Harald Thidemann Johansen

Bilde av Harald Thidemann Johansen
English version of this page
Telefon +47-22856595
Mobiltelefon 91674070 91674070
Rom 432
Brukernavn
Besøksadresse 0363 OSLO Gydasvei 8
Postadresse Postboks 1068 Blindern 0316 OSLO

Faglige interesser

Mine faglige interesser er knyttet til effektene av legemidler slik de beskrives i faget farmakologi. Forskningsmessig har jeg i alle år arbeidet med proteolytiske enzymer, altså enzymer som spalter proteiner. Jeg er spesielt interessert i cysteinproteaser og den rollen disse enzymene spiller i utviklingen av kreft og atherosklerose.

Undervisning

Emneansvarlig for FRM 3020.

Jeg underviser i farmakologi, fysiologi og farmakoterapi. Denne undervisningen foregår i følgende emner i farmasistudiet:

Bakgrunn

Jeg er utdannet Cand.pharm. fra Farmasøytisk institutt i 1979.

Verv

Vararepresentant i styret ved Farmasøytisk institutt

Emneord: Farmakologi, Biokjemi, Celle- og molekylærbiologi, Proteaser, Farmasi, Livsvitenskap - life science, Legemidler, Cathepsiner, Proteolytiske enzymer, Onkologi/kreft, Legumain, Cystatin, Fysiologi

