharm. fra UiO i 1997, Dr.scient. samme sted i 2003. I dag ansatt i 20 % stilling som professor II ved Farmasøytisk institutt, UiO. Hovedstillingen er Forskningsleder ved Senter for Psykofarmakologi, Diakonhjemmet sykehus.

Priser

Årets farmasøyt, Norsk Farmaceutisk Forening, 2006

Samarbeid

Samarbeidspartnere innen aktuelle forskningsprosjekter:

Professor Torgeir Bruun Wyller, Oslo Universitetssykehus, Avdeling Ullevål

Professor Anette Hylen Ranhoff, Diakonhjemmet sykehus

Professor Tommy B. Andersson, Astra Zeneca, Mölndal, Sverige

Professor Erik Eliasson, Karolinska institutet, Stockholm, Sverige

Emneord: Farmakologi, Farmakokinetikk, Farmakogenetikk, Legemiddelinteraksjoner, Cytokrom P450, Klinisk farmasi

Publikasjoner

  • Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Kyllesø, Lennart; Tran, Thu Thuy Anh; Tveito, Marit & Molden, Espen (2022). Effect of Valproic Acid on the Metabolic Spectrum of Clozapine in Patients With Schizophrenia. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 42(1), s. 43–50. doi: 10.1097/JCP.0000000000001507.
  • Schoretsanitis, Georgios; Smith, Robert Løvsletten; Molden, Espen; Solismaa, Anssi; Seppälä, Niko & Kopeček, Miloslav [Vis alle 13 forfattere av denne artikkelen] (2021). European Whites May Need Lower Minimum Therapeutic Clozapine Doses Than Those Customarily Proposed. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 41(2), s. 140–147. doi: 10.1097/JCP.0000000000001341.
  • Riede, Julia; Wollmann, Birgit Malene Tovik; Molden, Espen & Ingelman-Sundberg, Magnus (2021). Primary human hepatocyte spheroids as an in vitro tool for investigating drug compounds with low hepatic clearances. Drug Metabolism And Disposition. ISSN 0090-9556. 49(7), s. 501–508. doi: 10.1124/dmd.120.000340.
  • Molden, Espen (2021). Therapeutic drug monitoring of clozapine in adults with schizophrenia: a review of challenges and strategies. Expert Opinion on Drug Metabolism & Toxicology. ISSN 1742-5255. doi: 10.1080/17425255.2021.1974400.
  • Jukic, Marin M.; Smith, Robert Løvsletten; Molden, Espen & Ingelman-Sundberg, Magnus (2021). Evaluation of the CYP2D6 Haplotype Activity Scores Based on Metabolic Ratios of 4,700 Patients Treated With Three Different CYP2D6 Substrates. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 110(3), s. 750–758. doi: 10.1002/cpt.2246.
  • Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole A. & Molden, Espen (2021). Absolute and Dose-Adjusted Serum Concentrations of Clozapine in Patients Switching vs. Maintaining Treatment: An Observational Study of 1979 Patients. CNS Drugs. ISSN 1172-7047. 35, s. 999–1008. doi: 10.1007/s40263-021-00847-4. Fulltekst i vitenarkiv
  • Bråten, Line Skute; Haslemo, Tore; Jukić, Marin M.; Ivanov, Maxim; Ingelman-Sundberg, Magnus & Molden, Espen [Vis alle 7 forfattere av denne artikkelen] (2021). A Novel CYP2C-Haplotype Associated With Ultrarapid Metabolism of Escitalopram. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 110(3), s. 786–793. doi: 10.1002/cpt.2233.
  • Hole, Kristine; Arnestad, Marianne; Molden, Espen & Haslemo, Tore (2021). Dose-Dependent Inhibition of CYP2D6 by Bupropion in Patients with Depression. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 41(3), s. 281–285. doi: 10.1097/JCP.0000000000001387.
  • Molden, Espen & Jukić, Marin M. (2021). CYP2D6 Reduced Function Variants and Genotype/Phenotype Translations of CYP2D6 Intermediate Metabolizers: Implications for Personalized Drug Dosing in Psychiatry. Frontiers in Pharmacology. ISSN 1663-9812. 12. doi: 10.3389/fphar.2021.650750.
  • Cheng, Weiqiu; Frei, Oleksandr; van der Meer, Dennis; Wang, Yunpeng; O`Connell, Kevin & Chu, Yunhan [Vis alle 20 forfattere av denne artikkelen] (2021). Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness. JAMA psychiatry. ISSN 2168-6238. 78(9), s. 1020–1030. doi: 10.1001/jamapsychiatry.2021.1435. Fulltekst i vitenarkiv
  • Frederiksen, Trine; Smith, Robert L.; Wollmann, Birgit Malene Tovik; Areberg, Johan & Molden, Espen (2021). Validation of a Population Pharmacokinetic Model of Vortioxetine Using Therapeutic Drug Monitoring Data. Clinical Pharmacokinetics. ISSN 0312-5963. doi: 10.1007/s40262-021-01029-7.
