Our review paper on the role of the Unfolded Protein Response and hormone-regulated cancers is now published in Trends in Cancer
Targeting the Unfolded Protein Response in Hormone-Regulated Cancers
Jin, Y., and Saatcioglu, F. 2020 Feb;6(2):160-171. doi: 10.1016/j.trecan.2019.12.001.
Cancer cells exploit many of the cellular adaptive responses to support their survival needs. One of these is the unfolded protein response (UPR), a highly conserved signaling pathway that is mounted in response to endoplasmic reticulum (ER) stress. Recent work showed that steroid hormones, in particular estrogens and androgens, regulate the canonical UPR pathways in breast cancer (BCa) and prostate cancer (PCa). In addition, UPR has pleiotropic effects in advanced disease and development of therapy resistance. These findings implicate the UPR pathway as a novel target in hormonally regulated cancers in the clinic. Here, we review the potential therapeutic value of recently developed small molecule inhibitors of UPR in hormone regulated cancers.