Krister Gjestvang Grønlien

• Grønlien, Krister Gjestvang; Pedersen, Mona Elisabeth & Tønnesen, Hanne Hjorth (2020). A natural deep eutectic solvent (NADES) as potential excipient in collagen-based products. International Journal of Biological Macromolecules.  ISSN 0141-8130.  156, s 394- 402 . doi: 10.1016/j.ijbiomac.2020.04.026 Fulltekst i vitenarkiv. Vis sammendrag

  Natural deep eutectic solvents (NADES) have previously shown antibacterial properties alone or in combination with photosensitizers and light. In this study, we investigated the behavior of the structural protein collagen in a NADES solution. A combination of collagen and NADES adds the unique wound healing properties of collagen to the potential antibacterial effect of the NADES. The behavior of collagen in a NADES composed of citric acid and xylitol and aqueous dilutions thereof was assessed by spectroscopic, calorimetric and viscosity methods. Collagen exhibited variable unfolding properties dependent on the type of material (telo- or atelocollagen) and degree of aqueous dilution of the NADES. The results indicated that both collagen types were susceptible to unfolding in undiluted NADES. Collagen dissolved in highly diluted NADES showed similar results to collagen dissolved in acetic acid (i.e., NADES network possibly maintained). Based on the ability to dissolve collagen while maintaining its structural properties, NADES is regarded as a potential excipient in collagen-based products. This is the first study describing the solubility and structural changes of an extracellular matrix protein in NADES.

• Thapa, Raj Kumar; Cazzador, Flavio; Grønlien, Krister Gjestvang & Tønnesen, Hanne Hjorth (2020). Effect of curcumin and cosolvents on the micellization of Pluronic F127 in aqueous solution. Colloids and Surfaces B: Biointerfaces.  ISSN 0927-7765.  195 . doi: https://doi.org/10.1016/j.colsurfb.2020.111250
• Grønlien, Krister Gjestvang; Pedersen, Mona Elisabeth; Sanden, Karen Wahlstrøm; Høst, Vibeke; Karlsen, Jan & Tønnesen, Hanne Hjorth (2019). Collagen from Turkey (Meleagris gallopavo) tendon: A promising sustainable biomaterial for pharmaceutical use. Sustainable Chemistry and Pharmacy.  ISSN 2352-5541.  13, s 1- 10 . doi: 10.1016/j.scp.2019.100166 Fulltekst i vitenarkiv.

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• Grønlien, Krister Gjestvang; Wikene, Kristine Opsvik; Bruzell, Ellen Merete; Valen, Håkon & Tønnesen, Hanne Hjorth (2019). Photostability of an anionic porphyrin in natural deep eutectic solvents (NADES).
• Grønlien, Krister Gjestvang & Tønnesen, Hanne Hjorth (2018). Characterization of collagen from turkey for application in pharmaceutical preparations.
• Grønlien, Krister Gjestvang (2016). Bruk av norskprodusert kollagen fra kalkun til formulering av legemidler. Norsk Farmaceutisk Tidsskrift.  ISSN 0029-1935.  (12), s 29- 29
• Sørheim, Kristin; Brunberg, Emma; Grøva, Lise; Lande, Unni Støbet; Tovsen, Marianne Lilletvedt; Grønlien, Krister Gjestvang; Tønnesen, Hanne Hjorth; Karlsen, Jan; Skulberg, Olav & Mysterud, Ivar (2016). Alveld hos lam - kan vi forebygge sykdommen?.

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