  • Jukic, Marin M.; Smith, Robert Løvsletten; Haslemo, Tore; Molden, Espen & Ingelman-Sundberg, Magnus (2021). Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study. The Lancet Psychiatry. ISSN 2215-0374. 6(5), s. 418–426. doi: 10.1016/S2215-0366%2819%2930088-4.
  • Tveito, Marit; Høiseth, Gudrun; Haslemo, Tore; Molden, Espen & Smith, Robert Løvsletten (2021). Impact of age and gender on paliperidone exposure in patients after administration of long-acting injectable formulations—an observational study using blood samples from 1223 patients. European Journal of Clinical Pharmacology. ISSN 0031-6970. 77(9), s. 1201–1208. doi: 10.1007/s00228-021-03114-z.
  • Thorén, Linda; Lindh, Jonatan D.; Ackehed, Gerd; Kringen, Marianne K.; Hall, Per & Bergh, Jonas [Vis alle 9 forfattere av denne artikkelen] (2020). Impairment of endoxifen formation in tamoxifen‐treated premenopausal breast cancer patients carrying reduced‐function CYP2D6 alleles. British Journal of Clinical Pharmacology. ISSN 0306-5251. doi: 10.1111/bcp.14500.
  • Anstensrud, Anne Kristine; Molden, Espen; Haug, Hans Jørgen; Qazi, Rehman Ul-Haq; Muriq, Hysen & Fosshaug, Linn Elisabeth Lillerud [Vis alle 8 forfattere av denne artikkelen] (2020). Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study. European Journal of Clinical Pharmacology. ISSN 0031-6970. 76, s. 673–683. doi: 10.1007/s00228-020-02832-0. Fulltekst i vitenarkiv
  • Lea, Marianne; Mowe, Morten; Molden, Espen; Kvernrød, Kristin; Skovlund, Eva & Mathiesen, Liv (2020). Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial. BMJ Open. ISSN 2044-6055. 10. doi: 10.1136/bmjopen-2020-041558. Fulltekst i vitenarkiv
  • Milosavljević, Filip; Bukvić, Nikola; Pavlović, Zorana; Miljević, Čedo; Pešić, Vesna & Molden, Espen [Vis alle 9 forfattere av denne artikkelen] (2020). Association of CYP2C19 and CYP2D6 Poor and Intermediate Metabolizer Status with Antidepressant and Antipsychotic Exposure: A Systematic Review and Meta-analysis. JAMA psychiatry. ISSN 2168-6238. doi: 10.1001/jamapsychiatry.2020.3643.
  • Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jucik, Marin M.; Ingelman-Sundberg, Magnus & Andreassen, Ole Andreas [Vis alle 7 forfattere av denne artikkelen] (2020). Rates of complete nonadherence among atypical antipsychotic drugs: A study using blood samples from 13,217 outpatients with psychotic disorders. Schizophrenia Research. ISSN 0920-9964. 228, s. 590–596. doi: 10.1016/j.schres.2020.11.025.
  • Smith, Robert Løvsletten; O`Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K. & Andreassen, Ole Andreas [Vis alle 7 forfattere av denne artikkelen] (2020). Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits. Translational Psychiatry. ISSN 2158-3188. 10(1), s. 1–10. doi: 10.1038/s41398-020-00888-1. Fulltekst i vitenarkiv
  • Kringen, Marianne K.; Bråten, Line Skute; Haslemo, Tore & Molden, Espen (2020). The Influence of Combined CYP2D6 and CYP2C19 Genotypes on Venlafaxine and O -Desmethylvenlafaxine Concentrations in a Large Patient Cohort. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 40(2), s. 137–144. doi: 10.1097/JCP.0000000000001174.
