Sjannie Lefevre

Associate Professor
Image of Sjannie Lefevre
Norwegian version of this page
Phone +4722859061
Room 2603
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Visiting address Blindernveien 31 Kristine Bonnevies Hus 0371 Oslo
Postal address PB 1066 Blindern 0366 Oslo

Academic Interests

My overall interest has long been cardio-respiratory physiology of animals, in particular fish. I have worked a lot on the whole-animal level, i.e. using methods such as respirometry to investigate the effect of different environmental factors on respiration and aerobic scope, and in air-breathing fish also the effects on partioning of oxygen uptake between water and air. Currently I am interested in the molecular mechanisms enabling the anoxia-tolerant crucian carp to survive without any oxygen for extended periods of time, and in particular how they survive the stress of subsequent re-oxygenation. We are using discovery-driven approaches such as metabolomics, transcriptomics and translatomics (aka riboseq or ribosomal footprint profiling) to discover potentially unknown mechanisms. I also aim to use single-cell RNA sequencing, to further tease apart some of the many, many transcriptional changes we have observed in the brain. In additon to the work on crucian carp, I have been working on the effects of climate change on coral reef fish, and a tropical jumping snail.

Other activities

In addition to my research, I am also chair of the Norwegian Physiological Society (Norsk Fysiologisk Forening) and I am an executive officer of the Scandinavian Physiological Society. I am also a Loyal Member of the Society for Experimental Biology, and I recently started as academic editor of the journal Biology Open. Lastly, I am deputy leader of a collaborative project called "Availability and function of donor organs: Debating the dead donor rule (3DR)", lead by Kåre-Olav Stensløkken and funded by UiO Life Science. I am leading a work package aiming to uncover the mechanisms regulating hypometabolism in the crucian carp.

Higher education and employment history

  • 2020-present: Associate Professor, Section for Physiology and Cell Biology (FYSCELL), Dept. of Biosciences, Univ. of Oslo, Norway
  • 2017-2020: Researcher, Section for Physiology and Cell Biology (FYSCELL), Dept. of Biosciences, Univ. of Oslo, Norway
  • 2014-2017: Postdoctoral Fellow (funding from the Research Council of Norway), FYSCELL, Dept. of Biosciences, Univ. of Oslo, Norway
  • 2012-2014: Researcher (funded by a Personal Postdoctoral Fellowship from the Carlsberg Foundation, Denmark) Department of Biosciences, University of Oslo, Norway
  • Ph.D., Dep. Bioscience, Zoophysiology, Aarhus University, Denmark, March 14th 2012

  • B.Sc., Dep. Bioscience, Genetics and Ecology, Aarhus University, Denmark, June 1st 2007                                         

Grants

  • Research Council of Norway 2021 (Researcher Project, FORSKER21): Epigenetic mechanisms and cell-type specific gene expression during anoxia and re-oxygenation in crucian carp brain

  • Research Council of Norway 2017 (Young Research Talent, FRIMEDBIO): Re-oxygenation resilience - the overlooked element of anoxic survival

  • Nansen Foundation, December 2015: The effects of hypoxia acclimation on the air-breathing Alaska blackfish

  • Nansen Foundation, December 2013: Jumping tropical snails: a model for studying effects of global change on respiratory performance in coral reef invertebrates

  • Individual postdoctoral fellowship, Carlsberg foundation 2013-2014: Regulation of apoptosis in anoxic crucian carp

  • Company of Biologists (section Journal of Experimental Biology), March-April 2013: The importance of air-breathing for Alaska blackfish Dallia pectoralis

  • Company of Biologists (through Society of Experimental Biology), March-April 2013: The importance of air-breathing for Alaska blackfish Dallia pectoralis

Work abroad

Jumping snail in respirometer during jump, cone snail to the left of the respirometer
Jumping snail actually jumping in respirometer, stimulated by the odour from a cone snail (Conus marmoreus). Photo: Sjannie Lefevre.

Several trips to Lizard Island Research Station (Queensland, Australia), investigating temperature effects on the physiology of the conch, Gibberulus gibberulus gibbosus, aka "the jumping snail". This research was featured by the New York Times (Sciencetake), Science News (Science Ticker and It’s Alive) and Discovery Channel Canada.

