Tore Bonge-Hansen

Associate Professor - Organic chemistry
Image of Tore Bonge-Hansen
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Phone +47 22855386
Room Ø 303
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Visiting address Sem Sælands vei 26 0371 Oslo
Postal address Postboks 1033 0315 Oslo

Academic Interests

Our research interests are within the areas of asymmetric organic synthesis and medicinal chemistry.

We focus on the development of new reactions and new reagents which can be useful for the synthesis of drugs and pharmaceutical ingredients.

Our medicinal chemistry focus is on CNS-related diseases such as depression.

Teaching

Tags: Chemistry, Organic chemistry

Publications

  • Peeters, Sara; Berntsen, Linn Neerbye; Rongved, Pål & Bonge-Hansen, Tore (2019). Cyclopropanation–ring expansion of 3-chloroindoles with α-halodiazoacetates: novel synthesis of 4-quinolone-3-carboxylic acid and norfloxacin. Beilstein Journal of Organic Chemistry. ISSN 2195-951X. 15, p. 2156–2160. doi: 10.3762/bjoc.15.212 Full text in Research Archive
  • Levchenko, Vladimir; Sundsli, Bård Edgar Vestheim; Øien-Ødegaard, Sigurd; Tilset, Mats; Hansen, Finn Knut & Hansen, Tore Bonge (2018). Bottom-Up Synthesis of Acrylic and Styrylic Rh11 Carboxylate Polymer Beads: Solid-Supported Analogs Rh2(OAc)4. European Journal of Organic Chemistry. ISSN 1434-193X. p. 6150–6157. doi: 10.1002/ejoc.201800953
  • Viktorsson, Elvar Örn; Grøthe, Bendik Melling; Aesoy, Reidun; Sabir, Misbah; Snellingen, Simen & Åstrand, Ove Alexander Høgmoen [Show all 11 contributors for this article] (2017). Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 25(7), p. 2285–2293. doi: 10.1016/j.bmc.2017.02.058
  • Mortén, Magnus; Hennum, Martin & Bonge-Hansen, Tore (2016). On the cause of low thermal stability of ethyl halodiazoacetates. Beilstein Journal of Organic Chemistry. ISSN 2195-951X. 12, p. 1590–1597. doi: 10.3762/bjoc.12.155
  • Mortén, Magnus; Hennum, Martin & Bonge-Hansen, Tore (2015). Synthesis of quinoline-3-carboxylates by a Rh(II)-catalyzed cyclopropanation-ring expansion reaction of indoles with halodiazoacetates. Beilstein Journal of Organic Chemistry. ISSN 2195-951X. 11, p. 1944–1949. doi: 10.3762/bjoc.11.210
  • Yadav, Vitthal Narayan; Comotti, Angiolina; Sozzani, Piero; Bracco, Silvia; Bonge-Hansen, Tore & Hennum, Martin [Show all 7 contributors for this article] (2015). Microporous Molecular Materials from Dipeptides Containing Non-proteinogenic Residues. Angewandte Chemie International Edition. ISSN 1433-7851. 54(52), p. 15684–15688. doi: 10.1002/anie.201507321
  • Bolsønes, Marianne; Bonge, Hanne Therese & Bonge-Hansen, Tore (2014). Intramolecular cyclopropanation of bromodiazoacetates. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. ISSN 0936-5214. 25(2), p. 221–224. doi: 10.1055/s-0033-1340170
