Selected publications

Falnes, P.Ø., Johansen, R. F., and Seeberg, E.C. (2002) AlkB-mediated oxidative demethylation reverses DNA damage in Escherischia coli. Nature 419, 178-182.

Ougland, R., Zhang, C.M., Liiv, A., Johansen, R.F., Seeberg, E., Hou, Y.M, Remme, J., and Falnes, P.Ø. (2004) AlkB Restores the Biological Function of mRNA and tRNA Inactivated by Chemical Methylation. Mol. Cell 16, 107-116.

van den Born, E., Omelchenko, M., Bekkelund, A., Leihne, V, Koonin, E.V., Dolja, V.V, and Falnes, P. Ø. (2008) Viral AlkB proteins repair RNA damage by oxidative demethylation. Nucl. Acids Res 36, 5451-61

van den Born, E., Vågbø, C., Songe-Møller, L., Leihne, V., Lien, G.F., Leszczynska, G., Malkiewicz, A., Krokan, H.E., Kirpekar, F., Klungland, A. , and  Falnes, P.Ø. (2011) ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA, Nat. Commun. 2,  #172

Kernstock,S., Davydova,E., Jakobsson,M., Moen,A., Pettersen,S., Maelandsmo,G.M., Egge-Jacobsen,W. and Falnes,P.Ø. (2012) Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Nat.Commun.3, #1038

Jakobsson,M., Moen,A., Bousset, L., Egge-Jacobsen,W. Kernstock,S., Melki, R., and Falnes,P.Ø. (2013) Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation. J. Biol. Chem. 288, 27752–27763

Davydova, E., Ho, A.A.Y.,  Malecki, J., Moen, A., Enserink, J.M., Jakobsson,M., Loenarz, C., and Falnes, P.Ø. (2014) Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). J. Biol. Chem. 289, 30499-30510

Małecki, J., Ho, A.Y., Moen, A., Dahl, H.-A. and Falnes§, P.Ø. (2014** /2015) Human METTL20 is a Mitochondrial Lysine Methyltransferase that Targets the Beta Subunit of Electron Transfer Flavoprotein (ETFβ) and Modulates Its Activity. J. Biol. Chem., 290, 423-434

Falnes, P.Ø., Jakobsson, M.E., Davydova, E., Ho, A.Y., and Małecki, J. (2016) Protein lysine methylation by seven-β-strand methyltransferases (2016) J. Biochem. J., 473, 1995-2009 (Review article)

Jakobsson, M.E., Moen, A., and Falnes, P.Ø. (2016) Correspondence: On the enzymology and significance of HSPA1 lysine methylation, Nat.Commun., 7,  #11464

Malecki, J., Aileni V.K.,†, Ho, A.Y.Y., Schwarz, J., Moen A., Sørensen, V., Nilges, B.S.,  Jakobsson, M.E., Leidel, S.A.,  Falnes, P.Ø. (2017) The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). Nucl. Acids Res., 45, 4370-4389.

Jakobsson§, M.E., Malecki, J., Aileni V.K., Nilges, B.S., Moen A., Leidel, S.A., Falnes§, P.Ø. (2017) Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation. Nucl. Acids Res., 45, 8239-8254

Małecki, J., Jakobsson, M.E., Ho, A.Y.Y., Moen, A., Rustan, A., Falnes, P.Ø. (2017) Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation. J Biol Chem. 292, 17950-17962