Sjannie Lefevre

Associate Professor
Image of Sjannie Lefevre
Norwegian version of this page
Mobile phone +4748364745
Room 2603
Username
Visiting address Blindernveien 31 Kristine Bonnevies Hus 0371 Oslo
Postal address PB 1066 Blindern 0366 Oslo

Academic Interests

My overall interest has long been cardio-respiratory physiology of animals, in particular fish. I have worked a lot on the whole-animal level, i.e. using methods such as respirometry to investigate the effect of different environmental factors on respiration and aerobic scope, and in air-breathing fish also the effects on partioning of oxygen uptake between water and air. Currently I am interested in the molecular mechanisms enabling the anoxia-tolerant crucian carp to survive without any oxygen for extended periods of time, and in particular how they survive the stress of subsequent re-oxygenation. We are using discovery-driven approaches such as metabolomics, transcriptomics and translatomics (aka riboseq or ribosomal footprint profiling) to discover potentially unknown mechanisms. I also aim to use single-cell RNA sequencing, to further tease apart some of the many, many transcriptional changes we have observed in the brain. In addition to the work on crucian carp, I have been working on the effects of climate change on coral reef fish, and a tropical jumping snail.

Other activities

In addition to my research, I am also chair of the Norwegian Physiological Society (Norsk Fysiologisk Forening) and convenor for the Comparative Physiology Special Interest Group of the Scandinavian Physiological Society. I am also a Loyal Member of the Society for Experimental Biology, and I have worked as an academic editor of the journal Biology Open since 2019. Lastly, I am deputy leader of a collaborative project called "Availability and function of donor organs: Debating the dead donor rule (3DR)", lead by Kåre-Olav Stensløkken and funded by UiO Life Science. I am leading a work package aiming to uncover the mechanisms regulating hypometabolism in the crucian carp.

Higher education and employment history

  • 2020-present: Associate Professor, Section for Physiology and Cell Biology (FYSCELL), Dept. of Biosciences, Univ. of Oslo, Norway
  • 2017-2020: Researcher, Section for Physiology and Cell Biology (FYSCELL), Dept. of Biosciences, Univ. of Oslo, Norway
  • 2014-2017: Postdoctoral Fellow (funding from the Research Council of Norway), FYSCELL, Dept. of Biosciences, Univ. of Oslo, Norway
  • 2012-2014: Researcher (funded by a Personal Postdoctoral Fellowship from the Carlsberg Foundation, Denmark) Department of Biosciences, University of Oslo, Norway
  • Ph.D., Dep. Bioscience, Zoophysiology, Aarhus University, Denmark, March 14th 2012

  • B.Sc., Dep. Bioscience, Genetics and Ecology, Aarhus University, Denmark, June 1st 2007                                         

Grants

  • Research Council of Norway 2021 (Researcher Project, FORSKER21): Epigenetic mechanisms and cell-type specific gene expression during anoxia and re-oxygenation in crucian carp brain

  • Research Council of Norway 2017 (Young Research Talent, FRIMEDBIO): Re-oxygenation resilience - the overlooked element of anoxic survival

  • Nansen Foundation, December 2015: The effects of hypoxia acclimation on the air-breathing Alaska blackfish

  • Nansen Foundation, December 2013: Jumping tropical snails: a model for studying effects of global change on respiratory performance in coral reef invertebrates

  • Individual postdoctoral fellowship, Carlsberg foundation 2013-2014: Regulation of apoptosis in anoxic crucian carp

  • Company of Biologists (section Journal of Experimental Biology), March-April 2013: The importance of air-breathing for Alaska blackfish Dallia pectoralis

  • Company of Biologists (through Society of Experimental Biology), March-April 2013: The importance of air-breathing for Alaska blackfish Dallia pectoralis

Teaching

BIOS5810/9810 - Comparative and Ecological Physiology (leader)

BIOS5812 - Advanced Physiology and Neurobiology (teacher)

BIOS3800 - Human Physiology (teacher)

BIOS1110 - Celle- og molekylærbiologi (co-leader)

    

