Exercise is Regenerative Medicine: Impact on Aging and Parkinson’s Disease
Seminar by Prof. Marcas Bamman
Department of Cell, Developtmental and Integrative Biology and Director of the Center for Exercise Medicine, University of Alabama at Birmingham, USA
Prof. Marcas Bamman
Prof. Marcas Bamman's research is focused on understanding the mechanisms of adult human skeletal myogenesis and muscle mass regulation remain, with a prominent emphasis on the aging muscle.
Muscle atrophy and reduced functional capacity are well-established, deleterious consequences of acute (e.g., burn, trauma, disuse) and chronic (e.g., OA/HIV/RA/cancer cachexia, COPD, diabetes mellitus, spinal cord injury) conditions—the most widespread and insidious of which is the degenerative process of normal aging. Because the metabolic and contractile properties of skeletal muscle play essential roles in the overall health and function of the organism, gaining a better understanding of the mechanisms underlying muscle mass and phenotype regulation, as well as key processes to exploit in countermeasure development, is of utmost importance. The primary research objectives of his laboratory span three, inter-related focus areas in human subjects:
Objective 1) to determine the cellular and molecular mechanisms driving muscle regeneration following damage or injury, while identifying differences responsible for regeneration impairment in the aging muscle.
Objective 2) to better understand the primary etiology of muscle atrophy in acute (burn, trauma) and chronic (sarcopenia, cachexia) conditions.
Objective 3) to determine key processes responsible for myofiber hypertrophy in response to mechanical overload, and to exploit these processes with countermeasures to promote muscle re-growth in atrophied patients.
To meet these objectives, they are using genomic, proteomic, and in vitro approaches to study the molecular regulation of muscle protein synthesis, proteolysis, and stem (satellite) cell function in humans experiencing atrophy and resistance training-induced hypertrophy. This translational research program takes full advantage of cellular and molecular studies in our Core Muscle Research Laboratory and in vivo functional assessments during clinical trials in the UAB Center for Exercise Medicine.
More about his research activites can be found here: www.uab.edu/exercise