 

 

Alaska blackfish in aquarium.
Alaska blackfish. Photo: Sjannie Lefevre.

Investigating the effect of temperature and hypoxia on the respiratory physiology of Alaska blackfish, Dallia pectoralis, together with Jonathan Stecyk at University of Alaska Anchorage. The Alaska blackfish even ended up on the cover of the Journal of Experimental Biology (JEB Cover).​​

 

 

Pangasius on table, Sjannie inserting depth and oxygen loggers
Sjannie Lefevre in the field, implanting depth and oxygen loggers in a pangasius. Photo: Mark Bayley.

Experimental work during PhD study: “Oxygen requirements of the two air-breathing fish Pangasianodon hypophthalmus and Channa striata”, Can Tho City, Vietnam (21 months).​

                                      

 

Butterfly
Gulf fritillary (Agraulis vanillae) sitting in a Cordia globosa flower. Photo: Sjannie Lefevre.

Experimental work during BSc study: “Morphology, visitation and pollen deposition in Cordia globosa and Morinda citrifolia, two common Caribbean shrubs”. The Commonwealth of Dominica (The West Indies), 5 months.​​

 

 

 

    

Tags: Comparative physiology, Respiration, Fish, Hypoxia, Anoxia, Respirometry, Molecular biology, Transcriptomics, Metabolomics

Publications

Earlier publications:

8.  Sjannie Lefevre, Do Thi Thanh Huong, Tobias Wang, Nguyen Thanh Phuong, Mark Bayley (2012) Effects of hypoxia on the rise in metabolism and partitioning of oxygen uptake during digestion in the air-breathing fish Channa striata. Aquaculture 364–365, pp. 137–142.

7.  Sjannie Lefevre, Frank B Jensen, Do Thi Thanh Huong, Tobias Wang, Nguyen Thanh Phuong, Mark Bayley (2012) Haematological and ion regulatory effects of nitrite in the air-breathing snakehead fish Channa striata. Aquatic Toxicology 118-119, pp. 48-53.

6.  Angela Fago, Frank B. Jensen, Bruno Tota, Martin Feelisch, Kenneth R. Olson, Signe Helbo, Sjannie Lefevre, Daniele Mancardi, Anna Palumbo, Guro K. Sandvik, Nini Skovgaard (2012) Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: A comparative approach. Comparative Biochemistry and Physiology Part A 162(1), pp. 1-6.

5.  Sjannie Lefevre, Frank B Jensen, Do Thi Thanh Huong, Tobias Wang, Nguyen Thanh Phuong, Mark Bayley (2011) Effects of nitrite exposure on functional haemoglobin levels, bimodal respiration, and swimming performance in the facultative air-breathing fish Pangasianodon hypophthalmus. Aquatic Toxicology 104, pp. 86-93.

4.  Sjannie Lefevre, Do Thi Thanh Huong, Nguyen Thi Kim Ha, Tobias Wang, Nguyen Thanh Phuong, Mark Bayley (2011) A telemetry study of swimming depth and oxygen level in a Pangasius pond in the Mekong Delta. Aquaculture 315, pp. 410-413.

3.  Sjannie Lefevre, Do Thi Thanh Huong, Tobias Wang, Nguyen Thanh Phuong, Mark Bayley (2011) Hypoxia tolerance and partitioning of bimodal respiration in the striped catfish (Pangasianodon hypophthalmus). Comparative Biochemistry and Physiology Part A 158(2), pp. 207-214

2.  Nguyen Huong Thuy, Lam Anh Tien, Phuong Nguyen Tuyet, Do Thi Thanh Huong, Nguyen Van Cong, Mark Bayley, Tobias Wang, Sjannie Lefevre (2010) Critical oxygen tension increases during digestion in the perch Perca fluviatilis. Journal of Fish Biology 76, pp. 1025-1031.

1.  Tobias Wang, Sjannie Lefevre, Do Thi Thanh Huong, Nguyen Van Cong, Mark Bayley (2009) Impact of hypoxia on growth and digestion. In: Fish Physiology vol. 27 Hypoxia (eds. J.G. Richards, A. P. Farrell, C. J. Brauner), pp. 363-397. Academic Press / Elsevier.