  • Lao, Yvonne Elisabeth; Molden, Espen; Kringen, Marianne K.; Annexstad, Ellen Johanne; Sæverud, Håvard Andreassen & Jacobsen, Dag [Vis alle 7 forfattere av denne artikkelen] (2020). Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 127(1), s. 47–51. doi: 10.1111/bcpt.13389. Fulltekst i vitenarkiv
  • Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen & Høiseth, Gudrun (2020). Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients. European Journal of Clinical Pharmacology. ISSN 0031-6970. 77, s. 215–221. doi: 10.1007/s00228-020-03002-y. Fulltekst i vitenarkiv
  • Romskaug, Rita; Wyller, Torgeir Bruun; Straand, Jørund; Kersten, Hege & Molden, Espen (2020). Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy. Drugs & Aging. ISSN 1170-229X. 37(6), s. 425–433. doi: 10.1007/s40266-020-00763-0. Fulltekst i vitenarkiv
  • Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole Andreas & Molden, Espen (2020). Undetectable or subtherapeutic serum levels of antipsychotic drugs preceding switch to clozapine. Nature NPJ Schizophrenia. ISSN 2334-265X. 6. doi: 10.1038/s41537-020-0107-7. Fulltekst i vitenarkiv
  • Tveit, Kristine; Hermann, Monica; Waade, Ragnhild Birkeland; Nilsen, Roy Miodini; Wallerstedt, Susanna M. & Molden, Espen (2020). Use of Antidepressants in Older People during a 10-Year Period: An Observational Study on Prescribed Doses and Serum Levels. Drugs & Aging. ISSN 1170-229X. 37, s. 691–701. doi: 10.1007/s40266-020-00784-9. Fulltekst i vitenarkiv
  • Smith, Robert Løvsletten; Tveito, Marit; Kyllesø, Lennart; Jukic, Marin M.; Ingelman-Sundberg, Magnus & Andreassen, Ole A [Vis alle 7 forfattere av denne artikkelen] (2020). Impact of antipsychotic polypharmacy on nonadherence of oral antipsychotic drugs – A study based on blood sample analyses from 24,239 patients. European Neuropsychopharmacology. ISSN 0924-977X. 37, s. 64–69. doi: 10.1016/j.euroneuro.2020.06.007.
  • Tveito, Marit; Molden, Espen; Høiseth, Gudrun; Correll, Christoph U. & Smith, Robert Løvsletten (2019). Impact of age and CYP2D6 genetics on exposure of aripiprazole and dehydroaripiprazole in patients using long-acting injectable versus oral formulation: relevance of poor and intermediate metabolizer status. European Journal of Clinical Pharmacology. ISSN 0031-6970. 76, s. 41–49. doi: 10.1007/s00228-019-02768-0.
  • Bråten, Line Skute; Haslemo, Tore; Jukic, Marin M.; Ingelman-Sundberg, Magnus; Molden, Espen & Kringen, Marianne K. (2019). Impact of CYP2C19 genotype on sertraline exposure in 1200 Scandinavian patients. Neuropsychopharmacology. ISSN 0893-133X. 45, s. 570–576. doi: 10.1038/s41386-019-0554-x.
  • Tveito, Marit; Smith, Robert Løvsletten; Høiseth, Gudrun & Molden, Espen (2019). The Effect of Valproic Acid on Olanzapine Serum Concentration: A Study Including 2791 Patients Treated With Olanzapine Tablets or Long-Acting Injections. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 39(6), s. 561–566. doi: 10.1097/JCP.0000000000001126.
  • Romskaug, Rita; Skovlund, Eva; Straand, Jørund; Molden, Espen; Kersten, Hege & Pitkala, Kaisu H [Vis alle 8 forfattere av denne artikkelen] (2019). Effect of clinical geriatric assessments and collaborative medication reviews by geriatrician and family physician for improving health-related quality of life in home-dwelling older patients receiving polypharmacy: a cluster randomized clinical trial. JAMA Internal Medicine. ISSN 2168-6106. doi: 10.1001/jamainternmed.2019.5096. Fulltekst i vitenarkiv
  • Smith, Robert Løvsletten; Kyllesø, Lennart; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2019). Reduction in N-desmethylclozapine level is determined by daily dose but not serum concentration of valproic acid-indications of a presystemic interaction mechanism. Therapeutic Drug Monitoring. ISSN 0163-4356. 41(4), s. 503–508. doi: 10.1097/FTD.0000000000000619.
  • Lea, Marianne; Mowe, Morten; Mathiesen, Liv; Kvernrød, Kristin; Skovlund, Eva & Molden, Espen (2019). Prevalence and risk factors of drug-related hospitalizations in multimorbid patients admitted to an internal medicine ward. PLOS ONE. ISSN 1932-6203. 14(7). doi: 10.1371/journal.pone.0220071. Fulltekst i vitenarkiv
  • Gjestad, Caroline; Hole, Kristine; Haslemo, Tore; Diczfalusy, Ulf & Molden, Espen (2019). Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite 4β-Hydroxycholesterol—an Interaction Study in Healthy Volunteers. AAPS Journal. ISSN 1550-7416. 21(58). doi: 10.1208/s12248-019-0330-1.
  • Jukic, Marin M.; Smith, Robert Løvsletten; Haslemo, Tore; Molden, Espen & Ingelman-Sundberg, Magnus (2019). Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study. The Lancet Psychiatry. ISSN 2215-0374. 6(5), s. 418–426. doi: 10.1016/S2215-0366%2819%2930088-4.
  • Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Vis alle 11 forfattere av denne artikkelen] (2019). Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI. Psychoneuroendocrinology. ISSN 0306-4530. 103, s. 87–95. doi: 10.1016/j.psyneuen.2019.01.001. Fulltekst i vitenarkiv
  • Wollmann, Birgit Malene Tovik; Lunde, Hilde; Støten, Lene; Lunder, Niclas & Molden, Espen (2019). Substantial Differences in Serum Concentrations of Psychoactive Drugs Measured in Samples Stored for 2 Days or More on Standard Serum Tubes Versus Serum Tubes Containing Gel Separators. Therapeutic Drug Monitoring. ISSN 0163-4356. 41(3), s. 396–400. doi: 10.1097/FTD.0000000000000592.
  • Smith, Robert Løvsletten; Haslemo, Tore; Chan, Hilde Fauskrud; Refsum, Helge & Molden, Espen (2018). Clinically Relevant Effect of UGT1A4*3 on Lamotrigine Serum Concentration Is Restricted to Postmenopausal Women—A Study Matching Therapeutic Drug Monitoring and Genotype Data From 534 Patients. Therapeutic Drug Monitoring. ISSN 0163-4356. 40(5), s. 567–571. doi: 10.1097/FTD.0000000000000540.
  • Haslemo, Tore; Eliasson, Erik; Jukic, Marin M.; Ingelman-Sundberg, Magnus & Molden, Espen (2018). Significantly lower CYP2D6 metabolism measured as the O/N-desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients. British Journal of Clinical Pharmacology. ISSN 0306-5251. doi: 10.1111/bcp.13788.
  • Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Anderssen, Jannicke Fjæra [Vis alle 11 forfattere av denne artikkelen] (2018). Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication. Journal of Psychiatric Research. ISSN 0022-3956. 106, s. 74–81. doi: 10.1016/j.jpsychires.2018.09.014.
  • Viktil, Kirsten Kilvik; Lehre, Ina; Ranhoff, Anette Hylen & Molden, Espen (2018). Serum concentrations and elimination rates of direct-acting oral anticoagulants (DOACs) in older hip fracture patients hospitalized for surgery: a pilot study. Drugs & Aging. ISSN 1170-229X. 36(1), s. 65–71. doi: 10.1007/s40266-018-0609-4.
  • Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen; Haslemo, Tore; Refsum, Helge & Hartberg, Cecilie Bhandari [Vis alle 8 forfattere av denne artikkelen] (2018). Age Impacts Olanzapine Exposure Differently During Use of Oral Versus Long-Acting Injectable Formulations: An Observational Study Including 8,288 Patients. Journal of Clinical Psychopharmacology. ISSN 0271-0749. 38(6), s. 570–576. doi: 10.1097/JCP.0000000000000961.
  • Jukic, Marin M.; Haslemo, Tore; Molden, Espen & Ingelman-Sundberg, Magnus (2018). Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients. American Journal of Psychiatry. ISSN 0002-953X. 175(5), s. 463–470. doi: 10.1176/appi.ajp.2017.17050550.
  • Wollmann, Birgit Malene Tovik; Syversen, Silje Watterdal; Vistnes, Maria; Lie, Elisabeth; Mehus, Lise Larsen & Molden, Espen (2018). Associations between cytokine levels and CYP3A4 phenotype in patients with rheumatoid arthritis. Drug Metabolism And Disposition. ISSN 0090-9556. 46(10), s. 1384–1389. doi: 10.1124/dmd.118.082065.
  • Hole, Kristine; Wollmann, Birgit Malene Tovik; Nguyen, Camilla; Haslemo, Tore & Molden, Espen (2018). Comparison of CYP3A4-Inducing Capacity of Enzyme-Inducing Antiepileptic Drugs Using 4β-Hydroxycholesterol as Biomarker. Therapeutic Drug Monitoring. ISSN 0163-4356. 40(4), s. 463–468. doi: 10.1097/FTD.0000000000000518.
  • Hole, Kristine; Heiberg, Petra Lybæk; Gjestad, Caroline; Mehus, Lise Larsen; Rø, Øyvind & Molden, Espen (2018). Elevated 4β‐hydroxycholesterol/cholesterol ratio in anorexianervosa patients. Pharmacology Research & Perspectives. ISSN 2052-1707. 6(5), s. 1–5. doi: 10.1002/prp2.430. Fulltekst i vitenarkiv
  • Pardiñas, Antonio F.; Holmans, Peter; Pocklington, Andrew J.; Escott-Price, Valentina; Ripke, Stephan & Carrera, Noa [Vis alle 73 forfattere av denne artikkelen] (2018). Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics. ISSN 1061-4036. 50(3), s. 381–389. doi: 10.1038/s41588-018-0059-2.