Tags: Comparative physiology, Respiration, Fish, Hypoxia, Anoxia, Respirometry, Transcriptomics, Metabolomics

Publications

  • Gerber, Lucie Claire Lola; Resseguier, Julien Alain Andre; Helle-Valle, Tellef; Farhat, Elie; Nilsson, Göran Erik & Nilsson, Sjannie Lefevre (2023). Expression of prolyl hydroxylase domains, the upstream regulators of HIF, in the brain of the anoxia-tolerant crucian carp during anoxia-reoxygenation. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. ISSN 0363-6119. 326(2), p. R184–R195. doi: 10.1152/ajpregu.00211.2023.
  • Lefevre, Sjannie & Nilsson, Göran E. (2023). Two decades of research on anoxia tolerance – mitochondria, -omics and physiological diversity. Journal of Experimental Biology. ISSN 0022-0949. 226(7), p. 1–10. doi: 10.1242/jeb.245584. Full text in Research Archive
  • Downie, Adam T.; Lefevre, Sjannie; Illing, Björn; Harris, Jessica; Jarrold, Michael D. & McMcormick, Mark I. [Show all 8 contributors for this article] (2023). Rapid physiological and transcriptomic changes associated with oxygen delivery in larval anemonefish suggest a role in adaptation to life on hypoxic coral reefs. PLoS Biology. ISSN 1544-9173. 21(5), p. 1–28. doi: 10.1371/journal.pbio.3002102. Full text in Research Archive
  • Dahl, Helge-Andre; Johansen, Anette; Nilsson, Göran Erik & Lefevre, Sjannie (2021). The Metabolomic Response of Crucian Carp (Carassius carassius) to Anoxia and Reoxygenation Differs between Tissues and Hints at Uncharacterized Survival Strategies. Metabolites. ISSN 2218-1989. 11(7), p. 1–26. doi: 10.3390/metabo11070435. Full text in Research Archive
  • Lefevre, Sjannie; Wang, Tobias & McKenzie, David J. (2021). The role of mechanistic physiology in investigating impacts of global warming on fishes. Journal of Experimental Biology. ISSN 0022-0949. 224, p. 1–13. doi: 10.1242/jeb.238840. Full text in Research Archive
  • Lefevre, Sjannie (2019). Effects of high CO2 on oxygen consumption rates, aerobic scope and swimming performance. In Grosell, Martin; Munday, Philip L.; Farrell, P. & Brauner, Colin J. (Ed.), Carbon Dioxide. Elsevier. ISSN 978-0-12-817609-2. p. 195–244. doi: 10.1016/bs.fp.2019.08.001.
  • Thomsen, Mikkel T; Lefevre, Sjannie; Nilsson, Göran Erik; Wang, Tobias & Bayley, Mark (2019). Effects of lactate ions on the cardiorespiratory system in rainbow trout (Oncorhynchus mykiss). American Journal of Physiology. Regulatory Integrative and Comparative Physiology. ISSN 0363-6119. 316(5), p. R607–R620. doi: 10.1152/ajpregu.00395.2018. Full text in Research Archive
  • Riggs, Claire L.; Summers, Amanda; Warren, Daniel E.; Nilsson, Göran Erik; Lefevre, Sjannie & Dowd, Wesley W. [Show all 8 contributors for this article] (2018). Small non-coding RNA expression and vertebrate anoxia tolerance. Frontiers in Genetics. ISSN 1664-8021. 9:230, p. 1–22. doi: 10.3389/fgene.2018.00230. Full text in Research Archive
  • Lefevre, Sjannie; McKenzie, David J. & Nilsson, Göran Erik (2018). In modelling effects of global warming, invalid assumptions lead to unrealistic projections. Global Change Biology. ISSN 1354-1013. 24(2), p. 553–556. doi: 10.1111/gcb.13978. Full text in Research Archive
  • Lefevre, Sjannie; Stecyk, Jonathan Anthony William; Torp, May-Kristin; Løvold, Lisa Yuen; Sørensen, Christina & Johansen, Ida Beitnes [Show all 10 contributors for this article] (2017). Re-oxygenation after anoxia induces brain cell death and memory loss in the anoxia-tolerant crucian carp. Journal of Experimental Biology. ISSN 0022-0949. 220(21), p. 3883–3895. doi: 10.1242/jeb.165118. Full text in Research Archive
  • Lefevre, Sjannie; McKenzie, David J. & Nilsson, Göran E. (2017). Models projecting the fate of fish populations under climate change need to be based on valid physiological mechanisms. Global Change Biology. ISSN 1354-1013. 23(9), p. 3449–3459. doi: 10.1111/gcb.13652. Full text in Research Archive