  • Aasheim, Jens Harald; Fliegl, Heike; Uggerud, Einar; Bonge-Hansen, Tore & Eisenstein, Odile (2014). Stereoselectivity through a network of non-classical CH weak interactions: A prospective study of a bicyclic organocatalytic scaffold. New Journal of Chemistry. ISSN 1144-0546. 38(12), p. 5975–5982. doi: 10.1039/c4nj01460j
  • Kaupang, Åsmund; Gorbitz, Carl Henrik & Bonge-Hansen, Tore (2013). A solid-state oxidation of 1,1,3,3-tetramethylguanidinium 4-methylbenzenesulfinate to 1,1,3,3-tetramethylguanidinium 4-methylbenzenesulfonate. Acta Crystallographica Section C: Crystal Structure Communications. ISSN 0108-2701. 69, p. 778–+. doi: 10.1107/S0108270113015011
  • Kaupang, Åsmund & Bonge-Hansen, Tore (2013). α-Bromodiazoacetamides – a new class of diazo compounds for catalyst-free, ambient temperature intramolecular C–H insertion reactions. Beilstein Journal of Organic Chemistry. ISSN 2195-951X. 9, p. 1407–1413. doi: 10.3762/bjoc.9.157
  • Kaupang, Åsmund; Gorbitz, Carl Henrik & Bonge-Hansen, Tore (2013). N,N'-Bis(2-diazoacetyl)piperazine. Acta Crystallographica Section E: Structure Reports Online. ISSN 1600-5368. 69(8). doi: 10.1107/S1600536813018801
  • Rulli, Giuseppe; Fredriksen, Kim Alex; Duangdee, Nongnaphat; Bonge-Hansen, Tore; Berkessel, Albrecht & Gröger, Harald (2013). Asymmetric Organocatalytic Aldol Reaction in Water: Mechanistic Insights and Development of a Semi-Continuously Operating Process. Synthesis (Stuttgart). ISSN 0039-7881. 45(18), p. 2512–2519. doi: 10.1055/s-0033-1338509
  • Schnaars, Christian; Hennum, Martin & Bonge-Hansen, Tore (2013). Nucleophilic Halogenations of Diazo Compounds, a Complementary Principle for the Synthesis of Halodiazo Compounds: Experimental and Theoretical Studies. Journal of Organic Chemistry. ISSN 0022-3263. 78(15), p. 7488–7497. doi: 10.1021/jo401050c
  • Hughes, Rachael Anne; Tølløfsrud, Magnus; Bryant, Nathan; Kaboli, Massoud; Hennum, Martin & Bonge-Hansen, Tore (2013). Diastereoselective synthesis of cyclopropyl melatonin analogues. Tetrahedron Letters. ISSN 0040-4039. 54(4), p. 318–320. doi: 10.1016/j.tetlet.2012.11.037
  • Bonge, Hanne Therese & Hansen, Tore (2011). Halodiazoacetates as useful tools for selective halo-functionalization. Pure and Applied Chemistry. ISSN 0033-4545. 83(3), p. 565–575. doi: 10.1351/PAC-CON-10-10-18
  • Yadav, Vitthal Narayan; Hansen, Tore & Gorbitz, Carl Henrik (2011). 1,1 '-(4,4 '-Bipiperidine-1,1 '-diyl)bis(2,2,2-trifluoroethanone). Acta Crystallographica Section E: Structure Reports Online. ISSN 1600-5368. 67, p. O1691–U733. doi: 10.1107/S1600536811022434
  • Kaupang, Åsmund; Gorbitz, Carl Henrik & Hansen, Tore (2011). 2-Diazo-1-(1,1-dioxothiomorpholin-4-yl)ethanone. Acta Crystallographica Section E: Structure Reports Online. ISSN 1600-5368. 67, p. O1844–U2037. doi: 10.1107/S1600536811023774
