Matthew Yoke Wui Ng
The cell adapts to an array of stresses such as nutrient starvation and hypoxia, in part, through an elegant lysosomal degradative pathway called autophagy. This pathway was first described by Christian de Duve, the discoverer of lysosomes, in 1963 and has only recently been brought back into the spotlight. Autophagy has been found to be a double edged sword, playing roles in both promoting and inhibiting tumorigenesis. I am especially interested in understanding the role of the autophagic machinery and lysosomal signaling in the clearance of cellular organelles.
- Abudu, Yakubu Princely; Pankiv, Serhiy; Mathai, Benan John; Lystad, Alf Håkon; Bindesbøll, Christian; Brenne, Hanne Britt; Ng, Matthew Yoke Wui; Thiede, Bernd; Yamamoto, Ai; Nthiga, Thaddaeus Mutugi; Lamark, Trond; Esguerra, Camila Vicencio; Johansen, Terje & Simonsen, Anne (2019). NIPSNAP1 and NIPSNAP2 act as “eat-me signal” for mitophagy. Developmental Cell. ISSN 1534-5807. 49(4), s 509- 525.e12 . doi: 10.1016/j.devcel.2019.03.013
- Repnik, Urska; Distefano, Marita Borg; Speth, Martin; NG, Matthew Yoke Wui; Progida, Cinzia; Hoflack, Bernard; Gruenberg, Jean & Griffiths, Gareth (2017). L-leucyl-L-leucine methyl ester does not release cysteine cathepsins to the cytosol but inactivates them in transiently permeabilized lysosomes. Journal of Cell Science. ISSN 0021-9533. 130(18), s 3124- 3140 . doi: 10.1242/jcs.204529