  • Lefevre, Sjannie; Wang, Tobias & McKenzie, David J. (2021). The role of mechanistic physiology in investigating impacts of global warming on fishes. Journal of Experimental Biology. ISSN 0022-0949. 224. doi: 10.1242/jeb.238840. Full text in Research Archive
  • Dahl, Helge-Andre; Johansen, Anette; Nilsson, Göran Erik & Lefevre, Sjannie (2021). The Metabolomic Response of Crucian Carp (Carassius carassius) to Anoxia and Reoxygenation Differs between Tissues and Hints at Uncharacterized Survival Strategies. Metabolites. ISSN 2218-1989. 11(7). doi: 10.3390/metabo11070435. Full text in Research Archive
  • Lefevre, Sjannie (2019). Effects of high CO2 on oxygen consumption rates, aerobic scope and swimming performance. In Grosell, Martin; Munday, Philip L.; Farrell, P. & Brauner, Colin J. (Ed.), Carbon Dioxide. Elsevier. ISSN 978-0-12-817609-2. p. 195–244. doi: 10.1016/bs.fp.2019.08.001.
  • Thomsen, Mikkel T; Lefevre, Sjannie; Nilsson, Göran Erik; Wang, Tobias & Bayley, Mark (2019). Effects of lactate ions on the cardiorespiratory system in rainbow trout (Oncorhynchus mykiss). American Journal of Physiology. Regulatory Integrative and Comparative Physiology. ISSN 0363-6119. 316(5), p. R607–R620. doi: 10.1152/ajpregu.00395.2018. Full text in Research Archive
  • Riggs, Claire L.; Summers, Amanda; Warren, Daniel E.; Nilsson, Göran Erik; Lefevre, Sjannie & Dowd, Wesley W. [Show all 8 contributors for this article] (2018). Small non-coding RNA expression and vertebrate anoxia tolerance. Frontiers in Genetics. ISSN 1664-8021. 9:230, p. 1–22. doi: 10.3389/fgene.2018.00230. Full text in Research Archive
  • Lefevre, Sjannie; McKenzie, David J. & Nilsson, Göran Erik (2018). In modelling effects of global warming, invalid assumptions lead to unrealistic projections. Global Change Biology. ISSN 1354-1013. 24(2), p. 553–556. doi: 10.1111/gcb.13978. Full text in Research Archive
  • Lefevre, Sjannie; Stecyk, Jonathan Anthony William; Torp, May-Kristin; Løvold, Lisa Yuen; Sørensen, Christina & Johansen, Ida Beitnes [Show all 10 contributors for this article] (2017). Re-oxygenation after anoxia induces brain cell death and memory loss in the anoxia-tolerant crucian carp. Journal of Experimental Biology. ISSN 0022-0949. 220(21), p. 3883–3895. doi: 10.1242/jeb.165118. Full text in Research Archive
  • Lefevre, Sjannie; McKenzie, David J. & Nilsson, Göran E. (2017). Models projecting the fate of fish populations under climate change need to be based on valid physiological mechanisms. Global Change Biology. ISSN 1354-1013. 23(9), p. 3449–3459. doi: 10.1111/gcb.13652. Full text in Research Archive
  • Nilsson, Göran Erik & Lefevre, Sjannie (2016). Physiological challenges to fishes in a warmer and acidified future. Physiology. ISSN 1548-9213. 31(6), p. 409–417. doi: 10.1152/physiol.00055.2015.
  • Mckenzie, David J.; Axelsson, Michael; Chabot, Denis; Claireaux, Guy; Cooke, Steven J. & Corner , Richard A. [Show all 29 contributors for this article] (2016). Conservation physiology of marine fishes: state of the art and prospects for policy. Conservation Physiology. ISSN 2051-1434. 4(1). doi: 10.1093/conphys/cow046.
  • Regan, Matthew D.; Turko, Andy J.; Heras, Joseph; Andersen, Mads Kuhlmann; Lefevre, Sjannie & Wang, Tobias [Show all 11 contributors for this article] (2016). Ambient CO2, fish behaviour and altered GABAergic neurotransmission: Exploring the mechanism of CO2-altered behaviour by taking a hypercapnia dweller down to low CO2 levels. Journal of Experimental Biology. ISSN 0022-0949. 219(1), p. 109–118. doi: 10.1242/jeb.131375.
