BMB seminar: Host-pathogen interaction studies to identify targets for host-directed therapies in Tuberculosis

Prof. Dr. Ulrich E. Schaible, Deputy Director - Research Center Borstel - Leibniz Lung Center, Director - Priority Program Infection Parkallee 1, 23845 Borstel

 

foto: fz-borstel

Tuberculosis (TB) is the most important bacterial infection of humans worldwide challenging global health with the emergence of multi drug resistant cases in alarming numbers. Its agent, Mycobacterium tuberculosis (Mtb), is a facultative intracellular pathogen, which can survive and proliferate inside innate host defense cells including macrophages. We study host-pathogen interactions in TB on the molecular, cellular, animal model level and recently extended it to TB patients. We focus on the question how the intracellular niche of Mtb determines the pathogen’s fate and its transmission, innate and acquired immune responses, pathogenesis, anti-mycobacterial drug efficacy and, ultimately outcome in patients. Research topics include (i) Characterizing the intracellular trafficking of mycobacteria, (ii) Role of mycobacterial cell wall lipids in mycobacterial virulence and immunity, (iii) Neutrophil - macrophage interactions in TB, (iv) Host-directed-therapy and Point-of Care diagnostics in TB, (v) Transmission of mycobacteria containing aerosols, (vi) Nano-particle based delivery of anti-TB drugs, (vii) Imaging of infection and immune processes in TB, (viii) Pulmonary micro ecology and lower respiratory tract microbiota, (ix)

Published Mar. 19, 2018 3:25 PM - Last modified Mar. 19, 2018 3:25 PM