Ove Alexander Høgmoen Åstrand

Bilde av Ove Alexander Høgmoen Åstrand
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Telefon +47-22854478
Rom Ø179 Fysikkbygningen
Brukernavn
Besøksadresse Sem Sælands vei 3 Farmasibygningen 0371 OSLO
Postadresse Postboks 1068 Blindern 0316 OSLO

Faglige interesser

Organisk kjemi, legemiddelkjemi, organometallisk kjemi, katalyse, ingeniørfag, formidling og eksplosivkjemi

Undervisning

Underviser i laboratoriekursene i:

Bakgrunn

  • Sivilingeniør i organisk kjemi fra NTNU i Trondheim, 2009
  • Utenlandsopphold ved University of California, Berkeley, 2007/2008

 

Emneord: Kjemi, Toksikologi, Legemidler, Legemiddelkjemi, Livsvitenskap - life science, Legemiddelkjemi

Publikasjoner

  • Kildahl-Andersen, Geir; Schnaars, Christian; Prandina, Anthony; Radix, Sylvie; Le Borgne, Marc; Jordheim, Lars Petter; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Lauksund, Silje; Fröhlich, Christopher; Samuelsen, Ørjan; Rongved, Pål & Åstrand, Ove Alexander Høgmoen (2019). Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors. MedChemComm.  ISSN 2040-2503.  10(4), s 528- 537 . doi: 10.1039/c8md00578h
  • Prandina, Anthony; Radix, Sylvie; Le Borgne, Marc; Jordheim, Lars Petter; Bousfiha, Zineb; Fröhlich, Christopher; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Frøvold, Espen; Rongved, Pål & Åstrand, Ove Alexander Høgmoen (2019). Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors. Tetrahedron.  ISSN 0040-4020.  75(11), s 1525- 1540 . doi: 10.1016/j.tet.2019.02.004
  • Pöthig, Alexander; Sara, Ahmed; Winther-Larsen, Hanne Cecilie; Guan, Shengyang; Altmann, Philipp J.; Kundermann, Jürgen; Andresen, Adriana Magalhaes Santos; Gjøen, Tor & Åstrand, Ove Alexander Høgmoen (2018). Antimicrobial Activity and Cytotoxicity of Ag(I) and Au(I) Pillarplexes. Frontiers in Chemistry.  ISSN 2296-2646.  6 . doi: 10.3389/fchem.2018.00584
  • Schnaars, Christian; kildahl-Andersen, Geir; Prandina, Anthony; Popal, Roya; Radix, Sylvie; Le Borgne, Marc; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Heikal, Adam; Økstad, Ole Andreas Løchen; Fröhlich, Christopher; Samuelsen, Ørjan; Lauksund, Silje; Jordheim, Lars Petter; Rongved, Pål & Åstrand, Ove Alexander Høgmoen (2018). Synthesis and preclinical evaluation of TPA-based zinc chelators as metallo-β-lactamase inhibitors. ACS Infectious Diseases.  ISSN 2373-8227.  4(19), s 1407- 1422 . doi: 10.1021/acsinfecdis.8b00137
  • Viktorsson, Elvar Örn; Gabrielsen, Mari; Kumarachandran, Nugalya; Sylte, Ingebrigt; Rongved, Pål; Åstrand, Ove Alexander Høgmoen & Kase, Eili Tranheim (2017). Regulation of liver X receptor target genes by 22-functionalized oxysterols. Synthesis, in silico and in vitro evaluations. Steroids.  ISSN 0039-128X.  118, s 119- 127 . doi: 10.1016/j.steroids.2016.12.003
  • Viktorsson, Elvar Örn; Grøthe, Bendik Melling; Aesoy, Reidun; Sabir, Misbah; Snellingen, Simen; Åstrand, Ove Alexander Høgmoen; Prandina, Anthony; Bonge-Hansen, Tore; Doskeland, Stein Ove; Herfindal, Lars & Rongved, Pål (2017). Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  25(7), s 2285- 2293 . doi: 10.1016/j.bmc.2017.02.058