  • Thvedt, Thor Håkon Krane; Kristensen, Tor Erik Holt; Sundby, Eirik; Hansen, Tore & Hoff, Bård Helge (2011). Enantioselectivity, swelling and stability of 4-hydroxyprolinol containing acrylic polymer beads in the asymmetric reduction of ketones. Tetrahedron: asymmetry. ISSN 0957-4166. 22(24), p. 2172–2178. doi: 10.1016/j.tetasy.2011.12.001 Full text in Research Archive
  • Kaupang, Åsmund; Gorbitz, Carl Henrik & Hansen, Tore (2010). tert-Butyl 4-(2-diazoacetyl)piperazine-1-carboxylate. Acta Crystallographica Section E: Structure Reports Online. ISSN 1600-5368. 66, p. O2199–U467. doi: 10.1107/S1600536810016211
  • Bonge, Hanne Therese & Hansen, Tore (2010). Computational Study of Cyclopropanation Reactions with Halodiazoacetates. Journal of Organic Chemistry. ISSN 0022-3263. 75(7), p. 2309–2320. doi: 10.1021/jo100113b
  • Kristensen, Tor Erik Holt & Hansen, Tore (2010). Polymer-Supported Chiral Organocatalysts: Synthetic Strategies for the Road Towards Affordable Polymeric Immobilization. European Journal of Organic Chemistry. ISSN 1434-193X. p. 3179–3204. doi: 10.1002/ejoc.201000319
  • Kristensen, Tor Erik Holt; Vestli, Kristian; Jakobsen, Martin Gjerde; Hansen, Finn Knut & Hansen, Tore (2010). General Approach for Preparation of Polymer-Supported Chiral Organocatalysts via Acrylic Copolymerization. Journal of Organic Chemistry. ISSN 0022-3263. 75(5), p. 1620–1629. doi: 10.1021/jo902585j
  • Bonge, Hanne Therese & Hansen, Tore (2010). Computational Study of C-H Insertion Reactions with Ethyl Bromodiazoacetate. European Journal of Organic Chemistry. ISSN 1434-193X. p. 4355–4359. doi: 10.1002/ejoc.201000531
  • Bonge, Hanne Therese & Hansen, Tore (2010). Insights on Rh(II) carbenoid reactivity. Tetrahedron Letters. ISSN 0040-4039. 51(41), p. 5378–5381. doi: 10.1016/j.tetlet.2010.07.116
  • Bonge, Hanne Therese & Hansen, Tore (2010). Computational comparison of Rh-2(esp)(2) and Rh-2(O2CH)(4) as catalysts in a carbenoid reaction. Tetrahedron Letters. ISSN 0040-4039. 51(40), p. 5298–5301. doi: 10.1016/j.tetlet.2010.07.169
  • Bonge, Hanne Therese; Kaboli, Massoud & Hansen, Tore (2010). Rh(II) catalysts with 4-hydroxyproline-derived ligands. Tetrahedron Letters. ISSN 0040-4039. 51(41), p. 5375–5377. doi: 10.1016/j.tetlet.2010.07.115
  • Bonge, Hanne Therese & Hansen, Tore (2009). Intermolecular C-H and Si-H Insertion Reactions with Halodiazoacetates. Synthesis (Stuttgart). ISSN 0039-7881. p. 91–96. doi: 10.1055/s-0028-1083272
  • Kristensen, Tor Erik Holt; Hansen, Finn Knut & Hansen, Tore (2009). The Selective O-Acylation of Hydroxyproline as a Convenient Method for the Large-Scale Preparation of Novel Proline Polymers and Amphiphiles. European Journal of Organic Chemistry. ISSN 1434-193X. p. 387–395. doi: 10.1002/ejoc.200800941
  • Gorbitz, Carl Henrik; Hansen, Tore & Vestli, Kristian (2009). (1S,5R)-1-(4-Fluorophenyl)-3-azoniabicyclo[3.1.0]hexane chloride. Acta Crystallographica Section E: Structure Reports Online. ISSN 1600-5368. 65. doi: 10.1107/S1600536809006953