Publikasjoner

  • Bosnjak, Tatjana; Solberg, Rigmor; Hemati, Paya Diana; Jafari, Abbas; Kassem, Moustapha & Johansen, Harald Thidemann (2019). Lansoprazole inhibits the cysteine protease legumain by binding to the active site. Basic & Clinical Pharmacology & Toxicology.  ISSN 1742-7835.  125(2), s 89- 99 . doi: 10.1111/bcpt.13230
  • Lunde, Ngoc Dieu Nguyen; Bosnjak, Tatjana; Solberg, Rigmor & Johansen, Harald Thidemann (2019). Mammalian legumain - A lysosomal cysteine protease with extracellular functions?. Biochimie.  ISSN 0300-9084.  166, s 77- 83 . doi: 10.1016/j.biochi.2019.06.002 Vis sammendrag
  • Pischke, Søren; Hestenes, Siv Merete; Johansen, Harald Thidemann; Fure, Hilde; Bugge, Jan F; Espinoza, Andreas Westenvik; Skulstad, Helge; Edvardsen, Thor; Fosse, Erik; Mollnes, Tom Eirik; Halvorsen, Per Steinar & Nielsen, Erik Waage (2019). Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model. PLOS ONE.  ISSN 1932-6203.  14:e0218624(6) . doi: 10.1371/journal.pone.0218624 Fulltekst i vitenarkiv.
  • Jafari, Abbas; Qanie, Diyako; Andersen, Thomas L.; Zhang, Yuxi; Chen, Li; Postert, Benno; Parsons, Stuart; Ditzel, Nicholas; Khosla, Sundeep; Johansen, Harald Thidemann; Kjærsgaard-Andersen, Per; Delaissé, Jean-Marie; Abdallah, Basem M.; Hesselson, Daniel; Solberg, Rigmor & Kassem, Moustapha (2017). Legumain regulates differentiation fate of human bone marrow stromal cells and is altered in postmenopausal osteoporosis. Stem Cell Reports.  ISSN 2213-6711.  8(2), s 373- 386 . doi: 10.1016/j.stemcr.2017.01.003 Fulltekst i vitenarkiv.
  • Lunde, Ngoc Nguyen Dieu; Haugen, Mads Haugland; Larsen, Kristina Broe Bodin; Damgaard, Ingrid; Pettersen, Solveig; Kasem, Roya; Rut, Wioletta; Drag, Marcin; Poreba, Marcin; Johansen, Harald Thidemann & Solberg, Rigmor (2017). Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions. Biochimie.  ISSN 0300-9084.  139, s 27- 37 . doi: 10.1016/j.biochi.2017.05.009
  • Lunde, Ngoc Nguyen Dieu; Holm, Sverre; Dahl, Tuva Børresdatter; Inass, Elyouncha; Sporsheim, Bjørnar; Gregersen, Ida; Abbas, Azhar; Skjelland, Mona; Espevik, Terje; Solberg, Rigmor; Johansen, Harald Thidemann & Halvorsen, Bente (2017). Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis. Atherosclerosis.  ISSN 0021-9150.  257, s 216- 223 . doi: 10.1016/j.atherosclerosis.2016.11.026 Vis sammendrag
  • Johansen, Harald Thidemann; Seip, Knut Fredrik & Nielsen, Erik Waage (2016). Bradykininutløste angioødemer. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  124(4), s 31- 35
  • Seip, Knut Fredrik; Evjenth, Bjørg; Hovland, Anders; Dybwik, Knut Gustav; Johansen, Harald Thidemann; Fure, Hilde; Mollnes, Tom Eirik & Nielsen, Erik Waage (2016). Bradykinin-Induced Shock Increase Exhaled Nitric Oxide, Complement Activation and Cytokine Production in Pigs. Journal of Cardiology & Clinical Research.  ISSN 2333-6676.  4(2) Fulltekst i vitenarkiv.
  • Berven, Lise; Skjeldal, Frode Miltzow; Prydz, Kristian; Zubaidi, Layla Mohammad Khader; Ballance, Simon; Johansen, Harald Thidemann & Samuelsen, Anne Berit C. (2015). Particulate yeast β-glucan is internalized by RAW 264.7 macrophages and reduces the activity of the tumor-associated protease legumain. Bioactive Carbohydrates and Dietary Fibre.  ISSN 2212-6198.  6(1), s 15- 23 . doi: 10.1016/j.bcdf.2015.06.003
  • Seip, Knut Fredrik; Bjerknes, Kari Christiane; Johansen, Harald Thidemann; Nielsen, Erik Waage; Landrø, Linn Aina Ysland & Reubsaet, Leon (2014). Bradykinin analysis revived - A validated method for determination of its stable metabolite in whole blood by LC-MS/MS. Journal of chromatography. B.  ISSN 1570-0232.  947-948, s 139- 144 . doi: 10.1016/j.jchromb.2013.12.033
  • Smith, Robert; Solberg, Rigmor; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild; Thoresen, G. Hege & Johansen, Harald Thidemann (2014). Simvastatin inhibits glucose metabolism and legumain activity in human myotubes. PLOS ONE.  ISSN 1932-6203.  9(1:85721) . doi: 10.1371/journal.pone.0085721
  • Smith, Robert; Åstrand, Ove Alexander Høgmoen; Nguyen, Luan Minh; Elvestrand, Tina; Hagelin, Gunnar; Solberg, Rigmor; Johansen, Harald Thidemann & Rongved, Pål (2014). Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  22(13), s 3309- 3315 . doi: 10.1016/j.bmc.2014.04.056