  • Baftiu, Arton; Feet, Silje Andrea; Larsson, Pål Gunnar; Burns, Margrete Larsen; Henning, Oliver Johannes & Sætre, Erik [Vis alle 10 forfattere av denne artikkelen] (2018). Utilisation and polypharmacy aspects of antiepileptic drugs in elderly versus younger patients with epilepsy: A pharmacoepidemiological study of CNS-active drugs in Norway, 2004-2015. Epilepsy Research. ISSN 0920-1211. 139, s. 35–42. doi: 10.1016/j.eplepsyres.2017.11.001.
  • Iversen, Trude Seselie Jahr; Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Mørch, Ragni Helene & Gardsjord, Erlend Strand [Vis alle 11 forfattere av denne artikkelen] (2018). Side effect burden of antipsychotic drugs in real life - Impact of gender and polypharmacy. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 82, s. 263–271. doi: 10.1016/j.pnpbp.2017.11.004.
  • Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Castberg, Ingrid Mehli & Spigset, Olav (2017). Treatment with antipsychotics in pregnancy: changes in drug disposition. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 103(3), s. 477–484. doi: 10.1002/cpt.770. Fulltekst i vitenarkiv
  • Smith, Robert Løvsletten; Haslemo, Tore; Andreassen, Ole Andreas; Eliasson, Erik; Dahl, Marja-Liisa & Spigset, Olav [Vis alle 7 forfattere av denne artikkelen] (2017). Correlation between serum concentrations of N-desmethylclozapine and granulocyte levels in patients with schizophrenia: a retrospective observational study. CNS Drugs. ISSN 1172-7047. 31(11), s. 991–997. doi: 10.1007/s40263-017-0469-1.
  • Kringen, Marianne K.; Chalabianloo, Fatemeh; Bernard, Jean-Paul Anthony; Bramness, Jørgen Gustav; Molden, Espen & Høiseth, Gudrun (2017). Combined Effect of CYP2B6 Genotype and Other Candidate Genes on a Steady-State Serum Concentration of Methadone in Opioid Maintenance Treatment. Therapeutic Drug Monitoring. ISSN 0163-4356. 39(5), s. 550–555. doi: 10.1097/FTD.0000000000000437.
  • Solhaug, Vigdis & Molden, Espen (2017). Individual variability in clinical effect and tolerability of opioid analgesics ? Importance of drug interactions and pharmacogenetics. Scandinavian Journal of Pain. ISSN 1877-8860. 17, s. 193–200. doi: 10.1016/j.sjpain.2017.09.009.
  • Gjestad, Caroline; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2017). 4β-Hydroxycholesterol level significantly correlates with steady-state serum concentration of the CYP3A4 substrate quetiapine in psychiatric patients. British Journal of Clinical Pharmacology. ISSN 0306-5251. 83(11), s. 2398–2405. doi: 10.1111/bcp.13341.
  • Hole, Kristine; Størset, Elisabet; Olastuen, Ane; Haslemo, Tore; Kro, Grete Birkeland & Midtvedt, Karsten [Vis alle 8 forfattere av denne artikkelen] (2017). Recovery of CYP3A Phenotype after Kidney Transplantation. Drug Metabolism And Disposition. ISSN 0090-9556. 45(12), s. 1260–1265. doi: 10.1124/dmd.117.078030.
  • Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik & Spigset, Olav (2017). Selective serotonin reuptake inhibitors and venlafaxine in pregnancy: Changes in drug disposition. PLOS ONE. ISSN 1932-6203. 12(7). doi: 10.1371/journal.pone.0181082. Fulltekst i vitenarkiv
  • Waade, Ragnhild Birkeland; Molden, Espen; Martinsen, Mette; Hermann, Monica & Ranhoff, Anette Hylen (2017). Psychotropics and weak opioid analgesics in plasma samples of older hip fracture patients - detection frequencies and consistency with drug records. British Journal of Clinical Pharmacology. ISSN 0306-5251. 83(7), s. 1397–1404. doi: 10.1111/bcp.13244.
  • Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Aadal, Marianne & Spigset, Olav (2017). Changes in drug disposition of lithium during pregnancy: A retrospective observational study of patient data from two routine therapeutic drug monitoring services in Norway. BMJ Open. ISSN 2044-6055. 7(3). doi: 10.1136/bmjopen-2016-015738. Fulltekst i vitenarkiv
  • Størset, Elisabet; Hole, Kristine; Midtvedt, Karsten; Bergan, Stein; Molden, Espen & Åsberg, Anders (2017). The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation. British Journal of Clinical Pharmacology. ISSN 0306-5251. 83(7), s. 1457–1465. doi: 10.1111/bcp.13248. Fulltekst i vitenarkiv
  • Wollmann, Birgit Malene Tovik; Syversen, Silje Watterdal; Lie, Elisabeth; Gjestad, Caroline; Mehus, Lise Larsen & Olsen, Inge Christoffer [Vis alle 7 forfattere av denne artikkelen] (2017). 4β-hydroxycholesterol level in patients with rheumatoid arthritis before vs. after initiation of bDMARDs and correlation with inflammatory state. Clinical and Translational Science (CTS). ISSN 1752-8054. 10(1), s. 42–49. doi: 10.1111/cts.12431.
