Pål Falnes

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Emneord: Livsvitenskap - life science

Publikasjoner

  • Aileni, Vinay Kumar; Davydova, Erna; Moen, Anders & Falnes, Pål (2017). A System for Enzymatic Lysine Methylation in a Desired Sequence Context. ACS Omega.  ISSN 2470-1343.  2, s 462- 469 . doi: 10.1021/acsomega.6b00486
  • Jakobsson, Magnus; Malecki, Jedrzej Mieczyslaw; Nilges, Benedikt S.; Moen, Anders; Leidel, Sebastian A. & Falnes, Pål (2017). Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation. Nucleic Acids Research.  ISSN 0305-1048.  45, s 8239- 8254 . doi: 10.1093/nar/gkx432
  • Malecki, Jedrzej Mieczyslaw; Aileni, Vinay Kumar; Ho, Angela Yeuan Yen; Schwarz, Juliane; Moen, Anders; Sørensen, Vigdis; Nilges, Benedikt S.; Jakobsson, Magnus; Leidel, Sebastian A. & Falnes, Pål (2017). The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). Nucleic Acids Research.  ISSN 0305-1048.  45(8), s 4370- 4389 . doi: 10.1093/nar/gkx002
  • Falnes, Pål; Jakobsson, Magnus; Davydova, Erna; Ho, Angela Yeuan Yen & Malecki, Jedrzej Mieczyslaw (2016). Protein lysine methylation by seven-β-strand methyltransferases. Biochemical Journal.  ISSN 0264-6021.  473(14), s 1995- 2009 . doi: 10.1042/BCJ20160117
  • Malecki, Jedrzej Mieczyslaw; Dahl, Helge-Andre; Moen, Anders; Davydova, Erna & Falnes, Pål (2016). The METTL20 homologue from agrobacterium tumefaciens is a dual specificity protein-lysine methyltransferase that targets ribosomal protein L7/L12 and the β subunit of electron transfer flavoprotein (ETFβ). Journal of Biological Chemistry.  ISSN 0021-9258.  291(18), s 9581- 9595 . doi: 10.1074/jbc.M115.709261
  • Fusser, Markus; Kernstock, Stefan; Aileni, Vinay Kumar; Jacobsen, Wolfgang Mathias; Falnes, Pål & Klungland, Arne (2015). Lysine methylation of the valosin-containing protein (VCP) is dispensable for development and survival of mice. PLoS ONE.  ISSN 1932-6203.  10(11) . doi: 10.1371/journal.pone.0141472 Fulltekst i vitenarkiv.
  • Jakobsson, Magnus; Davydova, Erna; Malecki, Jedrzej Mieczyslaw; Moen, Anders & Falnes, Pål (2015). Saccharomyces cerevisiae eukaryotic elongation factor 1A (eEF1A) is methylated at Lys-390 by a METTL21-like methyltransferase. PLoS ONE.  ISSN 1932-6203.  10(6) . doi: 10.1371/journal.pone.0131426 Fulltekst i vitenarkiv.
  • Jakobsson, Magnus; Moen, Anders; Davidson, Ben & Falnes, Pål (2015). Hsp70 (HSPA1) lysine methylation status as a potential prognostic factor in metastatic high-grade serous carcinoma. PLoS ONE.  ISSN 1932-6203.  10:e0140168(10) . doi: 10.1371/journal.pone.0140168 Fulltekst i vitenarkiv.
  • Malecki, Jedrzej Mieczyslaw; Ho, Angela Yeuan Yen; Moen, Anders; Dahl, Helge-Andre & Falnes, Pål (2015). Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity. Journal of Biological Chemistry.  ISSN 0021-9258.  290(1), s 423- 434 . doi: 10.1074/jbc.M114.614115
  • Zdzalik, Daria; Domanska, Anna; Prorok, Paulina; Kosicki, Konrad; Van den Born, Erwin; Falnes, Pål; Rizzo, Carmelo J.; Guengerich, F.Peter & Tudek, Barbara (2015). Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. DNA Repair.  ISSN 1568-7864.  30, s 1- 10 . doi: 10.1016/j.dnarep.2015.02.021
  • Davydova, Erna; Ho, Angela Yeuan Yen; Malecki, Jedrzej Mieczyslaw; Moen, Anders; Enserink, Jorrit; Jakobsson, Magnus; Loenarz, Christoph & Falnes, Pål (2014). Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). Journal of Biological Chemistry.  ISSN 0021-9258.  289(44), s 30499- 30510 . doi: 10.1074/jbc.M114.601658
  • Zdzalik, Daria; Vågbø, Cathrine Broberg; Kirpekar, F; Davydova, Erna; Puścian, Alicja; Maciejewska, Agnieszka M.; Krokan, Hans Einar; Klungland, Arne; Tudek, Barbara; Van den Born, Erwin & Falnes, Pål (2014). Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities. PLoS ONE.  ISSN 1932-6203.  9(6) . doi: 10.1371/journal.pone.0098729 Fulltekst i vitenarkiv.
