Photonic forces, cellular dynamics and molecular motors
Felix Kohler, postdoc at the Condensed matter physic group (UiO), will give a talk.
Immune system cell takes up latex beads offered by an optical trap
Life implies motion and every motion results from forces. The forces produced on molecular and cellular levels are in the range of pico- to nanonewton. Since the forces on a bead in an optical trap are in a similar range, optical tweezers are a good tool to investigate molecular processes and cellular dynamics. In this talk, optical tweezers based investigations of mechanical concepts of cellular subsystems, like filopodial cell protrusions, will be shown. In order to study physical parameters, such as the velocity of retraction and transport, the stiffness of binding and bending as well as force dependencies, both the mean movement and fluctuations have been analyzed.
It is generally assumed that molecular motors are involved in most dynamic cellular processes including the filopodial dynamics. In this talk, the contribution of molecular motors to the filopodial dynamics as well as the mutual interaction of such motors in general will be described. A model for the cooperative behavior of molecular motors will be presented and compared to Brownian dynamics simulations and to the results of various experiments.