New paper about perineuronal nets in entorhinal cortex
Perineuronal nets (PNNs) are proposed as a key regulator of plasticity in the adult brain.
In this paper we show that the expression of PNNs differ between visual cortex, hippocampus and the medial entorhinal cortex (mEC).
Perineuronal nets in CA2, but not in CA1.
- While perineuronal nets colocalize with inhibitory PV+ neurons in visual cortex, they colocalize with excitatory (CaMKII) neurons in hippocampus area CA2.
- In entorhinal cortex PNNs assembles during postnatal development which coincides with reports on development of the grid cell’s activity pattern.
- Furthermore PV+ cells mature at an much earlier timepoint in entorhinal cortex compared to neocortex.
- The variable expression patterns of PNNs may reflect different levels of plasticity and wiring of the neural networks.
Congratulations to our PhD students Kristian Lensjø, Charlotte Christiansen og Simen Tennø for a great job!
Check out the paper in eNeuro: eNeuro 25 May 2017, ENEURO.0379-16.2017; DOI: https://doi.org/10.1523/ENEURO.0379-16.2017