  • Jakobsson, Magnus; Moen, Anders; Bousset, Luc; Jacobsen, Wolfgang Mathias; Kernstock, Jens Stefan; Melki, Ronald & Falnes, Pål (2013). Identification and characterization of a novel human methyltransferase modulating hsp70 Protein function through lysine methylation. Journal of Biological Chemistry.  ISSN 0021-9258.  288(39), s 27752- 27763 . doi: 10.1074/jbc.M113.483248
  • Lin, Fu-Jung; Shen, Li; Jang, Chuan-Wei; Falnes, Pål & Zhang, Yi (2013). Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression. PLoS Genetics.  ISSN 1553-7390.  9(5) . doi: 10.1371/journal.pgen.1003516
  • Bjørnstad, Linn; Meza, Trine Johansen; Otterlei, Marit; Olafsrud, Solveig Mjelstad; Meza-Zepeda, Leonardo Andrés & Falnes, Pål (2012). Human ALKBH4 Interacts with Proteins Associated with Transcription. PLoS ONE.  ISSN 1932-6203.  7(11) . doi: 10.1371/journal.pone.0049045 Fulltekst i vitenarkiv.
  • Kernstock, Jens Stefan; Davydova, Erna; Jakobsson, Magnus; Moen, Anders; Pettersen, Solveig; Mælandsmo, Gunhild; Jacobsen, Wolfgang Mathias & Falnes, Pål (2012). Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Nature Communications.  ISSN 2041-1723.  3 . doi: 10.1038/ncomms2041
  • Korvald, Hanne; Falnes, Pål; Lærdahl, Jon Kristen; Bjørås, Magnar & Alseth, Ingrun (2012). The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity. DNA Repair.  ISSN 1568-7864.  11(5), s 453- 462 . doi: 10.1016/j.dnarep.2012.01.014
  • Meza, Trine Johansen; Moen, Marivi; Vågbø, Cathrine Broberg; Krokan, Hans Einar; Klungland, Arne; Grini, Paul Eivind & Falnes, Pål (2012). The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Nucleic Acids Research.  ISSN 0305-1048.  40(14), s 6620- 6631 . doi: 10.1093/nar/gks327
  • Bjørnstad, Linn; Zoppellaro, Giorgio; Tomter, Ane Berg; Falnes, Pål & Andersson, K. Kristoffer (2011). Spectroscopic and Magnetic Studies of wild-type and mutant forms of the FeII and 2-oxoglutarate dependent decarboxylase ALKBH4. Biochemical Journal.  ISSN 0264-6021.  434(3), s 391- 398 . doi: 10.1042/BJ20101667 Vis sammendrag
  • Leihne, VIbeke; Kirpekar, F; Vågbø, Cathrine Broberg; Van den Born, Erwin; Krokan, Hans Einar; Grini, Paul Eivind; Meza, Trine Johansen & Falnes, Pål (2011). Roles of Trm9-and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA. Nucleic Acids Research.  ISSN 0305-1048.  39(17), s 7688- 7701 . doi: 10.1093/nar/gkr406
  • Van den Born, Erwin; Vågbø, Cathrine Broberg; Songe-Møller, Lene; Leihne, VIbeke; Lien, Guro Flor; Leszczynska, G; Malkiewicz, A; Krokan, Hans Einar; Kirpekar, F; Klungland, Arne & Falnes, Pål (2011). ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nature Communications.  ISSN 2041-1723.  2 . doi: 10.1038/ncomms1173
  • Songe-Møller, Lene; Van den Born, Erwin; Leihne, V; Vågbø, Cathrine Broberg; Kristoffersen, T; Krokan, Hans Einar; Kirpekar, F; Falnes, PO & Klungland, A (2010). Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding. Molecular and Cellular Biology.  ISSN 0270-7306.  30(7), s 1814- 1827 . doi: 10.1128/MCB.01602-09
  • Falnes, Pål; Van den Born, Erwin & Meza, Trine Johansen (2009). Demethylation of DNA and RNA by AlkB proteins, In Henri Grosjean (ed.),  DNA and RNA modification enzymes.  Landes Bioscience.  ISBN 978-1-58706-329-9.  Chapter 14.  s 170 - 180