  • Åstrand, Ove Alexander Høgmoen; Viktorsson, Elvar Örn; Kristensen, Aleksander Lim; Ekeberg, Dag; Røberg-Larsen, Hanne; Wilson, Steven Ray Haakon; Gabrielsen, Mari; Sylte, Ingebrigt; Rustan, Arild; Thoresen, G. Hege; Rongved, Pål & Kase, Eili Tranheim (2017). Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors. Journal of Steroid Biochemistry and Molecular Biology.  ISSN 0960-0760.  165, s 323- 330 . doi: 10.1016/j.jsbmb.2016.07.010 Fulltekst i vitenarkiv.
  • Viktorsson, Elvar Örn; Åstrand, Ove Alexander Høgmoen; Haseeb, Rasha Sabah; Gorbitz, Carl Henrik & Rongved, Pål (2015). Crystal structure of (S)-2-[(3S,8S,9S,10R,13S,14S,-17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,-12,13,14,15,16,17-tetradecahydro-1 H-cyclopenta-[a]phenanthren-17-yl]-N-methoxy-N-methylpro-panamide (Fernholz Weinreb amide). Acta Crystallographica Section E: Structure Reports Online.  ISSN 1600-5368.  71(3), s 275- 277 . doi: 10.1107/S2056989015001747 Fulltekst i vitenarkiv.
  • Smith, Robert; Åstrand, Ove Alexander Høgmoen; Nguyen, Luan Minh; Elvestrand, Tina; Hagelin, Gunnar; Solberg, Rigmor; Johansen, Harald Thidemann & Rongved, Pål (2014). Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  22(13), s 3309- 3315 . doi: 10.1016/j.bmc.2014.04.056
  • Åstrand, Ove Alexander Høgmoen; Gikling, Ingveig; Sylte, Ingebrigt; Rustan, Arild; Thoresen, G. Hege; Rongved, Pål & Kase, Eili Tranheim (2014). Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. European Journal of Medicinal Chemistry.  ISSN 0223-5234.  74, s 258- 263 . doi: 10.1016/j.ejmech.2014.01.003
  • Åstrand, Ove Alexander Høgmoen; Sandberg, Marcel; Sylte, Ingebrigt; Gorbitz, Carl Henrik; Thoresen, G. Hege; Kase, Eili Tranheim & Rongved, Pål (2014). Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  22(1), s 643- 650 . doi: 10.1016/j.bmc.2013.10.024
  • Åstrand, Ove Alexander Høgmoen; Austdal, Lars Peter Engeset; Paulsen, Ragnhild Elisabeth; Hansen, Trond Vidar & Rongved, Pål (2013). Synthesis and characterization of new selective Zn2+ fluorescent probes for functionalization: in vitro Cell imaging applications. Tetrahedron.  ISSN 0040-4020.  49(40), s 8645- 8654 . doi: 10.1016/j.tet.2013.07.049
  • Åstrand, Ove Alexander Høgmoen; Gorbitz, Carl Henrik; Kristoffersen, Kenneth Aase & Rongved, Pål (2013). Acetonitrile){2-[bis(pyridin-2-ylmethyl-κ2 N)amino-κN]-N-(2,6-dimethylphenyl)acetamide-κO}(perchlorato-κO)zinc (acetonitrile){2-[bis(pyridin-2-ylmethyl-κ2 N)amino-κN]-N-(2,6-dimethylphenyl)acetamide-κO}zinc tris(perchlorate). Acta Crystallographica Section E: Structure Reports Online.  ISSN 1600-5368.  69(2), s m112- m113 . doi: 10.1107/S1600536813001396
  • Åstrand, Ove Alexander; Aziz, Gul zeb; Ali, Sidra Farzand; Paulsen, Ragnhild Elisabeth; Hansen, Trond Vidar & Rongved, Pål (2013). Synthesis and initial in vitro biological evaluation of two new zinc-chelating compounds: Comparison with TPEN and PAC-1. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  21(17), s 5175- 5181 . doi: 10.1016/j.bmc.2013.06.037
  • Åstrand, Ove Alexander; Iqbal, Zeshan; Sandberg, Marcel; Kase, Eili Tranheim; Gorbitz, Carl Henrik & Rongved, Pål (2013). (2S,3S)-2,6-Dimethylheptane-1,3-diol, the oxygenated side chain of 22(S)-hydroxycholestrol, and its synthetic precursor (R)-4-benzyl-3-[(2R,3S)-3-hydroxy-2,6-dimethylheptanoyl]-1,3-oxazolidin-2-one. Acta Crystallographica Section C: Crystal Structure Communications.  ISSN 0108-2701.  69, s 647- + . doi: 10.1107/S0108270113011852