  • Solberg, Rigmor; Smith, Robert; Almlöf, Maria; Tewolde, Eyassu Araia; Nilsen, Hilde & Johansen, Harald Thidemann (2014). Atorvastatin inhibits processing, activity and secretion of legumain in macrophages. Biological chemistry.  ISSN 1431-6730.  396(1), s 71- 80 . doi: 10.1515/hsz-2014-0172
  • Solberg, Rigmor; Smith, Robert; Almlöf, Maria; Tewolde, Eyassu Araia; Nilsen, Hilde & Johansen, Harald Thidemann (2014). Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin. Biological chemistry.  ISSN 1431-6730.  396(1), s 71- 80 . doi: 10.1515/hsz-2014-0172
  • Berven, Lise; Johansen, Harald Thidemann; Solberg, Rigmor; Kolset, Svein Olav & Samuelsen, Anne Berit C. (2013). Autoactivation of prolegumain is accelerated by glycosaminoglycans. Biochimie.  ISSN 0300-9084.  95(4), s 772- 781 . doi: 10.1016/j.biochi.2012.11.002 Vis sammendrag
  • Berven, Lise; Solberg, Rigmor; Truong, Hoa Hong Thi; Arlov, Øystein; Aachmann, Finn Lillelund; Skjåk-Bræk, Gudmund; Jacobsen, Wolfgang Mathias; Johansen, Harald Thidemann & Samuelsen, Anne Berit C. (2013). Alginates induce legumain activity in RAW 264.7 cells and accelerate autoactivation of prolegumain. Bioactive Carbohydrates and Dietary Fibre.  ISSN 2212-6198.  2, s 30- 44 . doi: 10.1016/j.bcdf.2013.08.003
  • Haugen, Mads Haugland; Johansen, Harald Thidemann; Pettersen, Solveig; Solberg, Rigmor; Brix, Klaudia; Flatmark, Kjersti & Mælandsmo, Gunhild (2013). Nuclear Legumain Activity in Colorectal Cancer. PLOS ONE.  ISSN 1932-6203.  8(1) . doi: 10.1371/journal.pone.0052980 Fulltekst i vitenarkiv.
  • Johansen, Harald Thidemann & Solberg, Rigmor (2012). Extracellular functions of cystein proteases, In Nikos K Karamanos (ed.),  Extracellular matrix: Pathobiology and signaling.  Walter de Gruyter.  ISBN 978-3-11-025876-9.  Kapittel 4.2.  s 239 - 260
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Haugen, Mads Haugland; Pettersen, Solveig; Mælandsmo, Gunhild; Abrahamson, Magnus & Solberg, Rigmor (2012). Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M. Biochimie.  ISSN 0300-9084.  94(12), s 2590- 2599 . doi: 10.1016/j.biochi.2012.07.026
  • Barratt-Due, Andreas; Johansen, Harald Thidemann; Sokolov, Andrey; Thorgersen, Ebbe Billmann; Hellerud, Bernt C; Reubsaet, Leon; Seip, Knut Fredrik; Tønnessen, Tor Inge; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Castellheim, Albert; Mollnes, Tom Eirik & Nielsen, Erik Waage (2011). The Role of Bradykinin and the Effect of the Bradykinin Receptor Antagonist Icatibant in Porcine Sepsis. Shock.  ISSN 1073-2322.  36(5), s 517- 523 . doi: 10.1097/SHK.0b013e3182336a34
  • Cordara, Gabriele; Jacobsen, Wolfgang Mathias; Johansen, Harald Thidemann; Winter, Harry C.; Goldstein, IJ; Sandvig, Kirsten & Krengel, Ute (2011). Marasmius oreades agglutinin (MOA) is a chimerolectin with proteolytic activity. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  408(3), s 405- 410 . doi: 10.1016/j.bbrc.2011.04.031
  • Øverbye, Anders; Sætre, Frank Ove; Hagen, Linda K Korsberg; Johansen, Harald Thidemann & Seglen, Per O. (2011). Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain. Autophagy.  ISSN 1554-8627.  7(9), s 1011- 1027 . doi: 10.4161/auto.7.9.16436
  • Briggs, Jon; Haugen, Mads Haugland; Johansen, Harald Thidemann; Riker, Adam I; Abrahamson, Magnus; Fodstad, Øystein; Mælandsmo, Gunhild M & Solberg, Rigmor (2010). Cystatin E/M suppresses legumain activity and invasion of human melanoma. BMC Cancer.  ISSN 1471-2407.  10(1), s 17 . doi: 10.1186/1471-2407-10-17
  • Thorgersen, Ebbe Billmann; Hellerud, Bernt C; Nielsen, Erik Waage; Barratt-Due, Andreas; Fure, Hilde; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Fosse, Erik; Tønnessen, Tor Inge; Johansen, Harald Thidemann; Castellheim, Albert & Mollnes, Tom Eirik (2010). CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs. The FASEB Journal.  ISSN 0892-6638.  24(3), s 712- 722 . doi: 10.1096/fj.09-140798
  • Elenjord, Renate; Allen, Jasmine Blue; Johansen, Harald Thidemann; Johansen, Harald T.; Kildalsen, hanne; Svineng, Gunbjørg; Mælandsmo, Gunhild; Loennechen, Thrina & Winberg, Jan-Olof (2009). Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. The FEBS Journal.  ISSN 1742-464X.  276(18), s 5275- 5286 . doi: 10.1111/j.1742-4658.2009.07223.x