  • Van den Born, Erwin; Bekkelund, Anders; Moen, Marivi; Omelchenko, M.V.; Klungland, Arne & Falnes, Pål (2009). Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria. Nucleic Acids Research.  ISSN 0305-1048.  37(21) . doi: 10.1093/nar/gkp774
  • Ringvoll, Jeanette; Moen, Marivi N.; Nordstrand, Line M.; Meira, Lisiane B.; Pang, Bo; Bekkelund, Anders; Dedon, Peter C.; Bjelland, Svein; Samson, Leona D.; Falnes, Pål Ø. & Klungland, Arne (2008). AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Research.  ISSN 0008-5472.  68(11), s 4142- 4149 Vis sammendrag
  • Van den Born, Erwin; Omelchenko, M.V.; Bekkelund, Anders; Leihne, VIbeke; Koonin, E. V.; Dolja, V.V. & Falnes, Pål (2008). Viral AlkB proteins repair RNA damage by oxidative demethylation. Nucleic Acids Research.  ISSN 0305-1048.  36(17), s 5451- 5461 . doi: 10.1093/nar/gkn519
  • Wærsted, Jeanette Ringvoll; Nabong, Marivi; Nordstrand, Line Mari; Meira, LB; Pang, B; Bekkelund, Anders; Dedon, PC; Bjelland, S; Samson, LD; Falnes, Pål & Klungland, Arne (2008). AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Research.  ISSN 0008-5472.  68(11), s 4142- 4149 . doi: 10.1158/0008-5472.CAN-08-0796 Vis sammendrag
  • Falnes, Pål; Klungland, Arne & Alseth, Ingrun (2007). Repair of methyl lesions in DNA and RNA by oxidative demethylation. Neuroscience.  ISSN 0306-4522.  145 . doi: 10.1016/j.neuroscience.2006.11.018
  • Ringvoll, Jeanette; Ringvoll, Jeanette; Nordstrand, Line M.; Vågbø, Cathrine Broberg; Vagbo, CB; Talstad, Vivi; Reite, Karen; Aas, Per Arne; Lauritzen, Knut H.; Liabakk, Nina-Beate; Bjørk, Alexandra; Doughty, Richard William; Falnes, Pål Ø.; Krokan, Hans Einar & Klungland, Arne (2006). Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO Journal.  ISSN 0261-4189.  25, s 2189- 2198
  • Falnes, Pål (2005). RNA repair - the latest addition to the toolbox for macromolecular maintenance. RNA Biology.  ISSN 1547-6286.  2(1), s 14- 16
  • Falnes, Pål (2004). Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins. Nucleic Acids Research.  ISSN 0305-1048.  32(21), s 6260- 6267
  • Ougland, Rune; Zhang, Chun-mei; Liiv, Aivar; Johansen, Rune F.; Seeberg, Erling Christen; Hou, Ya-ming; Remme, Jaanus & Falnes, Pål (2004). AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation. Molecular Cell.  ISSN 1097-2765.  16(1), s 107- 116
  • Aamodt, Randi; Falnes, Pål; Johansen, RF; Seeberg, Erling Christen & Bjørås, Magnar (2004). The Bacillus subtilis counterpart of the mammalian 3-methyladenine DNA glycosylase has hypoxanthine and 1,N-6-ethenoadenine as preferred substrates. Journal of Biological Chemistry.  ISSN 0021-9258.  279, s 13601- 13606
  • Falnes, Pål; Bjørås, Magnar; Bjoras, M; Aas, PA; Sundheim, Ottar & Seeberg, E (2004). Substrate specificities of bacterial and human AlkB proteins. Nucleic Acids Research.  ISSN 0305-1048.  30(11), s 3456- 3461
  • Falnes, Pål & Rognes, Torbjørn (2003). DNA repair by bacterial AlkB proteins. Research in Microbiology.  ISSN 0923-2508.  154, s 0923- 2508
  • Aas, Per Arne; Otterlei, Marit; Falnes, P.Ø; Vågbø, Cathrine; Skorpen, Frank; Akbari, Mansour; Sundheim, Ottar; Bjørås, Magnar; Slupphaug, Geir; Seeberg, Erling Christen & Krokan, Hans Einar (2003). Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature.  ISSN 0028-0836.  421, s 859- 863
  • Falnes, Pål; Johansen, R. F. & Seeberg, Erling Christen (2002). AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature.  ISSN 0028-0836.  419, s 178- 182 Vis sammendrag