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  • Viktorsson, Elvar Örn; Åstrand, Ove Alexander Høgmoen; Bonge-Hansen, Tore; Doskeland, Stein Ove; Herfindal, Lars & Rongved, Pål (2016). Total synthesis and initial antileukemic evaluation of the phenazine 5,10-dioxide natural products iodinin and myxin.
  • Åstrand, Ove Alexander Høgmoen; Cokoja, Mirza; Pöthig, Alexander & Kühn, Fritz E. (2016). Zinc complexes in catalysis - Potential applications.
  • Åstrand, Ove Alexander Høgmoen; Schnaars, Christian; Kildahl-Andersen, Geir & Rongved, Pål (2016). Overcoming b-lactam resistance - A potential solution to antibiotic resistance.
  • Grøthe, Bendik Melling; Snellingen, Simen; Viktorsson, Elvar Örn; Prandina, Anthony; Åstrand, Ove Alexander Høgmoen; Bonge-Hansen, Tore & Rongved, Pål (2015). The first efficient synthesis and preliminary biological effect of the 1,6-dihydroxyphenazine-N5,N10-dioxide (Iodinin) and 1-hydroxy-6-methoxyphenazine-N5,N10-dioxide (Myxin).
  • Haseeb, Rasha Sabah; Viktorsson, Elvar Örn; Åstrand, Ove Alexander Høgmoen & Rongved, Pål (2015). Synthetic efforts towards oxysterol-based LXR-modulators.
  • Prandina, Anthony; Frøvold, Espen; Åstrand, Ove Alexander Høgmoen & Rongved, Pål (2015). Synthetic efforts towards new agents against resistant bacteria.
  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan & Leiros, Hanna-Kirsti S. (2015). The fight against metallo-beta-lactamases and antibiotic resistance.
  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samuelsen, Ørjan & Leiros, Hanna-Kirsti S. (2015). The fight against metallo-beta-lactamases and antibiotic resistance.
  • Skagseth, Susann; Carlsen, Trine Josefine Olsen; Christopeit, Tony; Akhter, Sundus; Zeeshan, Muhammad; Åstrand, Ove Alexander Høgmoen; Bayer, Annette; Rongved, Pål; Samulesen, Ørjan & Leiros, Hanna-Kirsti S. (2015). The fight against metallo-beta-lactamases and antibiotic resistance.
  • Viktorsson, Elvar Örn; Åstrand, Ove Alexander Høgmoen; Rustan, Arild; Thoresen, G. Hege; Kase, Eili Tranheim & Rongved, Pål (2015). Analogs of 22-S-hydroxycholesterol as potential Liver X Receptor-modulators: Synthesis and biological evaluation.
  • Åstrand, Ove Alexander Høgmoen; Leiros, Hanna-Kirsti S.; Samuelsen, Ørjan; Bayer, Annette & Rongved, Pål (2015). Overcoming b-lactam resistance - A potential solution to multi-drug resistant bacteria.
  • Åstrand, Ove Alexander Høgmoen & Rongved, Pål (2015). OVERCOMING ANTIBIOTIC RESISTANCE - DEVELOPMENT OF NEW MBL INHIBITORS.
  • Tina, Elvestrand; Åstrand, Ove Alexander; Smith, Robert; Rongved, Pål; Nilsen, Hilde; Solberg, Rigmor & Johansen, Harald Thidemann (2013). Cellular effects of a colchicine-prodrug cleaved by legumain.
  • Åstrand, Ove Alexander Høgmoen (2013). Drug discovery and design: Lead identifcation and discoveries made with zinc chelators, Liver X Receptor modulators and prodrug strategies. Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo.. 1429.
  • Åstrand, Ove Alexander; Hansen, Trond Vidar & Rongved, Pål (2011). Synthesis of new zinc2+ chelating molecules.
  • Åstrand, Ove Alexander; Hansen, Trond Vidar & Rongved, Pål (2010). Development of new selctive chelating agents for zinc.
  • Melnes, Silje; Åstrand, Ove Alexander; Reian, Gard; Aaseng, Jon Erik & Gautun, Odd Reidar (2009). Asymmetric catalytic aziridination of 1,2-dihydronaphtalenes.
  • Åstrand, Ove Alexander; Melnes, Silje & Gautun, Odd Reidar (2009). Preparation of New Ru-salen Complexes for the Catalytic Asymmetric Aziridination of Alkenes.

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Publisert 3. juni 2014 11:29 - Sist endret 3. juni 2014 11:31

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