  • Mckenzie, David J.; Axelsson, Michael; Chabot, Denis; Claireaux, Guy; Cooke, Steven J. & Corner , Richard A. [Show all 29 contributors for this article] (2016). Conservation physiology of marine fishes: state of the art and prospects for policy. Conservation Physiology. ISSN 2051-1434. 4(1). doi: 10.1093/conphys/cow046.
  • Nilsson, Göran Erik & Lefevre, Sjannie (2016). Physiological challenges to fishes in a warmer and acidified future. Physiology. ISSN 1548-9213. 31(6), p. 409–417. doi: 10.1152/physiol.00055.2015.
  • Regan, Matthew D.; Turko, Andy J.; Heras, Joseph; Andersen, Mads Kuhlmann; Lefevre, Sjannie & Wang, Tobias [Show all 11 contributors for this article] (2016). Ambient CO2, fish behaviour and altered GABAergic neurotransmission: Exploring the mechanism of CO2-altered behaviour by taking a hypercapnia dweller down to low CO2 levels. Journal of Experimental Biology. ISSN 0022-0949. 219(1), p. 109–118. doi: 10.1242/jeb.131375.
  • Lefevre, Sjannie (2016). Are global warming and ocean acidification conspiring against marine ectotherms? Are meta-analysis of the respiratory effects of elevated temperature, high CO2, and their interaction. Conservation Physiology. ISSN 2051-1434. 4(1). doi: 10.1093/conphys/cow009.
  • Lefevre, Sjannie; Bayley, Mark & Mckenzie, David J. (2016). Measuring oxygen uptake in fishes with bimodal respiration. Journal of Fish Biology. ISSN 0022-1112. 88(1), p. 206–231. doi: 10.1111/jfb.12698.
  • Lefevre, Sjannie; Findorf, Inge; Bayley, Mark; Huong, Do Thi Thanh & Wang, Tobias (2015). Increased temperature tolerance of the air-breathing Asian swamp eel Monopterus albus after high-temperature acclimation is not explained by improved cardiorespiratory performance. Journal of Fish Biology. ISSN 0022-1112. doi: 10.1111/jfb.12696.
  • Lefevre, Sjannie; Watson, Sue-Ann; Munday, Philip L. & Nilsson, Göran Erik (2015). Will jumping snails prevail? Influence of near-future CO2, temperature and hypoxia on respiratory performance in the tropical conch Gibberulus gibberulus gibbosus. Journal of Experimental Biology. ISSN 0022-0949. 218(19), p. 2991–3001. doi: 10.1242/jeb.120717.
  • Wang, Tobias; Lefevre, Sjannie; Iversen, Nina K.; Findorf, Inge; Buchanan, Rasmus & Mckenzie, David J. (2014). Anaemia only causes a small reduction in the upper critical temperature of sea bass: Is oxygen delivery the limiting factor for tolerance of acute warming in fishes? Journal of Experimental Biology. ISSN 0022-0949. 217(24), p. 4275–4278. doi: 10.1242/jeb.104166.
  • Lefevre, Sjannie; Damsgaard, Christian; Pascale, Desirae R.; Nilsson, Göran Erik & Stecyk, Jonathan Anthony William (2014). Air breathing in the Arctic: influence of temperature, hypoxia, activity and restricted air access on respiratory physiology of the Alaska blackfish Dallia pectoralis. Journal of Experimental Biology. ISSN 0022-0949. 217(24), p. 4387–4398. doi: 10.1242/jeb.105023.
  • Cook, D.G.; Brown, Eric Joel; Lefevre, Sjannie; Domenici, Paolo & Fleng Steffensen, John (2014). The response of striped surfperch embiotoca lateralis to progressive hypoxia: Swimming activity, shoal structure, and estimated metabolic expenditure. Journal of Experimental Marine Biology and Ecology. ISSN 0022-0981. 460, p. 162–169. doi: 10.1016/j.jembe.2014.07.002.
  • Lefevre, Sjannie; Domenici, Paolo & Mckenzie, David J. (2014). Swimming in air-breathing fishes. Journal of Fish Biology. ISSN 0022-1112. 84(3), p. 661–681. doi: 10.1111/jfb.12308.
  • Watson, Sue; Lefevre, Sjannie; McCormick, Mark I.; Domenici, Paolo; Nilsson, Göran Erik & Munday, Philip L. (2013). Marine mollusc predator-escape behaviour altered by near-future carbon dioxide levels. Proceedings of the Royal Society of London. Biological Sciences. ISSN 0962-8452. 281(1774). doi: 10.1098/rspb.2013.2377.
  • Lefevre, Sjannie; Wang, Tobias; Huong, Do Thi Thanh; Phuong, Nguyen Thanh & Bayley, Mark (2013). Partitioning of oxygen uptake and cost of surfacing during swimming in the air-breathing catfish Pangasianodon hypophthalmus. Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology. ISSN 0174-1578. 183, p. 215–221. doi: 10.1007/s00360-012-0701-8.

