BMB Section Seminar: Long circulating NP accumulate in granulomas via an EPR-related mechanism
Dr. Federico Fenaroli, Postdoc Section for Physiology and Cell Biology, IBV, UiO
The use of nano-sized carriers for drug delivery is are a promising therapeutic approach for the treatment of cancer and infectious diseases. Cancer in particular has attracted most attention and decades of studies have converged on a mechanism that explain how nanoparticles can reach solid tumors, the enhanced permeability and retention effect. Our work in zebrafish and mouse models shows that a related process is happening also during tuberculosis infection, a finding that may be of high importance in the design of new nanotherapeutics for treating this disease.