  • Gorbitz, Carl Henrik; Hansen, Tore & Vestli, Kristian (2009). (1S,5R)-1-(3,4-Dichlorophenyl)-3-oxabicyclo[3.1.0]hexan-2-one. Acta Crystallographica Section E: Structure Reports Online. ISSN 1600-5368. 65. doi: 10.1107/S1600536809007533
  • Kristensen, Tor Erik Holt; Vestli, Kristian; Fredriksen, Kim A; Hansen, Finn Knut & Hansen, Tore (2009). Synthesis of Acrylic Polymer Beads for Solid-Supported Proline-Derived Organocatalysts. Organic Letters. ISSN 1523-7060. 11(14), p. 2968–2971. doi: 10.1021/ol901134v
  • Kristensen, Tor Erik Holt; Vestli, Kristian; Hansen, Finn Knut & Hansen, Tore (2009). New Phenylglycine-Derived Primary Amine Organocatalysts for the Preparation of Optically Active Warfarin. European Journal of Organic Chemistry. ISSN 1434-193X. p. 5185–5191. doi: 10.1002/ejoc.200900664
  • Rosenberg, Marianne Lenes; Aasheim, Jens Harald; Trebbin, M; Uggerud, Einar & Hansen, Tore (2009). Synthesis of a 1,3,4,5-tetrahydrobenzindole beta-ketoester. Tetrahedron Letters. ISSN 0040-4039. 50(47), p. 6506–6508. doi: 10.1016/j.tetlet.2009.09.032
  • Bonge, Hanne Therese & Hansen, Tore (2008). Rhodium(II) catalysed three-component coupling: a novel reaction of in situ generated iodonium ylides. Tetrahedron Letters. ISSN 0040-4039. 49, p. 57–61. doi: 10.1016/j.tetlet.2007.11.021
  • Bonge, Hanne Therese; Pintea, Beniamin Nicolae & Hansen, Tore (2008). Highly efficient formation of halodiazoacetates and their use in stereoselective synthesis of halocyclopropanes. Organic and biomolecular chemistry. ISSN 1477-0520. 6(20), p. 3670–3672. doi: 10.1039/b814374a
  • Kaupang, Åsmund; Bolsones, M; Gamadeku, T; Hansen, Tore; Hennum, MJ & Gorbitz, Carl Henrik (2008). 2SR,3RS)-Benzyl[4-chloro-1-(4-chlorophenyl)-1-methoxycarbonyl-2-butyl]ammonium chloride. Acta Crystallographica Section E: Structure Reports Online. ISSN 1600-5368. 64, p. O2038–U4798. doi: 10.1107/S1600536808030742
  • Roggen, Heidi; Kehler, J; Stensbol, TB & Hansen, Tore (2007). Synthesis of enantiomerically pure milnacipran analogs and inhibition of dopamine, serotonin, and norepinephrine transporters. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 17. doi: 10.1016/j.bmcl.2007.02.054
  • Bruvoll, M; Hansen, Tore & Uggerud, Einar (2007). Organocatalysis: quantum of nuclephilic addition to alpha,beta-unsaturated carbonyl compounds. Journal of Physical Organic Chemistry. ISSN 0894-3230. 20, p. 206–213. doi: 10.1002/poc.1170
  • Melby, Trude; Hughes, Rachael Anne & Hansen, Tore (2007). Diastereoselective synthesis of 1-aryl-2-amino-cyclopropane carboxylates. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. ISSN 0936-5214. p. 2277–2279. doi: 10.1055/s-2007-985587
  • Bonge, Hanne Therese & Hansen, Tore (2007). Cyclopropanation of olefins with nitromethane. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. ISSN 0936-5214. doi: 10.1055/s-2006-958437