View all works in Cristin

  • Gerber, Lucie; Helle-Valle, Tellef; Resseguier, Julien Alain Andre; Torp, May-Kristin; Dahl, Helge Andre & Nilsson, Göran Erik [Show all 8 contributors for this article] (2022). Prolyl Hydroxylase Domains in the Anoxia Tolerant Crucian Carp (c. carassius): Insights into the Regulation of the HIF Response to Anoxia-Reoxygenation.
  • Gerber, Lucie; Helle-Valle, Tellef; Resseguier, Julien Alain Andre; Torp, May-Kristin; Dahl, Helge Andre & Nilsson, Göran Erik [Show all 8 contributors for this article] (2022). Prolyl Hydroxylase Domains in the Anoxia Tolerant Crucian Carp (c. carassius): Insights into the Regulation of the HIF Response to Anoxia-Reoxygenation.
  • Gerber, Lucie; Torp, May-Kristin; Nilsson, Göran Erik; Stensløkken, Kåre-Olav & Lefevre, Sjannie (2022). Mitochondrial Functions in the Anoxia Tolerant Crucian Carp. .
  • Gerber, Lucie; Torp, May-Kristin; Nilsson, Göran Erik; Lefevre, Sjannie & Stensløkken, Kåre-Olav (2022). Improving organ preservation: Another lesson from the champion of anoxia tolerance, the crucian carp (C. carassius).
  • Gerber, Lucie; Torp, May-Kristin; Nilsson, Göran Erik; Lefevre, Sjannie & Stensløkken, Kåre-Olav (2022). Improving organ preservation: Another lesson from the champion of anoxia tolerance, the crucian carp (C. carassius).
  • Valencia Pesqueira, Laura Maria; Jentoft, Sissel & Lefevre, Sjannie (2022). De novo assembly of the crucian carp genome .
  • Lefevre, Sjannie & Dahl, Helge Andre (2022). Insights from ‘omics’ about crucian carp anoxia tolerance.
  • Lefevre, Sjannie (2022). Partitioning of oxygen uptake in air-breathing fishes.
  • Lefevre, Sjannie; Downie, Adam; Rummer, Jodie L. & Nilsson, Göran Erik (2022). Changes in haemoglobin gene expression during development of a coral reef fish.
  • Gerber, Lucie; Nilsson, Göran Erik & Lefevre, Sjannie (2021). Kan en fisk fra Nordmarka hjelpe oss?
  • Lefevre, Sjannie (2021). The role of transcription and translation dynamics in the response to anoxia and re-oxygenation in the crucian carp.
  • Lefevre, Sjannie (2021). Strategies that allow the crucian carp to survive periods of anoxia that would kill a mammal.
  • Lefevre, Sjannie (2019). SENSING AND ADAPTING TO OXYGEN AVAILABILITY: Fuelling the fire of life and the 2019 Nobel Prize. NBS-nytt. ISSN 0801-3535. 4.
  • Lefevre, Sjannie; McKenzie, David J. & Nilsson, Göran Erik (2019). Global warming and future fish size: thoughts on the gill-oxygen limitation hypothesis.
  • Lefevre, Sjannie (2019). Global warming and future fish size:What can we learn from the gill-oxygen limitation hypothesis (GOLT)? .