  • Falnes, P.Ø.; Ariansen, Sarah Louise & Sandvig, Kirsten (2000). Requirement for prolonged action in the cytosol for optimal protein synthesis inhibition by diphteria toxin. Journal of Biological Chemistry.  ISSN 0021-9258.  275, s 4363- 4368
  • Falnes, P.Ø. & Sandvig, Kirsten (2000). Penetration of protein toxins into cells. Current Opinion in Cell Biology.  ISSN 0955-0674.  12, s 407- 413
  • Falnes, P.Ø.; Ariansen, Sarah Louise; Sandvig, Kirsten & Olsnes, Sjur (2000). Requirement for prolonged action in the cytosol for optimal protein synthesis inhibition by diphteria toxin. Journal of Biological Chemistry.  ISSN 0021-9258.  275, s 4363- 4368
  • Lanzrein, Markus; Falnes, P.Ø.; Sand, Olav & Olsnes, Sjur (1997). Structure-function relationship of the ion channel formed by diphtheria toxin in Vero cell membrane. Journal of Membrane Biology.  ISSN 0022-2631.  156, s 141- 148
  • Olsnes, Sjur; Klingenberg, Olav; Muños, R.; Rapak, A.; Falnes, P.Ø. & Wiedlocha, Antoni (1997). Toxins as transporting tools, In K. Aktories (ed.),  Bacterial toxins.  Chapman & Hall, Weinheim..  s 273 - 294
  • Rapak, A.; Falnes, P.Ø. & Olsnes, Sjur (1997). Retrogade transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  94, s 3783- 3788
  • Falnes, Pål & Olsnes, Sjur (1996). Farnesylation of a CaaX-motif as a measure of translocation of an externally added protein to the cytosol. Zentrbl. Bact. suppl..  28, s 343- 344
  • Olsnes, Sjur; Klingenberg, Olav; Falnes, Pål; Valdizan, Elsa; Lanzrein, Markus & Wiedlocha, Antoni (1996). Translocation of diphtheria toxin across cellular membranes. Zentrbl. Bact. suppl..  28, s 154- 160

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  • Falnes, Pål (2017). Identification and characterisation of lysine-specific methyltransferases in humans.
  • Aileni, Vinay Kumar; Davydova, Erna; Kernstock, Jens Stefan; Moen, Anders & Falnes, Pål (2016). VCP-KMT (METTL21D)-mediated lysine methylation of histone H3 peptide sequences grafted onto a VCP-derived scaffold.
  • Falnes, Pål (2016). Lysine methylation of non-histone proteins - new enzymes, new functions.
  • Falnes, Pål (2016). Metylering av DNA og proteiner - både skadelig og nødvendig.
  • Jakobsson, Magnus; Moen, Anders; Davidson, Ben & Falnes, Pål (2016). METTL21A-catalysed lysine methylation of Hsp70 proteins.
  • Jakobsson, Magnus; Moen, Anders & Falnes, Pål (2016). Correspondence: On the enzymology and significance of HSPA1 lysine methylation. Nature Communications.  ISSN 2041-1723.  7 . doi: 10.1038/ncomms11464
  • Falnes, Pål (2015). Discovering new human enzymes involved in methylation and demethylation of nucleic acids and proteins.
  • Falnes, Pål (2015). Discovering new human enzymes involved in methylation and demethylation of nucleic acids and proteins.
  • Falnes, Pål (2015). Merkelapper på DNA og proteiner – både skadelig og nødvendig..
  • Falnes, Pål (2015). Metylering av DNA og proteiner– skadelig og nødvendig.
  • Falnes, Pål & Ho, Angela Yeuan Yen (2015). Role of ALKBH8 in the Synthesis of Wobble Uridine Modifications in tRNA, In Christopher J. Schofield & Robert Hausinger (ed.),  2-Oxoglutarate-Dependent Oxygenases.  Royal Society of Chemistry.  ISBN 978-1-84973-950-4.  CHAPTER 10:.  s 275 - 288
  • Falnes, Pål (2014). Discovering new human enzymes involved in methylation and demethylation of nucleic acids and proteins.