  • Castellheim, A; Thorgersen, EB; Hellerud, BC; Pharo, A; Johansen, HT; Brosstad, F; Gaustad, P; Brun, H; Fosse, E; Tønnessen, Tor Inge; Tonnessen, TI; Nielsen, Erik Waage & Mollnes, Tom Erik (2008). New biomarkers in an acute model of live Escherichia coli-induced sepsis in pigs. Scandinavian Journal of Immunology.  ISSN 0300-9475.  68, s 75- 84 . doi: 10.1111/j.1365-3083.2008.02122.x
  • Bah, Sekou; Paulsen, Berit Smestad; Diallo, Drissa & Johansen, Harald Thidemann (2006). Characterization of cysteine proteases in Malian medicinal plants. Journal of Ethnopharmacology.  ISSN 0378-8741.  107(2), s 189- 198
  • Johansen, Harald Thidemann (2002). Fysiologi for farmasøyter - erfaringer med utviklingen av et fjernundervisningskurs basert på bruk av Internett, I: Per Arneberg & Olav Skare (red.),  SOFF-rapport nr. 2/2002.  SOFF - Sentralorganet for fleksibel læring i høgre utdanning.  ISBN 82-91308-28-4.  s 55 - 59
  • Bjørnland, Kristin; Bratland, Åse; Rugnes, Elin; Pettersen, Solveig; Johansen, Harald Thidemann; Aasen, Ansgar Oddne; Fodstad, Øystein; Ree, Anne Hansen & Mælandsmo, Gunhild Mari (2001). Expression of matrix metalloproteinases and the matastasis-associated gene S100A4 in human neuroblastoma and primitive neuroectodermal tumor cell lines. Journal of Pediatric Surgery.  ISSN 0022-3468.  s 1040- 1044
  • Fiane, Arnt E.; Videm, Vibeke; Johansen, Harald Thidemann; Mellbye, Ove J.; Waage - Nielsen, E. & Mollnes, Tom Eirik (1999). C1 inhibitor prevents hyperacute rejection and inhibits complement, leukocyte and platelet activation in an ex vivo pig - to - human perfusion model. Immunopharmacology.  ISSN 0162-3109.
  • Fiane, Arnt E.; Videm, Vibeke; Johansen, Harald Thidemann; Mellbye, Ove J.; Waage - Nielsen, E. & Mollnes, Tom Eirik (1999). Ci inhibitor prevents hyperacute rejection and inhibits complement, leukocyte and platelet activation in an ex vivo pig - to - human perfusion model. Immunopharmacology.  ISSN 0162-3109.
  • Johansen, Harald Thidemann; Knight, C. Graham & Barrett, Alan J. (1999). Colorimetric and Fluorimetric Microplate Assays for Legumain and a Staining Reaction for Detection of the Enzyme after Electrophoresis. Analytical Biochemistry.  ISSN 0003-2697.  273, s 278- 283
  • Bjørnland, Kristin; Lehne, Gustav; Johansen, Harald Thidemann; Fodstad, Øystein; Rugstad, Hans Erik; Aasen, Ansgar Oddne & Ree, Anne Hansen (1998). Human hepatoma cells rich in P-glycoprotein display enhanced in vitro invasive properties compared to P-glycoprotein-poor hepatoma cells. Oncology Research.  ISSN 0965-0407.  10, s 255- 262 Vis sammendrag
  • Ree, Anne Hansen; Bjørnland, Kristin; Brunner, N.; Johansen, Harald Thidemann; Pedersen, Kjetil Boye; Aasen, Ansgar Oddne & Fodstad, Øystein (1998). Regulation of tissue-degrading factors and in vitro invasiveness in progression of breast cancer cells. Clinical and Experimental Metastasis.  ISSN 0262-0898.  16, s 205- 215
  • Bjørnland, Kristin; Buø, Laila; Kjøniksen, Inge; Larsen, John Karl; Fodstad, Øystein; Johansen, Harald Thidemann & Aasen, Ansgar Oddne (1996). Cysteine proteinase inhibitors reduce malignant melanoma cell invasion in vitro. Anticancer Research.  ISSN 0250-7005.  16, s 1627- 1632
  • Karlsrud, Tove Sigstad; Buø, Laila; Aasen, Ansgar Oddne & Johansen, Harald Thidemann (1996). Cleavage of plasma high molecular weight kininogen in surgical ICU patients. Intensive Care Medicine.  ISSN 0342-4642.  22, s 760- 765
  • Karlsrud, Tove Sigstad; Buø, Laila; Aasen, Ansgar Oddne & Johansen, Harald Thidemann (1996). Quantification of kininogens in plasma. A functional method based on the cysteine proteinase inhibitor activity. Thrombosis Research.  ISSN 0049-3848.  s 265- 273
  • Nielsen, E. Waage; Gran, Jan Tore; Straume, Bjørn; Mellbye, Ove J.; Johansen, Harald Thidemann & Mollnes, Tom Eirik (1996). Hereditary angioedema. New clinical observations autoimmune screening, complement and kallikrein kinin analyses. Journal of Internal Medicine.  ISSN 0954-6820.  239, s 119- 130 Vis sammendrag