  • Lefevre, Sjannie; Bayley, Mark & Mckenzie, David J. (2016). Measuring oxygen uptake in fishes with bimodal respiration. Journal of Fish Biology. ISSN 0022-1112. 88(1), p. 206–231. doi: 10.1111/jfb.12698.
  • Lefevre, Sjannie (2016). Are global warming and ocean acidification conspiring against marine ectotherms? Are meta-analysis of the respiratory effects of elevated temperature, high CO2, and their interaction. Conservation Physiology. ISSN 2051-1434. 4(1). doi: 10.1093/conphys/cow009.
  • Lefevre, Sjannie; Watson, Sue-Ann; Munday, Philip L. & Nilsson, Göran Erik (2015). Will jumping snails prevail? Influence of near-future CO2, temperature and hypoxia on respiratory performance in the tropical conch Gibberulus gibberulus gibbosus. Journal of Experimental Biology. ISSN 0022-0949. 218(19), p. 2991–3001. doi: 10.1242/jeb.120717.
  • Lefevre, Sjannie; Findorf, Inge; Bayley, Mark; Huong, Do Thi Thanh & Wang, Tobias (2015). Increased temperature tolerance of the air-breathing Asian swamp eel Monopterus albus after high-temperature acclimation is not explained by improved cardiorespiratory performance. Journal of Fish Biology. ISSN 0022-1112. doi: 10.1111/jfb.12696.
  • Cook, D.G.; Brown, Eric Joel; Lefevre, Sjannie; Domenici, Paolo & Fleng Steffensen, John (2014). The response of striped surfperch embiotoca lateralis to progressive hypoxia: Swimming activity, shoal structure, and estimated metabolic expenditure. Journal of Experimental Marine Biology and Ecology. ISSN 0022-0981. 460, p. 162–169. doi: 10.1016/j.jembe.2014.07.002.
  • Lefevre, Sjannie; Domenici, Paolo & Mckenzie, David J. (2014). Swimming in air-breathing fishes. Journal of Fish Biology. ISSN 0022-1112. 84(3), p. 661–681. doi: 10.1111/jfb.12308.
  • Wang, Tobias; Lefevre, Sjannie; Iversen, Nina K.; Findorf, Inge; Buchanan, Rasmus & Mckenzie, David J. (2014). Anaemia only causes a small reduction in the upper critical temperature of sea bass: Is oxygen delivery the limiting factor for tolerance of acute warming in fishes? Journal of Experimental Biology. ISSN 0022-0949. 217(24), p. 4275–4278. doi: 10.1242/jeb.104166.
  • Lefevre, Sjannie; Damsgaard, Christian; Pascale, Desirae R.; Nilsson, Göran Erik & Stecyk, Jonathan Anthony William (2014). Air breathing in the Arctic: influence of temperature, hypoxia, activity and restricted air access on respiratory physiology of the Alaska blackfish Dallia pectoralis. Journal of Experimental Biology. ISSN 0022-0949. 217(24), p. 4387–4398. doi: 10.1242/jeb.105023.
  • Watson, Sue; Lefevre, Sjannie; McCormick, Mark I.; Domenici, Paolo; Nilsson, Göran Erik & Munday, Philip L. (2013). Marine mollusc predator-escape behaviour altered by near-future carbon dioxide levels. Proceedings of the Royal Society of London. Biological Sciences. ISSN 0962-8452. 281(1774). doi: 10.1098/rspb.2013.2377.
  • Lefevre, Sjannie; Wang, Tobias; Huong, Do Thi Thanh; Phuong, Nguyen Thanh & Bayley, Mark (2013). Partitioning of oxygen uptake and cost of surfacing during swimming in the air-breathing catfish Pangasianodon hypophthalmus. Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology. ISSN 0174-1578. 183, p. 215–221. doi: 10.1007/s00360-012-0701-8.