  • Hole, Kristine; Gjestad, Caroline; Heitmann, Kristine; Haslemo, Tore; Molden, Espen & Bremer, Sara (2017). Impact of genetic and nongenetic factors on interindividual variability in 4β-hydroxycholesterol concentration. European Journal of Clinical Pharmacology. ISSN 0031-6970. 73(3), s. 317–324. doi: 10.1007/s00228-016-2178-y.
  • Svendsen, Torleiv; Brodtkorb, Eylert; Reimers, Arne; Molden, Espen; Sætre, Erik & Johannessen, Svein Ivar [Vis alle 7 forfattere av denne artikkelen] (2017). Pharmacokinetic variability, efficacy and tolerability of eslicarbazepine acetate – A national approach to the evaluation of therapeutic drug monitoring data and clinical outcome. Epilepsy Research. ISSN 0920-1211. 129, s. 125–131. doi: 10.1016/j.eplepsyres.2016.12.001.
  • Molden, Espen; Waade, Ragnhild Birkeland; Hoff, Maren & Haslemo, Tore (2016). Impact of Ageing on Serum Concentrations of Risperidone and Its Active Metabolite in Patients with Known CYP2D6 Genotype. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 119(5), s. 470–475. doi: 10.1111/bcpt.12614.
  • Smith, Robert Løvsletten; Haslemo, Tore; Refsum, Helge & Molden, Espen (2016). Impact of age, gender and CYP2C9/2C19 genotypes on dose-adjusted steady-state serum concentrations of valproic acid—a large-scale study based on naturalistic therapeutic drug monitoring data. European Journal of Clinical Pharmacology. ISSN 0031-6970. 72(9), s. 1099–1104. doi: 10.1007/s00228-016-2087-0.
  • Mannheimer, Buster; Haslemo, Tore; Lindh, Jonatan D.; Eliasson, Erik & Molden, Espen (2016). Risperidone and Venlafaxine Metabolic Ratios Strongly Predict a CYP2D6 Poor Metabolizing Genotype. Therapeutic Drug Monitoring. ISSN 0163-4356. 38(1), s. 127–134. doi: 10.1097/FTD.0000000000000251.
  • Gjestad, Caroline; Huynh, Duy Khanh; Haslemo, Tore & Molden, Espen (2016). 4β-Hydroxycholesterol correlates with dose but not steady-state concentration of carbamazepine: indication of intestinal CYP3A in biomarker formation? British Journal of Clinical Pharmacology. ISSN 0306-5251. 81(2), s. 269–276. doi: 10.1111/bcp.12833.
  • Lea, Marianne; Barstad, Ingeborg; Mathiesen, Liv; Mowe, Morten & Molden, Espen (2016). Effect of teaching and checklist implementation on accuracy of medication history recording at hospital admission. International Journal of Clinical Pharmacy. ISSN 2210-7703. 38(1), s. 20–24. doi: 10.1007/s11096-015-0218-9.
  • Høiseth, Gudrun; Haslemo, Tore; Uthus, Linda Hårstad & Molden, Espen (2015). Effect of CYP2B6*6 on steady-state serum concentrations of bupropion and hydroxybupropion in psychiatric patients: A study based on therapeutic drug monitoring data. Therapeutic Drug Monitoring. ISSN 0163-4356. 37(5), s. 589–593. doi: 10.1097/FTD.0000000000000183.
  • Hermann, Monica; Waade, Ragnhild Birkeland & Molden, Espen (2015). Therapeutic drug monitoring of selective serotonin reuptake inhibitors in elderly patients. Therapeutic Drug Monitoring. ISSN 0163-4356. 37(4), s. 546–549. doi: 10.1097/FTD.0000000000000169.
  • Bakken, Gry Vibeke; Molden, Espen & Hermann, Monica (2015). Impact of genetic variability in CYP2D6, CYP3A5, and ABCB1 on serum concentrations of quetiapine and N-desalkylquetiapine in psychiatric patients. Therapeutic Drug Monitoring. ISSN 0163-4356. 37(2), s. 256–261. doi: 10.1097/FTD.0000000000000135.