Se alle arbeider i Cristin

  • Awale, Mustafa; Bosnjak, Tatjana; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann (2019). Effekten av kjønnshormoner på differensiering av stamceller til osteoblaster og regulering av cysteinproteasene legumain og cathepsin B.
  • Bosnjak, Tatjana; Solberg, Rigmor; Arnekleiv, Guro L.; Nilsen, Hilde; Jafari, Abbas; Bassatne, A.; Fuleihan, G.E.H.; Kassem, Moustapha & Johansen, Harald Thidemann (2019). Vitamin D3 upregulates legumain in the early phase of osteoblast differentiation.
  • Abbas, Iram; Nilsen, Hilde; Johansen, Harald Thidemann & Solberg, Rigmor (2018). Deksametason hemmer differensiering av humane mesenkymale stamceller til osteoblaster og regulerer cysteinproteasene legumain og cathepsin B.
  • Bosnjak, Tatjana; Hemati, Paya Diana; Solberg, Rigmor & Johansen, Harald Thidemann (2018). Cysteine proteases as Targets for Proton Pump Inhibitors (PPIs).
  • Gjonbalaj, Nora; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann (2018). Effekt av inflammasjon på regulering av cysteinproteasene legumain og cathepsin B under differensiering av humane mesenkymale stamceller til osteoblaster.
  • Lunde, Ngoc Nguyen Dieu; Gregersen, Ida; Holm, Sverre; Michelsen, Annika; Sporsheim, Bjørnar; Espevik, Terje; Solberg, Rigmor; Johansen, Harald Thidemann & Halvorsen, Bente (2018). Platelet-derived legumain, a cysteine protease involved in atherosclerosis.
  • Lunde, Ngoc Nguyen Dieu; Holm, Sverre; Dahl, Tuva Børresdatter; Elyouncha, Inass; Sporsheim, Bjørnar; Gregersen, Ida; Abbas, Azhar; Skjelland, Mona; Espevik, Terje; Solberg, Rigmor; Johansen, Harald Thidemann & Halvorsen, Bente (2018). Plasma and plaques from patients with carotid atherosclerosis have increased levels of legumain.
  • Arnekleiv, Guro L.; Nilsen, Hilde; Lunde, Ngoc Nguyen Dieu; Solberg, Rigmor & Johansen, Harald Thidemann (2017). Effekt av vitamin D3 på uttrykk, aktivitet og sekresjon av cysteinproteasen legumain studert i ulike cellemodeller.
  • Bosnjak, Tatjana; Hemati, Paya Diana; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann (2017). Legumain as a target for proton pump inhibitors (PPIs): Importance for off-target effects of PPIs?.
  • Hemati, Paya Diana; Bosnjak, Tatjana; Nilsen, Hilde; Lunde, Ngoc Nguyen Dieu; Johansen, Harald Thidemann & Solberg, Rigmor (2017). The Proton Pump Inhibitor Lansoprazole Inhibits Protease Activity of Legumain.
  • Lunde, Ngoc Nguyen Dieu; Holm, Sverre; Dahl, Tuva B.; Elyoncha, Inass; Sporsheim, Bjørnar; Gregersen, Ida; Abbas, Azhar; Skjelland, Mona; Espevik, Terje; Solberg, Rigmor; Johansen, Harald Thidemann & Halvorsen, Bente (2017). Plasma and plaques from patients with carotid atherosclerosis have increased levels of legumain.
  • Solberg, Rigmor; Bosnjak, Tatjana; Nilsen, Hilde; Jafari, Abbas; Kassem, Moustapha & Johansen, Harald Thidemann (2017). Regulation of legumain and cysteine cathepsins during differentiation of human bone marrow stromal cells towards osteoblasts.
  • Abdukadir, Nuriddin; Lunde, Ngoc Nguyen Dieu; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann (2016). Regulering av cysteinproteaser ved differensiering av monocytter til makrofager.
  • Johansen, Harald Thidemann (2016). Type 2 cystatins as inhibitors of legumain.
  • Larsen, Kristina Broe Bodin; Johansen, Harald Thidemann; Solberg, Rigmor & Lunde, Ngoc Nguyen Dieu (2016). Betydning av glykosylering for internalisering og aktivering av prolegumain i humane tykktarmskreftceller.