  • Lefevre, Sjannie; Lau, Gigi Yik Chee; Dahl, Helge-Andre & Nilsson, Göran Erik (2019). Re-oxygenation resilience - the other aspect of the crucian carp’s anoxia tolerance.
  • Lefevre, Sjannie; Lau, Gigi Yik Chee; Dahl, Helge-Andre & Nilsson, Göran Erik (2019). Crucian carp: mitochondria, anoxia and reoxygenation.
  • Lefevre, Sjannie (2018). Re-oxygenation resilience - the other element of the crucian carp's anoxia tolerance.
  • Haugnes, Gunhild M.; Tallaksen, Lena M.; Vogt, Rolf David; Storelvmo, Trude; Hessen, Dag Olav & Stordal, Frode [Show all 9 contributors for this article] (2018). Klimaforskerne tar temperaturen på tropesommeren. [Journal]. Titan.uio.no.
  • Dahl, Helge-Andre & Lefevre, Sjannie (2018). Protection against reperfusion injury: can insight be gained from crucian carp?
  • Lefevre, Sjannie (2018). Long-term hypoxia acclimation has minor effects on respiratory physiology of Alaska blackfish.
  • Lefevre, Sjannie (2018). Are there CO2 effects on oxygen uptake as predicted by the OCLTT hypothesis?
  • Lefevre, Sjannie (2018). Global warming and future fish size (or how not to interpret aerobic scope).
  • Lefevre, Sjannie (2018). Global warming and future fish size: Unfounded assumptions lead to absurd predictions.
  • Jutfelt, Fredrik; Norin, Tommy; Ern, Rasmus; Overgaard, Johannes; Wang, Tobias & McKenzie, David J. [Show all 28 contributors for this article] (2018). Oxygen- and capacity-limited thermal tolerance: blurring ecology and physiology. Journal of Experimental Biology. ISSN 0022-0949. 221(1). doi: 10.1242/jeb.169615.
  • Lefevre, Sjannie (2016). Are respiratory effects of global warming and ocean acidification explained by a unifying OCLTT concept?
  • Lefevre, Sjannie (2016). The transcriptomic response of crucian carp to anoxia and re-oxygenation.
  • Lefevre, Sjannie & Nilsson, Göran E. (2015). Temperature acclimation in jumping snails (Gibberulus gibberulus) reduces heart rate, but not oxygen uptake, and only marginally improves heat tolerance.
  • Lefevre, Sjannie (2015). Snails in the fast-lane: Physiology and Climate Change perspectives. NBS-nytt. ISSN 0801-3535. 39(4), p. 20–21.
  • Lefevre, Sjannie; Bayley, Mark; Mckenzie, David J. & Craig, John F. (2014). Air-breathing fishes. Journal of Fish Biology. ISSN 0022-1112. 84(3), p. 547–553. doi: 10.1111/jfb.12349.
  • Lefevre, Sjannie; Watson, Sue-Ann; Munday, Philip L. & Nilsson, Göran Erik (2014). Golbal warming: Will jumping snails prevail?
  • Lefevre, Sjannie; Stecyk, Jonathan A. W.; Torp, May-Kristin & Nilsson, Göran Erik (2014). HOW TOLERANT IS AN ANOXIA-TOLERANT VERTEBRATE?

View all works in Cristin

Published Mar. 6, 2013 2:36 PM - Last modified Jan. 14, 2024 10:55 AM