  • Kersten, Hege; Wyller, Torgeir Bruun & Molden, Espen (2014). Association between inherited CYP2D6/2C19 phenotypes and anticholinergic measures in elderly patients using anticholinergic drugs. Therapeutic Drug Monitoring. ISSN 0163-4356. 36(1), s. 125–130. doi: 10.1097/FTD.0b013e31829da990.
  • Söderberg, Mao Mao; Molden, Espen & Dahl, Marja-Liisa (2014). No influence of CYP3A43 rs472660G>A on steady-state serum olanzapine concentrations in White psychiatric patients. Pharmacogenetics & Genomics. ISSN 1744-6872. 24(5), s. 272–275. doi: 10.1097/FPC.0000000000000041.
  • Waade, Ragnhild Birkeland; Hermann, Monica; Moe, Hanne Louise & Molden, Espen (2014). Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups. European Journal of Clinical Pharmacology. ISSN 0031-6970. 70(8), s. 933–940. doi: 10.1007/s00228-014-1696-8.
  • Hendset, Magnhild; Molden, Espen; Knape, Magnus & Hermann, Monica (2014). Serum concentrations of risperidone and aripiprazole in subgroups encoding CYP2D6 intermediate metabolizer phenotype. Therapeutic Drug Monitoring. ISSN 0163-4356. 36(1), s. 80–85. doi: 10.1097/FTD.0000000000000018.
  • Robertsen, Ida; Åsberg, Anders; Granseth, Tone; Vethe, Nils Tore; Akhlaghi, Fatemeh & Ghareeb, Mwlod [Vis alle 10 forfattere av denne artikkelen] (2014). More potent lipid-lowering effect by rosuvastatin compared with fluvastatin in everolimus-treated renal transplant recipients. Transplantation. ISSN 0041-1337. 97(12), s. 1266–1272. doi: 10.1097/01.TP.0000443225.66960.7e.
  • Watne, Leiv Otto; Hall, Roanna J.; Molden, Espen; Ræder, Johan; Frihagen, Frede Jon & MacLullich, Alasdair M.J. [Vis alle 10 forfattere av denne artikkelen] (2014). Anticholinergic activity in cerebrospinal fluid and serum in individuals with hip fracture with and without delirium. Journal of The American Geriatrics Society. ISSN 0002-8614. 62(1), s. 94–102. doi: 10.1111/jgs.12612.
  • Kersten, Hege; Molden, Espen; Willumsen, Tiril; Engedal, Knut Arne & Wyller, Torgeir Bruun (2013). Higher anticholinergic drug scale (ADS) scores are associated with peripheral but not cognitive markers of cholinergic blockade. Cross sectional data from 21 Norwegian nursing homes. British Journal of Clinical Pharmacology. ISSN 0306-5251. 75(3), s. 842–849. doi: 10.1111/j.1365-2125.2012.04411.x.

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  • Tveit, Kristine; Hermann, Monica; Waade, Ragnhild Birkeland & Molden, Espen (2019). Dose intensity of antidepressants in older persons 2007-2017 – a study based on therapeutic drug monitoring data .
  • Olsen, Thomasch R. Risom; Rasmussen, Anders R.; Kringen, Marianne K. & Molden, Espen (2019). En jente i tidlig skolealder uten effekt av opioider ved generell anestesi. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(7). doi: 10.4045/tidsskr.18.0561.
  • Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna & Laskemoen, Jannicke F. [Vis alle 11 forfattere av denne artikkelen] (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders? Journal of Psychiatric Research. ISSN 0022-3956. doi: 10.1016/j.jpsychires.2018.11.012.
  • Dyrkorn, Roar; Lundgaard, Halvor; Stokes, Charlotte Lorentze; Molden, Espen & Spigset, Olav (2018). Serumkonsentrasjonsmålinger av DOAK-legemidler. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(7), s. 620–621. doi: 10.4045/tidsskr.18.0237.
  • Gjestad, Caroline; Haslemo, Tore; Andreassen, Ole Andreas & Molden, Espen (2018). Gjestad et al. reply to 'Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?' by Neuhoff and Tucker. British Journal of Clinical Pharmacology. ISSN 0306-5251. 84(7), s. 1624–1625. doi: 10.1111/bcp.13606.
  • Ihle-Hansen, Håkon; Hagberg, Guri; Molden, Espen & Myrstad, Marius (2018). Hvem bør få klopidogrel etter hjerneslag? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(9). doi: 10.4045/tidsskr.18.0277.
  • Solberg, Dag; Refsum, Helge & Molden, Espen (2017). Hvis du skal gjøre det, gjør det riktig! Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(12/13), s. 854–854. doi: 10.4045/tidsskr.17.0441.
  • Lea, Marianne; Mathiesen, Liv; Mowe, Morten & Molden, Espen (2017). Baseline characteristics of multimorbid patients included in an RCT.