  • Lunde, Ngoc Nguyen Dieu; Dahl, Tuva Børresdatter; Abdukadir, Nuriddin; Halvorsen, Bente; Solberg, Rigmor & Johansen, Harald Thidemann (2016). Increased secretion of legumain from pro-inflammatory M1 compared to M2 macrophages.
  • Manna, Dipankar; Krengel, Ute & Johansen, Harald Thidemann (2016). Structure-function characterization and cytotoxicity studies of fungal chimerolectins.
  • Solberg, Rigmor & Johansen, Harald Thidemann (2016). Involvement of the cysteine protease legumain in human health and disease.
  • Johansen, Harald Thidemann; Elyouncha, Inass; Lunde, Ngoc Nguyen Dieu; Williams, Rich; Solberg, Rigmor; Nilsen, Hilde & Halvorsen, Bente (2015). Opposing effects of glucose on legumain and cysteine cathepsins.
  • Lunde, Ngoc Nguyen Dieu; Nilsen, Hilde; Damgaard, Ingrid; Kasem, Roya; Solberg, Rigmor; Haugen, Mads Haugland & Johansen, Harald Thidemann (2015). Importance of glycosylation for legumain and cystatin E/M functions.
  • Nielsen, Erik Waage; Lappegård, Knut Tore & Johansen, Harald Thidemann (2015). Re: Ny og bedre medisin mot hjertesvikt. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  135(9), s 830- 831 . doi: 10.4045/tidsskr.15.0486
  • Haugen, Mads Haugland; Flatmark, Kjersti; Tamhane, Tripti; Boye, Kjetil; Pettersen, Solveig; Solberg, Rigmor; Johansen, Harald Thidemann; Brix, Klaudia & Mælandsmo, Gunhild (2013). Nuclear localized legumain in colorectal cancer.
  • Johansen, Harald Thidemann; Solberg, Rigmor; Nilsen, Hilde & Smith, Robert (2013). Effects and interplay of legumain and cystatin E/M om migration and invasion of macrophages.
  • Seip, Knut Fredrik; Bjerknes, Kari Christiane; Johansen, Harald Thidemann; Landrø, Linn Aina Ysland; Helsing, Per; Reubsaet, Leon & Nielsen, Erik Waage (2013). Investigating bradykinin exposure in hereditary angioedema through the metabolite BK1-5.
  • Smith, Robert; Johansen, Harald Thidemann; Jacobsen, Linn Løkken; Voreland, Anette Larsen; Rustan, Arild; Thoresen, G. Hege & Solberg, Rigmor (2013). Simvastatin inhibits legumain activity and processing in human myotubes.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde & Solberg, Rigmor (2013). Effects and interplay of legumain and cystatin E/M on migration and invasion of macrophages.
  • Tina, Elvestrand; Åstrand, Ove Alexander; Smith, Robert; Rongved, Pål; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann (2013). Cellular effects of a colchicine-prodrug cleaved by legumain.
  • Voreland, Anette; Smith, Robert; Thoresen, G. Hege; Johansen, Harald Thidemann & Solberg, Rigmor (2013). The cysteine protease legumain is downregulated by simvastatin in primary human skeletal muscle cells.
  • Ånonsen, Kjersti Bergh; Nilsen, Hilde; Smith, Robert; Johansen, Harald Thidemann & Solberg, Rigmor (2013). Regulering av legumain i samspillet mellom makrofager og kreftceller.
  • Berven, Lise; Johansen, Harald Thidemann; Solberg, Rigmor; Kolset, Svein Olav & Samuelsen, Anne Berit C. (2012). INTERACTIONS BETWEEN PROLEGUMAIN AND GLYCOSAMINOGLYCANS.
  • Bjerknes, Kari Christiane; Seip, Knut Fredrik; Johansen, Harald Thidemann; Landrø, Linn Aina Ysland; Nielsen, Erik Waage & Reubsaet, Leon (2012). Bradykinins rolle ved arvelig angiødemanfall – LC-MS/MS bestemmelse via metabolitten BK1-5 i fullblod.