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  • Viktorsson, Elvar Örn; Åstrand, Ove Alexander Høgmoen; Bonge-Hansen, Tore; Doskeland, Stein Ove; Herfindal, Lars & Rongved, Pål (2016). Total synthesis and initial antileukemic evaluation of the phenazine 5,10-dioxide natural products iodinin and myxin.
  • Levchenko, Vladimir; Øien-Ødegaard, Sigurd; Tilset, Mats & Bonge-Hansen, Tore (2015). Novel strategy for Synthesis of Rhodium(II)-containing Polymer Catalysts.
  • Grøthe, Bendik Melling; Snellingen, Simen; Viktorsson, Elvar Örn; Prandina, Anthony; Åstrand, Ove Alexander Høgmoen & Bonge-Hansen, Tore [Show all 7 contributors for this article] (2015). The first efficient synthesis and preliminary biological effect of the 1,6-dihydroxyphenazine-N5,N10-dioxide (Iodinin) and 1-hydroxy-6-methoxyphenazine-N5,N10-dioxide (Myxin).
  • Kristensen, Tor Erik & Bonge-Hansen, Tore (2013). Polymer and Mesoporous Material Supported Organocatalysts. In Dalko, Peter I. (Eds.), Comprehensive Enantioselective Organocatalysis: Catalysts, Reactions, and Applications, Volume 2. Wiley-VCH. ISSN 978-3-527-33236-6. p. 651–672. doi: 10.1002/9783527658862.ch23
  • Hennum, Martin; Odden, Hege Hortemo; Gundersen, Lise-Lotte & Hansen, Tore (2012). Methodology towards the total synthesis of asmarines.
  • Kristensen, Tor Erik & Bonge-Hansen, Tore (2011). Synthesis of Chiral Catalysts Supported on Organic Polymers. In Gruttadauria, Michelangelo & Giacalone, Francesco (Ed.), Catalytic Methods in Asymmetric Synthesis: Advanced Materials, Techniques, and Applications. John Wiley & Sons. ISSN 978-0-470-64136-1. p. 209–256. doi: 10.1002/9781118087992.ch4
  • Bonge, Hanne Therese & Hansen, Tore (2008). Novel carbenoid reactions.
  • Kristensen, Tor Erik & Hansen, Tore (2008). Immobilization of proline by polymerization of acrylic derivatives.
  • Hansen, Finn Knut; Hansen, Tore & Kristensen, Tor Erik (2007). Solid phase organocatalysis.
  • Bonge, Hanne Therese & Hansen, Tore (2007). Nitromethane as a iodonium ylide precursor.
  • Rosenberg, Marianne Lenes & Hansen, Tore (2007). Synthesis of an analogue of Uhle's ketone.
  • Aasheim, Jens & Hansen, Tore (2007). Investigating organocatalytic reactions by supercomputing.
  • Boman, Kjartan & Hansen, Tore (2007). New catalysts for asymmetric organocatalysis.
  • Berntsen, Linn Neerbye; Hansen, Tore Bonge & Rongved, Pål (2018). Rh(II)-catalyzed cyclopropanation-ring expansion of 7-azaindoles with halodiazoacetates and indoles with halodiazophosphonates. Kjemisk Institutt, Universitetet i Oslo.
  • Levchenko, Vladimir; Bonge-Hansen, Tore & Tilset, Mats (2016). Design and Synthesis of Novel Rh(II)-containing Polymer Catalysts. Organometallic Gold(III) Catalysis in Organic Synthesis. Universitetet i Oslo.
  • Araba, Taofik Olasile; Bonge-Hansen, Tore & Hansen, Finn Knut (2016). Progress towards the synthesis and self-assembly of amphiphilic drug conjugates of Iodinin. Universitetet i Oslo.
  • Grøthe, Bendik Melling; Bonge-Hansen, Tore & Rongved, Pål (2015). Syntese av myxin og myxinderivater som potensielle legemidler mot akutt myelogen leukemi. Universitetet i Oslo.
  • Yadav, Vitthal Narayan; Görbitz, Carl Henrik & Bonge-Hansen, Tore (2013). Design and Synthesis of Microporous Dipeptide Structures and Guanidinium-carboxylate-based Organic Supramolecular Materials. Universitetet i Oslo.

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Published Nov. 11, 2010 9:00 AM - Last modified Sep. 24, 2012 11:41 AM

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