Xian Hu

Image of Xian Hu
Norwegian version of this page
Phone +47 22840527
Username
Visiting address Ullernchausséen 70 0379 Oslo
Postal address Postboks 4950 0424 Oslo

I hold a background in molecular biology and mechanobiology with specialization in microscopy imaging. Over the course of my career, I have also garnered experience in facility management. I am commonly referred to as Edna.

I am poised to assume the role of Facility Manager at the Light Microscopy Imaging Facility within the Life Science Building of the university, which will be operated jointly by OUS and UiO. Prior to the completion of the Life Science Building, my work distribution will involve spending 40% of my time at the Advanced Imaging Facility at Radium Hospital (on Wednesdays and Thursdays) and 60% at the NorMIC Imaging Platform at IBV (on Mondays, Tuesdays, and Fridays).

My areas of expertise encompass live cell imaging with a focus on high temporal and spatial resolution, as well as proficiency in various super-resolution microscopy technologies. Additionally, I serve as the principal organizer of the NorMIC imaging workshop series.

In addition to my responsibilities within the platform, I actively engage in my own research project to stay abreast of cutting-edge developments in the field of biological imaging. My primary research interests revolve around bio-imaging-based mechanobiology and intracellular trafficking.

Key Work Experience:

2020-2023  Institute Lab Manager of NCMM

2017-2020 Imaging Scientist at NorMIC Imaging Platform

2019-2020: Visiting Researcher at Mechanobiology Institute, Singapore

2009- 2011 Light Microscopy Facility Manager of Mechanobiology Institute, Singapore

The Mechanobiology Institute is a Research Center of Excellence established in 2009 with an initial funding of approximately 800 million NOK, of which roughly 300 million NOK was allocated for optical microscopes. Over the course of its first decade, the institute has produced over 800 publications with impact factors consistently at or above 10.

Education:

2011-2016 PhD, Mechanobiology Institute, National University of Singapore, Supervisor: Prof Michael Sheetz and Prof Alexander Bershadsky

2002-2006 Bachelors with Hons (with scholarship from Ministry of Education, Singapore), National University of Singapore, Major: Life Sciences(Biomedical Sciences), Minor: Management and IT

Selected Publications:

1. Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin (Plos Bio, 2011) Felix Margadant, Li Li Chew, Xian Hu, Hanry Yu, Neil Bate, Xian Zhang, Michael Sheetz

2. Nanolithographic Control of the Spatial Organization of Cellular Adhesion Receptors at the Single-Molecule Level(Nano Letters, 2011) Mark Schvartzman, Matteo Palma, Julia Sable, Justin Abramson, Xian Hu, Michael P Sheetz, Shalom J Wind

3. Kinectin-mediated endoplasmic reticulum dynamics supports focal adhesion growth in the cellular lamella (JCS, 2010) Xin Zhang, Yee Han Tee, Justin K Heng, Yajuan Zhu, Xian Hu, Felix Margadant, Christoph Ballestrem, Alexander Bershadsky, Gareth Griffiths, Hanry Yu

4.  Super Resolution Imaging Reveals that Talin is an Antiparallel Dimer that Cooperatively Binds Vinculin (ACS Nano Letters, 2016) Xian Hu, Chaoran Jing, Xiaochun Xu, Naotaka Nakazawa, Virginia W. Cornish, Felix Margadant and Michael P. Sheetz (Impact Factor 12.279)

5. The Mechanical Response of Talin (Nature Communication, 2016) Mingxi Yao, Benjamin T. Goult, Benjamin Klapholz, Xian Hu, Christopher P. Toseland, Yingjian Guo, Peiwen Cong, Michael Sheetz and Jie Yan

6. Molecular Stretching Modulates Signaling Pathways (Protein Science, 2017) Xian Hu, Felix Margadant, Mingxi Yao, Michael Sheetz

7. Distortion Correction for Pillar Tracking Caused by Specimen and Devices (Sciforum, 2017, DOI: 10.3390/OPTOFLUIDICS2017-04182 ) Xiaochun Xu, Xian Hu, Michael Patrick Sheetz, Felix Margadant

8. Mechanotransmission and mechanosensing of human alpha-actinin 1(Cell Report, 2018) ) Shimin Le, Xian Hu, Mingxi Yao, Hu Chen, Xiaochun Xu, Naotaka Nakazawa, Felix Margadant, Michael Patrick Sheetz, Jie Yan

9. Rab18 regulates focal adhesion dynamics through recruitment of kinectin-1 at the endoplasmic reticulum(Journal of cell biology, 2020) Guadagno Noemi Antonella, Kjos Ingrid, Xu Xiaochun, Xian Hu, Bakke Oddmund, Margadant Felix, Progida Cinzia

10. Streak microscopy for particle and object tracking(Journal of Cell Science, 2020) Xian Hu, Michael Sheetz, Oddmund Bakke* & Felix Margadant*

11. Co-moving frame of observation for super-resolution microscopy Xian Hu, Felix Margadant, Oddmund Bakke (patent)

12. Targeting rock1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma (biochemical pharmacology, 2021) Hua Wu, Yuyuan Chen, Bin Li, Chun Li, Jun Guo, Jia You, Xian Hu, Dong Kuang, Shibo Qi, Pin Liu, Lei Li, Chuanrui Xu.

13. De novo formation of early endosome during rab5-to- rab7a transition(Journal of cell sciences, 2021), Frode Miltzow Skjeldal, Linda Hofstad Haugen, Duarte Mateus, Dominik m Frei, Anna Vik Rødseth, Xian Hu, Oddmund Bakke

14. Rapid genome editing by crispr-cas9-pold3 fusion (elife, 2021), Ganna reint, Zhuokun Li, Kornel Labun, Salla Keskitalo, Inkeri Soppa, Katariina Mamia, Eero Tolo, Monika Szymanska, Leonardo a Meza-zepeda, Susanne Lorenz, Artur Cieslar-pobuda, Xian Hu, Diana l Bordin, Judith Staerk, Eivind Valen, Bernhard Schmierer, Markku Varjosalo, Jussi Taipale, Emma Haapaniemi

 

 

 

Published Oct. 19, 2023 5:22 PM - Last modified Mar. 19, 2024 12:54 PM