  • Bjerknes, Kari Christiane; Seip, Knut Fredrik; Reubsaet, Leon; Nielsen, Erik Waage & Johansen, Harald Thidemann (2012). The role of Bradykinin in attacks of angioedema - Development of a method for measuring the stable metabolite BK1-5.
  • Jacobsen, Linn Løkken; Smith, Robert; Thoresen, G. Hege; Solberg, Rigmor & Johansen, Harald Thidemann (2012). Are the cysteine proteases legumain and cathepsins involved in statin-induced myotoxicity?.
  • Samuelsen, Anne Berit C.; Berven, Lise; Solberg, Rigmor; Johansen, Harald Thidemann & Truong, Hong Hoa Thi (2012). Effekt av alginat på legumain, en protease involvert i kreftutvikling.
  • Seip, Knut Fredrik; Bjerknes, Kari Christiane; Johansen, Harald Thidemann; Landrø, Linn Aina Ysland; Helsing, Per; Reubsaet, Leon & Nielsen, Erik Waage (2012). Investigating bradykinin exposure in hereditary angioedema through the metabolite BK1-5.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Yassen, Islam M.; Haugen, Mads Haugland; Pettersen, Solveig; Mælandsmo, Gunhild; Abrahamson, Magnus & Solberg, Rigmor (2012). SECRETION, INTERNALIZATION AND INTERPLAY OF LEGUMAIN AND CYSTATIN E/M.
  • Tran, Anny T.; Smith, Robert; Solberg, Rigmor & Johansen, Harald Thidemann (2012). Effects of atorvastatin on regulation of protease activities in macrophages.
  • Haugen, Mads Haugland; Mælandsmo, Gunhild; Johansen, Harald Thidemann; Solberg, Rigmor; Pettersen, Solveig; Boye, Kjetil & Flatmark, Kjersti (2011). Nuclear activity of the cysteine protease legumain in colorectal carcinoma.
  • Johansen, Harald Thidemann; Smith, Robert; Tewolde, Eyassu; Nilsen, Hilde & Solberg, Rigmor (2011). ATORVASTATIN INHIBITS LEGUMAIN ACTIVITY IN AND PROLEGUMAIN SECRETION FROM HUMAN ACTIVATED MACROPHAGES.
  • Samuelsen, Anne Berit C.; Berven, Lise; Solberg, Rigmor; Johansen, Harald Thidemann & Nguyen, Nga Thi (2011). Studier av alginats effekt på prolegumain og cellesekresjon av matriksmetalloproteaser.
  • Smith, Robert; Johansen, Harald Thidemann; Nilsen, Hilde; Yassen, Islam M.; Haugen, Mads Haugland; Pettersen, Solveig J. & Solberg, Rigmor (2011). SUBCELLULAR LOCALIZATION, INTERPLAY AND SECRETION OF LEGUMAIN AND CYSTATIN E/M IN HEK 293 CELLS.
  • Smith, Robert; Johansen, Harald Thidemann & Solberg, Rigmor (2011). Cellular localization and interplay between legumain and its endogenous inhibitor cystatin E/M.
  • Thorgersen, Ebbe Billmann; Hellerud, Bernt C; Nielsen, Erik Waage; Barratt-Due, Andreas; Fure, Hilde; Lindstad, Julie Katrine; Pharo, Anne Margrethe; Fosse, Erik; Tønnessen, Tor Inge; Johansen, Harald Thidemann; Castellheim, Albert & Mollnes, Tom Eirik (2010). Upstream inhibition of key innate immune pathways in vivo in sepsis. Molecular Immunology.  ISSN 0161-5890.  47(13), s 2268- 2268 . doi: 10.1016/j.molimm.2010.05.209
  • Briggs, Jon; Haugen, Mads Haugland; Johansen, Harald Thidemann; Riker, Adam I; Abrahamson, Magnus; Fodstad, Øystein; Mælandsmo, Gunhild Mari & Solberg, Rigmor (2009). Cystatin E/M suppresses legumain activity and invasion of human melanoma.
  • Haugen, Mads Haugland; Johansen, Harald Thidemann; Solberg, Rigmor; Flatmark, Kjersti & Mælandsmo, Gunhild M (2009). Expression and activity of the cysteine protease legumain in colorectal carcinoma cell lines.