  • Størset, Elisabet; Hole, Kristine; Midtvedt, Karsten; Bergan, Stein; Molden, Espen & Åsberg, Anders (2017). Response to: ‘Response to: Bodyweightadjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance’. British Journal of Clinical Pharmacology. ISSN 0306-5251. 83(6), s. 1357–1358. doi: 10.1111/bcp.13276.
  • Størset, Elisabet; Hole, Kristine; Midtvedt, Karsten; Bergan, Stein; Molden, Espen & Åsberg, Anders (2017). Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance. British Journal of Clinical Pharmacology. ISSN 0306-5251. 83(6), s. 1350–1352. doi: 10.1111/bcp.13188.
  • Romskaug, Rita; Molden, Espen; Straand, Jørund; Kersten, Hege; Skovlund, Eva & Pitkala, Kaisu H [Vis alle 7 forfattere av denne artikkelen] (2017). Cooperation between geriatricians and general practitioners for improved pharmacotherapy in home-dwelling elderly people receiving polypharmacy - the COOP Study: Study protocol for a cluster randomised controlled trial. Trials. ISSN 1745-6215. 18(1). doi: 10.1186/s13063-017-1900-0. Fulltekst i vitenarkiv
  • Lundgaard, Halvor; Dyrkorn, Roar; Stokes, Charlotte Lorentze; Molden, Espen & Spigset, Olav (2016). Tryggere behandling med serumkonsentrasjonsmåling av de nye antikoagulasjonsmidlene? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(18), s. 1556–1560. doi: 10.4045/tidsskr.16.0255.
  • Lea, Marianne; Engnes, Anette; Mathiesen, Liv; Mowe, Morten & Molden, Espen (2016). Drug-related problems at hospital admission in multimorbid internal medical patients.
  • Solhaug, Vigdis & Molden, Espen (2016). Genetisk betinget variasjon i bioaktivering av tamoksifen og klopidogrel :. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(5), s. 434–436. doi: 10.4045/tidsskr.15.0555.
  • Waade, Ragnhild Birkeland; Ranhoff, Anette Hylen; Hermann, Monica; Martinsen, Mette & Molden, Espen (2015). Screening of psychotropic drugs and mild opioid analgesics in older hip fracture patients at hospital admission.
  • Waade, Ragnhild Birkeland; Hermann, Monica; Ranhoff, Anette Hylen; Martinsen, Mette & Molden, Espen (2015). Therapeutic drug monitoring of psychotropic drugs and mild opioid analgesics in elderly hip fracture patients at hospital admission.
  • Hendset, Magnhild; Hermann, Monica; Moe, Hanne L & Molden, Espen (2014). Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups.
  • Landmark, Cecilie Johannessen; Svendsen, Torleiv; Reimers, Arne; Brodtkorb, Eylert; Sætre, Erik & Molden, Espen [Vis alle 7 forfattere av denne artikkelen] (2014). Experience of therapeutic drug monitoring of eslicarbazepine acetate in clinical practice in Norway.
  • Landmark, Cecilie Johannessen; Svendsen, Torleiv; Reimers, Arne; Brodtkorb, Eylert; Sætre, Erik & Molden, Espen [Vis alle 7 forfattere av denne artikkelen] (2014). Klinisk erfaring med terapeutisk legeiddelmonitorering for eslicarbazepin acetat i Norge.
  • Lundereng, Kristine; Sund, Janne Kutschera; Sporsem, Hilde Margrete; Pedersen, R. & Molden, Espen (2013). Frequency and Management of Drug Realted Problems in an Intensive Care Unit.
  • Waade, Ragnhild Birkeland; Moe, Hanne Louise; Hermann, Monica & Molden, Espen (2013). Aldersbetinget variasjon i serumkonsentrasjon av venlafaksin og escitalopram i relasjon til CYP-genotype.
  • Lundereng, Kristine; Sund, Janne Kutschera; Sporsem, Hilde Margrete; Pedersen, R. & Molden, Espen (2013). Prevalence and management of drug related problems at an intensive care unit. International Journal of Clinical Pharmacology Research. ISSN 0251-1649. 35(5), s. 927–927.
  • Halbostad, Terje; Molden, Espen & Hagen, Håvard (2014). Implementering av et strukturert kvalitetssikringsverktøy for identifisering og håndtering av legemiddelrelaterte problemer ved geriatrisk sengepost. Universitetet i Oslo.
  • Bakken, Gry Vibeke; Hermann, Monica; Molden, Espen & Refsum, Helge (2013). Pharmacokinetic variabilityof quatiapine and the active metabolite N-desalkylquatiapine. Universitetet i Oslo.

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Publisert 3. nov. 2010 15:41 - Sist endret 15. okt. 2021 06:33