  • Falnes, Pål (2014). Functional characterization of a novel family of protein lysine methyltransferases.
  • Falnes, Pål (2013). Role of the bifunctional ALKBH8 enzyme in the formation of modified wobble uridines in tRNA.
  • Falnes, Pål (2012). Merkelapper på DNA og proteiner – både skadelig og nødvendig.
  • Falnes, Pål (2012). Merkelapper på DNA og proteiner –både skadelig og nødvendig.
  • Bjørnstad, Linn; Zoppellaro, Giorgio; Tomter, Ane Berg; Falnes, Pål & Andersson, K. Kristoffer (2011). Spectroscopic and Magnetic Studies of wild-type and mutant forms of the FeII and 2-oxoglutarate dependent decarboxylase ALKBH4.
  • Meza, Trine Johansen; Moen, Marivi N.; Vågbø, Cathrine B.; Ulleland, Marius; Krokan, Hans Einar; Arne, Klungland; Grini, Paul Eivind & Falnes, Pål Ø. (2010). The DNA dioxygenase AtALKBH2 protects Arabidopsis thaliana against methylation damage.
  • Falnes, Pål (2009). AlkB-like dioxygenases - roles in nucleic acid repair and modification.
  • Falnes, Pål (2009). Oxidative demethylation of RNA by AlkB proteins.
  • Falnes, Pål; Van den Born, Erwin; Leihne, VIbeke; Meza, Trine Johansen; Songe-Møller, Lene & Klungland, Arne (2009). AlkB-like dioxygenases-roles in nucleic acid repair and modification.
  • Falnes, Pål (2008). "DNA and RNA repair by AlkB-mediated oxidative demethylation".
  • Falnes, Pål (2008). RNA repair by oxidative demethylation.
  • Falnes, Pål (2007). DNA and RNA repair by human and bacterial AlkB proteins.
  • Falnes, Pål (2007). Oxidative demethylation of DNA, RNA, and proteins by AlkB-like enzymes.
  • Falnes, Pål (2006). A novel mechanism for demethylation of DNA, RNA, and proteins.
  • Falnes, Pål (2006). Repair of methyl lesions in DNA and RNA by oxidative demetylation.
  • Falnes, Pål; Ougland, Rune; Bekkelund, Anders & Ulleland, Marius Andreas (2006). DNA and RNA repair by human and bacterial ALkB proteins.
  • Falnes, Pål (2005). AlkB proteins – in general and in Arabidopsis.
  • Ougland, Rune; Zhang, Chun-mei; Liiv, Aivar; Johansen, Rune F.; Seeberg, Erling; Hou, Ya-ming; Remme, Jaanus & Falnes, Pål (2005). Functional recovery of chemically methylated mRNA and tRNA by AlkB-mediated repair.
  • Falnes, Pål (2004). Recovery of RNA function upon AlkB mediated repair of alkyl lesions.
  • Falnes, Pål (2004). Repair of alkylation damage in DNA and RNA.
  • Ougland, Rune; Zhang, Chun-mei; Liiv, Aivar; Johansen, Rune F.; Seeberg, Erling Christen; Remme, Jaanus; Hou, Ya-ming & Falnes, Pål (2004). AlkB mediated repair of methyl lesions in mRNA and tRNA is accompanied by functional recovery.
  • Falnes, Pål (2003). Repair of DNA and RNA by AlkB mediated oxidative demethylation.
  • Falnes, Pål (2003). Repair of alkylated DNA by oxidative demethylation.
  • Falnes, Pål (2003). Repair of both DNA and RNA by AlkB mediated oxidative demethylation.
  • Falnes, Pål; Johansen, Rune F. & Seeberg, Erling Christen (2003). A third mechanism for DNA damage reversal catalysed by AlkB protein in E. coli.
  • Eriksen, Stig; Falnes, Pål; Sandvik, K.; Olsnes, Sjur & Sand, Olav (1993). Diphteria toxin induces a cation-selective conductance increase and membrane depolarization in Vero cells. Acta Physiologica Scandinavica.  ISSN 0001-6772.  140, s 13A

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Publisert 4. nov. 2010 14:38 - Sist endret 29. mars 2017 15:38