  • Solberg, Rigmor; Almlöf, Maria; Nilsen, Hilde; Ali, Zana Abdullrahman; Abrahamson, Magnus & Johansen, Harald Thidemann (2009). Asparaginyl endopeptidase activity is upregulated during differentiation of monocytes to macrophages but only partly mediated by legumain.
  • Ben Omar, Sakina; Johansen, Harald Thidemann; Aukrust, Pål; Halvorsen, Bente & Solberg, Rigmor (2008). Lysosomal cysteine proteases in atherosclerosis: Do inflammatory modulators regulate expression and activity?.
  • Almlöf, Maria; Solberg, Rigmor & Johansen, Harald Thidemann (2007). Regulation of cystein proteases in monocytes/macrophages and in tumorigenesis.
  • Solberg, Rigmor; Nilsen, Hilde; Johansen, Harald Thidemann; Mælandsmo, Gunhild M. & Briggs, Jon (2007). SCREENING OF THE EXPRESSIONS OF LEGUMAIN AND ITS SPECIFIC INHIBITOR CYSTATIN M IN VARIOUS MELANOMA CELLS.
  • Almlöf, Maria; Elenjord, Renate; Solberg, Rigmor; Winberg, Jan Olof; Loennechen, Thrina & Johansen, Harald Thidemann (2006). The expression and activity of legumain is highly increased in malignant osteosarcoma cells compared to non-malignant cells.
  • Almlöf, Maria; Elenjord, Renate; Solberg, Rigmor; Winberg, Jan-Olof; Loennechen, Thrina & Johansen, Harald Thidemann (2006). Malignant osteosarcoma cells express higher levels of legumain compared to non-malignant cells.
  • Almlöf, Maria; Solberg, Rigmor; Nilsen, Hilde & Johansen, Harald Thidemann (2006). Legumain expression and activity is highly increased as monocytes differentiate toward macrophages.
  • Almløf, M; Elenjord, Renate; Solberg, R; Winberg, Jan-Olof; Loennechen, thrina & Johansen, HT (2006). Legumain activity is increased in malignant osteosarcoma cells compared to non-malignant cells.
  • Bah, Sekou; Diallo, Drissa; Paulsen, Berit Smestad & Johansen, Harald Thidemann (2006). Characterisation and partial purification of cystatins from Malian medicinal plants.
  • Bah, Sekou; Johansen, Harald Thidemann; Paulsen, Berit Smestad & Diallo, Drissa (2005). Characterization of cysteine proteases in medicinal plants from Mali.
  • Bah, Sekou; Johansen, Harald Thidemann; Paulsen, Berit Smestad & Diallo, Drissa (2005). Pharmacology of medicinal plants from Mali: Antiplasmodial amd Antischistosomial Activities.
  • Johansen, Harald Thidemann & Tangen-Jordan, Lise von (2002). Isolated cystatin domains from L-kininogen are not active as inhibitors of mammalian legumain. Vis sammendrag
  • Johansen, Harald Thidemann (2001). Legemidler som hemmer blodplateaggregasjonen. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  109(3), s 16- 18
  • Johansen, Harald Thidemann (2001). Legemidler som hemmer blodplateaggregasjonen. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  109(3), s 16- 18
  • Johansen, Harald Thidemann (2000). Spironolakton - et gammelt legemiddel med nye muligheter. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  108(3), s 12- 15
  • Bjørnland, Kristin; Rugnes, Elin; Pettersen, Solveig; Johansen, Harald Thidemann & Aasen, Ansgar Oddne (1999). neuroblastoma cell invasion in vitro correlates with expression of matrix metalloproteinase-2.
  • Bjørnland, Kristin; Rugnes, Elin; Mælandsmo, Gunhild Mari; Ree, Anne Hansen; Johansen, Harald Thidemann & Aasen, Ansgar Oddne (1999). expression of matrix metalloproteinases in neuroblastoma cells.

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Publisert 3. nov. 2010 15:39 - Sist endret 3. mars 2014 11:42

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