View all works in Cristin

  • Lefevre, Sjannie (2021). The role of transcription and translation dynamics in the response to anoxia and re-oxygenation in the crucian carp.
  • Lefevre, Sjannie (2021). Strategies that allow the crucian carp to survive periods of anoxia that would kill a mammal.
  • Lefevre, Sjannie; Lau, Gigi Yik Chee; Dahl, Helge-Andre & Nilsson, Göran Erik (2019). Crucian carp: mitochondria, anoxia and reoxygenation.
  • Lefevre, Sjannie; Lau, Gigi Yik Chee; Dahl, Helge-Andre & Nilsson, Göran Erik (2019). Re-oxygenation resilience - the other aspect of the crucian carp’s anoxia tolerance.
  • Lefevre, Sjannie (2019). Global warming and future fish size:What can we learn from the gill-oxygen limitation hypothesis (GOLT)? .
  • Lefevre, Sjannie; McKenzie, David J. & Nilsson, Göran Erik (2019). Global warming and future fish size: thoughts on the gill-oxygen limitation hypothesis.
  • Lefevre, Sjannie (2019). SENSING AND ADAPTING TO OXYGEN AVAILABILITY: Fuelling the fire of life and the 2019 Nobel Prize. NBS-nytt. ISSN 0801-3535. 4.
  • Lefevre, Sjannie (2018). Re-oxygenation resilience - the other element of the crucian carp's anoxia tolerance.
  • Lefevre, Sjannie (2018). Long-term hypoxia acclimation has minor effects on respiratory physiology of Alaska blackfish.
  • Lefevre, Sjannie (2018). Global warming and future fish size: Unfounded assumptions lead to absurd predictions.
  • Lefevre, Sjannie (2018). Are there CO2 effects on oxygen uptake as predicted by the OCLTT hypothesis?
  • Lefevre, Sjannie (2018). Global warming and future fish size (or how not to interpret aerobic scope).
  • Dahl, Helge-Andre & Lefevre, Sjannie (2018). Protection against reperfusion injury: can insight be gained from crucian carp?
  • Haugnes, Gunhild M.; Tallaksen, Lena M.; Vogt, Rolf David; Storelvmo, Trude; Hessen, Dag Olav & Stordal, Frode [Show all 9 contributors for this article] (2018). Klimaforskerne tar temperaturen på tropesommeren. [Journal]. Titan.uio.no.
  • Jutfelt, Fredrik; Norin, Tommy; Ern, Rasmus; Overgaard, Johannes; Wang, Tobias & McKenzie, David J. [Show all 28 contributors for this article] (2018). Oxygen- and capacity-limited thermal tolerance: blurring ecology and physiology. Journal of Experimental Biology. ISSN 0022-0949. 221(1). doi: 10.1242/jeb.169615.
  • Lefevre, Sjannie (2016). Are respiratory effects of global warming and ocean acidification explained by a unifying OCLTT concept?
  • Lefevre, Sjannie (2016). The transcriptomic response of crucian carp to anoxia and re-oxygenation.
  • Lefevre, Sjannie (2015). Snails in the fast-lane: Physiology and Climate Change perspectives. NBS-nytt. ISSN 0801-3535. 39(4), p. 20–21.
  • Lefevre, Sjannie & Nilsson, Göran E. (2015). Temperature acclimation in jumping snails (Gibberulus gibberulus) reduces heart rate, but not oxygen uptake, and only marginally improves heat tolerance.
  • Lefevre, Sjannie; Stecyk, Jonathan A. W.; Torp, May-Kristin & Nilsson, Göran Erik (2014). HOW TOLERANT IS AN ANOXIA-TOLERANT VERTEBRATE?
  • Lefevre, Sjannie; Watson, Sue-Ann; Munday, Philip L. & Nilsson, Göran Erik (2014). Golbal warming: Will jumping snails prevail?
  • Lefevre, Sjannie; Bayley, Mark; Mckenzie, David J. & Craig, John F. (2014). Air-breathing fishes. Journal of Fish Biology. ISSN 0022-1112. 84(3), p. 547–553. doi: 10.1111/jfb.12349.

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Published Mar. 6, 2013 2:36 PM - Last modified July 15, 2021 1:32 PM